{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:19:18Z","timestamp":1791317958332,"version":"4.3.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,2,18]],"date-time":"2014-02-18T00:00:00Z","timestamp":1392681600000},"content-version":"vor","delay-in-days":382,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.jacc.2012.11.025","type":"journal-article","created":{"date-parts":[[2013,1,2]],"date-time":"2013-01-02T15:45:33Z","timestamp":1357141533000},"page":"615-621","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"title":["Intracoronary Enalaprilat to Reduce Microvascular Damage During Percutaneous Coronary Intervention (ProMicro) Study"],"prefix":"10.1016","volume":"61","author":[{"given":"Fabio","family":"Mangiacapra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron J.","family":"Peace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Di Serafino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stylianos A.","family":"Pyxaras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jozef","family":"Bartunek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Wyffels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy R.","family":"Heyndrickx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Wijns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"De Bruyne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Barbato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2012.11.025_bib1","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1056\/NEJM199209033271001","article-title":"Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction","volume":"327","author":"Pfeffer","year":"1992","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2012.11.025_bib2","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/0140-6736(93)90604-F","article-title":"ACE inhibitors for myocardial infarction and unstable angina","volume":"341","author":"Yusuf","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2012.11.025_bib3","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1056\/NEJM200001203420301","article-title":"Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators","volume":"342","author":"Yusuf","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2012.11.025_bib4","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/S0140-6736(03)14286-9","article-title":"Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study)","volume":"362","author":"Fox","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2012.11.025_bib5","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/j.jacc.2007.01.060","article-title":"Pretreatment with intracoronary enalaprilat protects human myocardium during percutaneous coronary angioplasty","volume":"49","author":"Leesar","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2012.11.025_bib6","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1365-2796.2006.01757.x","article-title":"Intracoronary enalaprilat during angioplasty for acute myocardial infarction: alleviation of postischaemic neurohumoral and inflammatory stress?","volume":"261","author":"Schaefer","year":"2007","journal-title":"J Intern Med"},{"key":"10.1016\/j.jacc.2012.11.025_bib7","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/S0735-1097(98)00611-1","article-title":"Abnormal flow-mediated epicardial vasomotion in human coronary arteries is improved by angiotensin-converting enzyme inhibition: a potential role of bradykinin","volume":"33","author":"Prasad","year":"1999","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2012.11.025_bib8","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1161\/01.CIR.0000017433.90061.2E","article-title":"Angiotensin-converting enzyme inhibitors improve coronary flow reserve in dilated cardiomyopathy by a bradykinin-mediated, nitric oxide-dependent mechanism","volume":"105","author":"Nikolaidis","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2012.11.025_bib9","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/S0002-9149(01)02112-9","article-title":"Effects of intracoronary low-dose enalaprilat as an adjunct to primary percutaneous transluminal coronary angiography in acute myocardial infarction","volume":"88","author":"Kurz","year":"2001","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2012.11.025_bib10","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1161\/01.CIR.0000017199.09457.3D","article-title":"Coronary thermodilution to assess flow reserve","volume":"105","author":"Pijls","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2012.11.025_bib11","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1016\/j.jacc.2003.03.001","article-title":"Effects intravenous dobutamine on coronary vasomotion in humans","volume":"42","author":"Barbato","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2012.11.025_bib12","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1161\/01.CIR.0000080700.98607.D1","article-title":"Novel index for invasively assessing the coronary microcirculation","volume":"107","author":"Fearon","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2012.11.025_bib13","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1161\/01.CIR.0000143893.18451.0E","article-title":"Epicardial stenosis severity does not affect minimal microcirculatory resistance","volume":"110","author":"Aarnoudse","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2012.11.025_bib14","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1161\/CIRCULATIONAHA.105.603522","article-title":"Invasive assessment of the coronary microcirculation: superior reproducibility and less hemodynamic dependence of index of microcirculatory resistance compared with coronary flow reserve","volume":"113","author":"Ng","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2012.11.025_bib15","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jacc.2009.06.062","article-title":"Current concepts of integrated coronary physiology in the catheterization