{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:38:44Z","timestamp":1793813924446,"version":"4.6.1"},"reference-count":26,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T00:00:00Z","timestamp":1453852800000},"content-version":"vor","delay-in-days":391,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.jacc.2014.10.050","type":"journal-article","created":{"date-parts":[[2015,1,19]],"date-time":"2015-01-19T20:45:11Z","timestamp":1421700311000},"page":"246-254","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":138,"title":["The Risk for Type B Aortic Dissection in Marfan Syndrome"],"prefix":"10.1016","volume":"65","author":[{"given":"Alexander W.","family":"den Hartog","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romy","family":"Franken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aeilko H.","family":"Zwinderman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janneke","family":"Timmermans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur J.","family":"Scholte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten P.","family":"van den Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"de Waard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Pals","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara J.M.","family":"Mulder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"Groenink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2014.10.050_bib1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0002-9149(00)80066-1","article-title":"Life expectancy in the Marfan syndrome","volume":"75","author":"Silverman","year":"1995","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2014.10.050_bib2","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1093\/eurheartj\/ehi396","article-title":"The spectrum of adult congenital heart disease in Europe: morbidity and mortality in a 5 year follow-up period. The Euro Heart Survey on adult congenital heart disease","volume":"26","author":"Engelfriet","year":"2005","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2014.10.050_bib3","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1136\/hrt.82.4.499","article-title":"Survival and complication free survival in Marfan\u2019s syndrome: implications of current guidelines","volume":"82","author":"Groenink","year":"1999","journal-title":"Heart"},{"key":"10.1016\/j.jacc.2014.10.050_bib4","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1093\/eurheartj\/ehu281","volume":"35","author":"Erbel","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2014.10.050_bib5","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1136\/hrt.2005.081638","article-title":"Beyond the root: dilatation of the distal aorta in Marfan\u2019s syndrome","volume":"92","author":"Engelfriet","year":"2006","journal-title":"Heart"},{"key":"10.1016\/j.jacc.2014.10.050_bib6","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1136\/jmg.2009.072785","article-title":"The revised Ghent nosology for the Marfan syndrome","volume":"47","author":"Loeys","year":"2010","journal-title":"J\u00a0Med Genet"},{"key":"10.1016\/j.jacc.2014.10.050_bib7","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S0022-5223(19)33323-9","article-title":"Surgical management of dissecting aneurysms of the aorta","volume":"49","author":"Debakey","year":"1965","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jacc.2014.10.050_bib8","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0003-4975(10)65594-4","article-title":"Management of acute\u00a0aortic dissections","volume":"10","author":"Daily","year":"1970","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jacc.2014.10.050_bib9","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1148\/radiol.13122310","article-title":"Aortic disease in patients with Marfan syndrome: aortic volume assessment for surveillance","volume":"269","author":"den Hartog","year":"2013","journal-title":"Radiology"},{"key":"10.1016\/j.jacc.2014.10.050_bib10","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1067\/mtc.2002.122310","article-title":"Diameters of the thoracic aorta throughout life as measured with helical computed tomography","volume":"123","author":"Hager","year":"2002","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jacc.2014.10.050_bib11","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0002-9149(98)00315-4","article-title":"Changes in aortic distensibility and pulse wave velocity assessed with magnetic resonance imaging following beta-blocker therapy in the Marfan syndrome","volume":"82","author":"Groenink","year":"1998","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2014.10.050_bib12","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1002\/sim.1802","article-title":"Overall C as a measure of discrimination in survival analysis: model specific population value and confidence interval estimation","volume":"23","author":"Pencina","year":"2004","journal-title":"Stat Med"},{"key":"10.1016\/j.jacc.2014.10.050_bib13","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jcmg.2007.11.005","article-title":"Aortic size assessment by noncontrast cardiac computed tomography: normal limits by age, gender, and body surface area","volume":"1","author":"Wolak","year":"2008","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jacc.2014.10.050_bib14","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.ejcts.2004.01.034","article-title":"Reoperations and late adverse outcome in Marfan patients following cardiovascular surgery","volume":"25","author":"Carrel","year":"2004","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.jacc.2014.10.050_bib15","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1007\/BF03086183","article-title":"The distal aorta in the Marfan syndrome","volume":"16","author":"Mulder","year":"2008","journal-title":"Neth Heart J"},{"key":"10.1016\/j.jacc.2014.10.050_bib16","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1161\/01.CIR.91.3.728","article-title":"Marfan syndrome. Long-term survival and complications after aortic aneurysm repair","volume":"91","author":"Finkbohner","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2014.10.050_bib17","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ejvs.2007.10.013","article-title":"Thoracoabdominal aortic aneurysm repair in patients with Marfan syndrome","volume":"35","author":"Mommertz","year":"2008","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jacc.2014.10.050_bib18","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1016\/j.athoracsur.2007.05.038","article-title":"Safety of thoracic aortic surgery in the present era","volume":"84","author":"Achneck","year":"2007","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jacc.2014.10.050_bib19","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1093\/eurheartj\/eht334","article-title":"Losartan reduces aortic dilatation rate in adults with Marfan syndrome: a randomized controlled trial","volume":"34","author":"Groenink","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2014.10.050_bib20","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1056\/NEJMoa1404731","article-title":"Atenolol versus losartan in children and young adults with Marfan's syndrome","volume":"371","author":"Lacro","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2014.10.050_bib21","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.acvd.2010.04.008","article-title":"Rationale and design of a randomized clinical trial (Marfan Sartan) of angiotensin II receptor blocker therapy versus placebo in individuals with Marfan syndrome","volume":"103","author":"Detaint","year":"2010","journal-title":"Arch Cardiovasc Dis"},{"key":"10.1016\/j.jacc.2014.10.050_bib22","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.recesp.2011.02.009","article-title":"Study of the efficacy and safety of losartan versus atenolol for aortic dilation in patients with Marfan syndrome","volume":"64","author":"Forteza","year":"2011","journal-title":"Rev Esp Cardiol"},{"key":"10.1016\/j.jacc.2014.10.050_bib23","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1126\/science.1192152","article-title":"Angiotensin II type 2 receptor signaling attenuates aortic aneurysm in mice through ERK antagonism","volume":"332","author":"Habashi","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.jacc.2014.10.050_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jvs.2010.02.264","article-title":"Use of angiotensin converting enzyme inhibitors is associated with increased growth rate of abdominal aortic aneurysms","volume":"52","author":"Sweeting","year":"2010","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jacc.2014.10.050_bib25","doi-asserted-by":"crossref","first-page":"309","DOI":"10.2214\/ajr.146.2.309","article-title":"Magnetic resonance imaging of thoracic aortic aneurysms: comparison with other imaging methods","volume":"146","author":"Dinsmore","year":"1986","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.jacc.2014.10.050_bib26","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1023\/A:1006429603062","article-title":"Aortic root asymmetry in Marfan patients; evaluation by magnetic resonance imaging and comparison with standard echocardiography","volume":"16","author":"Meijboom","year":"2000","journal-title":"Int J Card Imaging"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109714070077?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109714070077?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T03:43:19Z","timestamp":1598672599000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109714070077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["S0735109714070077"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2014.10.050","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Risk for Type B Aortic Dissection in Marfan Syndrome","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2014.10.050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}