{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T22:34:56Z","timestamp":1784327696696,"version":"3.55.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"13","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,30]],"date-time":"2015-09-30T00:00:00Z","timestamp":1443571200000},"content-version":"vor","delay-in-days":394,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.jacc.2014.07.948","type":"journal-article","created":{"date-parts":[[2014,9,22]],"date-time":"2014-09-22T15:45:25Z","timestamp":1411400725000},"page":"1310-1319","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":105,"title":["Cardiovascular Function and Predictors of\u00a0Exercise Capacity in Patients With Colorectal Cancer"],"prefix":"10.1016","volume":"64","author":[{"given":"Larissa","family":"Cramer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert","family":"Hildebrandt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Kung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Wichmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Springer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfram","family":"Doehner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Sandek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslava","family":"Valentova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Stojakovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Scharnagl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanno","family":"Riess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan D.","family":"Anker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"von Haehling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2014.07.948_bib1","unstructured":"Stuart BW, Kleihues P. World Cancer Report 2003. Available at: http:\/\/www.scribd.com\/doc\/2350813\/World-Cancer-Report-2003-Stuart-e-Kleihues-WHO-e-IARC. Accessed August 15,\u00a02012."},{"key":"10.1016\/j.jacc.2014.07.948_bib2","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/sj.bjc.6602012","article-title":"Fatigue and cancer: causes, prevalence and treatment approaches","volume":"5","author":"Wagner","year":"2004","journal-title":"Br J Cancer"},{"key":"10.1016\/j.jacc.2014.07.948_bib3","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1186\/1471-2407-10-272","article-title":"Physical Activity during Cancer Treatment (PACT) Study: design of a randomised clinical trial","volume":"10","author":"Velthuis","year":"2010","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jacc.2014.07.948_bib4","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s00508-009-1194-7","article-title":"Neurohormonal activation and inflammation in chronic cardiopulmonary disease: a brief systematic review","volume":"9-10","author":"Doehner","year":"2009","journal-title":"Wien Klin Wochenschr"},{"key":"10.1016\/j.jacc.2014.07.948_bib5","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1373\/clinchem.2005.051110","article-title":"Measurement of midregional proadrenomedullin in plasma with an immunoluminometric assay","volume":"10","author":"Morgenthaler","year":"2005","journal-title":"Clin Chem"},{"key":"10.1016\/j.jacc.2014.07.948_bib6","doi-asserted-by":"crossref","first-page":"e14506","DOI":"10.1371\/journal.pone.0014506","article-title":"Identification of chronic heart failure patients with a high 12-month mortality risk using biomarkers including plasma C-terminal pro-endothelin-1","volume":"1","author":"Jankowska","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jacc.2014.07.948_bib7","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1373\/clinchem.2003.021204","article-title":"Immunoluminometric assay for the midregion of pro-atrial natriuretic peptide in human plasma","volume":"1","author":"Morgenthaler","year":"2004","journal-title":"Clin Chem"},{"key":"10.1016\/j.jacc.2014.07.948_bib8","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1373\/clinchem.2005.060038","article-title":"Assay for the measurement of copeptin, a stable peptide derived from the precursor of vasopressin","volume":"1","author":"Morgenthaler","year":"2006","journal-title":"Clin Chem"},{"key":"10.1016\/j.jacc.2014.07.948_bib9","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.echo.2005.10.005","volume":"12","author":"Lang","year":"2005","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.jacc.2014.07.948_bib10","doi-asserted-by":"crossref","unstructured":"Vanderlei LC, Pastre CM, Hoshi RA, Carvalho TD, Godoy MF. Basic notions of heart rate variability and its clinical applicability. Rev Bras Cir Cardiovasc 2009;2:205\u2013217.","DOI":"10.1590\/S0102-76382009000200018"},{"key":"10.1016\/j.jacc.2014.07.948_bib11","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1053\/euhj.1999.1715","article-title":"Aerobic group training improves exercise capacity and heart rate variability in elderly patients with a recent coronary event. A randomized controlled study","volume":"22","author":"St\u00e2hle","year":"1999","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2014.07.948_bib12","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1023\/A:1007785314462","article-title":"Effects of long-term digoxin therapy on heart rate variability, baroreceptor sensitivity, and exercise capacity in patients with heart failure","volume":"1","author":"Vardas","year":"1998","journal-title":"Cardiovasc Drugs Ther"},{"key":"10.1016\/j.jacc.2014.07.948_bib13","first-page":"217","article-title":"Lifelong physical training prevents the age-related impairment of heart rate variability and exercise capacity in elderly people","volume":"2","author":"Galetta","year":"2005","journal-title":"J\u00a0Sports Med Phys Fitness"},{"key":"10.1016\/j.jacc.2014.07.948_bib14","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s00399-006-0530-0","article-title":"(Sports