{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T02:35:41Z","timestamp":1771382141889,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"15","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T00:00:00Z","timestamp":1539129600000},"content-version":"vor","delay-in-days":374,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","onlinejacc.org","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.jacc.2017.08.022","type":"journal-article","created":{"date-parts":[[2017,10,2]],"date-time":"2017-10-02T18:16:33Z","timestamp":1506968193000},"page":"1861-1871","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Heart Rate and Outcomes in Hospitalized\u00a0Patients With Heart Failure With Preserved Ejection\u00a0Fraction"],"prefix":"10.1016","volume":"70","author":[{"given":"Phillip H.","family":"Lam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Dooley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prakash","family":"Deedwania","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven N.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepak L.","family":"Bhatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charity J.","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javed","family":"Butler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selma F.","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Chih","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gurusher","family":"Panjrath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Zile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cherinne","family":"Arundel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas E.","family":"Love","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc R.","family":"Blackman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard M.","family":"Allman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilbert S.","family":"Aronow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan D.","family":"Anker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregg C.","family":"Fonarow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2017.08.022_bib1","doi-asserted-by":"crossref","first-page":"e146","DOI":"10.1161\/CIR.0000000000000485","article-title":"Heart disease and stroke statistics-2017 update: a report from the American Heart Association","volume":"135","author":"Benjamin","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2017.08.022_bib2","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0140-6736(08)61171-X","article-title":"Heart rate as a prognostic risk factor in patients with coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a subgroup analysis of a randomised controlled trial","volume":"372","author":"Fox","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2017.08.022_bib3","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/S0140-6736(10)61259-7","article-title":"Heart rate as a risk factor in chronic heart failure (SHIFT): the association between heart rate and outcomes in a randomised placebo-controlled trial","volume":"376","author":"Bohm","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2017.08.022_bib4","first-page":"488","article-title":"The prognostic significance of heart rate in patients hospitalized for heart failure with reduced ejection fraction in sinus rhythm: insights from the EVEREST (Efficacy of Vasopressin Antagonism in Heart Failure: Outcome Study With Tolvaptan) trial","volume":"1","author":"Greene","year":"2013","journal-title":"J\u00a0Am Coll Cardiol HF"},{"key":"10.1016\/j.jacc.2017.08.022_bib5","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S0140-6736(10)61198-1","article-title":"Ivabradine\u00a0and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study","volume":"376","author":"Swedberg","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2017.08.022_bib6","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.cardfail.2010.04.013","article-title":"Heart rate predicts mortality in patients with heart failure and preserved systolic function","volume":"16","author":"Kapoor","year":"2010","journal-title":"J\u00a0Card Fail"},{"key":"10.1016\/j.jacc.2017.08.022_bib7","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.jacc.2007.04.064","article-title":"Characteristics, treatments, and outcomes of patients with preserved systolic function hospitalized for heart failure: a report from the OPTIMIZE-HF registry","volume":"50","author":"Fonarow","year":"2007","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2017.08.022_bib8","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ahj.2004.03.004","article-title":"Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF): rationale and design","volume":"148","author":"Fonarow","year":"2004","journal-title":"Am Heart J"},{"key":"10.1016\/j.jacc.2017.08.022_bib9","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.ijcard.2011.10.089","article-title":"Design and rationale of studies of neurohormonal blockade and outcomes in diastolic heart failure using OPTIMIZE-HF registry linked to Medicare data","volume":"166","author":"Zhang","year":"2013","journal-title":"Int\u00a0J