{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T15:06:49Z","timestamp":1786633609945,"version":"build-2736575974"},"reference-count":45,"publisher":"Elsevier BV","issue":"16","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,10,18]],"date-time":"2017-10-18T00:00:00Z","timestamp":1508284800000},"content-version":"vor","delay-in-days":382,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.jacc.2016.07.756","type":"journal-article","created":{"date-parts":[[2016,10,10]],"date-time":"2016-10-10T14:30:19Z","timestamp":1476109819000},"page":"1741-1752","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"title":["Impact of Ischemic Heart Failure Etiology on Cardiac Recovery During Mechanical\u00a0Unloading"],"prefix":"10.1016","volume":"68","author":[{"given":"James","family":"Wever-Pinzon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig H.","family":"Selzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Stoddard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Wever-Pinzon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Catino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdallah G.","family":"Kfoury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos A.","family":"Diakos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce B.","family":"Reid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"McKellar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bonios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antigone","family":"Koliopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Budge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Kelkhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Stehlik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stavros G.","family":"Drakos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2016.07.756_bib1","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.healun.2014.04.010","article-title":"Sixth INTERMACS annual report: a 10,000-patient database","volume":"33","author":"Kirklin","year":"2014","journal-title":"J\u00a0Heart Lung Transplant"},{"key":"10.1016\/j.jacc.2016.07.756_bib2","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1056\/NEJMoa053063","article-title":"Left ventricular assist device and drug therapy for the reversal of heart failure","volume":"355","author":"Birks","year":"2006","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2016.07.756_bib3","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.jtcvs.2005.05.016","article-title":"Who would be a candidate for bridge to recovery during prolonged mechanical left ventricular support in idiopathic dilated cardiomyopathy?","volume":"130","author":"Matsumiya","year":"2005","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jacc.2016.07.756_bib4","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1161\/CIRCULATIONAHA.109.933960","article-title":"Reversal of severe heart failure with a continuous-flow left ventricular assist device and pharmacological therapy: a prospective study","volume":"123","author":"Birks","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2016.07.756_bib5","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.healun.2012.11.019","article-title":"Combining neurohormonal blockade with continuous-flow left ventricular assist device support for myocardial recovery: a single-arm prospective study","volume":"32","author":"Patel","year":"2013","journal-title":"J\u00a0Heart Lung Transplant"},{"key":"10.1016\/j.jacc.2016.07.756_bib6","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.healun.2014.09.015","article-title":"Ventricular reconditioning and pump explantation in patients supported by continuous-flow left ventricular assist devices","volume":"34","author":"Frazier","year":"2015","journal-title":"J\u00a0Heart Lung Transplant"},{"key":"10.1016\/j.jacc.2016.07.756_bib7","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1161\/01.CIR.0000129233.51320.92","article-title":"Clinical recovery from end-stage heart failure using left-ventricular assist device and pharmacological therapy correlates with increased sarcoplasmic reticulum calcium content but not with regression of cellular hypertrophy","volume":"109","author":"Terracciano","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2016.07.756_bib8","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1093\/eurheartj\/ehl365","article-title":"Molecular signature of recovery following combination left ventricular assist device (LVAD) support and pharmacologic therapy","volume":"28","author":"Hall","year":"2007","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2016.07.756_bib9","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.jacc.2014.12.027","article-title":"Human ventricular unloading induces cardiomyocyte proliferation","volume":"65","author":"Canseco","year":"2015","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2016.07.756_bib10","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1161\/CIRCULATIONAHA.111.040261","article-title":"Bridge to recovery: understanding the disconnect between clinical and biological outcomes","volume":"126","author":"Drakos","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2016.07.756_bib11","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1161\/01.CIR.0000036014.90197.FA","article-title":"Left ventricular remodeling after primary coronary angioplasty: patterns of left ventricular dilation and long-term prognostic implications","volume":"106","author":"Bolognese","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2016.07.756_bib12","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ejheart.2004.04.011","article-title":"Heart failure after myocardial infarction: clinical presentation and