{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:45:59Z","timestamp":1791902759164,"version":"4.3.4"},"reference-count":29,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T00:00:00Z","timestamp":1585180800000},"content-version":"vor","delay-in-days":391,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.jacc.2018.12.066","type":"journal-article","created":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T14:05:53Z","timestamp":1552917953000},"page":"1250-1260","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":205,"title":["Initial Feasibility Study of a New\u00a0Transcatheter Mitral Prosthesis"],"prefix":"10.1016","volume":"73","author":[{"given":"Paul","family":"Sorajja","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Moat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay","family":"Badhwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren","family":"Walters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Paone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Bethea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Bae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gry","family":"Dahle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mubashir","family":"Mumtaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Grayburn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Kapadia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasilis","family":"Babaliaros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayra","family":"Guerrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lowell","family":"Satler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Thourani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Bedogni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Rizik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Denti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Dumonteil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Modine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Sinhal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey J.","family":"Popma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Blanke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathon","family":"Leipsic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Muller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2018.12.066_bib1","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0140-6736(06)69208-8","article-title":"Burden of valvular heart diseases: a population-based study","volume":"368","author":"Nkomo","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2018.12.066_bib2","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.jacc.2015.02.009","article-title":"Secondary mitral regurgitation in heart failure: pathophysiology, prognosis, and therapeutic considerations","volume":"65","author":"Asgar","year":"2015","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2018.12.066_bib3","first-page":"652","article-title":"Evolution of functional mitral regurgitation and prognosis in medically managed heart failure patients with reduced ejection fraction","volume":"5","author":"Nasser","year":"2017","journal-title":"J\u00a0Am Coll Cardiol HF"},{"key":"10.1016\/j.jacc.2018.12.066_bib4","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1136\/hrt.2011.225789","article-title":"Independent prognostic value of functional mitral regurgitation in patients with heart failure. A quantitative analysis of 1256 patients with ischaemic and non-ischaemic dilated cardiomyopathy","volume":"97","author":"Rossi","year":"2011","journal-title":"Heart"},{"key":"10.1016\/j.jacc.2018.12.066_bib5","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1161\/01.CIR.103.13.1759","article-title":"Ischemic mitral regurgitation: long-term outcome and prognostic implications with quantitative Doppler assessment","volume":"103","author":"Grigioni","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2018.12.066_bib6","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1161\/CIRCIMAGING.113.001251","article-title":"Long-term mortality associated with left ventricular dysfunction in mitral regurgitation due to flail leaflets: a multicenter analysis","volume":"7","author":"Tribouilloy","year":"2014","journal-title":"Circ Cardiovasc Img"},{"key":"10.1016\/j.jacc.2018.12.066_bib7","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1056\/NEJMoa041451","article-title":"Quantitative determinants of the outcome of asymptomatic mitral regurgitation","volume":"352","author":"Enriquez-Sarano","year":"2005","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2018.12.066_bib8","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.jacc.2017.03.011","article-title":"2017 AHA\/ACC focused update of the 2014 AHA\/ACC Guideline for the Management of Patients With Valvular Heart Disease: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"70","author":"Nishimura","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2018.12.066_bib9","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1093\/eurheartj\/ehx391","article-title":"2017 ESC\/EACTS guidelines for the management of valvular heart disease","volume":"38","author":"Baumgartner","year":"2017","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2018.12.066_bib10","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1093\/eurheartj\/ehm001","article-title":"What are the characteristics of patients with severe, symptomatic, mitral regurgitation who are denied surgery?","volume":"28","author":"Mirabel","year":"2007","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2018.12.066_bib11","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1056\/NEJMoa1806640","article-title":"Transcatheter mitral-valve repair in patients with heart failure","volume":"379","author":"Stone","year":"2018","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2018.12.066_bib12","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1056\/NEJMoa1805374","article-title":"Percutaneous repair or medical treatment for secondary mitral regurgitation","volume":"379","author":"Obadia","year":"2018","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2018.12.066_bib13","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jacc.2013.08.723","article-title":"Prevalence and outcomes of unoperated