{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T08:11:41Z","timestamp":1791447101450,"version":"4.3.3"},"reference-count":19,"publisher":"Elsevier BV","issue":"14","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T00:00:00Z","timestamp":1503014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.jacc.2017.08.026","type":"journal-article","created":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T16:15:30Z","timestamp":1506356130000},"page":"1720-1728","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":123,"title":["Dual-Chamber Pacing With Closed\u00a0Loop\u00a0Stimulation in Recurrent\u00a0Reflex\u00a0Vasovagal Syncope"],"prefix":"10.1016","volume":"70","author":[{"given":"Gonzalo","family":"Baron-Esquivias","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.","family":"Morillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"Moya-Mitjans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus","family":"Martinez-Alday","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Ruiz-Granell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Lacunza-Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Garcia-Civera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Encarnacion","family":"Gutierrez-Carretero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Romero-Garrido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2017.08.026_bib1","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.jacc.2017.03.002","article-title":"2017 ACC\/AHA\/HRS guideline for the evaluation and management of patients with syncope: executive summary: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society","volume":"70","author":"Shen","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2017.08.026_bib2","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1161\/hc2601.091708","article-title":"Permanent cardiac pacing versus medical treatment for the prevention of recurrent vasovagal syncope: a multicenter, randomized, controlled trial","volume":"104","author":"Ammirati","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2017.08.026_bib3","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1161\/01.CIR.102.3.294","article-title":"Dual-chamber pacing in the treatment of neurally mediated tilt-positive cardioinhibitory syncope: pacemaker versus no therapy: a multicenter randomized study","volume":"102","author":"Sutton","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2017.08.026_bib4","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1001\/jama.289.17.2224","article-title":"Pacemaker therapy for prevention of syncope in patients with recurrent severe vasovagal syncope: Second Vasovagal Pacemaker Study (VPS II): a randomized trial","volume":"289","author":"Connolly","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.jacc.2017.08.026_bib5","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/j.ehj.2004.06.031","article-title":"A\u00a0randomized, double-blind, placebo-controlled study of permanent cardiac pacing for the treatment of recurrent tilt-induced vasovagal syncope. The vasovagal syncope and pacing trial (SYNPACE)","volume":"25","author":"Raviele","year":"2004","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2017.08.026_bib6","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1161\/CIRCULATIONAHA.111.082313","article-title":"Pacemaker therapy in patients with neurally mediated syncope and documented asystole: Third International Study on Syncope of Uncertain Etiology (ISSUE-3): a randomized trial","volume":"125","author":"Brignole","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2017.08.026_bib7","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.eupc.2004.08.009","article-title":"Closed loop stimulation in prevention of vasovagal syncope. Inotropic Controlled Pacing in Vasovagal syncope (INVASY): a multicentre randomized, single-blind, controlled study","volume":"6","author":"Ochetta","year":"2004","journal-title":"Europace"},{"key":"10.1016\/j.jacc.2017.08.026_bib8","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10840-009-9452-1","article-title":"Preliminary observations on the use of closed-loop cardiac pacing in patients with refractory neurocardiogenic syncope","volume":"27","author":"Kanjwal","year":"2010","journal-title":"J\u00a0Interv Card Electrophysiol"},{"key":"10.1016\/j.jacc.2017.08.026_bib9","doi-asserted-by":"crossref","first-page":"242","DOI":"10.2459\/JCM.0b013e328351daf5","article-title":"Long-term follow-up of DDDR closed-loop cardiac pacing for the prevention of recurrent vasovagal syncope","volume":"13","author":"Bortnik","year":"2012","journal-title":"J\u00a0Cardiovasc Med"},{"key":"10.1016\/j.jacc.2017.08.026_bib10","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1093\/europace\/eur419","article-title":"Closed-loop cardiac pacing vs. conventional dual-chamber pacing with specialized sensing and pacing algorithms for syncope prevention in patients with refractory vasovagal syncope: results of a long-term follow-up","volume":"14","author":"Palmisano","year":"2012","journal-title":"Europace"},{"key":"10.1016\/j.jacc.2017.08.026_bib11","author":"Palmisano","year":"2017","journal-title":"Europace"},{"key":"10.1016\/j.jacc.2017.08.026_bib12","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0735-1097(91)90714-K","article-title":"Methodology of head-up tilt testing in patients with unexplained syncope","volume":"17","author":"Fitzpatrick","year":"1991","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2017.08.026_bib13","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1053\/eupc.2000.0125","article-title":"\u2018The Italian protocol\u2019: a simplified head-up tilt testing potentiated with oral nitroglycerin to assess patients with unexplained syncope","volume":"2","author":"Bartoletti","year":"2000","journal-title":"Europace"},{"key":"10.1016\/j.jacc.2017.08.026_bib14","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1053\/eupc.1999.0064","article-title":"New classification of haemodynamics of vasovagal syncope: beyond the VASIS classification. Analysis of the pre-syncopal phase of the tilt test without and with nitroglycerin challenge. Vasovagal Syncope International Study","volume":"2","author":"Brignole","year":"2000","journal-title":"Europace"},{"key":"10.1016\/j.jacc.2017.08.026_bib15","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1161\/CIRCEP.113.001103","article-title":"Benefit of pacemaker therapy in patients with presumed neurally mediated syncope and documented asystole is greater when tilt test is negative: an analysis from the third International Study on Syncope of Uncertain Etiology (ISSUE-3)","volume":"7","author":"Brignole","year":"2014","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.jacc.2017.08.026_bib16","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/s13063-017-1941-4","article-title":"Benefit of dual-chamber pacing with closed loop stimulation in tilt-induced cardio-inhibitory reflex syncope (BIOSync trial): study protocol for a randomized controlled trial","volume":"18","author":"Brignole","year":"2017","journal-title":"Trials"},{"key":"10.1016\/j.jacc.2017.08.026_bib17","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.amjmed.2006.05.046","article-title":"The expectation effect and cardiac pacing for refractory vasovagal syncope","volume":"120","author":"Sud","year":"2007","journal-title":"Am J Med"},{"key":"10.1016\/j.jacc.2017.08.026_bib18","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1111\/j.1540-8159.1992.tb02968.x","article-title":"Intracardiac impedance to determine sympathetic activity in rate responsive pacing","volume":"15","author":"Schaldach","year":"1992","journal-title":"Pacing Clin Electrophysiol"},{"key":"10.1016\/j.jacc.2017.08.026_bib19","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/S0735-1097(97)00047-8","article-title":"Timing of first recurrence of syncope predicts syncopal frequency after a positive tilt table test result","volume":"29","author":"Malik","year":"1997","journal-title":"J\u00a0Am Coll Cardiol"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109717393166?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109717393166?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:13:16Z","timestamp":1760015596000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109717393166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":19,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["S0735109717393166"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2017.08.026","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dual-Chamber Pacing With Closed\u00a0Loop\u00a0Stimulation in Recurrent\u00a0Reflex\u00a0Vasovagal Syncope","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2017.08.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}]}}