{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:27:40Z","timestamp":1761863260243,"version":"build-2065373602"},"reference-count":29,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,2,11]],"date-time":"2015-02-11T00:00:00Z","timestamp":1423612800000},"content-version":"vor","delay-in-days":375,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"crossref"}]},{"name":"ISIS Pharmaceuticals"},{"DOI":"10.13039\/100004328","name":"Genentech","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004328","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.jacc.2013.08.1639","type":"journal-article","created":{"date-parts":[[2013,10,23]],"date-time":"2013-10-23T22:15:51Z","timestamp":1382566551000},"page":"478-480","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["New Therapeutic Targets for Calcific Aortic Valve Stenosis"],"prefix":"10.1016","volume":"63","author":[{"given":"Ming-Yow","family":"Hung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph L.","family":"Witztum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sotirios","family":"Tsimikas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2013.08.1639_bib1","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1161\/CIRCULATIONAHA.110.006767","article-title":"Calcific aortic valve disease: not simply a degenerative process. A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: calcific aortic valve disease\u20142011 update","volume":"124","author":"Rajamannan","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2013.08.1639_bib2","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1161\/01.ATV.0000280571.28102.d4","article-title":"New insights into the role of lipoprotein(a)-associated lipoprotein-associated phospholipase A2 in atherosclerosis and cardiovascular disease","volume":"27","author":"Tsimikas","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jacc.2013.08.1639_bib3","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.jacc.2012.04.038","article-title":"Lipoprotein(a) as a potential causal genetic risk factor of cardiovascular disease: a rationale for increased efforts to understand its pathophysiology and develop targeted therapies","volume":"60","author":"Tsimikas","year":"2012","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2013.08.1639_bib4","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1056\/NEJMoa1109034","article-title":"Genetic associations with valvular calcification and aortic stenosis","volume":"368","author":"Thanassoulis","year":"2013","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2013.08.1639_bib5","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1161\/ATVBAHA.112.251306","article-title":"Mechanisms of lipoprotein(a) pathogenicity","volume":"32","author":"Spence","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jacc.2013.08.1639_bib6","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1365-2796.2012.02592.x","article-title":"Lipoprotein(a): resurrected by genetics","volume":"273","author":"Kronenberg","year":"2013","journal-title":"J\u00a0Int Med"},{"key":"10.1016\/j.jacc.2013.08.1639_bib7","doi-asserted-by":"crossref","first-page":"673","DOI":"10.2217\/bmm.11.60","article-title":"Oxidized phospholipids on apolipoprotein B-100 (OxPL\/apoB) containing lipoproteins: a biomarker predicting cardiovascular disease and cardiovascular events","volume":"5","author":"Taleb","year":"2011","journal-title":"Biomarkers Med"},{"key":"10.1016\/j.jacc.2013.08.1639_bib8","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1194\/jlr.M800174-JLR200","article-title":"A\u00a0novel function of lipoprotein [a] as a preferential carrier of oxidized phospholipids in human plasma","volume":"49","author":"Bergmark","year":"2008","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.jacc.2013.08.1639_bib9","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1194\/jlr.P027235","article-title":"Acute impact of apheresis on oxidized phospholipids in patients with familial hypercholesterolemia","volume":"53","author":"Arai","year":"2012","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.jacc.2013.08.1639_bib10","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1016\/j.jacc.2012.08.979","article-title":"Oxidation-specific biomarkers, prospective 15-year cardiovascular and stroke outcomes, and net reclassification of cardiovascular events","volume":"60","author":"Tsimikas","year":"2012","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2013.08.1639_bib11","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s10557-008-6133-8","article-title":"Biology of platelet-activating factor acetylhydrolase (PAF-AH, lipoprotein associated phospholipase A2)","volume":"23","author":"Stafforini","year":"2009","journal-title":"Cardiovasc Drugs Ther"},{"key":"10.1016\/j.jacc.2013.08.1639_bib12","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0021-9150(96)05872-8","article-title":"PAF-acetylhydrolase activity of Lp(a) before and during Cu(2+)-induced oxidative modification in\u00a0vitro","volume":"125","author":"Karabina","year":"1996","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jacc.2013.08.1639_bib13","doi-asserted-by":"crossref","first-page":"31151","DOI":"10.1074\/jbc.270.52.31151","article-title":"Enhanced association of platelet-activating factor acetylhydrolase with lipoprotein(a) in comparison with low density lipoprotein","volume":"270","author":"Blencowe","year":"1995","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jacc.2013.08.1639_bib14","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1161\/ATVBAHA.107.145805","article-title":"Oxidized phospholipids, lipoprotein(a), lipoprotein-associated phospholipase A2 activity, and 10-year cardiovascular outcomes: prospective results from the Bruneck