{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:38:40Z","timestamp":1790419120748,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"14","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,4,9]],"date-time":"2014-04-09T00:00:00Z","timestamp":1397001600000},"content-version":"vor","delay-in-days":373,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.jacc.2012.11.070","type":"journal-article","created":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T17:20:04Z","timestamp":1364836804000},"page":"1489-1495","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":109,"title":["Outcome of Combined Stenotic and Regurgitant Aortic Valve Disease"],"prefix":"10.1016","volume":"61","author":[{"given":"Robert","family":"Zilberszac","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Gabriel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schemper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Zahler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Czerny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Maurer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Rosenhek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2012.11.070_bib1","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0140-6736(06)69208-8","article-title":"Burden of valvular heart diseases: a population-based study","volume":"368","author":"Nkomo","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2012.11.070_bib2","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0195-668X(03)00201-X","article-title":"A prospective survey of patients with valvular heart disease in Europe: the Euro Heart Survey on Valvular Heart Disease","volume":"24","author":"Iung","year":"2003","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2012.11.070_bib3","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1136\/hrt.2010.212282","article-title":"Management of multiple valve disease","volume":"97","author":"Unger","year":"2011","journal-title":"Heart"},{"key":"10.1016\/j.jacc.2012.11.070_bib4","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1093\/eurheartj\/ehr061","article-title":"ESC Working Group on Valvular Heart Disease position paper: assessing the risk of interventions in patients with valvular heart disease","volume":"33","author":"Rosenhek","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2012.11.070_bib5","first-page":"230","article-title":"Guidelines on the management of valvular heart disease: the Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology","volume":"28","author":"Vahanian","year":"2007","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2012.11.070_bib6","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jacc.2008.05.007","volume":"52","author":"Bonow","year":"2008","journal-title":"J Am Coll Cardiol"},{"issue":"Suppl 1","key":"10.1016\/j.jacc.2012.11.070_bib7","first-page":"61","article-title":"Aortic stenosis","volume":"38","author":"Ross","year":"1968","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2012.11.070_bib8","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1161\/01.CIR.99.14.1851","article-title":"Mortality and morbidity of aortic regurgitation in clinical practice: a long-term follow-up study","volume":"99","author":"Dujardin","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2012.11.070_bib9","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0002-9149(82)90184-9","article-title":"Timing of operation for chronic aortic regurgitation","volume":"50","author":"Bonow","year":"1982","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2012.11.070_bib10","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/S0735-1097(97)00205-2","article-title":"Optimizing timing of surgical correction in patients with severe aortic regurgitation: role of symptoms","volume":"30","author":"Klodas","year":"1997","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2012.11.070_bib11","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0002-8703(95)90450-6","article-title":"Clinical outcome of severe asymptomatic chronic aortic regurgitation: a long-term prospective follow-up study","volume":"130","author":"Tornos","year":"1995","journal-title":"Am Heart J"},{"key":"10.1016\/j.jacc.2012.11.070_bib12","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1056\/NEJM200008313430903","article-title":"Predictors of outcome in severe, asymptomatic aortic stenosis","volume":"343","author":"Rosenhek","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2012.11.070_bib13","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1161\/01.CIR.95.9.2262","article-title":"Prospective study of asymptomatic valvular aortic stenosis: clinical, echocardiographic, and exercise predictors of outcome","volume":"95","author":"Otto","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2012.11.070_bib14","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ehj.2003.12.002","article-title":"Mild and moderate aortic stenosis: natural history and risk stratification by echocardiography","volume":"25","author":"Rosenhek","year":"2004","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2012.11.070_bib15","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1161\/CIRCULATIONAHA.109.894170","article-title":"Natural history of very severe aortic stenosis","volume":"121","author":"Rosenhek","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2012.11.070_bib16","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0735-1097(86)80460-0","article-title":"Determination of the stenotic aortic valve area in adults using Doppler echocardiography","volume":"7","author":"Otto","year":"1986","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2012.11.070_bib17","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/ejechocard\/jeq030","article-title":"European Association of Echocardiography recommendations for the assessment of valvular regurgitation","volume":"11","author":"Lancellotti","year":"2010","journal-title":"Eur J Echocardiogr"},{"key":"10.1016\/j.jacc.2012.11.070_bib18","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0894-7317(03)00335-3","article-title":"Recommendations for evaluation of the severity of native valvular regurgitation with two-dimensional and Doppler echocardiography","volume":"16","author":"Zoghbi","year":"2003","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jacc.2012.11.070_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ejechocard\/jen303","article-title":"Echocardiographic assessment of valve stenosis: EAE\/ASE recommendations for clinical practice","volume":"10","author":"Baumgartner","year":"2009","journal-title":"Eur J Echocardiogr"},{"key":"10.1016\/j.jacc.2012.11.070_bib20","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1161\/01.CIR.102.5.558","article-title":"Assessment of severity of aortic regurgitation using the width of the vena contracta: a clinical color Doppler imaging study","volume":"102","author":"Tribouilloy","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2012.11.070_bib21","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0197-2456(96)00075-X","article-title":"A note on quantifying follow-up in studies of failure time","volume":"17","author":"Schemper","year":"1996","journal-title":"Control Clin Trials"},{"key":"10.1016\/j.jacc.2012.11.070_bib22","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1161\/01.CIR.0000155623.48408.C5","article-title":"Frequency by decades of unicuspid, bicuspid, and tricuspid aortic valves in adults having isolated aortic valve replacement for aortic stenosis, with or without associated aortic regurgitation","volume":"111","author":"Roberts","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2012.11.070_bib23","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0025-6196(12)60317-6","article-title":"Surgical pathology of combined aortic stenosis and insufficiency: a study of 213 cases","volume":"60","author":"Subramanian","year":"1985","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.jacc.2012.11.070_bib24","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1136\/hrt.82.5.607","article-title":"Influence of left ventricular relaxation on the pressure half time of aortic regurgitation","volume":"82","author":"de Marchi","year":"1999","journal-title":"Heart"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073510971300394X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073510971300394X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T12:58:31Z","timestamp":1760014711000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S073510971300394X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":24,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["S073510971300394X"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2012.11.070","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Outcome of Combined Stenotic and Regurgitant Aortic Valve Disease","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2012.11.070","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}