survival","volume":"7","author":"Hellermann","year":"2005","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jacc.2016.07.756_bib13","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.cardfail.2012.01.020","article-title":"Young patients with nonischemic cardiomyopathy have higher likelihood of left ventricular recovery during left ventricular assist device support","volume":"18","author":"Goldstein","year":"2012","journal-title":"J\u00a0Card Fail"},{"key":"10.1016\/j.jacc.2016.07.756_bib14","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.healun.2008.05.007","article-title":"Which factors predict the recovery of natural heart function after insertion of a left ventricular assist system?","volume":"27","author":"Mano","year":"2008","journal-title":"J\u00a0Heart Lung Transplant"},{"key":"10.1016\/j.jacc.2016.07.756_bib15","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1016\/j.jacc.2013.01.072","article-title":"Magnitude and time course of changes induced by continuous-flow left ventricular assist device unloading in chronic heart failure: insights into cardiac recovery","volume":"61","author":"Drakos","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2016.07.756_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"28","author":"Lang","year":"2015","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.jacc.2016.07.756_bib17","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.echo.2008.11.023","article-title":"Recommendations for the evaluation of left ventricular diastolic function by echocardiography","volume":"22","author":"Nagueh","year":"2009","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.jacc.2016.07.756_bib18","first-page":"1905","article-title":"ICH harmonised tripartite guideline: statistical principles for clinical trials","volume":"18","year":"1999","journal-title":"Stat Med"},{"key":"10.1016\/j.jacc.2016.07.756_bib19","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1136\/bmj.322.7292.989","article-title":"Interpreting the results of secondary end points and subgroup analyses in clinical trials: should we lock the crazy aunt in the attic?","volume":"322","author":"Freemantle","year":"2001","journal-title":"BMJ"},{"key":"10.1016\/j.jacc.2016.07.756_bib20","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1161\/01.CIR.98.22.2383","article-title":"Low incidence of myocardial recovery after left ventricular assist device implantation in patients with chronic heart failure","volume":"98","author":"Mancini","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2016.07.756_bib21","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s10047-014-0802-0","article-title":"Hemodynamic changes during left ventricular assist device-off test correlate with the degree of cardiac fibrosis and predict the outcome after device explantation","volume":"18","author":"Saito","year":"2015","journal-title":"J\u00a0Artif Organs"},{"key":"10.1016\/j.jacc.2016.07.756_bib22","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/j.1540-8191.2008.00665.x","article-title":"Explantation of INCOR left ventricular assist device after myocardial recovery","volume":"23","author":"Komoda","year":"2008","journal-title":"J\u00a0Card Surg"},{"issue":"Suppl 9","key":"10.1016\/j.jacc.2016.07.756_bib23","first-page":"I32","article-title":"Myocardial recovery using ventricular assist devices: prevalence, clinical characteristics, and outcomes","volume":"112","author":"Simon","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2016.07.756_bib24","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/S1053-2498(01)00408-9","article-title":"Long-term follow-up of Thoratec ventricular assist device bridge-to-recovery patients successfully removed from support after recovery of ventricular function","volume":"21","author":"Farrar","year":"2002","journal-title":"J\u00a0Heart Lung Transplant"},{"key":"10.1016\/j.jacc.2016.07.756_bib25","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.healun.2014.01.856","article-title":"Results of the post-market Registry to Evaluate the HeartWare Left Ventricular Assist System (ReVOLVE)","volume":"33","author":"Strueber","year":"2014","journal-title":"J\u00a0Heart Lung Transplant"},{"key":"10.1016\/j.jacc.2016.07.756_bib26","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1161\/CIRCULATIONAHA.106.633180","article-title":"Cardiac improvement during mechanical circulatory support: a prospective multicenter study of the LVAD Working Group","volume":"115","author":"Maybaum","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2016.07.756_bib27","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.yjmcc.2007.05.020","article-title":"Reverse remodeling during long-term mechanical unloading of the left ventricle","volume":"43","author":"Drakos","year":"2007","journal-title":"J\u00a0Mol Cell Cardiol"},{"issue":"Suppl 9","key":"10.1016\/j.jacc.2016.07.756_bib28","first-page":"I37","article-title":"Long-term results in patients with idiopathic dilated cardiomyopathy after weaning from left ventricular assist devices","volume":"112","author":"Dandel","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2016.07.756_bib29","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.cjca.2011.01.005","article-title":"Successful weaning and explantation of the Heartmate II left ventricular assist device","volume":"27","author":"Lamarche","year":"2011","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.jacc.2016.07.756_bib30","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S1053-2498(02)00485-0","article-title":"Dobutamine stress echocardiography predicts myocardial improvement in patients supported by left ventricular assist devices (LVADs): hemodynamic and histologic evidence of improvement before LVAD explantation","volume":"22","author":"Khan","year":"2003","journal-title":"J\u00a0Heart