{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:08:52Z","timestamp":1790482132047,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,26]],"date-time":"2017-01-26T00:00:00Z","timestamp":1485388800000},"content-version":"vor","delay-in-days":391,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.jacc.2015.10.092","type":"journal-article","created":{"date-parts":[[2016,1,18]],"date-time":"2016-01-18T19:31:54Z","timestamp":1453145514000},"page":"275-287","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":110,"title":["Myocardial Infarction Alters Adaptation of\u00a0the Tethered Mitral Valve"],"prefix":"10.1016","volume":"67","author":[{"given":"Jacob P.","family":"Dal-Bianco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Aikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce","family":"Bischoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Luis","family":"Guerrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"Hjortnaes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Beaudoin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Szymanski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp E.","family":"Bartko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margo M.","family":"Seybolt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D.","family":"Handschumacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Mauskapf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James S.","family":"Titus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Wylie-Sears","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whitney S.","family":"Irvin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Chaput","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Messas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert A.","family":"Hag\u00e8ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Carpentier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Levine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2015.10.092_bib1","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1161\/01.CIR.103.13.1759","article-title":"Ischemic mitral regurgitation: long-term outcome and prognostic implications with quantitative Doppler assessment","volume":"103","author":"Grigioni","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2015.10.092_bib2","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1016\/0735-1097(92)90455-V","article-title":"Left ventricular shape is the primary determinant of functional mitral regurgitation in heart failure","volume":"20","author":"Kono","year":"1992","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2015.10.092_bib3","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1161\/01.CIR.96.6.1999","article-title":"Insights from three-dimensional echocardiography into the mechanism of functional mitral regurgitation: direct in\u00a0vivo demonstration of altered leaflet tethering geometry","volume":"96","author":"Otsuji","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2015.10.092_bib4","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1161\/CIRCULATIONAHA.107.749440","article-title":"Mitral leaflet adaptation to ventricular remodeling: occurrence and adequacy in patients with functional mitral regurgitation","volume":"118","author":"Chaput","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2015.10.092_bib5","doi-asserted-by":"crossref","first-page":"S99","DOI":"10.1161\/CIRCULATIONAHA.109.844019","article-title":"Mitral leaflet adaptation to ventricular remodeling: prospective changes in a model of ischemic mitral regurgitation","volume":"120 11 Suppl","author":"Chaput","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2015.10.092_bib6","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jmbbm.2012.07.001","article-title":"Evidence of adaptive mitral leaflet growth","volume":"15","author":"Rausch","year":"2012","journal-title":"J\u00a0Mech Behav Biomed Mater"},{"key":"10.1016\/j.jacc.2015.10.092_bib7","first-page":"181","article-title":"Collagen synthesis is upregulated in mitral valves subjected to altered stress","volume":"43","author":"Quick","year":"1997","journal-title":"ASAIO J"},{"key":"10.1016\/j.jacc.2015.10.092_bib8","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.jtcvs.2005.04.019","article-title":"Mitral valve stiffening in end-stage heart failure: evidence of an organic contribution to functional mitral regurgitation","volume":"130","author":"Grande-Allen","year":"2005","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jacc.2015.10.092_bib9","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jacc.2004.06.079","article-title":"Apparently normal mitral valves in patients with heart failure demonstrate biochemical and structural derangements: an extracellular matrix and echocardiographic study","volume":"45","author":"Grande-Allen","year":"2005","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2015.10.092_bib10","doi-asserted-by":"crossref","first-page":"S198","DOI":"10.1016\/S0003-4975(98)01106-0","article-title":"Altered collagen concentration in mitral valve leaflets: biochemical and finite element analysis","volume":"66","author":"Kunzelman","year":"1998","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jacc.2015.10.092_bib11","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1056\/NEJMoa1312808","article-title":"Mitral-valve repair versus replacement for severe ischemic mitral regurgitation","volume":"370","author":"Acker","year":"2014","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2015.10.092_bib12","doi-asserted-by":"crossref","first-page":"II85","DOI":"10.1161\/01.CIR.0000138192.65015.45","article-title":"Mechanism of recurrent ischemic mitral regurgitation after annuloplasty: continued LV remodeling as a moving target","volume":"110","author":"Hung","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2015.10.092_bib13","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.jtcvs.2004.07.037","article-title":"Recurrent mitral regurgitation after annuloplasty for functional ischemic mitral