{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:03:21Z","timestamp":1778817801271,"version":"3.51.4"},"reference-count":30,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T00:00:00Z","timestamp":1487203200000},"content-version":"vor","delay-in-days":381,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.jacc.2015.11.039","type":"journal-article","created":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T22:37:52Z","timestamp":1454971072000},"page":"618-626","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"title":["Nonsyndromic Thoracic Aortic Aneurysm and Dissection"],"prefix":"10.1016","volume":"67","author":[{"given":"Andrew G.","family":"Sherrah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Andvik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise","family":"van der Linde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy","family":"Davies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul G.","family":"Bannon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ratnasari","family":"Padang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael P.","family":"Vallely","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael K.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony C.","family":"Keech","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richmond W.","family":"Jeremy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2015.11.039_bib1","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1136\/heartjnl-2013-305130","article-title":"The genetic basis for aortic aneurysmal disease","volume":"100","author":"Saratzis","year":"2014","journal-title":"Heart"},{"key":"10.1016\/j.jacc.2015.11.039_bib2","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.athoracsur.2006.04.098","article-title":"Familial thoracic aortic aneurysms and dissections - incidence, modes of inheritance, and phenotypic patterns","volume":"82","author":"Albornoz","year":"2006","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jacc.2015.11.039_bib3","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1001\/jama.300.11.1317","article-title":"Outcomes in adults with bicuspid aortic valves","volume":"300","author":"Tzemos","year":"2008","journal-title":"J\u00a0Am Med Assoc"},{"key":"10.1016\/j.jacc.2015.11.039_bib4","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/ng1511","article-title":"A\u00a0syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2","volume":"37","author":"Loeys","year":"2005","journal-title":"Nat Genet"},{"key":"10.1016\/j.jacc.2015.11.039_bib5","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.jacc.2011.12.052","article-title":"Aggressive cardiovascular phenotype of Aneurysms-Osteoarthritis Syndrome caused by pathogenic SMAD3 variants","volume":"60","author":"van der Linde","year":"2012","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2015.11.039_bib6","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/S0140-6736(05)67789-6","article-title":"Marfan's syndrome","volume":"366","author":"Judge","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2015.11.039_bib7","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.ajhg.2009.04.007","article-title":"Mutations in smooth muscle alpha-actin (ACTA2) cause coronary artery disease, stroke, and Moyamoya disease, along with thoracic aortic disease","volume":"84","author":"Guo","year":"2009","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jacc.2015.11.039_bib8","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/ng1721","article-title":"Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm\/aortic dissection and patent ductus arteriosus","volume":"38","author":"Zhu","year":"2006","journal-title":"Nat Genet"},{"key":"10.1016\/j.jacc.2015.11.039_bib9","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1056\/NEJM197204132861502","article-title":"Life expectancy and causes of death in the Marfan Ssyndrome","volume":"286","author":"Murdoch","year":"1972","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2015.11.039_bib10","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0002-9149(00)80066-1","article-title":"Life expectancy in the Marfan syndrome","volume":"75","author":"Silverman","year":"1995","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2015.11.039_bib11","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1136\/hrt.82.4.499","article-title":"Survival and complication free survival in Marfan's Syndrome: Implications of current guidelines","volume":"82","author":"Groenink","year":"1999","journal-title":"Heart"},{"key":"10.1016\/j.jacc.2015.11.039_bib12","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/j.1399-0004.1998.tb03714.x","article-title":"Life expectancy in British Marfan Syndrome populations","volume":"54","author":"Gray","year":"1998","journal-title":"Clin Genet"},{"key":"10.1016\/j.jacc.2015.11.039_bib13","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/S0003-4975(01)03336-7","article-title":"Aortic root replacement in 271 Marfan patients: A 24-year experience","volume":"73","author":"Gott","year":"2002","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jacc.2015.11.039_bib14","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1001\/jama.2011.1286","article-title":"Incidence of aortic complications in patients with bicuspid aortic valves","volume":"306","author":"Michelena","year":"2011","journal-title":"J\u00a0Am Med Assoc"},{"key":"10.1016\/j.jacc.2015.11.039_bib15","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.ijcard.2012.10.027","article-title":"Congenital