Lung Transplant"},{"key":"10.1016\/j.jacc.2016.07.756_bib31","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.cardfail.2012.08.001","article-title":"Left ventricular assist device support and myocardial recovery in recent onset cardiomyopathy","volume":"18","author":"Boehmer","year":"2012","journal-title":"J\u00a0Card Fail"},{"key":"10.1016\/j.jacc.2016.07.756_bib32","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.ejheart.2006.12.003","article-title":"The feasibility of left ventricular mechanical support as a bridge to cardiac recovery","volume":"9","author":"Liden","year":"2007","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jacc.2016.07.756_bib33","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.healun.2016.01.001","article-title":"Clinical myocardial recovery during long-term mechanical support in advanced heart failure: insights into moving the field forward","volume":"35","author":"Drakos","year":"2016","journal-title":"J\u00a0Heart Lung Transplant"},{"key":"10.1016\/j.jacc.2016.07.756_bib34","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.jacc.2010.04.019","article-title":"Impact of mechanical unloading on microvasculature and associated central remodeling features of the failing human heart","volume":"56","author":"Drakos","year":"2010","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2016.07.756_bib35","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/S0003-4975(01)03621-9","article-title":"Disease-specific remodeling of cardiac mitochondria after a left ventricular assist device","volume":"73","author":"Heerdt","year":"2002","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jacc.2016.07.756_bib36","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1152\/physiolgenomics.00004.2004","article-title":"Genomic profiling of the human heart before and after mechanical support with a ventricular assist device reveals alterations in vascular signaling networks","volume":"17","author":"Hall","year":"2004","journal-title":"Physiol Genomics"},{"key":"10.1016\/j.jacc.2016.07.756_bib37","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/S0735-1097(03)00043-3","article-title":"Differential gene expression and genomic patient stratification following left ventricular assist device support","volume":"41","author":"Blaxall","year":"2003","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2016.07.756_bib38","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1136\/hrt.80.6.559","article-title":"Prevalence of hibernating myocardium in patients with severely impaired ischaemic left ventricles","volume":"80","author":"al-Mohammad","year":"1998","journal-title":"Heart"},{"key":"10.1016\/j.jacc.2016.07.756_bib39","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1161\/01.CIR.99.22.2921","article-title":"Prevalence of myocardial viability as detected by positron emission tomography in patients with ischemic cardiomyopathy","volume":"99","author":"Auerbach","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2016.07.756_bib40","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S0002-9149(01)01741-6","article-title":"How many patients with ischemic cardiomyopathy exhibit viable myocardium?","volume":"88","author":"Schinkel","year":"2001","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2016.07.756_bib41","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1053\/euhj.2000.2289","article-title":"Coronary artery disease as the cause of incident heart failure in the population","volume":"22","author":"Fox","year":"2001","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2016.07.756_bib42","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1136\/heart.88.2.125","article-title":"Prevalence of myocardial viability assessed by single photon emission computed tomography in patients with chronic ischaemic left ventricular dysfunction","volume":"88","author":"Schinkel","year":"2002","journal-title":"Heart"},{"key":"10.1016\/j.jacc.2016.07.756_bib43","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1067\/mtc.2001.112632","article-title":"Time course of reverse remodeling of the left ventricle during support with a left ventricular assist device","volume":"121","author":"Madigan","year":"2001","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jacc.2016.07.756_bib44","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.healun.2006.10.016","article-title":"Determination of optimal duration of mechanical unloading for failing hearts to achieve bridge to recovery in a rat heterotopic heart transplantation model","volume":"26","author":"Oriyanhan","year":"2007","journal-title":"J\u00a0Heart Lung Transplant"},{"key":"10.1016\/j.jacc.2016.07.756_bib45","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1016\/j.jacc.2014.05.073","article-title":"Myocardial atrophy and chronic mechanical unloading of the failing human heart: implications for cardiac assist device-induced myocardial recovery","volume":"64","author":"Diakos","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109716349257?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109716349257?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T15:53:40Z","timestamp":1536335620000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109716349257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":45,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S0735109716349257"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2016.07.756","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of Ischemic Heart Failure Etiology on Cardiac Recovery During Mechanical\u00a0Unloading","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2016.07.756","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}