{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:05:12Z","timestamp":1793318712773,"version":"4.5.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,19]],"date-time":"2017-01-19T00:00:00Z","timestamp":1484784000000},"content-version":"vor","delay-in-days":384,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.jacc.2015.10.055","type":"journal-article","created":{"date-parts":[[2016,1,11]],"date-time":"2016-01-11T15:28:55Z","timestamp":1452526135000},"page":"193-201","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":160,"title":["Discordance Between Apolipoprotein B and LDL-Cholesterol in Young Adults Predicts Coronary Artery Calcification"],"prefix":"10.1016","volume":"67","author":[{"given":"John T.","family":"Wilkins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron C.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Sniderman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheeling","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald M.","family":"Lloyd-Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2015.10.055_bib1","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1161\/CIRCULATIONAHA.106.676890","article-title":"Subendothelial lipoprotein retention as the initiating process in atherosclerosis: update and therapeutic implications","volume":"116","author":"Tabas","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2015.10.055_bib2","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1365-2796.2006.01616.x","article-title":"Apo\u00a0B versus cholesterol in estimating cardiovascular risk and in guiding therapy: report of the thirty-person\/ten-country panel","volume":"259","author":"Barter","year":"2006","journal-title":"J\u00a0Intern Med"},{"key":"10.1016\/j.jacc.2015.10.055_bib3","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/j.jacc.2007.03.009","article-title":"Early adult risk factor levels and subsequent coronary artery calcification: the CARDIA Study","volume":"49","author":"Loria","year":"2007","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2015.10.055_bib4","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s10654-007-9165-7","article-title":"The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases","volume":"22","author":"Danesh","year":"2007","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.jacc.2015.10.055_bib5","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/MOL.0000000000000181","article-title":"Limitations in the conventional assessment of the incremental value of predictors of cardiovascular risk","volume":"26","author":"Sniderman","year":"2015","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.jacc.2015.10.055_bib6","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.atherosclerosis.2012.08.039","article-title":"Discordance analysis of apolipoprotein B and non-high density lipoprotein cholesterol as markers of cardiovascular risk in the INTERHEART study","volume":"225","author":"Sniderman","year":"2012","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jacc.2015.10.055_bib7","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/MOL.0000000000000127","article-title":"Discordance analysis and the Gordian Knot of LDL and non-HDL cholesterol versus apoB","volume":"25","author":"Sniderman","year":"2014","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.jacc.2015.10.055_bib8","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/0895-4356(88)90080-7","article-title":"CARDIA: study design, recruitment, and some characteristics of the examined subjects","volume":"41","author":"Friedman","year":"1988","journal-title":"J\u00a0Clin Epidemiol"},{"key":"10.1016\/j.jacc.2015.10.055_bib9","doi-asserted-by":"crossref","first-page":"68S","DOI":"10.1016\/0197-2456(87)90008-0","article-title":"Recruitment in the Coronary Artery Disease Risk Development in Young Adults (Cardia) Study","volume":"8","author":"Hughes","year":"1987","journal-title":"Control Clin Trials"},{"key":"10.1016\/j.jacc.2015.10.055_bib10","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1148\/radiol.2341040439","article-title":"Calcified coronary artery plaque measurement with cardiac CT in population-based studies: standardized protocol of Multi-Ethnic Study of Atherosclerosis (MESA) and Coronary Artery Risk Development in Young Adults (CARDIA) Study","volume":"234","author":"Carr","year":"2005","journal-title":"Radiology"},{"key":"10.1016\/j.jacc.2015.10.055_bib11","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0735-1097(90)90282-T","article-title":"Quantification of coronary artery calcium using ultrafast computed tomography","volume":"15","author":"Agatston","year":"1990","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2015.10.055_bib12","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1002\/(SICI)1097-0258(19970515)16:9<965::AID-SIM509>3.0.CO;2-O","article-title":"A\u00a0comparison of goodness-of-fit tests for the logistic regression model","volume":"16","author":"Hosmer","year":"1997","journal-title":"Stat