study","volume":"27","author":"Kiechl","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jacc.2013.08.1639_bib15","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1016\/j.jacc.2012.06.057","article-title":"Lipoprotein-associated phospholipase A(2) bound on high-density lipoprotein is associated with lower risk for cardiac death in stable coronary artery disease patients: a 3-year follow-up","volume":"60","author":"Rallidis","year":"2012","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2013.08.1639_bib16","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.jacc.2013.09.038","article-title":"Elevated lipoprotein(a) and risk of aortic valve stenosis in the general population","volume":"63","author":"Kamstrup","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2013.08.1639_bib17","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.jacc.2013.05.105","article-title":"Elevated expression of lipoprotein-associated phospholipase A2 in calcific aortic valve disease: implications for valve mineralization","volume":"63","author":"Mahmut","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2013.08.1639_bib18","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1055\/s-0038-1650639","article-title":"Correlation between oxidized low density lipoproteins and von Willebrand factor in chronic renal failure","volume":"76","author":"Holvoet","year":"1996","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jacc.2013.08.1639_bib19","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1194\/jlr.M600109-JLR200","article-title":"Autoantibody titers against OxLDL are correlated with Achilles tendon thickness in patients with familial hypercholesterolemia","volume":"47","author":"Tsouli","year":"2006","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.jacc.2013.08.1639_bib20","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1161\/01.ATV.19.5.1218","article-title":"Presence of oxidized low density lipoprotein in nonrheumatic stenotic aortic valves","volume":"19","author":"Olsson","year":"1999","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jacc.2013.08.1639_bib21","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1161\/ATVBAHA.107.154989","article-title":"Association between plasma LDL particle size, valvular accumulation of oxidized LDL, and inflammation in patients with aortic stenosis","volume":"28","author":"Mohty","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jacc.2013.08.1639_bib22","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1161\/01.ATV.17.4.680","article-title":"Lipid oxidation products have opposite effects on calcifying vascular cell and bone cell differentiation. A possible explanation for the paradox of arterial calcification in osteoporotic patients","volume":"17","author":"Parhami","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jacc.2013.08.1639_bib23","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0891-5849(01)00610-4","article-title":"Oxidative stress modulates osteoblastic differentiation of vascular and bone cells","volume":"31","author":"Mody","year":"2001","journal-title":"Free Rad Biol Med"},{"key":"10.1016\/j.jacc.2013.08.1639_bib24","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1194\/jlr.M036343","article-title":"MCP-1 binds to oxidized LDL and is carried by lipoprotein(a) in human plasma","volume":"54","author":"Wiesner","year":"2013","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.jacc.2013.08.1639_bib25","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1161\/CIRCULATIONAHA.106.634139","article-title":"Calcific aortic valve stenosis in old hypercholesterolemic mice","volume":"114","author":"Weiss","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2013.08.1639_bib26","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1161\/CIRCULATIONAHA.108.834614","article-title":"Lowering plasma cholesterol levels halts progression of aortic valve disease in mice","volume":"119","author":"Miller","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2013.08.1639_bib27","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1016\/j.jacc.2010.10.052","article-title":"Antisense oligonucleotide lowers plasma levels of apolipoprotein(a) and lipoprotein(a) in transgenic mice","volume":"57","author":"Merki","year":"2011","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2013.08.1639_bib28","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.coph.2013.02.005","article-title":"Oxidation-specific epitopes and immunological responses: translational biotheranostic implications for atherosclerosis","volume":"13","author":"Leibundgut","year":"2013","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.jacc.2013.08.1639_bib29","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.immuni.2013.06.009","article-title":"Immune effector mechanisms implicated in atherosclerosis: from mice to humans","volume":"38","author":"Libby","year":"2013","journal-title":"Immunity"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109713055836?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109713055836?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:04:43Z","timestamp":1760015083000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109713055836"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["S0735109713055836"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2013.08.1639","relation":{},"ISSN":["0735-1097"],"issn-type":[{"type":"print","value":"0735-1097"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"New Therapeutic Targets for Calcific Aortic Valve Stenosis","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2013.08.1639","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2013.09.038","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2013.05.105","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}