{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:14:20Z","timestamp":1785928460253,"version":"3.56.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"19","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T00:00:00Z","timestamp":1557878400000},"content-version":"vor","delay-in-days":379,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","onlinejacc.org","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.jacc.2018.02.072","type":"journal-article","created":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T20:37:30Z","timestamp":1525725450000},"page":"2136-2146","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":61,"title":["Platelet Count Affects Efficacy of Folic\u00a0Acid in Preventing First Stroke"],"prefix":"10.1016","volume":"71","author":[{"given":"Xiangyi","family":"Kong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaren","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lishun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genfu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan Fan","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoshu","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuiping","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianhui","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2018.02.072_bib1","series-title":"Global Health Estimates 2015: Deaths by Cause, Age, Sex, by Country and by Region, 2000-2015","year":"2016"},{"key":"10.1016\/j.jacc.2018.02.072_bib2","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1016\/S0140-6736(13)61097-1","article-title":"Rapid health transition in China, 1990-2010: findings from the Global Burden of Disease Study 2010","volume":"381","author":"Yang","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2018.02.072_bib3","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/S0140-6736(12)61728-0","article-title":"Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Lozano","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2018.02.072_bib4","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0140-6736(13)61953-4","article-title":"Global and regional burden of stroke during 1990-2010: findings from the Global Burden of Disease Study 2010","volume":"383","author":"Feigin","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2018.02.072_bib5","doi-asserted-by":"crossref","first-page":"3754","DOI":"10.1161\/STR.0000000000000046","article-title":"Guidelines for the primary prevention of stroke: a statement for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"45","author":"Meschia","year":"2014","journal-title":"Stroke"},{"key":"10.1016\/j.jacc.2018.02.072_bib6","first-page":"e46","article-title":"Heart disease and stroke statistics\u20142010 update: a report from the American Heart Association","volume":"121","author":"Lloyd-Jones","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2018.02.072_bib7","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1056\/NEJM198602203140806","article-title":"The pathogenesis of atherosclerosis\u2014an update","volume":"314","author":"Ross","year":"1986","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2018.02.072_bib8","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.06.018","article-title":"The role of circulating platelets microparticles and platelet parameters in acute ischemic stroke patients","volume":"24","author":"Chen","year":"2015","journal-title":"J\u00a0Stroke Cerebrovasc Dis"},{"key":"10.1016\/j.jacc.2018.02.072_bib9","doi-asserted-by":"crossref","first-page":"589","DOI":"10.2174\/157016112801784468","article-title":"Platelets in atherothrombosis\u2014diagnostic and prognostic value of platelet activation in patients with atherosclerotic diseases","volume":"10","author":"Bigalke","year":"2012","journal-title":"Curr Vasc Pharmacol"},{"key":"10.1016\/j.jacc.2018.02.072_bib10","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1538-7836.2008.03267.x","article-title":"Platelet count and the risk for thrombosis and death in the elderly","volume":"7","author":"van der Bom","year":"2009","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jacc.2018.02.072_bib11","first-page":"3527","article-title":"Endothelial cells in physiology and in the pathophysiology of vascular disorders","volume":"91","author":"Cines","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.jacc.2018.02.072_bib12","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1161\/STROKEAHA.116.015324","article-title":"Homocysteine and stroke risk: modifying effect of methylenetetrahydrofolate reductase C677T polymorphism and folic acid intervention","volume":"48","author":"Zhao","year":"2017","journal-title":"Stroke"},{"key":"10.1016\/j.jacc.2018.02.072_bib13","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1586\/17512433.2015.1010516","article-title":"Homocysteine and the pathogenesis of atherosclerosis","volume":"8","author":"McCully","year":"2015","journal-title":"Expert Rev Clin Pharmacol"},{"key":"10.1016\/j.jacc.2018.02.072_bib14","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1161\/01.CIR.96.8.2542","article-title":"Hyperhomocyst(e)inemia is a risk factor for arterial endothelial dysfunction in humans","volume":"96","author":"Woo","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2018.02.072_bib15","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1001\/jama.288.16.2015","article-title":"Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis","volume":"288","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.jacc.2018.02.072_bib16","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1136\/bmj.325.7374.1202","article-title":"Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis","volume":"325","author":"Wald","year":"2002","journal-title":"BMJ"},{"key":"10.1016\/j.jacc.2018.02.072_bib17","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1056\/NEJM197409122911101","article-title":"Homocystinemia. Vascular