medical aspects in cardiac risk stratification\u2013heart rate variability and exercise capacity)","volume":"4","author":"Banzer","year":"2006","journal-title":"Herzschrittmacherther Elektrophysiol"},{"key":"10.1016\/j.jacc.2014.07.948_bib15","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1016\/S0041-1345(98)00484-9","article-title":"Heart rate variability, exercise capacity, and O2 uptake kinetics in heart transplant recipients","volume":"5","author":"Mettauer","year":"1998","journal-title":"Transplant Proc"},{"key":"10.1016\/j.jacc.2014.07.948_bib16","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1007\/s11517-006-0119-0","article-title":"Heart rate variability: a review","volume":"12","author":"Rajendra Acharya","year":"2006","journal-title":"Med Biol Eng Comput"},{"key":"10.1016\/j.jacc.2014.07.948_bib17","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s10238-010-0114-5","article-title":"Comparison between clinical significance of serum proinflammatory proteins (IL-6 and CRP) and classic tumor markers (CEA and CA 19-9) in gastric cancer","volume":"2","author":"Lukaszewicz-Zaj\u0105c","year":"2011","journal-title":"Clin Exp Med"},{"key":"10.1016\/j.jacc.2014.07.948_bib18","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.3748\/wjg.v10.i8.1115","article-title":"C-reactive protein, procalcitonin, interleukin-6, vascular endothelial growth factor and oxidative metabolites in diagnosis of infection and staging in patients with gastric cancer","volume":"8","author":"Ilhan","year":"2004","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jacc.2014.07.948_bib19","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.2174\/092986706777441968","article-title":"Endothelin-1: the yin and yang on vascular function","volume":"14","author":"Marasciulo","year":"2006","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.jacc.2014.07.948_bib20","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.pharmthera.2005.11.001","article-title":"Cardiovascular endothelins: essential regulators of cardiovascular homeostasis","volume":"2","author":"Brunner","year":"2006","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jacc.2014.07.948_bib21","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.phrs.2011.01.014","article-title":"Role of endothelin in the cardiovascular system","volume":"6","author":"Rodr\u00edguez-Pascual","year":"2011","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.jacc.2014.07.948_bib22","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.ctrv.2010.11.001","article-title":"Cardiovascular effects of systemic cancer treatment","volume":"4","author":"Senkus","year":"2011","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.jacc.2014.07.948_bib23","first-page":"887","article-title":"Left ventricular function in colon cancer patients receiving adjuvant fluoro-folate chemotherapy: an echocardiographic study","volume":"4","author":"Balloni","year":"2000","journal-title":"Oncol Rep"},{"key":"10.1016\/j.jacc.2014.07.948_bib24","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/1097-0142(19930115)71:2<493::AID-CNCR2820710235>3.0.CO;2-C","article-title":"The syndrome of 5-fluorouracil cardiotoxicity. An elusive cardiopathy","volume":"2","author":"Robben","year":"1993","journal-title":"Cancer"},{"key":"10.1016\/j.jacc.2014.07.948_bib25","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1023\/A:1008263321681","article-title":"Noninvasive evaluation of cardiotoxicity of 5-fluorouracil and low doses of folinic acid: a one-year follow-up study","volume":"7","author":"Grandi","year":"1997","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jacc.2014.07.948_bib26","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/01.mco.0000165002.08955.5b","article-title":"Pathophysiology of peripheral muscle wasting in cardiac cachexia","volume":"3","author":"Filippatos","year":"2005","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.1016\/j.jacc.2014.07.948_bib27","doi-asserted-by":"crossref","first-page":"3060","DOI":"10.1161\/01.CIR.102.25.3060","article-title":"Plasma cytokine parameters and mortality in patients with chronic heart failure","volume":"25","author":"Rauchhaus","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2014.07.948_bib28","doi-asserted-by":"crossref","first-page":"6005","DOI":"10.1002\/cncr.27613","article-title":"Inflammation and fatigue dimensions in advanced cancer patients and cancer survivors: an explorative study","volume":"23","author":"De Raaf","year":"2012","journal-title":"Cancer"},{"key":"10.1016\/j.jacc.2014.07.948_bib29","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1158\/1078-0432.CCR-04-2000","article-title":"Elevated serum cytokines correlated with altered behavior, serum cortisol rhythm, and dampened 24-hour rest-activity patterns in patients with metastatic colorectal cancer","volume":"5","author":"Rich","year":"2005","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jacc.2014.07.948_bib30","doi-asserted-by":"crossref","first-page":"301","DOI":"10.2522\/ptj.20100273","article-title":"Exercise for managing cancer-related fatigue","volume":"3","author":"Litterini","year":"2011","journal-title":"Phys Ther"},{"key":"10.1016\/j.jacc.2014.07.948_bib31","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.lungcan.2011.01.006","article-title":"Exercise intervention to improve exercise capacity and health related quality of life for patients with non-small cell lung cancer: a systematic review","volume":"2","author":"Granger","year":"2011","journal-title":"Lung Cancer"},{"key":"10.1016\/j.jacc.2014.07.948_bib32","doi-asserted-by":"crossref","first-page":"3430","DOI":"10.1002\/cncr.23967","article-title":"Safety