{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:44:42Z","timestamp":1791179082395,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"19","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,5,14]],"date-time":"2014-05-14T00:00:00Z","timestamp":1400025600000},"content-version":"vor","delay-in-days":378,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1016\/j.jacc.2012.12.051","type":"journal-article","created":{"date-parts":[[2013,3,14]],"date-time":"2013-03-14T01:15:23Z","timestamp":1363223723000},"page":"1956-1961","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":172,"title":["Effect of Intensive Versus Moderate Lipid-Lowering Therapy on Epicardial Adipose Tissue in Hyperlipidemic Post-Menopausal Women"],"prefix":"10.1016","volume":"61","author":[{"given":"Nikolaos","family":"Alexopoulos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bekir H.","family":"Melek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chesnal D.","family":"Arepalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory-Randell","family":"Hartlage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengjia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungjin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur E.","family":"Stillman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Raggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2012.12.051_bib1","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.2174\/138161207781039670","article-title":"Epicardial adipose tissue as new cardio-metabolic risk marker and potential therapeutic target in the metabolic syndrome","volume":"13","author":"Iacobellis","year":"2007","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.jacc.2012.12.051_bib2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2217\/17584299.4.1.55","article-title":"Epicardial adipose tissue as a cardiovascular risk marker","volume":"4","author":"McLean","year":"2009","journal-title":"Clin Lipidol"},{"key":"10.1016\/j.jacc.2012.12.051_bib3","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.atherosclerosis.2009.11.020","article-title":"Epicardial adipose tissue and coronary artery plaque characteristics","volume":"210","author":"Alexopoulos","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jacc.2012.12.051_bib4","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ijcard.2011.04.021","article-title":"Association between epicardial adipose tissue volume and characteristics of non-calcified plaques assessed by coronary computed tomographic angiography","volume":"161","author":"Oka","year":"2012","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacc.2012.12.051_bib5","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.atherosclerosis.2012.02.029","article-title":"Association of pericardial fat and coronary high-risk lesions as determined by cardiac CT","volume":"222","author":"Schlett","year":"2012","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jacc.2012.12.051_bib6","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1001\/jama.291.9.1071","article-title":"Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis: a randomized controlled trial","volume":"291","author":"Nissen","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.jacc.2012.12.051_bib7","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1161\/CIRCULATIONAHA.104.512681","article-title":"Aggressive versus moderate lipid-lowering therapy in hypercholesterolemic postmenopausal women: Beyond Endorsed Lipid Lowering with EBT Scanning (BELLES)","volume":"112","author":"Raggi","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2012.12.051_bib8","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1148\/radiology.208.3.9722864","article-title":"Coronary artery disease: improved reproducibility of calcium scoring with an electron-beam CT volumetric method","volume":"208","author":"Callister","year":"1998","journal-title":"Radiology"},{"key":"10.1016\/j.jacc.2012.12.051_bib9","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.atherosclerosis.2012.06.006","article-title":"Epicardial adipose tissue is increased in patients with systemic lupus erythematosus","volume":"223","author":"Lipson","year":"2012","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jacc.2012.12.051_bib10","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.atherosclerosis.2011.10.014","article-title":"Weight change modulates epicardial fat burden: a 4-year serial study with non-contrast computed tomography","volume":"220","author":"Nakazato","year":"2012","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jacc.2012.12.051_bib11","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0021-9150(00)00709-7","article-title":"Pericardial fat accumulation in men as a risk factor for coronary artery disease","volume":"157","author":"Taguchi","year":"2001","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jacc.2012.12.051_bib12","doi-asserted-by":"crossref","first-page":"499","DOI":"10.3945\/ajcn.2008.27358","article-title":"The association of pericardial fat with incident coronary heart disease: the Multi-Ethnic Study of Atherosclerosis (MESA)","volume":"90","author":"Ding","year":"2009","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jacc.2012.12.051_bib13","doi-asserted-by":"crossref","first-page":"5163","DOI":"10.1210\/jc.2003-030698","article-title":"Echocardiographic epicardial adipose tissue is related to anthropometric and clinical parameters of metabolic syndrome: a new indicator of cardiovascular risk","volume":"88","author":"Iacobellis","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jacc.2012.12.051_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1475-2840-5-1","article-title":"Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease","volume":"5","author":"Baker","year":"2006","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.jacc.2012.12.051_bib15","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.amjcard.2011.06.012","article-title":"Cardiac 64-multislice computed tomography reveals increased epicardial fat volume in patients with acute coronary syndrome","volume":"108","author":"Harada","year":"2011","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2012.12.051_bib16","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.1161\/CIRCULATIONAHA.105.585703","article-title":"Determinants of arterial wall remodeling during lipid-lowering therapy: serial intravascular ultrasound observations from the Reversal of Atherosclerosis with Aggressive Lipid Lowering Therapy (REVERSAL) trial","volume":"113","author":"Schoenhagen","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2012.12.051_bib17","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1001\/jama.295.13.jpc60002","article-title":"Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial","volume":"295","author":"Nissen","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.jacc.2012.12.051_bib18","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1056\/NEJMoa040583","article-title":"Intensive