patients with severe symptomatic mitral regurgitation and heart failure: comprehensive analysis to determine the potential role of MitraClip for this unmet need","volume":"63","author":"Goel","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2018.12.066_bib14","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.jacc.2016.10.068","article-title":"Transcatheter mitral valve replacement for patients with symptomatic mitral regurgitation: a global feasibility trial","volume":"69","author":"Muller","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2018.12.066_bib15","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jacc.2017.10.061","article-title":"Early experience with new transcatheter mitral valve replacement","volume":"71","author":"Bapat","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2018.12.066_bib16","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1016\/j.jacc.2014.06.1208","article-title":"Short-term results of transapical transcatheter mitral valve implantation for mitral regurgitation","volume":"64","author":"Cheung","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2018.12.066_bib17","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.4244\/EIJY15M09_01","article-title":"Percutaneous transfemoral-transseptal implantation of a second-generation CardiAQ mitral valve bioprosthesis: first procedure description and 30-day follow-up","volume":"11","author":"Ussia","year":"2016","journal-title":"EuroIntervention"},{"key":"10.1016\/j.jacc.2018.12.066_bib18","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.jacc.2015.06.1322","article-title":"Initial experience of transcatheter mitral valve replacement with a novel transcatheter mitral valve: procedural and 6-month follow-up results","volume":"66","author":"Abdul-Jawad","year":"2015","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2018.12.066_bib19","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1016\/j.jcin.2017.05.032","article-title":"2-year outcomes after transcatheter mitral valve replacement","volume":"10","author":"Requeiro","year":"2017","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jacc.2018.12.066_bib20","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.jcmg.2014.07.028","article-title":"Mitral annular evaluation with CT in the context of transcatheter mitral valve replacement","volume":"8","author":"Blanke","year":"2015","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jacc.2018.12.066_bib21","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.jacc.2015.05.049","article-title":"Clinical trial design principles and endpoint definitions for transcatheter mitral valve repair and replacement: Part 2: endpoint definitions: a consensus document from the Mitral Valve Academic Research Consortium","volume":"66","author":"Stone","year":"2015","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2018.12.066_bib22","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jacc.2015.05.046","article-title":"Clinical trial design principles and endpoint definitions for transcatheter mitral valve repair and replacement: Part 1: clinical trial design principles: a consensus document from the Mitral Valve Academic Research Consortium","volume":"66","author":"Stone","year":"2015","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2018.12.066_bib23","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1161\/CIRCULATIONAHA.110.009449","article-title":"Standardized bleeding definitions for cardiovascular clinical trials: a consensus report from the Bleeding Academic Research Consortium","volume":"123","author":"Mehran","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2018.12.066_bib24","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1056\/NEJMoa1008232","article-title":"Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery","volume":"363","author":"Leon","year":"2010","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2018.12.066_bib25","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1016\/j.jacc.2017.09.015","article-title":"Outcomes with transcatheter mitral valve repair in the United States: an STS\/ACC TVT Registry report","volume":"70","author":"Sorajja","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2018.12.066_bib26","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa1805374","article-title":"Percutaneous repair or medical therapy\u00a0for\u00a0secondary mitral regurgitation","author":"Obadia","year":"2018","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2018.12.066_bib27","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1056\/NEJMoa1512913","article-title":"Two-year outcomes of surgical treatment of severe ischemic mitral regurgitation","volume":"374","author":"Goldstein","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2018.12.066_bib28","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jcct.2017.04.002","article-title":"Left\u00a0ventricular access point determination for a coaxial approach to the mitral annular landing zone in transcatheter mitral valve replacement","volume":"11","author":"Blanke","year":"2017","journal-title":"J\u00a0Cardiovasc Comput Tomogr"},{"key":"10.1016\/j.jacc.2018.12.066_bib29","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.jcmg.2016.01.005","article-title":"Predicting LVOT obstruction in transcatheter mitral valve implantation: concept of the neo-LVOT","volume":"10","author":"Blanke","year":"2017","journal-title":"J\u00a0Am Coll Cardiol Img"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109719303225?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109719303225?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:20:20Z","timestamp":1760016020000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109719303225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":29,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["S0735109719303225"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2018.12.066","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.735393010.793564327","asserted-by":"object"}]},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Initial Feasibility Study of a New\u00a0Transcatheter Mitral Prosthesis","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2018.12.066","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}