{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:43:17Z","timestamp":1792521797147,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,6]],"date-time":"2018-11-06T00:00:00Z","timestamp":1541462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","onlinejacc.org","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.jacc.2018.09.081","type":"journal-article","created":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T20:53:34Z","timestamp":1546980814000},"page":"29-40","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":250,"title":["Differential Impact of Heart Failure With\u00a0Reduced Ejection Fraction on\u00a0Men\u00a0and\u00a0Women"],"prefix":"10.1016","volume":"73","author":[{"given":"Pooja","family":"Dewan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasmus","family":"R\u00f8rth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pardeep S.","family":"Jhund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Raparelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark C.","family":"Petrie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William T.","family":"Abraham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshay S.","family":"Desai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Dickstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"K\u00f8ber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrik M.","family":"Mogensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milton","family":"Packer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean L.","family":"Rouleau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott D.","family":"Solomon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Swedberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Zile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.V.","family":"McMurray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2018.09.081_bib1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0002-9343(00)00529-5","article-title":"Sex-related differences in the use and adverse effects of angiotensin-converting enzyme inhibitors in heart failure: the study of patients intolerant of converting enzyme inhibitors registry","volume":"109","author":"Shah","year":"2000","journal-title":"Am J Med"},{"key":"10.1016\/j.jacc.2018.09.081_bib2","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1161\/01.CIR.103.3.375","article-title":"Sex differences in the prognosis of congestive heart failure results from the Cardiac Insufficiency Bisoprolol Study (CIBIS II)","volume":"103","author":"Simon","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2018.09.081_bib3","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1161\/01.CIR.0000012546.20194.33","article-title":"Metoprolol CR\/XL in female patients with heart failure: analysis of the experience in Metoprolol Extended-Release Randomized Intervention Trial in Heart Failure (MERIT-HF)","volume":"105","author":"Ghali","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2018.09.081_bib4","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1016\/j.jacc.2003.05.012","article-title":"Gender differences in advanced heart failure: insights from the BEST study","volume":"42","author":"Ghali","year":"2003","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2018.09.081_bib5","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ehj.2003.10.003","article-title":"Female sex is associated with a better long-term survival in patients hospitalized with congestive heart failure","volume":"25","author":"Gustafsson","year":"2004","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2018.09.081_bib6","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.amjcard.2004.10.026","article-title":"Comparison of treatment benefit and outcome in women versus men with chronic heart failure (from the Valsartan Heart Failure Trial)","volume":"95","author":"Majahalme","year":"2005","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2018.09.081_bib7","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.1161\/CIRCULATIONAHA.106.673442","article-title":"Sex differences in clinical characteristics and prognosis in a broad spectrum of patients with heart failure: results of the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM) program","volume":"115","author":"O\u2019Meara","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2018.09.081_bib8","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1111\/j.1540-8167.2008.01129.x","article-title":"Primary prevention with defibrillator therapy in women: Results from the sudden cardiac death in heart failure trial","volume":"19","author":"Russo","year":"2008","journal-title":"J\u00a0Cardiovasc Electrophysiol"},{"key":"10.1016\/j.jacc.2018.09.081_bib9","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ahj.2004.06.008","article-title":"Sex, quality of care, and outcomes of elderly patients hospitalized with heart failure: findings from the National Heart Failure Project","volume":"149","author":"Rathore","year":"2005","journal-title":"Am Heart J"},{"key":"10.1016\/j.jacc.2018.09.081_bib10","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.amjcard.2004.12.033","article-title":"Effect of gender on treatment, resource utilization, and outcomes in congestive heart failure in Quebec, Canada","volume":"95","author":"Sheppard","year":"2005","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2018.09.081_bib11","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.1136\/hrt.2006.099523","article-title":"Management of patients with heart failure in clinical practice: differences between men and women","volume":"94","author":"Lenzen","year":"2008","journal-title":"Heart"},{"key":"10.1016\/j.jacc.2018.09.081_bib12","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.ahj.2008.12.016","article-title":"Influence of patient age and sex on delivery of\u00a0guideline-recommended heart failure care in\u00a0the outpatient cardiology practice setting: Findings from IMPROVE HF","volume":"157","author":"Yancy","year":"2009","journal-title":"Am Heart J"},{"key":"10.1016\/j.jacc.2018.09.081_bib13","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1093\/europace\/euu205","article-title":"Gender, underutilization of cardiac resynchronization therapy, and prognostic impact of QRS prolongation and left bundle branch block in heart failure","volume":"17","author":"Linde","year":"2015","journal-title":"Europace"},{"key":"10.1016\/j.jacc.2018.09.081_bib14","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1093\/eurheartj\/ehw128","article-title":"2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"37","author":"Ponikowski","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2018.09.081_bib15","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.jacc.2017.04.025","volume":"70","author":"Yancy","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2018.09.081_bib16","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1056\/NEJMoa1409077","article-title":"Angiotensin\u2013neprilysin