{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:00:56Z","timestamp":1792800056729,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"22","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T00:00:00Z","timestamp":1493683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.jacc.2017.03.605","type":"journal-article","created":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T22:00:51Z","timestamp":1496181651000},"page":"2681-2691","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":145,"title":["Maternal and Fetal Outcomes of Anticoagulation in Pregnant Women With\u00a0Mechanical Heart\u00a0Valves"],"prefix":"10.1016","volume":"69","author":[{"given":"Zachary L.","family":"Steinberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara P.","family":"Dominguez-Islas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine M.","family":"Otto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen K.","family":"Stout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric V.","family":"Krieger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2017.03.605_bib1","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/j.1365-2141.2004.05041.x","article-title":"Hormones and pregnancy: thromboembolic risks for women","volume":"126","author":"Kujovich","year":"2004","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jacc.2017.03.605_bib2","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jacc.2008.05.007","volume":"52","author":"Bonow","year":"2008","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2017.03.605_bib3","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/0002-9343(80)90181-3","article-title":"Maternal and fetal sequelae of anticoagulation during pregnancy","volume":"68","author":"Hall","year":"1980","journal-title":"Am J Med"},{"key":"10.1016\/j.jacc.2017.03.605_bib4","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1056\/NEJM198611273152205","article-title":"Risks of anticoagulant therapy in pregnant women with artificial heart valves","volume":"315","author":"Iturbe-Alessio","year":"1986","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2017.03.605_bib5","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1016\/0002-9149(89)90008-8","article-title":"Maternal and fetal sequelae of anticoagulation during pregnancy in patients with mechanical heart valve prostheses","volume":"63","author":"Sareli","year":"1989","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2017.03.605_bib6","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1001\/archinte.160.2.191","article-title":"Anticoagulation of pregnant women with mechanical heart valves: a systematic review of the literature","volume":"160","author":"Chan","year":"2000","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jacc.2017.03.605_bib7","doi-asserted-by":"crossref","first-page":"e57","DOI":"10.1016\/j.jacc.2014.02.536","article-title":"2014 AHA\/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines [Published correction appears in J Am Coll Cardiol 2014;63:2489]","volume":"63","author":"Nishimura","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2017.03.605_bib8","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1093\/eurheartj\/ehr218","article-title":"ESC guidelines on the management of cardiovascular diseases during pregnancy: the Task Force on the Management of Cardiovascular Diseases during Pregnancy of the European Society of Cardiology (ESC)","volume":"32","author":"European Society of Gynecology (ESG)","year":"2011","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2017.03.605_bib9","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1080\/14767050600886666","article-title":"Low-molecular-weight heparin for thromboprophylaxis in pregnant women with mechanical heart valves","volume":"19","author":"James","year":"2006","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"key":"10.1016\/j.jacc.2017.03.605_bib10","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1160\/TH04-06-0337","article-title":"Low molecular weight heparin for the prophylaxis of thromboembolism in women with prosthetic mechanical heart valves during pregnancy","volume":"92","author":"Oran","year":"2004","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jacc.2017.03.605_bib11","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/0002-9149(83)90357-0","article-title":"Long-term results of tricuspid valve replacement and the problem of prosthetic valve thrombosis","volume":"51","author":"Thorburn","year":"1983","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2017.03.605_bib12","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3109\/14017438009109852","article-title":"Late thrombotic malfunction of the Bj\u00f6rk-Shiley tilting disc valve in the tricuspid position: principles for recognition and management","volume":"14","author":"P\u00e9terffy","year":"1980","journal-title":"Scand