valvular aortic stenosis in young adults: Predictors for rate of progression of stenosis and aortic dilatation","volume":"168","author":"van der Linde","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacc.2015.11.039_bib16","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/ajmg.1320290316","article-title":"International nosology of heritable disorders of connective tissue, Berlin, 1986","volume":"29","author":"Beighton","year":"1988","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.jacc.2015.11.039_bib17","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/(SICI)1096-8628(19960424)62:4<417::AID-AJMG15>3.0.CO;2-R","article-title":"Revised diagnostic criteria for the Marfan Syndrome","volume":"62","author":"de Paepe","year":"1996","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.jacc.2015.11.039_bib18","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1136\/jmg.2009.072785","article-title":"The revised Ghent nosology for the Marfan syndrome","volume":"47","author":"Loeys","year":"2010","journal-title":"J\u00a0Med Genet"},{"key":"10.1016\/j.jacc.2015.11.039_bib19","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/S0735-1097(03)01065-9","article-title":"ACC\/AHA\/ASE 2003 guideline update for the clinical application of echocardiography: Summary Article","volume":"42","author":"Cheitlin","year":"2003","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2015.11.039_bib20","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/j.jacc.2010.02.010","article-title":"2010 ACCF\/AHA\/AATS\/ACR\/ASA\/SCA\/SCAI\/SIR\/STS\/SVM guidelines for the diagnosis and management of patients with thoracic aortic disease: executive summary","volume":"55","author":"Hiratzka","year":"2010","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2015.11.039_bib21","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jcmg.2007.11.005","article-title":"Aortic size assessment by noncontrast cardiac computed tomography: Normal limits by age, gender, and body surface area","volume":"1","author":"Wolak","year":"2008","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jacc.2015.11.039_bib22","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1093\/eurheartj\/ehu281","article-title":"2014 ESC guidelines on the diagnosis and treatment of aortic diseases","volume":"35","author":"Erbel","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2015.11.039_bib23","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4","article-title":"Multivariable prognostic models: Issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors","volume":"15","author":"Harrell","year":"1996","journal-title":"Stat Med"},{"key":"10.1016\/j.jacc.2015.11.039_bib24","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1093\/eurjhf\/hfq127","article-title":"Evidence for Marfan cardiomyopathy","volume":"12","author":"Alpendurada","year":"2010","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jacc.2015.11.039_bib25","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.gene.2013.10.033","article-title":"Relation between genotype and left-ventricular dilatation in patients with Marfan syndrome","volume":"534","author":"Aalberts","year":"2014","journal-title":"Gene"},{"key":"10.1016\/j.jacc.2015.11.039_bib26","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/ajmg.a.35836","article-title":"GenTAC registry report: Gender differences among individuals with genetically triggered thoracic aortic aneurysm and dissection","volume":"161A","author":"Holmes","year":"2013","journal-title":"Am J Med Genet Part A"},{"key":"10.1016\/j.jacc.2015.11.039_bib27","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1161\/CIRCULATIONAHA.107.702720","article-title":"Aortic diameter\u00a0\u22655.5 cm is not a good predictor of type A aortic dissection: Observations from the International Registry of Acute Aortic Dissection (IRAD)","volume":"116","author":"Pape","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2015.11.039_bib28","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1001\/jama.284.7.835","article-title":"The TIMI risk score for unstable angina\/non-ST elevation MI","volume":"284","author":"Antman","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.jacc.2015.11.039_bib29","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/nature10145","article-title":"Lessons on the pathogenesis of aneurysm from heritable conditions","volume":"473","author":"Lindsay","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jacc.2015.11.039_bib30","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ijcard.2013.08.056","article-title":"Perturbations of mechanotransduction and aneurysm formation in heritable aortopathies","volume":"169","author":"Jeremy","year":"2013","journal-title":"Int J Cardiol"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109715076305?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109715076305?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,15]],"date-time":"2018-09-15T15:55:11Z","timestamp":1537026911000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109715076305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S0735109715076305"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2015.11.039","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nonsyndromic Thoracic Aortic Aneurysm and Dissection","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2015.11.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}