regurgitation","volume":"128","author":"McGee","year":"2004","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jacc.2015.10.092_bib14","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0008-6363(01)00434-5","article-title":"The inflammatory response in myocardial infarction","volume":"53","author":"Frangogiannis","year":"2002","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jacc.2015.10.092_bib15","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1146\/annurev.physiol.65.092101.142249","article-title":"Stress-activated cytokines and the heart: from adaptation to maladaptation","volume":"65","author":"Mann","year":"2003","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.jacc.2015.10.092_bib16","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1161\/01.RES.0000130526.20854.fa","article-title":"Inflammatory cytokines and postmyocardial infarction remodeling","volume":"94","author":"Nian","year":"2004","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2015.10.092_bib17","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S1054-8807(98)00021-0","article-title":"Correlation between clinical and histologic patterns of degenerative mitral valve insufficiency: a histomorphometric study of 130 excised segments","volume":"8","author":"Fornes","year":"1999","journal-title":"Cardiovasc Pathol"},{"key":"10.1016\/j.jacc.2015.10.092_bib18","doi-asserted-by":"crossref","first-page":"S243","DOI":"10.1161\/CIRCULATIONAHA.107.757526","article-title":"The effects of mitral regurgitation alone are sufficient for leaflet remodeling","volume":"118 14 Suppl","author":"Stephens","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2015.10.092_bib19","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1161\/CIRCULATIONAHA.108.846782","article-title":"Active adaptation of the tethered mitral valve: insights into a compensatory mechanism for functional mitral regurgitation","volume":"120","author":"Dal-Bianco","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2015.10.092_bib20","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1161\/CIRCULATIONAHA.105.591768","article-title":"Human semilunar cardiac valve remodeling by activated cells from fetus to adult: implications for postnatal adaptation, pathology, and tissue engineering","volume":"113","author":"Aikawa","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2015.10.092_bib21","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1161\/01.RES.0000141146.95728.da","article-title":"Heart valve development: endothelial cell signaling and differentiation","volume":"95","author":"Armstrong","year":"2004","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2015.10.092_bib22","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1161\/CIRCRESAHA.109.201566","article-title":"Heart valve development: regulatory networks in development and disease","volume":"105","author":"Combs","year":"2009","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2015.10.092_bib23","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1749-6632.2009.05098.x","article-title":"Developmental basis of adult cardiovascular diseases: valvular heart diseases","volume":"1188","author":"Markwald","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jacc.2015.10.092_bib24","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.cardiores.2006.10.002","article-title":"The role of TGF-beta signaling in myocardial infarction and cardiac remodeling","volume":"74","author":"Bujak","year":"2007","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jacc.2015.10.092_bib25","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1161\/01.RES.0000136520.07995.aa","article-title":"Valvular myofibroblast activation by transforming growth factor-beta: implications for pathological extracellular matrix remodeling in heart valve disease","volume":"95","author":"Walker","year":"2004","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2015.10.092_bib26","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.cardiores.2004.04.030","article-title":"TGF-beta1 and angiotensin networking in cardiac remodeling","volume":"63","author":"Rosenkranz","year":"2004","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jacc.2015.10.092_bib27","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1161\/CIRCRESAHA.110.217737","article-title":"Potential therapeutic targets for cardiac fibrosis: TGFbeta, angiotensin, endothelin, CCN2, and PDGF, partners in fibroblast activation","volume":"106","author":"Leask","year":"2010","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2015.10.092_bib28","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0022-5223(98)70326-5","article-title":"Infarct size and location determine development of mitral regurgitation in the sheep model","volume":"115","author":"Gorman","year":"1998","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jacc.2015.10.092_bib29","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1161\/CIRCIMAGING.113.000561","article-title":"Assessment of mitral valve adaptation with gated cardiac computed tomography: validation with three-dimensional echocardiography and mechanistic insight to functional mitral regurgitation","volume":"6","author":"Beaudoin","year":"2013","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.jacc.2015.10.092_bib30","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1161\/hc4601.099489","article-title":"Activated interstitial myofibroblasts express catabolic enzymes and mediate matrix remodeling in myxomatous heart valves","volume":"104","author":"Rabkin","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2015.10.092_bib31","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.cardiores.2006.03.022","article-title":"Collagen synthesis by mesenchymal stem cells and aortic valve interstitial cells in response to mechanical stretch","volume":"71","author":"Ku","year":"2006","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jacc.2015.10.092_bib32","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0074-7696(05)43005-3","article-title":"Cell biology of cardiac cushion