{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:37:27Z","timestamp":1792658247050,"version":"4.5.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":381,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1016\/j.jacc.2012.03.051","type":"journal-article","created":{"date-parts":[[2012,7,9]],"date-time":"2012-07-09T18:37:18Z","timestamp":1341859038000},"page":"224-229","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":143,"title":["The Immediate and Long-Term Impact of Pregnancy on Aortic Growth Rate and Mortality in Women With Marfan Syndrome"],"prefix":"10.1016","volume":"60","author":[{"given":"Ryan T.","family":"Donnelly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelangi M.","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Kocolas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anji T.","family":"Yetman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2012.03.051_bib1","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/humu.1380010504","article-title":"Clustering of fibrillin (FBN1) missense mutations in Marfan syndrome patients at cysteine residues in EGF-like domains","volume":"1","author":"Dietz","year":"1992","journal-title":"Hum Mutat"},{"key":"10.1016\/j.jacc.2012.03.051_bib2","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1161\/01.CIR.91.3.728","article-title":"Marfan syndrome","volume":"91","author":"Finkbohner","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2012.03.051_bib3","first-page":"137","article-title":"The prevalence and clinical impact of obesity in adults with Marfan syndrome","volume":"26","author":"Yetman","year":"2010","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.jacc.2012.03.051_bib4","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0301-2115(01)00314-1","article-title":"The Marfan syndrome and pregnancy: a retrospective study in a Dutch population","volume":"98","author":"Lind","year":"2001","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.jacc.2012.03.051_bib5","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1471-0528.1997.tb11045.x","article-title":"Outcome of pregnancy in women with Marfan syndrome","volume":"104","author":"Lipscomb","year":"1997","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.jacc.2012.03.051_bib6","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/0002-9343(81)90365-X","article-title":"Maternal and fetal complications of pregnancy in the Marfan syndrome","volume":"71","author":"Pyeritz","year":"1981","journal-title":"Am J Med"},{"key":"10.1016\/j.jacc.2012.03.051_bib7","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ijcard.2008.04.035","article-title":"Maternal complication of pregnancy in Marfan syndrome","volume":"136","author":"Pacini","year":"2009","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacc.2012.03.051_bib8","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ijcard.2005.07.017","article-title":"Obstetric complications in Marfan syndrome","volume":"110","author":"Meijboom","year":"2006","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacc.2012.03.051_bib9","first-page":"723","article-title":"Obstetric and gynecologic complications in women with Marfan syndrome","volume":"48","author":"Rahman","year":"2003","journal-title":"J Reprod Med"},{"key":"10.1016\/j.jacc.2012.03.051_bib10","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.1016\/j.jacc.2010.02.015","article-title":"2010 ACCF\/AHA\/AATS\/ACR\/ASA\/SCA\/SCAI\/SIR\/STS\/SVM guidelines for the diagnosis and management of patients with thoracic aortic disease","volume":"55","author":"Hiratzka","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2012.03.051_bib11","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/(SICI)1096-8628(19960424)62:4<417::AID-AJMG15>3.0.CO;2-R","article-title":"Revised diagnostic criteria for the Marfan syndrome","volume":"62","author":"DePaepe","year":"1996","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.jacc.2012.03.051_bib12","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/ng1511","article-title":"A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2","volume":"37","author":"Loeys","year":"2005","journal-title":"Nat Genet"},{"key":"10.1016\/j.jacc.2012.03.051_bib13","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.ahj.2007.06.024","article-title":"Rationale and design of a randomized clinical trial of beta-blocker therapy (atenolol) versus angiotensin II receptor blocker therapy (losartan) in individuals with Marfan syndrome","volume":"154","author":"Lacro","year":"2007","journal-title":"Am Heart J"},{"key":"10.1016\/j.jacc.2012.03.051_bib14","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/0002-9149(89)90430-X","article-title":"Two-dimensional echocardiographic aortic root dimensions in normal children and adults","volume":"64","author":"Roman","year":"1989","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2012.03.051_bib15","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/0002-9378(95)90655-X","article-title":"A prospective longitudinal evaluation of pregnancy in the Marfan syndrome","volume":"173","author":"Rossiter","year":"1995","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jacc.2012.03.051_bib16","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1093\/eurheartj\/ehi103","article-title":"Pregnancy and aortic root growth in the Marfan syndrome: a prospective study","volume":"26","author":"Meijboom","year":"2005","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2012.03.051_bib17","first-page":"1073","article-title":"Maternal hemodynamics and aortic diameter in normal and hypertensive pregnancies","volume":"78","author":"Easterling","year":"1991","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.jacc.2012.03.051_bib18","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1111\/j.1471-0528.2002.02028.x","article-title":"Marfan's syndrome: successful pregnancy after aortic root and arch replacement","volume":"109","author":"Williams","year":"2002","journal-title":"BJOG"},{"key":"10.1016\/j.jacc.2012.03.051_bib19","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.jtcvs.2006.03.059","article-title":"Valve-sparing operation in a young woman with Marfan syndrome: a word of caution","volume":"132","author":"Chavanon","year":"2006","journal-title":"J Thor Cardiovasc Surg"},{"key":"10.1016\/j.jacc.2012.03.051_bib20","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0195-668X(03)00098-8","article-title":"Expert consensus document on management of cardiovascular diseases during pregnancy","volume":"24","author":"de Oliveira","year":"2003","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2012.03.051_bib21","first-page":"e80","article-title":"Canadian Cardiovascular Society 2009 Consensus Conference on the management of adults with congenital heart disease: outflow tract obstruction, coarctation of the aorta, tetralogy of Fallot, Ebstein anomaly and Marfan's syndrome","volume":"26","author":"Silversides","year":"2010","journal-title":"Can J Cardiol"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109712015094?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109712015094?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T12:52:12Z","timestamp":1760014332000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109712015094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["S0735109712015094"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2012.03.051","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Immediate and Long-Term Impact of Pregnancy on Aortic Growth Rate and Mortality in Women With Marfan Syndrome","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2012.03.051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}