Cardiol"},{"key":"10.1016\/j.jacc.2017.08.022_bib10","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/biomet\/70.1.41","article-title":"The central role of propensity score in observational studies for causal effects","volume":"70","author":"Rosenbaum","year":"1983","journal-title":"Biometrika"},{"key":"10.1016\/j.jacc.2017.08.022_bib11","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1023\/A:1020363010465","article-title":"Using propensity score to help design observational studies: application to the tobacco litigation","volume":"2","author":"Rubin","year":"2001","journal-title":"Health Serv Outcomes Res Methodol"},{"key":"10.1016\/j.jacc.2017.08.022_bib12","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1093\/eurheartj\/ehi890","article-title":"Heart failure, chronic diuretic use, and increase in mortality and hospitalization: an observational study using propensity score methods","volume":"27","author":"Ahmed","year":"2006","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2017.08.022_bib13","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1161\/CIRCHEARTFAILURE.114.001301","article-title":"Calcium channel blockers and outcomes in older patients with heart failure and preserved ejection fraction","volume":"7","author":"Patel","year":"2014","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jacc.2017.08.022_bib14","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.amjmed.2014.11.036","article-title":"Beta-blocker use and 30-day all-cause readmission in Medicare beneficiaries with systolic heart failure","volume":"128","author":"Bhatia","year":"2015","journal-title":"Am J Med"},{"key":"10.1016\/j.jacc.2017.08.022_bib15","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.amjmed.2016.05.008","article-title":"Renin-angiotensin system inhibition and lower 30-day all-cause readmission in Medicare beneficiaries with heart failure","volume":"129","author":"Sanam","year":"2016","journal-title":"Am J Med"},{"key":"10.1016\/j.jacc.2017.08.022_bib16","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.jamda.2017.03.016","article-title":"Digoxin and 30-day all-cause readmission in long-term care residents hospitalized for heart failure","volume":"18","author":"Sheriff","year":"2017","journal-title":"J\u00a0Am Med Dir Assoc"},{"key":"10.1016\/j.jacc.2017.08.022_bib17","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1093\/eurheartj\/ehp222","article-title":"A\u00a0history of atrial fibrillation and outcomes in chronic advanced systolic heart failure: a propensity-matched study","volume":"30","author":"Ahmed","year":"2009","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2017.08.022_bib18","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.archger.2008.06.009","article-title":"A\u00a0propensity-matched study of outcomes of chronic heart failure (HF) in younger and older adults","volume":"49","author":"Wahle","year":"2009","journal-title":"Arch Gerontol Geriatr"},{"key":"10.1016\/j.jacc.2017.08.022_bib19","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1080\/01621459.1999.10474144","article-title":"A\u00a0Proportional Hazards Model for the Subdistribution of a Competing Risk","volume":"94","author":"Fine","year":"1997","journal-title":"J\u00a0Am Stat Assoc"},{"key":"10.1016\/j.jacc.2017.08.022_bib20","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/sim.3797","article-title":"Patient death as a censoring event or competing risk event in models of nursing home placement","volume":"29","author":"Szychowski","year":"2010","journal-title":"Stat Med"},{"key":"10.1016\/j.jacc.2017.08.022_bib21","series-title":"Observational Studies","first-page":"105","article-title":"Sensitivity to hidden bias","author":"Rosenbaum","year":"2002"},{"key":"10.1016\/j.jacc.2017.08.022_bib22","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1002\/sim.5984","article-title":"The use of propensity score methods with survival or time-to-event outcomes: reporting measures of effect similar to those used in randomized experiments","volume":"33","author":"Austin","year":"2014","journal-title":"Stat Med"},{"key":"10.1016\/j.jacc.2017.08.022_bib23","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1126\/science.6484569","article-title":"Retarding effect of lowered heart rate on coronary atherosclerosis","volume":"226","author":"Beere","year":"1984","journal-title":"Science"},{"key":"10.1016\/j.jacc.2017.08.022_bib24","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/0002-8703(87)90666-1","article-title":"Heart rate and cardiovascular mortality: the Framingham Study","volume":"113","author":"Kannel","year":"1987","journal-title":"Am Heart J"},{"key":"10.1016\/j.jacc.2017.08.022_bib25","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1097\/00004872-199917080-00011","article-title":"Sympathetic tone restrains arterial distensibility of healthy and atherosclerotic subjects","volume":"17","author":"Failla","year":"1999","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.jacc.2017.08.022_bib26","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1161\/hc3801.096325","article-title":"Left ventricular muscle mass and elevated heart rate are associated with