development","volume":"243","author":"Person","year":"2005","journal-title":"Int Rev Cytol"},{"key":"10.1016\/j.jacc.2015.10.092_bib33","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1016\/j.jacc.2013.01.064","article-title":"Mitral valve enlargement in chronic aortic regurgitation as a compensatory mechanism to prevent functional mitral regurgitation in the dilated left ventricle","volume":"61","author":"Beaudoin","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2015.10.092_bib34","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.jcmg.2011.10.004","article-title":"Influence of chronic tethering of the mitral valve on mitral leaflet size and coaptation in functional mitral regurgitation","volume":"5","author":"Saito","year":"2012","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jacc.2015.10.092_bib35","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/nm1613","article-title":"Endothelial-to-mesenchymal transition contributes to cardiac fibrosis","volume":"13","author":"Zeisberg","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.jacc.2015.10.092_bib36","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.2353\/ajpath.2008.080365","article-title":"Transforming growth factor-beta regulates in\u00a0vitro heart valve repair by activated valve interstitial cells","volume":"173","author":"Liu","year":"2008","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jacc.2015.10.092_bib37","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1038\/labinvest.3780119","article-title":"Roles and relationship of macrophages and monocyte chemotactic and activating factor\/monocyte chemoattractant protein-1 in the ischemic and reperfused rat heart","volume":"80","author":"Kakio","year":"2000","journal-title":"Lab Invest"},{"key":"10.1016\/j.jacc.2015.10.092_bib38","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.2277","article-title":"Cellular and molecular mechanisms of fibrosis","volume":"214","author":"Wynn","year":"2008","journal-title":"J\u00a0Pathol"},{"key":"10.1016\/j.jacc.2015.10.092_bib39","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.exphem.2010.03.004","article-title":"Fibrocytes in health and disease","volume":"38","author":"Herzog","year":"2010","journal-title":"Exp Hematol"},{"key":"10.1016\/j.jacc.2015.10.092_bib40","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.biocel.2009.10.014","article-title":"Fibrocytes: bringing new insights into mechanisms of inflammation and fibrosis","volume":"42","author":"Keeley","year":"2010","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.jacc.2015.10.092_bib41","doi-asserted-by":"crossref","first-page":"22910","DOI":"10.1074\/jbc.M703597200","article-title":"Differentiation of human circulating fibrocytes as mediated by transforming growth factor-beta and peroxisome proliferator-activated receptor gamma","volume":"282","author":"Hong","year":"2007","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jacc.2015.10.092_bib42","doi-asserted-by":"crossref","first-page":"18284","DOI":"10.1073\/pnas.0608799103","article-title":"Bone marrow-derived fibroblast precursors mediate ischemic cardiomyopathy in mice","volume":"103","author":"Haudek","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jacc.2015.10.092_bib43","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1161\/01.RES.0000207384.81818.d4","article-title":"An in\u00a0vivo analysis of hematopoietic stem cell potential: hematopoietic origin of cardiac valve interstitial cells","volume":"98","author":"Visconti","year":"2006","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2015.10.092_bib44","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jacc.2005.03.058","article-title":"Age-associated aortic stenosis in apolipoprotein E-deficient mice","volume":"46","author":"Tanaka","year":"2005","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2015.10.092_bib45","doi-asserted-by":"crossref","first-page":"5788","DOI":"10.1073\/pnas.84.16.5788","article-title":"Transforming growth factor type beta induces monocyte chemotaxis and growth factor production","volume":"84","author":"Wahl","year":"1987","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jacc.2015.10.092_bib46","first-page":"674","article-title":"Bone marrow-derived myofibroblasts are present in adult human heart valves","volume":"14","author":"Deb","year":"2005","journal-title":"J\u00a0Heart Valve Dis"},{"key":"10.1016\/j.jacc.2015.10.092_bib47","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1172\/JCI200422715","article-title":"TGF-beta-dependent pathogenesis of mitral valve prolapse in a mouse model of Marfan syndrome","volume":"114","author":"Ng","year":"2004","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jacc.2015.10.092_bib48","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1161\/01.CIR.0000049745.38594.6D","article-title":"Myocardial proinflammatory cytokine expression and left ventricular remodeling in patients with chronic mitral regurgitation","volume":"107","author":"Oral","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2015.10.092_bib49","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1161\/CIRCULATIONAHA.108.826230","article-title":"Microarray identifies extensive downregulation of noncollagen extracellular matrix and profibrotic growth factor genes in chronic isolated mitral regurgitation in the dog","volume":"119","author":"Zheng","year":"2009","journal-title":"Circulation"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109715075476?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109715075476?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T03:58:14Z","timestamp":1537070294000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109715075476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S0735109715075476"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2015.10.092","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Myocardial Infarction Alters Adaptation of\u00a0the Tethered Mitral Valve","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2015.10.092","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}