{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T18:42:08Z","timestamp":1792694528362,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T00:00:00Z","timestamp":1582070400000},"content-version":"vor","delay-in-days":383,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.jacc.2018.11.040","type":"journal-article","created":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T16:40:57Z","timestamp":1549903257000},"page":"684-693","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":213,"title":["Impact of Abnormal Coronary Reactivity on Long-Term Clinical Outcomes in\u00a0Women"],"prefix":"10.1016","volume":"73","author":[{"given":"Ahmed","family":"AlBadri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Noel","family":"Bairey Merz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. Delia","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puja K.","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galen","family":"Cook-Wiens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven E.","family":"Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheryl F.","family":"Kelsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Bittner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Sopko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslee J.","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl J.","family":"Pepine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bina","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2018.11.040_bib1","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1161\/01.CIR.101.16.1899","article-title":"Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease","volume":"101","author":"Schachinger","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2018.11.040_bib2","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1093\/eurheartj\/ehr331","article-title":"Stable angina pectoris with no obstructive coronary artery disease is associated with increased risks of major adverse cardiovascular events","volume":"33","author":"Jespersen","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2018.11.040_bib3","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1001\/archinternmed.2009.50","article-title":"Adverse cardiovascular outcomes in women with nonobstructive coronary artery disease: a report from the Women's Ischemia Syndrome Evaluation Study and the St James Women Take Heart Project","volume":"169","author":"Gulati","year":"2009","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jacc.2018.11.040_bib4","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1093\/eurheartj\/ehl040","article-title":"Persistent chest pain predicts cardiovascular events in women without obstructive coronary artery disease: results from the NIH-NHLBI-sponsored Women's Ischaemia Syndrome Evaluation (WISE) study","volume":"27","author":"Johnson","year":"2006","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2018.11.040_bib5","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1016\/j.jacc.2010.01.054","article-title":"Coronary microvascular reactivity to adenosine pre3dicts adverse outcome in women evaluated for suspected ischemia results from the National Heart, Lung and Blood Institute WISE (Women's Ischemia Syndrome Evaluation) study","volume":"55","author":"Pepine","year":"2010","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2018.11.040_bib6","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.jacc.2010.11.078","article-title":"Mortality risk in symptomatic patients with nonobstructive coronary artery disease: a prospective 2-center study of 2,583 patients undergoing 64-detector row coronary computed tomographic angiography","volume":"58","author":"Lin","year":"2011","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2018.11.040_bib7","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1161\/CIRCULATIONAHA.113.008507","article-title":"Effects of sex on coronary microvascular dysfunction and cardiac outcomes","volume":"129","author":"Murthy","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2018.11.040_bib8","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1056\/NEJM200003233421201","article-title":"Abnormal myocardial phosphorus-31 nuclear magnetic resonance spectroscopy in women with chest pain but normal coronary angiograms","volume":"342","author":"Buchthal","year":"2000","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2018.11.040_bib9","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/j.1540-8183.2010.00598.x","article-title":"An intravascular ultrasound analysis in women experiencing chest pain in the absence of obstructive coronary artery disease: a substudy from the National Heart, Lung and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE)","volume":"23","author":"Khuddus","year":"2010","journal-title":"J\u00a0Interv Cardiol"},{"key":"10.1016\/j.jacc.2018.11.040_bib10","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1067\/mhj.2001.114198","article-title":"Coronary microvascular dysfunction is highly prevalent in women with chest pain in the absence of coronary artery disease: results from the NHLBI WISE study","volume":"141","author":"Reis","year":"2001","journal-title":"Am Heart J"},{"key":"10.1016\/j.jacc.2018.11.040_bib11","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1161\/01.CIR.0000115525.92645.16","article-title":"Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women","volume":"109","author":"von Mering","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2018.11.040_bib12","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1161\/01.CIR.0000130642.79868.B2","article-title":"Prognosis in women with myocardial ischemia in the absence of obstructive coronary disease: results from the National Institutes of Health-National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE)","volume":"109","author":"Johnson","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2018.11.040_bib13","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1161\/CIRCULATIONAHA.105.609990","article-title":"The economic burden of angina in women with suspected ischemic heart disease: results from the National Institutes of Health--National Heart, Lung, and Blood Institute--sponsored Women's Ischemia Syndrome Evaluation","volume":"114","author":"Shaw","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2018.11.040_bib14","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/S0735-1097(99)00082-0","article-title":"The Women's Ischemia Syndrome Evaluation (WISE) study: protocol design, methodology and feasibility report","volume":"33","author":"Merz","year":"1999","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2018.11.040_bib15","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1161\/01.CIR.87.5.1461","article-title":"The nitrovasodilators. New ideas about old drugs","volume":"87","author":"Harrison","year":"1993","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2018.11.040_bib16","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1161\/01.CIR.85.5.1899","article-title":"Validation of a Doppler guide wire for