J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jacc.2017.03.605_bib13","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0022-5223(19)36477-3","article-title":"Experience with St. Jude Medical valve prosthesis in children: a word of caution regarding right-sided placement","volume":"93","author":"Ilbawi","year":"1987","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jacc.2017.03.605_bib14","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/jocs.12730","article-title":"Should a mechanical or biological prosthesis be used for a tricuspid valve replacement? A meta-analysis","volume":"31","author":"Liu","year":"2016","journal-title":"J\u00a0Cardiac Surg"},{"key":"10.1016\/j.jacc.2017.03.605_bib15","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0022-5223(19)36331-7","article-title":"Thrombosed St. Jude Medical valve prosthesis in the right side of the heart in patients with tetralogy of Fallot","volume":"94","author":"Miyamura","year":"1987","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jacc.2017.03.605_bib16","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1093\/icvts\/ivu009","article-title":"Limited dose warfarin throughout pregnancy in patients with mechanical heart valve prosthesis: a meta-analysis","volume":"18","author":"Hassouna","year":"2014","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"10.1016\/j.jacc.2017.03.605_bib17","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1111\/j.1471-0528.2012.03359.x","article-title":"Low-molecular-weight heparin or warfarin for anticoagulation in pregnant women with mechanical heart valves: what are the risks? A retrospective observational study","volume":"119","author":"Basude","year":"2012","journal-title":"BJOG"},{"key":"10.1016\/j.jacc.2017.03.605_bib18","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.jacc.2011.10.899","article-title":"Mechanical aortic valve replacement in young women planning on pregnancy: maternal and fetal outcomes under low oral anticoagulation, a pilot observational study on a comprehensive pre-operative counseling protocol","volume":"59","author":"De Santo","year":"2012","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2017.03.605_bib19","first-page":"117","article-title":"Pregnancy outcome after mechanical mitral valve replacement","volume":"7","author":"Samiei","year":"2012","journal-title":"J\u00a0Tehran Heart Cent"},{"key":"10.1016\/j.jacc.2017.03.605_bib20","first-page":"47","article-title":"Anti-coagulation during pregnancy in women with mechanical heart valves: a prospective study","volume":"5","author":"Khamoushi","year":"2011","journal-title":"Int J Fertil Steril"},{"key":"10.1016\/j.jacc.2017.03.605_bib21","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1177\/1076029610371470","article-title":"A\u00a0prospective trial showing the safety of adjusted-dose enoxaparin for thromboprophylaxis of pregnant women with mechanical prosthetic heart valves","volume":"17","author":"Saeed","year":"2011","journal-title":"Clin Appl Thromb Hemost"},{"key":"10.1016\/j.jacc.2017.03.605_bib22","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.thromres.2008.12.005","article-title":"Management of pregnant women with mechanical heart valve prosthesis: thromboprophylaxis with low molecular weight heparin","volume":"124","author":"Abildgaard","year":"2009","journal-title":"Thromb Res"},{"key":"10.1016\/j.jacc.2017.03.605_bib23","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.3324\/haematol.2008.002840","article-title":"Use of high intensity adjusted dose low molecular weight heparin in women with mechanical heart valves during pregnancy: a single-center experience","volume":"94","author":"Quinn","year":"2009","journal-title":"Haematologica"},{"key":"10.1016\/j.jacc.2017.03.605_bib24","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.amjcard.2009.06.040","article-title":"Use of low molecular weight heparin in pregnant women with mechanical heart valves","volume":"104","author":"Yinon","year":"2009","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2017.03.605_bib25","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1177\/021849230701500609","article-title":"Anticoagulation for prosthetic heart valves in pregnancy: is there an answer?","volume":"15","author":"Khamooshi","year":"2007","journal-title":"Asian Cardiovasc Thorac Ann"},{"key":"10.1016\/j.jacc.2017.03.605_bib26","doi-asserted-by":"crossref","first-page":"E267","DOI":"10.1532\/HSF98.20071024","article-title":"Anticoagulation in pregnant women with a bileaflet mechanical cardiac valve replacement","volume":"10","author":"Kim","year":"2007","journal-title":"Heart Surg Forum"},{"key":"10.1016\/j.jacc.2017.03.605_bib27","first-page":"679","article-title":"Low-molecular-weight heparin in pregnant women with prosthetic heart valves","volume":"15","author":"Descarries","year":"2006","journal-title":"J\u00a0Heart Valve Dis"},{"key":"10.1016\/j.jacc.2017.03.605_bib28","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.ajog.2004.05.064","article-title":"Pregnancy