inhibition versus enalapril in heart failure","volume":"371","author":"McMurray","year":"2014","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2018.09.081_bib17","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1056\/NEJMoa1514859","article-title":"Aliskiren, enalapril, or aliskiren and enalapril in heart failure","volume":"374","author":"McMurray","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2018.09.081_bib18","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/S0735-1097(00)00531-3","article-title":"Development and evaluation of the Kansas City cardiomyopathy questionnaire: a new health status measure for heart failure","volume":"35","author":"Green","year":"2000","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2018.09.081_bib19","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ejheart.2006.10.012","article-title":"Characterization of health-related quality of life in heart failure patients with preserved versus low ejection fraction in CHARM","volume":"9","author":"Lewis","year":"2007","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jacc.2018.09.081_bib20","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/S0002-8703(96)90365-8","article-title":"Adverse effects of enalapril in the Studies of Left Ventricular Dysfunction (SOLVD)","volume":"131","author":"Kostis","year":"1996","journal-title":"Am Heart J"},{"key":"10.1016\/j.jacc.2018.09.081_bib21","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1177\/000331979404500908","article-title":"ACE inhibitors and cough","volume":"45","author":"Yesil","year":"1994","journal-title":"Angiology"},{"key":"10.1016\/j.jacc.2018.09.081_bib22","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1056\/NEJMoa021266","article-title":"Sex-based differences in the effect of digoxin for the treatment of heart failure","volume":"347","author":"Rathore","year":"2002","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2018.09.081_bib23","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1016\/j.pec.2018.06.003","article-title":"How female and male physicians\u2019 communication is perceived differently","volume":"101","author":"Mast","year":"2018","journal-title":"Patient Educ Couns"},{"key":"10.1016\/j.jacc.2018.09.081_bib24","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1007\/s40615-016-0248-6","article-title":"Some advice for physicians and other\u00a0clinicians treating minorities, women, and other patients at risk of receiving health care disparities","volume":"4","author":"White","year":"2017","journal-title":"J\u00a0Racial Ethn Heal Disparities"},{"key":"10.1016\/j.jacc.2018.09.081_bib25","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1080\/08952841.2014.950910","article-title":"\u201cIt\u2019s my body, my future\u201d: older women\u2019s views of their interactions with physicians","volume":"28","author":"MacRae","year":"2016","journal-title":"J\u00a0Women Aging"},{"key":"10.1016\/j.jacc.2018.09.081_bib26","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.pec.2009.07.022","article-title":"The influence of gender on the doctor\u2013patient interaction","volume":"76","author":"Bertakis","year":"2009","journal-title":"Patient Educ Couns"},{"key":"10.1016\/j.jacc.2018.09.081_bib27","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/978-3-319-77932-4_34","article-title":"Cardiac rehabilitation for women","volume":"1065","author":"Bittner","year":"2018","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jacc.2018.09.081_bib28","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1097\/HJR.0b013e32830c1ce3","article-title":"Sex differences in completion of a 12-month cardiac rehabilitation programme: an analysis of 5922 women and men","volume":"15","author":"Marzolini","year":"2008","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.jacc.2018.09.081_bib29","first-page":"180","article-title":"Effects of exercise training on outcomes in women with heart failure: analysis of HF-ACTION (Heart Failure\u2013A Controlled Trial Investigating Outcomes of Exercise TraiNing) by sex","volume":"2","author":"Pi\u00f1a","year":"2014","journal-title":"J\u00a0Am Coll Cardiol HF"},{"key":"10.1016\/j.jacc.2018.09.081_bib30","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1001\/jamainternmed.2014.2717","article-title":"Cardiac resynchronization therapy in women: US food and drug administration meta-analysis of patient-level data","volume":"174","author":"Zusterzeel","year":"2014","journal-title":"JAMA Intern Med"},{"key":"10.1016\/j.jacc.2018.09.081_bib31","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.amjmed.2009.11.025","article-title":"Underuse of oral anticoagulants in atrial fibrillation: a systematic review","volume":"123","author":"Ogilvie","year":"2010","journal-title":"Am J Med"},{"key":"10.1016\/j.jacc.2018.09.081_bib32","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1054\/jcaf.2002.32195","article-title":"Gender differences in cardiac remodeling secondary to chronic volume overload","volume":"8","author":"Gardner","year":"2002","journal-title":"J\u00a0Card Fail"},{"key":"10.1016\/j.jacc.2018.09.081_bib33","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.jacc.2009.09.065","article-title":"Sex-related differences in myocardial remodeling","volume":"55","author":"Piro","year":"2010","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2018.09.081_bib34","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1161\/CIRCULATIONAHA.117.030526","article-title":"Sex difference in patients with ischemic heart failure undergoing surgical revascularization","volume":"137","author":"Pi\u00f1a","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2018.09.081_bib35","doi-asserted-by":"crossref","first-page":"e003924","DOI":"10.1161\/CIRCEP.115.003924","article-title":"Effect of gender on outcomes after cardiac resynchronization therapy in patients with a narrow QRS complex: a subgroup analysis of the EchoCRT trial","volume":"9","author":"Steffel","year":"2016","journal-title":"Circ Arrhythm Electrophysiol"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109718389794?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109718389794?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T20:08:33Z","timestamp":1558642113000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109718389794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["S0735109718389794"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2018.09.081","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential Impact of Heart Failure With\u00a0Reduced Ejection Fraction on\u00a0Men\u00a0and\u00a0Women","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2018.09.081","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}]}}