Med"},{"key":"10.1016\/j.jacc.2015.10.055_bib13","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0021-9150(95)05704-8","article-title":"The influence of age and relative weight on the presentation of familial combined hyperlipidemia in childhood","volume":"121","author":"Shamir","year":"1996","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jacc.2015.10.055_bib14","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1042\/CS20060234","article-title":"Effect of aging and obesity on the expression of dyslipidaemia in children from families with familial combined hyperlipidaemia","volume":"112","author":"Avest ter","year":"2007","journal-title":"Clin Sci"},{"key":"10.1016\/j.jacc.2015.10.055_bib15","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0002-9149(85)90363-7","article-title":"Familial aggregation and early expression of hyperapobetalipoproteinemia","volume":"55","author":"Sniderman","year":"1985","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2015.10.055_bib16","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1161\/01.CIR.0000145660.60487.94","article-title":"Comparison of the associations of apolipoprotein B and non-high-density lipoprotein cholesterol with other cardiovascular risk factors in patients with the metabolic syndrome in the Insulin Resistance Atherosclerosis Study","volume":"110","author":"Sattar","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2015.10.055_bib17","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1001\/jama.2009.1619","article-title":"Major lipids, apolipoproteins, and risk of vascular disease","volume":"302","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.jacc.2015.10.055_bib18","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1161\/CIRCOUTCOMES.110.959247","article-title":"A\u00a0meta-analysis of low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and apolipoprotein B as markers of cardiovascular risk","volume":"4","author":"Sniderman","year":"2011","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"10.1016\/j.jacc.2015.10.055_bib19","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.jacl.2007.10.001","article-title":"LDL particle number and risk of future cardiovascular disease in the Framingham Offspring Study\u2014implications\u00a0for LDL management","volume":"1","author":"Cromwell","year":"2007","journal-title":"J\u00a0Clin Lipidol"},{"key":"10.1016\/j.jacc.2015.10.055_bib20","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jacl.2011.02.001","article-title":"Clinical implications of discordance between low-density lipoprotein cholesterol and particle number","volume":"5","author":"Otvos","year":"2011","journal-title":"J\u00a0Clin Lipidol"},{"key":"10.1016\/j.jacc.2015.10.055_bib21","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.jacl.2013.08.004","article-title":"Is the superiority of apoB over non-HDL-C as a marker of cardiovascular risk in the INTERHEART study due to confounding by related variables?","volume":"7","author":"Sniderman","year":"2013","journal-title":"J\u00a0Clin Lipidol"},{"key":"10.1016\/j.jacc.2015.10.055_bib22","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1177\/2047487315569411","article-title":"Apolipoprotein B improves risk assessment of future coronary heart disease in the Framingham Heart Study beyond LDL-C and non-HDL-C","volume":"22","author":"Pencina","year":"2015","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.jacc.2015.10.055_bib23","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1161\/CIRCULATIONAHA.113.005873","article-title":"Discordance of LDL cholesterol with alternative LDL-related measures and future coronary events","volume":"129","author":"Mora","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2015.10.055_bib24","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1161\/CIRCULATIONAHA.108.816181","article-title":"Lipoprotein particle profiles by nuclear magnetic resonance\u00a0compared with standard lipids and apolipoproteins in predicting incident cardiovascular disease in women","volume":"119","author":"Mora","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2015.10.055_bib25","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1001\/jama.2010.461","article-title":"coronary artery calcium score and risk classification for coronary heart disease prediction","volume":"303","author":"Polonsky","year":"2010","journal-title":"JAMA"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109715072228?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109715072228?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T03:30:26Z","timestamp":1537068626000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109715072228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S0735109715072228"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2015.10.055","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discordance Between Apolipoprotein B and LDL-Cholesterol in Young Adults Predicts Coronary Artery Calcification","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2015.10.055","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}