outcome in women with prosthetic heart valves","volume":"191","author":"Nassar","year":"2004","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jacc.2017.03.605_bib29","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1001\/archinte.163.22.2788-a","article-title":"Anticoagulation of pregnant women with mechanical heart valves using low-molecular-weight heparin","volume":"163","author":"Bauersachs","year":"2003","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jacc.2017.03.605_bib30","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S1010-7940(02)00302-0","article-title":"Pregnancy and mechanical heart valves replacement: dilemma of anticoagulation","volume":"22","author":"Al-Lawati","year":"2002","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.jacc.2017.03.605_bib31","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1177\/021849230201000405","article-title":"Effect of oral anticoagulant during pregnancy with prosthetic heart valve","volume":"10","author":"Srivastava","year":"2002","journal-title":"Asian Cardiovasc Thorac Ann"},{"key":"10.1016\/j.jacc.2017.03.605_bib32","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4137\/CMC.S36740","article-title":"Maternal and fetal outcomes in pregnant women with a prosthetic mechanical heart valve","volume":"10","author":"Ayad","year":"2016","journal-title":"Clin Med Insights Cardiol"},{"key":"10.1016\/j.jacc.2017.03.605_bib33","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1161\/CIRCULATIONAHA.115.015242","article-title":"Pregnancy in women with a mechanical heart valve: data of the European Society of Cardiology Registry of Pregnancy and Cardiac Disease (ROPAC)","volume":"132","author":"van Hagen","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2017.03.605_bib34","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1214\/aoms\/1177729756","article-title":"Transformations related to the angular and the square root","author":"Freeman","year":"1950","journal-title":"Ann Math Stat"},{"key":"10.1016\/j.jacc.2017.03.605_bib35","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1136\/jech-2013-203104","article-title":"Meta-analysis of prevalence","volume":"67","author":"Barendregt","year":"2013","journal-title":"J\u00a0Epidemiol Community Health"},{"key":"10.1016\/j.jacc.2017.03.605_bib36","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1002\/sim.6383","article-title":"Statistical methods for meta-analyses including information from studies without any events: add nothing to nothing and succeed nevertheless","volume":"34","author":"Kuss","year":"2015","journal-title":"Stat Med"},{"key":"10.1016\/j.jacc.2017.03.605_bib37","first-page":"138","article-title":"The inverse of the Freeman-Tukey double arcsine transformation","volume":"32","author":"Miller","year":"1978","journal-title":"Am Stat"},{"key":"10.1016\/j.jacc.2017.03.605_bib38","series-title":"R: A Language and Environment for Statistical Computing","year":"2014"},{"key":"10.1016\/j.jacc.2017.03.605_bib39","first-page":"1","article-title":"Conducting meta-analyses in R with the metafor package","volume":"36","author":"Viechtbauer","year":"2010","journal-title":"J\u00a0Stat Softw"},{"key":"10.1016\/j.jacc.2017.03.605_bib40","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s00404-006-0152-0","article-title":"Anticoagulation therapy during pregnancy of patients with artificial heart valves: fetomaternal outcome","volume":"274","author":"Plesinac","year":"2006","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.jacc.2017.03.605_bib41","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1253\/circj.71.211","article-title":"Risks and pregnancy outcome in women with prosthetic mechanical heart valve replacement","volume":"71","author":"Kawamata","year":"2007","journal-title":"Circ J"},{"key":"10.1016\/j.jacc.2017.03.605_bib42","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/S0735-1097(99)00044-3","article-title":"Dose-dependent fetal complications of warfarin in pregnant women with mechanical heart valves","volume":"33","author":"Vitale","year":"1999","journal-title":"J\u00a0Am Coll Cardiol"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109717370821?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109717370821?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T21:01:29Z","timestamp":1602190889000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109717370821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":42,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["S0735109717370821"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2017.03.605","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maternal and Fetal Outcomes of Anticoagulation in Pregnant Women With\u00a0Mechanical Heart\u00a0Valves","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2017.03.605","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}]}}