{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:10:29Z","timestamp":1791141029204,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"23","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,12,10]],"date-time":"2014-12-10T00:00:00Z","timestamp":1418169600000},"content-version":"vor","delay-in-days":374,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.jacc.2013.05.089","type":"journal-article","created":{"date-parts":[[2013,8,28]],"date-time":"2013-08-28T17:46:25Z","timestamp":1377711985000},"page":"2188-2196","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"title":["Major Bleeding During HeartMate II Support"],"prefix":"10.1016","volume":"62","author":[{"given":"Matthew C.","family":"Bunte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene H.","family":"Blackstone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Thuita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Fowler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Joseph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aska","family":"Ozaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall C.","family":"Starling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas G.","family":"Smedira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria M.","family":"Mountis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2013.05.089_bib1","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.jacc.2009.03.055","article-title":"Extended mechanical circulatory support with a continuous-flow rotary left ventricular assist device","volume":"54","author":"Pagani","year":"2009","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2013.05.089_bib2","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1016\/j.jacc.2010.10.062","volume":"57","author":"Starling","year":"2011","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2013.05.089_bib3","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1056\/NEJMoa0909938","article-title":"Advanced heart failure treated with continuous-flow left ventricular assist device","volume":"361","author":"Slaughter","year":"2009","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2013.05.089_bib4","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1016\/j.athoracsur.2011.06.081","article-title":"Lessons learned from experience with over 100 consecutive HeartMate II left ventricular assist devices","volume":"92","author":"John","year":"2011","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jacc.2013.05.089_bib5","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1161\/CIRCULATIONAHA.111.040246","article-title":"Bleeding and thrombosis in patients with continuous-flow ventricular assist devices","volume":"125","author":"Eckman","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2013.05.089_bib6","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.athoracsur.2010.11.007","article-title":"Bleeding complications and blood product utilization with left ventricular assist device implantation","volume":"91","author":"Schaffer","year":"2011","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jacc.2013.05.089_bib7","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.jtcvs.2010.03.037","article-title":"Post-cardiac transplant survival after support with a continuous-flow left ventricular assist device: impact of duration of left ventricular assist device support and other variables","volume":"140","author":"John","year":"2010","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jacc.2013.05.089_bib8","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.healun.2010.01.011","article-title":"Clinical management of continuous-flow left ventricular assist devices in advanced heart failure","volume":"29","author":"Slaughter","year":"2010","journal-title":"J\u00a0Heart Lung Transplant"},{"key":"10.1016\/j.jacc.2013.05.089_bib9","unstructured":"INTERMACS Working Group (2008, Oct 30). Manual of Operations for the Interagency Registry for Mechanically Assisted Circulatory Support: Adverse Events Criteria (Version 2.3) [Word document]. Available at: http:\/\/www.uab.edu\/ctsresearch\/intermacs\/Appendices_092107.htm. Accessed July 6, 2010."},{"key":"10.1016\/j.jacc.2013.05.089_bib10","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)\u2013a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2009","journal-title":"J\u00a0Biomed Inform"},{"key":"10.1016\/j.jacc.2013.05.089_bib11","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.healun.2009.05.018","article-title":"Low thromboembolism and pump thrombosis with the HeartMate II left ventricular assist device: analysis of outpatient anti-coagulation","volume":"28","author":"Boyle","year":"2009","journal-title":"J\u00a0Heart Lung Transplant"},{"key":"10.1016\/j.jacc.2013.05.089_bib12","series-title":"Applied Life Data Analysis","author":"Nelson","year":"1982"},{"key":"10.1016\/j.jacc.2013.05.089_bib13","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1080\/01621459.1986.10478314","article-title":"The decomposition of time-varying hazard into phases, each incorporating a separate stream of concomitant information","volume":"81","author":"Blackstone","year":"1986","journal-title":"J\u00a0Am Stat