injury and arterial thrombosis","volume":"291","author":"Harker","year":"1974","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2018.02.072_bib18","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1172\/JCI108520","article-title":"Homocystine-induced arteriosclerosis. The role of endothelial cell injury and platelet response in its genesis","volume":"58","author":"Harker","year":"1976","journal-title":"J\u00a0Clinical Investigation"},{"key":"10.1016\/j.jacc.2018.02.072_bib19","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1001\/jama.2015.2274","article-title":"Efficacy of folic acid therapy in primary prevention of stroke among adults with hypertension in China: the CSPPT randomized clinical trial","volume":"313","author":"Huo","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.jacc.2018.02.072_bib20","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/S0735-1097(00)00809-3","article-title":"Effect of folic acid and antioxidant vitamins on endothelial dysfunction in patients with coronary artery disease","volume":"36","author":"Title","year":"2000","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2018.02.072_bib21","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1161\/hq0102.102190","article-title":"Folates and cardiovascular disease","volume":"22","author":"Verhaar","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jacc.2018.02.072_bib22","first-page":"171","article-title":"H-type hypertension and risk of stroke in Chinese adults: a prospective, nested case-control study","volume":"3","author":"Li","year":"2015","journal-title":"J\u00a0Translational Intern Med"},{"key":"10.1016\/j.jacc.2018.02.072_bib23","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1080\/00207454.2016.1183126","article-title":"Methylenetetrahydrofolate reductase C677T polymorphism, hypertension and risk of stroke: a prospective, nested case-control study","volume":"127","author":"Jiang","year":"2017","journal-title":"Int J Neurosci"},{"key":"10.1016\/j.jacc.2018.02.072_bib24","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1093\/ajcn\/82.4.806","article-title":"Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials","volume":"82","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jacc.2018.02.072_bib25","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.ymgme.2014.10.006","article-title":"Homocysteine and DNA methylation: a review of animal and human literature","volume":"113","author":"Mandaviya","year":"2014","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.jacc.2018.02.072_bib26","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1161\/CIRCULATIONAHA.106.612325","article-title":"5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling","volume":"114","author":"Antoniades","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2018.02.072_bib27","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/S0891-5849(01)00543-3","article-title":"Free radical scavenging behavior of folic acid: evidence for possible antioxidant activity","volume":"30","author":"Joshi","year":"2001","journal-title":"Free Radical Biology & Medicine"},{"key":"10.1016\/j.jacc.2018.02.072_bib28","doi-asserted-by":"crossref","first-page":"e82713","DOI":"10.1371\/journal.pone.0082713","article-title":"Folic acid protects against lipopolysaccharide-induced preterm delivery and intrauterine growth restriction through its anti-inflammatory effect in mice","volume":"8","author":"Zhao","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.jacc.2018.02.072_bib29","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1161\/CIRCULATIONAHA.112.093245","article-title":"The assessment of endothelial function: from research into clinical practice","volume":"126","author":"Flammer","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2018.02.072_bib30","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1093\/ajcn\/86.3.610","article-title":"Folic acid improves vascular reactivity in humans: a meta-analysis of randomized controlled trials","volume":"86","author":"de Bree","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jacc.2018.02.072_bib31","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.atherosclerosis.2014.03.032","article-title":"The effect of homocysteine-lowering therapy with folic acid on flow-mediated vasodilation in patients with coronary artery disease: a meta-analysis of randomized controlled trials","volume":"235","author":"Liu","year":"2014","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jacc.2018.02.072_bib32","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1093\/ajcn\/65.6.1790","article-title":"Unmetabolized folic acid in serum: acute studies in subjects consuming fortified food and supplements","volume":"65","author":"Kelly","year":"1997","journal-title":"Am J Clin Nutr"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109718336313?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109718336313?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T02:26:46Z","timestamp":1557887206000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109718336313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":32,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["S0735109718336313"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2018.02.072","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Platelet Count Affects Efficacy of Folic\u00a0Acid in Preventing First Stroke","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2018.02.072","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}