{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T22:27:58Z","timestamp":1783636078956,"version":"3.55.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T00:00:00Z","timestamp":1585785600000},"content-version":"vor","delay-in-days":367,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.jacc.2018.08.1030","type":"journal-article","created":{"date-parts":[[2018,8,17]],"date-time":"2018-08-17T08:30:56Z","timestamp":1534494656000},"page":"1564-1578","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Medical Therapy for Systemic Right\u00a0Ventricles: A Systematic Review\u00a0(Part 1) for the 2018 AHA\/ACC Guideline for the Management of Adults With Congenital Heart Disease"],"prefix":"10.1016","volume":"73","author":[{"given":"Elisa","family":"Zaragoza-Macias","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali N.","family":"Zaidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandini","family":"Dendukuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariane","family":"Marelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2018.08.1030_bib1","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.amjcard.2005.10.065","article-title":"Incidence and risk distribution of heart failure in adolescents and adults with congenital heart disease after cardiac surgery","volume":"97","author":"Norozi","year":"2006","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2018.08.1030_bib2","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/0735-1097(95)00567-6","article-title":"Congenitally corrected transposition of the great arteries in the adult: functional status and complications","volume":"27","author":"Connelly","year":"1996","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2018.08.1030_bib3","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1136\/hrt.2003.029769","article-title":"Late outcome of Senning and Mustard procedures for correction of transposition of the great arteries","volume":"91","author":"Dos","year":"2005","journal-title":"Heart"},{"key":"10.1016\/j.jacc.2018.08.1030_bib4","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1161\/hc1002.105182","article-title":"Heart failure and ventricular dysfunction in patients with single or systemic right ventricles","volume":"105","author":"Piran","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2018.08.1030_bib5","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0735-1097(00)00682-3","article-title":"Long-term outcome in congenitally corrected transposition of the great arteries: a multi-institutional study","volume":"36","author":"Graham","year":"2000","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2018.08.1030_bib6","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/S0002-9149(99)00019-3","article-title":"Arrhythmia and survival in patients >18 years of age after the mustard procedure for complete transposition of the great arteries","volume":"83","author":"Puley","year":"1999","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2018.08.1030_bib7","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jacc.2012.09.025","article-title":"ACCF\/AHA clinical practice guideline methodology summit report: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines","volume":"61","author":"Jacobs","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2018.08.1030_bib8","article-title":"2018 AHA\/ACC guideline for the management of adults with congenital heart disease: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","author":"Stout","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2018.08.1030_bib9","doi-asserted-by":"crossref","first-page":"d5928","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration\u2019s tool for assessing risk of bias in randomised trials","volume":"343","author":"Higgins","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.jacc.2018.08.1030_bib10","author":"Wells"},{"key":"10.1016\/j.jacc.2018.08.1030_bib11","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Control Clin Trials"},{"key":"10.1016\/j.jacc.2018.08.1030_bib12","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat Med"},{"key":"10.1016\/j.jacc.2018.08.1030_bib13","doi-asserted-by":"crossref","first-page":"267","DOI":"10.7326\/M13-2886","article-title":"Random-effects meta-analysis of inconsistent effects: a time for change","volume":"160","author":"Cornell","year":"2014","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jacc.2018.08.1030_bib14","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.2307\/2533446","article-title":"Operating characteristics of a rank correlation test for publication bias","volume":"50","author":"Begg","year":"1994","journal-title":"Biometrics"},{"key":"10.1016\/j.jacc.2018.08.1030_bib15","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"key":"10.1016\/j.jacc.2018.08.1030_bib16","first-page":"1","article-title":"Conducting meta-analyses in R\u00a0with the metafor package","volume":"36","author":"Viechtbauer","year":"2010","journal-title":"J\u00a0Stat Software"},{"key":"10.1016\/j.jacc.2018.08.1030_bib17","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1161\/CIRCULATIONAHA.112.135392","article-title":"Effect of valsartan on systemic right ventricular function: a double-blind, randomized, placebo-controlled pilot trial","volume":"127","author":"van der Bom","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2018.08.1030_bib18","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1161\/CIRCULATIONAHA.105.543470","article-title":"Angiotensin receptor blockade and exercise capacity in adults with systemic right ventricles: a multicenter, randomized, placebo-controlled clinical trial","volume":"112","author":"Dore","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2018.08.1030_bib19","doi-asserted-by":"crossref","first-page":"5167","DOI":"10.1016\/j.ijcard.2013.07.163","article-title":"Eplerenone in systemic right ventricle: double blind randomized clinical trial. The EVEDES Study","volume":"168","author":"Dos","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacc.2018.08.1030_bib20","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ijcard.2008.04.056","article-title":"Effect of angiotensin receptor blockade on systemic right ventricular function and size: a small, randomized, placebo-controlled study","volume":"129","author":"Therrien","year":"2008","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacc.2018.08.1030_bib21","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ijcard.2010.08.068","article-title":"Safety and efficiency of chronic ACE inhibition in symptomatic heart failure patients with a systemic right ventricle","volume":"154","author":"Tutarel","year":"2012","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacc.2018.08.1030_bib22","unstructured":"Higgins JPT, Green S, eds. Cochrane Handbook for\u00a0Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. Available at: http:\/\/handbook-5-1.cochrane.org. Accessed May 30,\u00a02018."