Assoc"},{"key":"10.1016\/j.jacc.2013.05.089_bib14","series-title":"The Statistical Analysis of Failure Time Data","author":"Kalbfleisch","year":"2002"},{"key":"10.1016\/j.jacc.2013.05.089_bib15","series-title":"Multiple Imputation for Nonresponse in Surveys","author":"Rubin","year":"1987"},{"key":"10.1016\/j.jacc.2013.05.089_bib16","series-title":"Analysis of Incomplete Multivariate Data","author":"Schafer","year":"1997"},{"key":"10.1016\/j.jacc.2013.05.089_bib17","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1023\/A:1018054314350","article-title":"Bagging predictors","volume":"24","author":"Breiman","year":"1996","journal-title":"Machine Learning"},{"key":"10.1016\/j.jacc.2013.05.089_bib18","doi-asserted-by":"crossref","unstructured":"Kransdorf E, Moriguchi J, Kittleson M, et\u00a0al. The use of the Model for End-Stage Liver Disease score predicts 90-day mortality in patients undergoing Heartmate II implantation. Paper presented at: American Heart Association Scientific Sessions; November 5, 2012; Los Angeles, CA.","DOI":"10.1161\/circ.126.suppl_21.A9724"},{"key":"10.1016\/j.jacc.2013.05.089_bib19","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1016\/j.jacc.2008.03.009","article-title":"The right ventricular failure risk score a pre-operative tool for assessing the risk of right ventricular failure in left ventricular assist device candidates","volume":"51","author":"Matthews","year":"2008","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2013.05.089_bib20","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1161\/CIRCULATIONAHA.108.838656","article-title":"Model for end-stage liver disease score predicts left ventricular assist device operative transfusion requirements, morbidity, and mortality","volume":"121","author":"Matthews","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2013.05.089_bib21","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.jtcvs.2009.11.020","article-title":"Right ventricular failure in patients with the HeartMate II continuous-flow left ventricular assist device: incidence, risk factors, and effect on outcomes","volume":"139","author":"Kormos","year":"2010","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jacc.2013.05.089_bib22","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.ejcts.2007.12.047","article-title":"Non-surgical bleeding in patients with ventricular assist devices could be explained by acquired von Willebrand disease","volume":"33","author":"Geisen","year":"2008","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.jacc.2013.05.089_bib23","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1016\/j.jacc.2009.02.048","article-title":"Severely impaired von Willebrand factor-dependent platelet aggregation in patients with a continuous-flow left ventricular assist device (HeartMate II)","volume":"53","author":"Klovaite","year":"2009","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2013.05.089_bib24","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1161\/CIRCHEARTFAILURE.109.877597","article-title":"Acquired von Willebrand syndrome in patients with an axial flow left ventricular assist device","volume":"3","author":"Meyer","year":"2010","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jacc.2013.05.089_bib25","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1056\/NEJMoa067758","article-title":"Use of a continuous-flow device in patients awaiting heart transplantation","volume":"357","author":"Miller","year":"2007","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2013.05.089_bib26","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.jacc.2010.05.016","article-title":"Acquired von Willebrand syndrome after continuous-flow mechanical device support contributes to a high prevalence of bleeding during long-term support and at the time of transplantation","volume":"56","author":"Uriel","year":"2010","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2013.05.089_bib27","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.jacc.2012.09.055","article-title":"Predicting survival in patients receiving continuous flow left ventricular assist devices: the HeartMate II risk score","volume":"61","author":"Cowger","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2013.05.089_bib28","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1016\/j.athoracsur.2009.08.011","article-title":"Evaluation of risk indices in continuous-flow left ventricular assist device patients","volume":"88","author":"Schaffer","year":"2009","journal-title":"Ann Thorac Surg"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109713039004?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109713039004?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:03:44Z","timestamp":1760015024000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109713039004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":28,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S0735109713039004"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2013.05.089","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Major Bleeding During HeartMate II Support","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2013.05.089","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}