{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T15:41:50Z","timestamp":1770910910357,"version":"3.50.1"},"reference-count":21,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":417,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1016\/j.jacc.2012.04.010","type":"journal-article","created":{"date-parts":[[2012,7,2]],"date-time":"2012-07-02T19:02:07Z","timestamp":1341255727000},"page":"157-164","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Assessment of Pulmonary Endothelial Function During Invasive Testing in Children and Adolescents With Idiopathic Pulmonary Arterial Hypertension"],"prefix":"10.1016","volume":"60","author":[{"given":"Christian","family":"Apitz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rainer","family":"Zimmermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Kreuder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Jux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heiner","family":"Latus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joern","family":"Pons-K\u00fchnemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ines","family":"Kock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Bride","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karsten Grosse","family":"Kreymborg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ina","family":"Michel-Behnke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dietmar","family":"Schranz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2012.04.010_bib1","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1097\/01.mop.0000163356.51027.c1","article-title":"Idiopathic pulmonary arterial hypertension in children","volume":"17","author":"Rosenzweig","year":"2005","journal-title":"Curr Opin Pediatr"},{"key":"10.1016\/j.jacc.2012.04.010_bib2","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1136\/heart.88.6.658","article-title":"Pulmonary hypertension in the young","volume":"88","author":"Haworth","year":"2002","journal-title":"Heart"},{"key":"10.1016\/j.jacc.2012.04.010_bib3","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1056\/NEJM199507273330403","article-title":"Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension","volume":"333","author":"Giaid","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2012.04.010_bib4","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1161\/01.CIR.87.2.440","article-title":"Impairment of endothelium-dependent pulmonary artery relaxation in children with congenital heart disease and abnormal pulmonary hemodynamics","volume":"87","author":"Celermajer","year":"1993","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2012.04.010_bib5","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1136\/hrt.69.4.298","article-title":"In vivo detection of endothelium dependent and independent pulmonary artery relaxation in children","volume":"69","author":"Celermajer","year":"1993","journal-title":"Br Heart J"},{"key":"10.1016\/j.jacc.2012.04.010_bib6","first-page":"208","article-title":"Pulmonary flow reserve in children with idiopathic pulmonary arterial hypertension: implications for diagnosis and therapy","volume":"11","author":"Zimmermann","year":"2006","journal-title":"Eur J Med Res"},{"key":"10.1016\/j.jacc.2012.04.010_bib7","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1253\/circj.70.49","article-title":"Comparable prognostic value of vasodilator response to acetylcholine in brachial and coronary arteries for predicting long-term cardiovascular events in suspected coronary artery disease","volume":"70","author":"Takase","year":"2006","journal-title":"Circ J"},{"key":"10.1016\/j.jacc.2012.04.010_bib8","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1183\/09031936.93.03060633","article-title":"Acetylcholine and adenosine diphosphate cause endothelium-dependent relaxation of isolated human pulmonary arteries","volume":"3","author":"Dinh-Xuan","year":"1990","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jacc.2012.04.010_bib9","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ppedcard.2009.09.003","article-title":"Pulmonary arterial hypertension in children: diagnostic work-up and challenges","volume":"27","author":"Rosenzweig","year":"2009","journal-title":"Prog Pediatr Cardiol"},{"key":"10.1016\/j.jacc.2012.04.010_bib10","doi-asserted-by":"crossref","first-page":"343","DOI":"10.7326\/0003-4819-115-5-343","article-title":"Survival in patients with primary pulmonary hypertension","volume":"115","author":"D'Alonzo","year":"1991","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jacc.2012.04.010_bib11","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1056\/NEJM199207093270203","article-title":"The effect of high doses of calcium-channel blockers on survival in primary pulmonary hypertension","volume":"327","author":"Rich","year":"1992","journal-title":"New Engl J Med"},{"key":"10.1016\/j.jacc.2012.04.010_bib12","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/j.jacc.2009.01.004","article-title":"ACCF\/AHA 2009 expert consensus document on pulmonary hypertension: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association","volume":"53","author":"McLaughlin","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2012.04.010_bib13","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1093\/eurheartj\/ehp297","volume":"30","author":"Gali\u00e8","year":"2009","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2012.04.010_bib14","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1136\/hrt.2009.182378","article-title":"Childhood idiopathic pulmonary arterial hypertension: a national cohort study","volume":"96","author":"Moledina","year":"2010","journal-title":"Heart"},{"key":"10.1016\/j.jacc.2012.04.010_bib15","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1161\/CIRCULATIONAHA.104.488486","article-title":"Long-term response to calcium channel blockers in idiopathic pulmonary arterial hypertension","volume":"111","author":"Sitbon","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2012.04.010_bib16","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1161\/01.CIR.99.9.1197","article-title":"Vasodilator therapy for primary pulmonary hypertension in children","volume":"99","author":"Barst","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2012.04.010_bib17","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1093\/eurheartj\/ehr282","article-title":"Acute pulmonary vasodilator response in paediatric and adult pulmonary arterial hypertension: occurrence and prognostic value when comparing three response criteria","volume":"32","author":"Douwes","year":"2011","journal-title":"Eur Heart J"},{"issue":"Suppl","key":"10.1016\/j.jacc.2012.04.010_bib18","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1016\/j.jacc.2009.04.018","article-title":"Cellular and molecular basis of pulmonary arterial hypertension","volume":"54","author":"Morrell","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2012.04.010_bib19","first-page":"134","article-title":"Role of the adventitia in pulmonary vascular remodeling","volume":"21","author":"Stenmark","year":"2006","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.jacc.2012.04.010_bib20","series-title":"Pediatric Pulmonary Hypertension","first-page":"315","article-title":"Medical management of severe pediatric pulmonary arterial hypertension","author":"Ivy","year":"2011"},{"key":"10.1016\/j.jacc.2012.04.010_bib21","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1161\/01.CIR.0000138104.83366.E9","article-title":"Outcomes in children with idiopathic pulmonary arterial hypertension","volume":"110","author":"Yung","year":"2004","journal-title":"Circulation"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073510971201409X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073510971201409X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T12:51:48Z","timestamp":1760014308000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S073510971201409X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["S073510971201409X"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2012.04.010","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessment of Pulmonary Endothelial Function During Invasive Testing in Children and Adolescents With Idiopathic Pulmonary Arterial Hypertension","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2012.04.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}