{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:55:47Z","timestamp":1791910547871,"version":"4.3.4"},"reference-count":8,"publisher":"Elsevier BV","issue":"15","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,23]],"date-time":"2020-04-23T00:00:00Z","timestamp":1587600000000},"content-version":"vor","delay-in-days":388,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.jacc.2019.02.025","type":"journal-article","created":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T15:48:02Z","timestamp":1555343282000},"page":"1958-1960","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Vascular Ehlers-Danlos Syndrome\u00a0Management"],"prefix":"10.1016","volume":"73","author":[{"given":"Julie","family":"De Backer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tine","family":"De Backer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2019.02.025_bib1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/ajmg.c.31553","article-title":"Diagnosis, natural history, and management in vascular Ehlers-Danlos syndrome","volume":"175","author":"Byers","year":"2017","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"10.1016\/j.jacc.2019.02.025_bib2","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1056\/NEJM200003093421001","article-title":"Clinical and genetic features of Ehlers-Danlos syndrome type IV, the vascular type","volume":"342","author":"Pepin","year":"2000","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2019.02.025_bib3","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/gim.2014.72","article-title":"Survival is\u00a0affected by mutation type and molecular mechanism in\u00a0vascular\u00a0Ehlers-Danlos syndrome (EDS type IV)","volume":"16","author":"Pepin","year":"2014","journal-title":"Genet. Med"},{"key":"10.1016\/j.jacc.2019.02.025_bib4","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1038\/ejhg.2015.32","article-title":"The type of variants at the COL3A1 gene associates with the phenotype and severity of vascular Ehlers-Danlos syndrome","volume":"23","author":"Frank","year":"2015","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.jacc.2019.02.025_bib5","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/S0140-6736(10)60960-9","article-title":"Effect of celiprolol on prevention of cardiovascular events in vascular Ehlers-Danlos syndrome: a prospective randomised, open, blinded-endpoints trial","volume":"376","author":"Ong","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2019.02.025_bib6","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/CRD.0000000000000159","article-title":"Celiprolol: a unique selective adrenoceptor modulator","volume":"25","author":"Nawarskas","year":"2017","journal-title":"Cardiol Rev"},{"key":"10.1016\/j.jacc.2019.02.025_bib7","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.tcm.2015.12.003","article-title":"Recent progress in understanding the natural and clinical histories of the Marfan syndrome","volume":"26","author":"Pyeritz","year":"2016","journal-title":"Trends Cardiovasc Med"},{"key":"10.1016\/j.jacc.2019.02.025_bib8","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1016\/j.jacc.2019.01.058","article-title":"Vascular\u00a0Ehlers-Danlos syndrome: long-term observational study","volume":"73","author":"Frank","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109719336927?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109719336927?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:20:28Z","timestamp":1760016028000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109719336927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":8,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["S0735109719336927"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2019.02.025","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vascular Ehlers-Danlos Syndrome\u00a0Management","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2019.02.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2019.01.058","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}