{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T17:51:34Z","timestamp":1783446694512,"version":"3.55.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,8,16]],"date-time":"2017-08-16T00:00:00Z","timestamp":1502841600000},"content-version":"vor","delay-in-days":380,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.jacc.2016.05.071","type":"journal-article","created":{"date-parts":[[2016,8,9]],"date-time":"2016-08-09T13:44:09Z","timestamp":1470750249000},"page":"688-697","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":72,"title":["Coronary Physiology During Exercise and Vasodilation in the Healthy Heart and in Severe Aortic Stenosis"],"prefix":"10.1016","volume":"68","author":[{"given":"Matthew","family":"Lumley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupert","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaleab N.","family":"Asrress","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satpal","family":"Arri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Briceno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronak","family":"Rajani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Siebes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan J.","family":"Piek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Clapp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon R.","family":"Redwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Marber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John B.","family":"Chambers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divaka","family":"Perera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2016.05.071_bib1","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1056\/NEJM198211253072202","article-title":"Decreased coronary reserve: a mechanism for angina pectoris in patients with aortic stenosis and normal coronary arteries","volume":"307","author":"Marcus","year":"1982","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2016.05.071_bib2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1136\/hrt.71.1.57","article-title":"Profiles of coronary blood flow velocity in patients with aortic stenosis and the effect of valve replacement: a transthoracic echocardiographic study","volume":"71","author":"Kenny","year":"1994","journal-title":"Br Heart J"},{"key":"10.1016\/j.jacc.2016.05.071_bib3","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1161\/CIRCOUTCOMES.111.000091","article-title":"Impact of aortic stenosis on postoperative outcomes after noncardiac surgeries","volume":"6","author":"Agarwal","year":"2013","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"10.1016\/j.jacc.2016.05.071_bib4","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1161\/CIRCULATIONAHA.112.094292","article-title":"Synergistic adaptations to exercise in the systemic and coronary circulations that underlie the warm-up angina phenomenon","volume":"126","author":"Lockie","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2016.05.071_bib5","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1161\/CIRCULATIONAHA.105.603050","article-title":"Evidence of a dominant backward-propagating \u201csuction\u201d wave responsible for diastolic coronary filling in humans, attenuated in left ventricular hypertrophy","volume":"113","author":"Davies","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2016.05.071_bib6","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1161\/CIRCULATIONAHA.110.011916","article-title":"Arterial pulse wave dynamics after percutaneous aortic valve replacement: fall in coronary diastolic suction with increasing heart rate as a basis for angina symptoms in aortic stenosis","volume":"124","author":"Davies","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2016.05.071_bib7","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1152\/jappl.2000.89.4.1636","article-title":"Wave-intensity analysis: a new approach to coronary hemodynamics","volume":"89","author":"Sun","year":"2000","journal-title":"J\u00a0Appl Physiol"},{"key":"10.1016\/j.jacc.2016.05.071_bib8","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1161\/CIRCINTERVENTIONS.112.973081","article-title":"Coronary wave energy a novel predictor of functional recovery after myocardial infarction","volume":"6","author":"De Silva","year":"2013","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.jacc.2016.05.071_bib9","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1161\/CIRCULATIONAHA.111.075606","article-title":"Improvement in coronary blood flow velocity with acute biventricular pacing is predominantly due to an increase in a diastolic backward-travelling decompression (suction) wave","volume":"126","author":"Kyriacou","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2016.05.071_bib10","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1021\/ac60319a045","article-title":"Smoothing and differentiation of data by simplified least square procedure","volume":"44","author":"Steinier","year":"1972","journal-title":"Anal Chem"},{"key":"10.1016\/j.jacc.2016.05.071_bib11","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.jacc.2011.11.003","article-title":"Development\u00a0and validation of a new adenosine-independent index of stenosis severity from coronary wave-intensity analysis: results of the ADVISE (ADenosine Vasodilator Independent Stenosis Evaluation) study","volume":"59","author":"Sen","year":"2012","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2016.05.071_bib12","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s11517-009-0439-y","article-title":"An introduction to wave intensity analysis","volume":"47","author":"Parker","year":"2009","journal-title":"Med Biol Eng Comput"},{"key":"10.1016\/j.jacc.2016.05.071_bib13","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.jcin.2013.11.023","article-title":"Coronary and microvascular physiology during intra-aortic balloon counterpulsation","volume":"7","author":"De Silva","year":"2014","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jacc.2016.05.071_bib14","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1161\/01.CIR.50.6.1179","article-title":"Hemodynamic predictors of myocardial oxygen consumption during static and dynamic exercise","volume":"50","author":"Nelson","year":"1974","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2016.05.071_bib15","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/S0735-1097(99)00066-2","article-title":"\u201cOverestimation\u201d of catheter gradients by Doppler ultrasound in patients with aortic stenosis: a predictable manifestation of pressure recovery","volume":"33","author":"Baumgartner","year":"1999","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2016.05.071_bib16","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1161\/hc0402.102931","article-title":"Mechanisms of coronary microcirculatory dysfunction in patients with aortic stenosis and angiographically normal coronary arteries","volume":"105","author":"Rajappan","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2016.05.071_bib17","doi-asserted-by":"crossref","first-page":"e002443","DOI":"10.1161\/CIRCINTERVENTIONS.114.002443","article-title":"Impact of aortic valve stenosis on coronary hemodynamics and the instantaneous effect of transcatheter aortic valve implantation","volume":"8","author":"Wiegerinck","year":"2015","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.jacc.2016.05.071_bib18","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1161\/01.CIR.0000074211.28917.31","article-title":"Functional changes in coronary microcirculation after valve replacement in patients with aortic stenosis","volume":"107","author":"Rajappan","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2016.05.071_bib19","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1007\/s00259-010-1540-z","article-title":"Myocardial oxidative metabolism is increased due to haemodynamic overload in patients with aortic valve stenosis: assessment using 11C-acetate positron emission tomography","volume":"37","author":"Naya","year":"2010","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.jacc.2016.05.071_bib20","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1093\/ehjci\/jev009","article-title":"Myocardial efficiency is an important determinant of functional improvement after aortic valve replacement in aortic valve stenosis patients: a combined PET and CMR study","volume":"16","author":"G\u00fc\u00e7l\u00fc","year":"2015","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.jacc.2016.05.071_bib21","doi-asserted-by":"crossref","first-page":"H1590","DOI":"10.1152\/ajpheart.01100.2001","article-title":"Effects of left ventricular contractility and coronary vascular resistance on coronary dynamics","volume":"286","author":"Sun","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jacc.2016.05.071_bib22","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00395-014-0405-1","article-title":"Wave\u00a0speed in human coronary arteries is not influenced by microvascular vasodilation: implications for wave intensity analysis","volume":"109","author":"Rolandi","year":"2014","journal-title":"Basic Res Cardiol"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109716334520?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109716334520?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T09:44:40Z","timestamp":1568281480000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109716334520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":22,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["S0735109716334520"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2016.05.071","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Coronary Physiology During Exercise and Vasodilation in the Healthy Heart and in Severe Aortic Stenosis","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2016.05.071","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 by the American College of Cardiology Foundation","name":"copyright","label":"Copyright"}]}}