laboratory","volume":"55","author":"Kern","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2012.11.025_bib16","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ehj.2003.11.009","article-title":"Validation of coronary flow reserve measurements by thermodilution in clinical practice","volume":"25","author":"Barbato","year":"2004","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2012.11.025_bib17","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1161\/01.CIR.0000153270.25541.72","article-title":"Role of \u03b22 adrenergic receptors in human atherosclerotic coronary arteries","volume":"111","author":"Barbato","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2012.11.025_bib18","doi-asserted-by":"crossref","first-page":"439","DOI":"10.2459\/JCM.0b013e328351725a","article-title":"High cholesterol levels are associated with coronary microvascular dysfunction","volume":"13","author":"Mangiacapra","year":"2012","journal-title":"J Cardiovasc Med"},{"key":"10.1016\/j.jacc.2012.11.025_bib19","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1161\/CIRCULATIONAHA.107.187397","article-title":"Universal definition of myocardial infarction","volume":"116","author":"Thygesen","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2012.11.025_bib20","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.jacc.2009.03.063","volume":"54","author":"Prasad","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2012.11.025_bib21","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.jacc.2007.11.059","article-title":"Direct stenting for stable angina pectoris is associated with reduced periprocedural microcirculatory injury compared with stenting after pre-dilation","volume":"51","author":"Cuisset","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2012.11.025_bib22","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/S0195-668X(02)00802-3","article-title":"Direct stenting","volume":"24","author":"Barbato","year":"2003","journal-title":"Eur Heart J"},{"issue":"Suppl J","key":"10.1016\/j.jacc.2012.11.025_bib23","first-page":"J2","article-title":"Mechanism of protective effects of ACE inhibition on coronary artery disease","volume":"19","author":"Dzau","year":"1998","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2012.11.025_bib24","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1161\/01.CIR.90.4.2056","article-title":"Emerging role of angiotensin-converting enzyme inhibitors in cardiac and vascular protection","volume":"90","author":"Lonn","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2012.11.025_bib25","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.atherosclerosis.2011.02.044","article-title":"Angiotensin converting enzyme inhibitors effect on endothelial dysfunction: a meta-analysis of randomised controlled trials","volume":"216","author":"Shahin","year":"2011","journal-title":"Atherosclerosis"},{"issue":"3A","key":"10.1016\/j.jacc.2012.11.025_bib26","doi-asserted-by":"crossref","first-page":"2H","DOI":"10.1016\/S0002-9149(98)00484-6","article-title":"Systemic hypertension and coronary artery disease: the link","volume":"82","author":"Lembo","year":"1998","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2012.11.025_bib27","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1161\/01.CIR.102.24.2938","article-title":"Randomized comparison of elective stent implantation and coronary balloon angioplasty guided by online quantitative angiography and intracoronary Doppler","volume":"102","author":"Di Mario","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2012.11.025_bib28","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1093\/eurheartj\/ehq277","article-title":"Guidelines on myocardial revascularization","volume":"31","author":"Wijns","year":"2010","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2012.11.025_bib29","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1016\/j.ehj.2004.09.003","article-title":"Alpha-adrenergic receptor blockade and hyperaemic response in patients with intermediate coronary stenoses","volume":"25","author":"Barbato","year":"2004","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2012.11.025_bib30","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/j.amjcard.2005.07.078","article-title":"Effect of phentolamine on the hyperemic response to adenosine in patients with microvascular disease","volume":"96","author":"Aarnoudse","year":"2005","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2012.11.025_bib31","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1136\/heart.87.6.549","article-title":"Prognostic implication of cardiac troponin T increase following stent implantation","volume":"87","author":"Herrmann","year":"2002","journal-title":"Heart"},{"key":"10.1016\/j.jacc.2012.11.025_bib32","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1016\/j.jacc.2006.04.102","article-title":"Isolated elevation in troponin T after percutaneous coronary intervention is associated with higher long-term mortality","volume":"48","author":"Prasad","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2012.11.025_bib33","first-page":"1020","article-title":"Prognostic value of cardiac troponin-I or troponin-T elevation following nonemergent percutaneous coronary intervention: a meta-analysis","volume":"77","author":"Feldman","year":"2011","journal-title":"Catheter Cardiovasc Interv"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109712056628?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109712056628?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T12:56:29Z","timestamp":1760014589000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109712056628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S0735109712056628"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2012.11.025","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intracoronary Enalaprilat to Reduce Microvascular Damage During Percutaneous Coronary Intervention (ProMicro) Study","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2012.11.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}