},{"key":"10.1016\/j.jacc.2018.08.1030_bib23","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1056\/NEJM199209033271001","article-title":"Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the Survival and Ventricular Enlargement Trial. The SAVE Investigators","volume":"327","author":"Pfeffer","year":"1992","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2018.08.1030_bib24","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1067\/mhj.2002.121269","article-title":"Effects of bisoprolol fumarate on left ventricular size, function, and exercise capacity in patients with heart failure: analysis with magnetic resonance myocardial tagging","volume":"143","author":"Dubach","year":"2002","journal-title":"Am Heart J"},{"key":"10.1016\/j.jacc.2018.08.1030_bib25","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1161\/CIRCULATIONAHA.105.571653","article-title":"Mineralocorticoid receptor antagonism ameliorates left ventricular diastolic dysfunction and myocardial fibrosis in mildly symptomatic patients with idiopathic dilated cardiomyopathy: a pilot study","volume":"112","author":"Izawa","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2018.08.1030_bib26","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1161\/01.CIR.94.11.2807","article-title":"Carvedilol produces dose-related improvements in left ventricular function and survival in subjects with chronic heart failure","volume":"94","author":"Bristow","year":"1996","journal-title":"MOCHA Investigators. Circulation"},{"key":"10.1016\/j.jacc.2018.08.1030_bib27","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1056\/NEJM199209033271003","article-title":"Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions","volume":"327","author":"Yusuf","year":"1992","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2018.08.1030_bib28","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ijcard.2008.10.040","article-title":"Endogenous catecholamine levels and function of the systemic right ventricle following atrial switch","volume":"138","author":"Szyma\u0144ski","year":"2010","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacc.2018.08.1030_bib29","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1161\/CIRCULATIONAHA.105.548727","article-title":"Ventricular fibrosis suggested by cardiovascular magnetic resonance in adults with repaired tetralogy of Fallot and its relationship to adverse markers of clinical outcome","volume":"113","author":"Babu-Narayan","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2018.08.1030_bib30","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/j.amjcard.2006.05.062","article-title":"Relation between right ventricular structural alterations and markers of adverse clinical outcome in adults with systemic right ventricle and either congenital complete (after Senning operation) or congenitally corrected transposition of the great arteries","volume":"98","author":"Giardini","year":"2006","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2018.08.1030_bib31","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/S0002-9149(00)01452-1","article-title":"Angiotensin-converting enzyme inhibitors in adults after the Mustard procedure","volume":"87","author":"Hechter","year":"2001","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2018.08.1030_bib32","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1017\/S1047951110000764","article-title":"Interest of \u03b2-blockers in patients with right ventricular systemic dysfunction","volume":"20","author":"Bouallal","year":"2010","journal-title":"Cardiol Young"},{"key":"10.1016\/j.jacc.2018.08.1030_bib33","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ijcard.2006.01.048","article-title":"A\u00a0pilot study on the effects of carvedilol on right ventricular remodelling and exercise tolerance in patients with systemic right ventricle","volume":"114","author":"Giardini","year":"2007","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacc.2018.08.1030_bib34","first-page":"769","article-title":"A\u00a0case series of systemic right ventricular dysfunction post atrial switch for simple D-transposition of the great arteries: the impact of beta-blockade","volume":"22","author":"Josephson","year":"2006","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.jacc.2018.08.1030_bib35","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.amjcard.2006.10.025","article-title":"Effect of beta blockers (carvedilol or metoprolol XL) in patients with transposition of great arteries and dysfunction of the systemic right ventricle","volume":"99","author":"Doughan","year":"2007","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2018.08.1030_bib36","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1161\/01.CIR.0000144474.65922.AA","article-title":"Effect of candesartan on cause-specific mortality in heart failure patients: the Candesartan in Heart failure Assessment of Reduction in Mortality and morbidity (CHARM) program","volume":"110","author":"Solomon","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2018.08.1030_bib37","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0140-6736(03)14285-7","article-title":"Effects of\u00a0candesartan in patients with chronic heart failure\u00a0and\u00a0preserved left-ventricular ejection fraction: the CHARM-Preserved Trial","volume":"362","author":"Yusuf","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2018.08.1030_bib38","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1093\/eurjhf\/hfs141","article-title":"Effects of carvedilol on heart failure with preserved ejection fraction: the Japanese Diastolic Heart Failure Study (J-DHF)","volume":"15","author":"Yamamoto","year":"2013","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jacc.2018.08.1030_bib39","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1056\/NEJMoa0805450","article-title":"Irbesartan in patients with heart failure and preserved\u00a0ejection fraction","volume":"359","author":"Massie","year":"2008","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2018.08.1030_bib40","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1056\/NEJMoa1313731","article-title":"Spironolactone for heart failure with preserved ejection fraction","volume":"370","author":"Pitt","year":"2014","journal-title":"N\u00a0Engl J Med"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109718368499?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109718368499?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:21:07Z","timestamp":1760016067000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109718368499"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":40,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["S0735109718368499"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2018.08.1030","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Medical Therapy for Systemic Right\u00a0Ventricles: A Systematic Review\u00a0(Part 1) for the 2018 AHA\/ACC Guideline for the Management of Adults With Congenital Heart Disease","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2018.08.1030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 by the American Heart Association, Inc., and the American College of Cardiology Foundation","name":"copyright","label":"Copyright"}]}}