and feasibility of aerobic training on cardiopulmonary function and quality of life in postsurgical nonsmall cell lung cancer patients: a pilot study","volume":"12","author":"Jones","year":"2008","journal-title":"Cancer"},{"key":"10.1016\/j.jacc.2014.07.948_bib33","doi-asserted-by":"crossref","first-page":"475","DOI":"10.2217\/17460816.3.5.475","article-title":"Heart rate variability as a biomarker of fibromyalgia syndrome","volume":"5","author":"Staud","year":"2008","journal-title":"Fut Rheumatol"},{"key":"10.1016\/j.jacc.2014.07.948_bib34","doi-asserted-by":"crossref","first-page":"87","DOI":"10.5213\/inj.2011.15.2.87","article-title":"Heart rate variability in men with erectile dysfunction","volume":"2","author":"Lee","year":"2011","journal-title":"Int Neurourol J"},{"key":"10.1016\/j.jacc.2014.07.948_bib35","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s00392-010-0236-5","article-title":"Heart rate variability and biomarkers of systemic inflammation in patients with stable coronary heart disease: findings from the Heart and Soul Study","volume":"3","author":"Von K\u00e4nel","year":"2011","journal-title":"Clin Res Cardiol"},{"key":"10.1016\/j.jacc.2014.07.948_bib36","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1249\/01.MSS.0000155388.39002.9D","article-title":"Effects of exercise on heart rate variability: inferences from meta-analysis","volume":"3","author":"Sandercock","year":"2005","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.jacc.2014.07.948_bib37","doi-asserted-by":"crossref","first-page":"364","DOI":"10.4093\/dmj.2011.35.4.364","article-title":"effects of aerobic exercise vs. resistance training on endothelial function in women with type 2 diabetes mellitus","volume":"4","author":"Kwon","year":"2011","journal-title":"Diabetes Metab J"},{"key":"10.1016\/j.jacc.2014.07.948_bib38","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/S0002-9149(98)00021-6","article-title":"Effects of cardiac rehabilitation and beta-blocker therapy on heart rate variability after first acute myocardial infarction","volume":"7","author":"Malfatto","year":"1998","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2014.07.948_bib39","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/S0002-8703(99)70219-X","article-title":"Long-term beta-blocker therapy improves autonomic nervous regulation in advanced congestive heart failure: a longitudinal heart rate variability study","volume":"4 Pt 1","author":"Lin","year":"1999","journal-title":"Am Heart J"},{"key":"10.1016\/j.jacc.2014.07.948_bib40","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0002-9149(02)03098-9","article-title":"Effects of propranolol on recovery of heart rate variability following acute myocardial infarction and relation to outcome in the Beta-Blocker Heart Attack Trial","volume":"2","author":"Lampert","year":"2003","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2014.07.948_bib41","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/clc.4960220606","article-title":"The effects of metoprolol and captopril on heart rate variability in patients with idiopathic dilated cardiomyopathy","volume":"6","author":"Jansson","year":"1999","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.jacc.2014.07.948_bib42","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1161\/01.CIR.102.6.677","article-title":"Nebivolol: a third-generation beta-blocker that augments vascular nitric oxide release: endothelial beta(2)-adrenergic receptor-mediated nitric oxide production","volume":"6","author":"Broeders","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2014.07.948_bib43","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1161\/01.ATV.0000065234.70518.26","article-title":"Nebivolol prevents vascular NOS III uncoupling in experimental hyperlipidemia and inhibits NADPH oxidase activity in inflammatory cells","volume":"4","author":"Mollnau","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jacc.2014.07.948_bib44","first-page":"129","article-title":"The effect of the year angiotensin-converting enzyme inhibitors (ACE I) intake on circadian heart rate variability in patients with primary hypertension","volume":"3","author":"Banach","year":"2001","journal-title":"Folia Med Cracov"},{"key":"10.1016\/j.jacc.2014.07.948_bib45","first-page":"32","article-title":"(Effect\u00a0of angiotensin converting enzyme inhibitors on oxidative stress, endothelial function in patients with myocardial infarction)","volume":"7-8","author":"Zdionchenko","year":"2009","journal-title":"Kardiologiia"},{"key":"10.1016\/j.jacc.2014.07.948_bib46","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/S0003-4975(01)02779-5","article-title":"High tissue affinity angiotensin-converting enzyme inhibitors improve endothelial function and reduce infarct size","volume":"2","author":"Lazar","year":"2001","journal-title":"Ann Thorac Surg"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109714056228?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109714056228?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,15]],"date-time":"2019-08-15T04:14:10Z","timestamp":1565842450000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109714056228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":46,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["S0735109714056228"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2014.07.948","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiovascular Function and Predictors of\u00a0Exercise Capacity in Patients With Colorectal Cancer","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2014.07.948","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}