coronary plaque disruption","volume":"104","author":"Heidland","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2017.08.022_bib27","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.ijcard.2007.08.077","article-title":"Elevated heart rate and atherosclerosis: an overview of the pathogenetic mechanisms","volume":"126","author":"Giannoglou","year":"2008","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacc.2017.08.022_bib28","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1161\/01.CIR.89.3.1068","article-title":"Reflex versus tonic vagal activity as a prognostic parameter in patients with sustained ventricular tachycardia or ventricular fibrillation","volume":"89","author":"Hohnloser","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2017.08.022_bib29","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1161\/CIRCULATIONAHA.109.909614","article-title":"Mode of death in patients with heart failure and a preserved ejection fraction: results from the Irbesartan in Heart Failure With Preserved Ejection Fraction Study (I-Preserve) trial","volume":"121","author":"Zile","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2017.08.022_bib30","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1016\/j.jacc.2011.12.044","article-title":"Association\u00a0of heart rate and outcomes in a broad spectrum of patients with chronic heart failure: results from the CHARM (Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity) program","volume":"59","author":"Castagno","year":"2012","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2017.08.022_bib31","doi-asserted-by":"crossref","first-page":"e001626","DOI":"10.1161\/JAHA.114.001626","article-title":"Heart rate at hospital discharge in patients with heart failure is associated with mortality and rehospitalization","volume":"4","author":"Laskey","year":"2015","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jacc.2017.08.022_bib32","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.ijcard.2014.03.005","article-title":"Beta-blockers in older patients with heart failure and preserved ejection fraction: class, dosage, and outcomes","volume":"173","author":"Patel","year":"2014","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacc.2017.08.022_bib33","first-page":"140","article-title":"Tolerability and feasibility of beta-blocker titration in HFpEF versus HFrEF: insights from the CIBIS-ELD trial","volume":"4","author":"Edelmann","year":"2016","journal-title":"J\u00a0Am Coll Cardiol HF"},{"key":"10.1016\/j.jacc.2017.08.022_bib34","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1016\/j.jacc.2009.02.046","article-title":"Beta-blockade with nebivolol in elderly heart failure patients with impaired and preserved left ventricular ejection fraction: data from SENIORS (Study of Effects of Nebivolol Intervention on Outcomes and Rehospitalization in Seniors With Heart Failure)","volume":"53","author":"van Veldhuisen","year":"2009","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2017.08.022_bib35","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1093\/eurjhf\/hfp104","article-title":"Efficacy and safety of nebivolol in elderly heart failure patients with impaired renal function: insights from the SENIORS trial","volume":"11","author":"Cohen-Solal","year":"2009","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jacc.2017.08.022_bib36","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1093\/eurjhf\/hfs141","article-title":"Effects of carvedilol on heart failure with preserved ejection fraction: the Japanese Diastolic Heart Failure Study (J-DHF)","volume":"15","author":"Yamamoto","year":"2013","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jacc.2017.08.022_bib37","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1161\/CIRCULATIONAHA.115.017119","article-title":"Effect of selective heart rate slowing in heart failure with preserved ejection fraction","volume":"132","author":"Pal","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2017.08.022_bib38","doi-asserted-by":"crossref","DOI":"10.1002\/ejhf.876","article-title":"Effect of ivabradine in patients with heart failure with preserved ejection fraction: the EDIFY randomized placebo-controlled trial","author":"Komajda","year":"2017","journal-title":"Eur J Heart Fail"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109717392744?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109717392744?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T12:44:26Z","timestamp":1719492266000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109717392744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":38,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["S0735109717392744"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2017.08.022","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Heart Rate and Outcomes in Hospitalized\u00a0Patients With Heart Failure With Preserved Ejection\u00a0Fraction","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2017.08.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier on behalf of the American College of Cardiology Foundation","name":"copyright","label":"Copyright"}]}}