versus moderate lipid lowering with statins after acute coronary syndromes","volume":"350","author":"Cannon","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2012.12.051_bib19","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1056\/NEJMoa042378","article-title":"C-reactive protein levels and outcomes after statin therapy","volume":"352","author":"Ridker","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2012.12.051_bib20","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1056\/NEJMoa0807646","article-title":"Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein","volume":"359","author":"Ridker","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2012.12.051_bib21","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1161\/CIRCULATIONAHA.105.568147","article-title":"Effect of intensive versus standard lipid-lowering treatment with atorvastatin on the progression of calcified coronary atherosclerosis over 12 months: a multicenter, randomized, double-blind trial","volume":"113","author":"Schmermund","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2012.12.051_bib22","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1161\/01.CIR.104.3.249","article-title":"Effects of lipid-lowering by simvastatin on human atherosclerotic lesions: a longitudinal study by high-resolution, noninvasive magnetic resonance imaging","volume":"104","author":"Corti","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2012.12.051_bib23","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1161\/hq1001.098463","article-title":"Effects of prolonged intensive lipid-lowering therapy on the characteristics of carotid atherosclerotic plaques in vivo by MRI: a case-control study","volume":"21","author":"Zhao","year":"2001","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jacc.2012.12.051_bib24","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1161\/ATVBAHA.107.160663","article-title":"Effects of statins on adipose tissue inflammation: their inhibitory effect on MyD88-independent IRF3\/IFN-beta pathway in macrophages","volume":"28","author":"Abe","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jacc.2012.12.051_bib25","doi-asserted-by":"crossref","first-page":"5262","DOI":"10.1210\/en.2009-0603","article-title":"Impact of simvastatin on adipose tissue: pleiotropic effects in vivo","volume":"150","author":"Khan","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.jacc.2012.12.051_bib26","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s00259-011-1994-7","article-title":"The effects of 3-month atorvastatin therapy on arterial inflammation, calcification, abdominal adipose tissue and circulating biomarkers","volume":"39","author":"Wu","year":"2012","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.jacc.2012.12.051_bib27","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1111\/eci.12000","article-title":"Effects of ezetimibe on visceral fat in the metabolic syndrome: a randomised controlled study","volume":"42","author":"Takase","year":"2012","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.jacc.2012.12.051_bib28","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1161\/01.CIR.85.1.391","article-title":"A definition of the intima of human arteries and of its atherosclerosis-prone regions","volume":"85","author":"Stary","year":"1992","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2012.12.051_bib29","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1742-4682-9-11","article-title":"Neovascularization of coronary tunica intima (DIT) is the cause of coronary atherosclerosis","volume":"9","author":"Subbotin","year":"2012","journal-title":"Theor Biol Med Model"},{"key":"10.1016\/j.jacc.2012.12.051_bib30","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1161\/CIRCULATIONAHA.105.578955","article-title":"Neovascularization in human atherosclerosis","volume":"113","author":"Moreno","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2012.12.051_bib31","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1148\/radiol.11101264","article-title":"Carotid artery atherosclerosis: effect of intensive lipid therapy on the vasa vasorum-evaluation by using dynamic contrast-enhanced MR imaging","volume":"260","author":"Dong","year":"2011","journal-title":"Radiology"},{"key":"10.1016\/j.jacc.2012.12.051_bib32","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.jcct.2008.08.008","article-title":"Volumetric measurement of pericardial adipose tissue from contrast-enhanced coronary computed tomography angiography: a reproducibility study","volume":"2","author":"Nichols","year":"2008","journal-title":"J Cardiovasc Comput Tomogr"},{"key":"10.1016\/j.jacc.2012.12.051_bib33","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1007\/s12350-010-9235-1","article-title":"Epicardial adipose tissue volume and coronary artery calcium to predict myocardial ischemia on positron emission tomography-computed tomography studies","volume":"17","author":"Janik","year":"2010","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.jacc.2012.12.051_bib34","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.amjcard.2008.04.002","article-title":"Relation of epicardial and pericoronary fat to coronary atherosclerosis and coronary artery calcium in patients undergoing coronary angiography","volume":"102","author":"Gorter","year":"2008","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2012.12.051_bib35","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.atherosclerosis.2011.09.041","article-title":"Increased volume of epicardial fat is an independent risk factor for accelerated progression of sub-clinical coronary atherosclerosis","volume":"220","author":"Yerramasu","year":"2012","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jacc.2012.12.051_bib36","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.jacc.2005.03.077","article-title":"Early and late benefits of high-dose atorvastatin in patients with acute coronary syndromes: results from the PROVE IT-TIMI 22 trial","volume":"46","author":"Ray","year":"2005","journal-title":"J Am Coll Cardiol"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109713010024?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109713010024?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T12:58:59Z","timestamp":1760014739000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109713010024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":36,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["S0735109713010024"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2012.12.051","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of Intensive Versus Moderate Lipid-Lowering Therapy on Epicardial Adipose Tissue in Hyperlipidemic Post-Menopausal Women","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2012.12.051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}