{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:55:50Z","timestamp":1792205750157,"version":"4.4.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,8,5]],"date-time":"2015-08-05T00:00:00Z","timestamp":1438732800000},"content-version":"vor","delay-in-days":369,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001674","name":"Leducq Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["13EIA14420025"],"award-info":[{"award-number":["13EIA14420025"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL113006"],"award-info":[{"award-number":["R01 HL113006"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH U01 HL099776"],"award-info":[{"award-number":["NIH U01 HL099776"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH R24 HL117756"],"award-info":[{"award-number":["NIH R24 HL117756"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.jacc.2014.04.057","type":"journal-article","created":{"date-parts":[[2014,7,28]],"date-time":"2014-07-28T15:47:34Z","timestamp":1406562454000},"page":"451-459","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":156,"title":["Genome Editing of Isogenic Human Induced Pluripotent Stem Cells Recapitulates Long QT Phenotype for Drug Testing"],"prefix":"10.1016","volume":"64","author":[{"given":"Yongming","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haodi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leszek","family":"Lisowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxia","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Kay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fyodor D.","family":"Urnov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami","family":"Shinnawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph D.","family":"Gold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lior","family":"Gepstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph C.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2014.04.057_bib1","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.jacc.2014.04.057_bib2","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1126\/science.282.5391.1145","article-title":"Embryonic stem cell lines derived from human blastocysts","volume":"282","author":"Thomson","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.jacc.2014.04.057_bib3","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1161\/CIRCULATIONAHA.113.001883","article-title":"Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity","volume":"127","author":"Liang","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2014.04.057_bib4","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.stem.2012.10.010","article-title":"Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells","volume":"12","author":"Lan","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jacc.2014.04.057_bib5","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1126\/scitranslmed.3003552","article-title":"Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy","volume":"4","author":"Sun","year":"2012","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jacc.2014.04.057_bib6","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nature09855","article-title":"Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome","volume":"471","author":"Yazawa","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jacc.2014.04.057_bib7","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/nature09005","article-title":"Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome","volume":"465","author":"Carvajal-Vergara","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.jacc.2014.04.057_bib8","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature11799","article-title":"Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs","volume":"494","author":"Kim","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.jacc.2014.04.057_bib9","doi-asserted-by":"crossref","first-page":"240ra74","DOI":"10.1126\/scitranslmed.3008008","article-title":"Identification of a new modulator of the intercalated disc in a zebrafish model of arrhythmogenic cardiomyopathy","volume":"6","author":"Asimaki","year":"2014","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jacc.2014.04.057_bib10","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nature09747","article-title":"Modelling the long QT syndrome with induced pluripotent stem cells","volume":"471","author":"Itzhaki","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jacc.2014.04.057_bib11","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1056\/NEJMoa0908679","article-title":"Patient-specific induced pluripotent stem-cell models for long-QT syndrome","volume":"363","author":"Moretti","year":"2010","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2014.04.057_bib12","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.stem.2012.11.011","article-title":"A\u00a0TALEN genome-editing system for generating human stem cell-based disease models","volume":"12","author":"Ding","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jacc.2014.04.057_bib13","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1038\/emboj.2013.240","article-title":"Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome","volume":"32","author":"Bellin","year":"2013","journal-title":"EMBO J"},{"key":"10.1016\/j.jacc.2014.04.057_bib14","doi-asserted-by":"crossref","first-page":"E1801","DOI":"10.1002\/humu.21341","article-title":"LQTS gene LOVD database","volume":"31","author":"Zhang","year":"2010","journal-title":"Hum Mutat"},{"key":"10.1016\/j.jacc.2014.04.057_bib15","doi-asserted-by":"crossref","first-page":"5539","DOI":"10.1158\/0008-5472.CAN-09-4238","article-title":"Effects of ionizing radiation on self-renewal and pluripotency of human embryonic stem cells","volume":"70","author":"Wilson","year":"2010","journal-title":"Cancer Res"},{"key":"10.1016\/j.jacc.2014.04.057_bib16","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1101\/gr.106773.110","article-title":"Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome","volume":"20","author":"DeKelver","year":"2010","journal-title":"Genome Res"},{"key":"10.1016\/j.jacc.2014.04.057_bib17","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1111\/j.1540-8167.1999.tb00262.x","article-title":"Functional effects of mutations in KvLQT1 that cause long QT syndrome","volume":"10","author":"Wang","year":"1999","journal-title":"J\u00a0Cardiovasc Electrophysiol"},{"key":"10.1016\/j.jacc.2014.04.057_bib18","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1161\/CIRCRESAHA.112.274969","article-title":"Genome editing of human embryonic stem cells and induced pluripotent stem cells with zinc finger nucleases for cellular imaging","volume":"111","author":"Wang","year":"2012","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2014.04.057_bib19","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/stem.1278","article-title":"MicroRNA-302 increases reprogramming efficiency via repression of NR2F2","volume":"31","author":"Hu","year":"2013","journal-title":"Stem Cells"},{"key":"10.1016\/j.jacc.2014.04.057_bib20","first-page":"896","article-title":"Genome editing of human pluripotent stem cells to generate human cellular disease models","volume":"6","author":"Musunuru","year":"2013","journal-title":"Dis Model Mech"},{"key":"10.1016\/j.jacc.2014.04.057_bib21","doi-asserted-by":"crossref","first-page":"e3474","DOI":"10.1371\/journal.pone.0003474","article-title":"Transcriptional and functional profiling of human embryonic stem cell-derived cardiomyocytes","volume":"3","author":"Cao","year":"2008","journal-title":"PloS One"},{"key":"10.1016\/j.jacc.2014.04.057_bib22","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1634\/stemcells.2006-0054","article-title":"Genome-wide transcriptional profiling of human embryonic stem cells differentiating to cardiomyocytes","volume":"24","author":"Beqqali","year":"2006","journal-title":"Stem Cells"},{"key":"10.1016\/j.jacc.2014.04.057_bib23","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1161\/01.CIR.0000068356.38592.68","article-title":"Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cells","volume":"107","author":"Mummery","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2014.04.057_bib24","doi-asserted-by":"crossref","first-page":"5277","DOI":"10.1016\/j.ijcard.2013.08.015","article-title":"Modeling type 3 long QT syndrome with cardiomyocytes derived from patient-specific induced pluripotent stem cells","volume":"168","author":"Ma","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacc.2014.04.057_bib25","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1085\/jgp.201210899","article-title":"Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics","volume":"141","author":"Terrenoire","year":"2013","journal-title":"J\u00a0Gen Physiol"},{"key":"10.1016\/j.jacc.2014.04.057_bib26","doi-asserted-by":"crossref","first-page":"239ps6","DOI":"10.1126\/scitranslmed.3008921","article-title":"Human stem cells for modeling heart disease and for drug discovery","volume":"6","author":"Matsa","year":"2014","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jacc.2014.04.057_bib27","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nature07677","article-title":"Induced pluripotent stem cells from a spinal muscular atrophy patient","volume":"457","author":"Ebert","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.jacc.2014.04.057_bib28","first-page":"2286","article-title":"Modelling familial dysautonomia in human induced pluripotent stem cells","volume":"366","author":"Lee","year":"2011","journal-title":"Philos Trans R Soc London, Series B Biol Sci"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109714027429?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109714027429?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:07:26Z","timestamp":1760015246000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109714027429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S0735109714027429"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2014.04.057","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genome Editing of Isogenic Human Induced Pluripotent Stem Cells Recapitulates Long QT Phenotype for Drug Testing","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2014.04.057","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}