intravascular measurement of coronary artery flow velocity","volume":"85","author":"Doucette","year":"1992","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2018.11.040_bib17","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0002-9149(01)01424-2","article-title":"Detailed angiographic analysis of women with suspected ischemic chest pain (pilot phase data from the NHLBI-sponsored Women's Ischemia Syndrome Evaluation [WISE] Study Angiographic Core Laboratory)","volume":"87","author":"Sharaf","year":"2001","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2018.11.040_bib18","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1161\/01.CIR.101.9.948","article-title":"Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction","volume":"101","author":"Suwaidi","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2018.11.040_bib19","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1093\/eurheartj\/eht132","article-title":"Coronary endothelial dysfunction in patients with early coronary artery disease is associated with the increase in intravascular lipid core plaque","volume":"34","author":"Choi","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2018.11.040_bib20","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1161\/01.CIR.0000025404.78001.D8","article-title":"Prognostic value of coronary vascular endothelial dysfunction","volume":"106","author":"Halcox","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2018.11.040_bib21","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0008-6363(03)00353-5","article-title":"Plaque-associated endothelial dysfunction in apolipoprotein E-deficient mice on a regular diet. Effect of human apolipoprotein AI","volume":"59","author":"Crauwels","year":"2003","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jacc.2018.11.040_bib22","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/j.1365-2141.1991.tb08623.x","article-title":"Platelet aggregation is inhibited by a nitric oxide-like factor released from human neutrophils in\u00a0vitro","volume":"77","author":"Faint","year":"1991","journal-title":"Brit J Haematol"},{"key":"10.1016\/j.jacc.2018.11.040_bib23","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/S0008-6363(99)00171-6","article-title":"Nitric oxide and the proliferation of vascular smooth muscle cells","volume":"43","author":"Jeremy","year":"1999","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jacc.2018.11.040_bib24","doi-asserted-by":"crossref","first-page":"13944","DOI":"10.1074\/jbc.M111.332767","article-title":"Increased atherosclerosis and endothelial dysfunction in mice bearing constitutively deacetylated alleles of Foxo1 gene","volume":"287","author":"Qiang","year":"2012","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jacc.2018.11.040_bib25","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1172\/JCI118074","article-title":"Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines","volume":"96","author":"De Caterina","year":"1995","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jacc.2018.11.040_bib26","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1161\/01.CIR.89.1.36","article-title":"Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology","volume":"89","author":"van der Wal","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2018.11.040_bib27","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3121\/cmr.4.1.53","article-title":"Recent advances in understanding endothelial dysfunction in atherosclerosis","volume":"4","author":"Yang","year":"2006","journal-title":"Clin Med Res"},{"key":"10.1016\/j.jacc.2018.11.040_bib28","doi-asserted-by":"crossref","first-page":"726","DOI":"10.2967\/jnumed.110.081828","article-title":"Prediction of short-term cardiovascular events using quantification of global myocardial flow reserve in patients referred for clinical 82Rb PET perfusion imaging","volume":"52","author":"Fukushima","year":"2011","journal-title":"J\u00a0Nucl Med"},{"key":"10.1016\/j.jacc.2018.11.040_bib29","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1161\/CIRCULATIONAHA.111.050427","article-title":"Improved cardiac risk assessment with noninvasive measures of coronary flow reserve","volume":"124","author":"Murthy","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2018.11.040_bib30","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1161\/01.CIR.96.10.3369","article-title":"Prognostic value of intracoronary flow velocity and diameter stenosis in assessing the short- and long-term outcomes of coronary balloon angioplasty: the DEBATE Study (Doppler Endpoints Balloon Angioplasty Trial Europe)","volume":"96","author":"Serruys","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2018.11.040_bib31","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1161\/CIRCULATIONAHA.114.011939","article-title":"Global coronary flow reserve is associated with adverse cardiovascular events independently of luminal angiographic severity and modifies the effect of early revascularization","volume":"131","author":"Taqueti","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2018.11.040_bib32","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/0735-1097(93)90255-Y","article-title":"Assessment of coronary conductance and resistance vessel reactivity in response to nitroglycerin, ergonovine and adenosine: in\u00a0vivo studies with simultaneous intravascular two-dimensional and Doppler ultrasound","volume":"21","author":"Sudhir","year":"1993","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2018.11.040_bib33","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1161\/01.RES.68.3.847","article-title":"Mechanisms responsible for the heterogeneous coronary microvascular response to nitroglycerin","volume":"68","author":"Kurz","year":"1991","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2018.11.040_bib34","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1016\/j.jacc.2018.09.006","article-title":"Stratified medical therapy using invasive coronary function testing in angina: CorMicA trial","volume":"72 Pt A","author":"Ford","year":"2018","journal-title":"JJ Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2018.11.040_bib35","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/S0735-1097(03)00994-X","article-title":"The clinical implications of endothelial dysfunction","volume":"42","author":"Widlansky","year":"2003","journal-title":"J\u00a0Am Coll Cardiol"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109718394634?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109718394634?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:19:09Z","timestamp":1760015949000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109718394634"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["S0735109718394634"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2018.11.040","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of Abnormal Coronary Reactivity on Long-Term Clinical Outcomes in\u00a0Women","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2018.11.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}