{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T14:51:36Z","timestamp":1774104696533,"version":"3.50.1"},"reference-count":13,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T00:00:00Z","timestamp":1597881600000},"content-version":"vor","delay-in-days":385,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.jacc.2019.06.033","type":"journal-article","created":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T15:53:54Z","timestamp":1565625234000},"page":"871-873","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Should Left Atrial Size Influence the Decision to Intervene in Degenerative\u00a0Mitral Regurgitation?"],"prefix":"10.1016","volume":"74","author":[{"given":"William A.","family":"Zoghbi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2019.06.033_bib1","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.jacc.2017.03.011","article-title":"2017 AHA\/ACC focused update of the 2014 AHA\/ACC Guideline for the Management of Patients With Valvular Heart Disease: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"70","author":"Nishimura","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2019.06.033_bib2","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1093\/eurheartj\/ehx391","article-title":"2017 ESC\/EACTS guidelines for the management of valvular heart disease","volume":"38","author":"Baumgartner","year":"2017","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2019.06.033_bib3","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jtcvs.2015.04.009","article-title":"Is there an outcome penalty linked to guideline-based indications for valvular surgery? Early and long-term analysis of patients with organic mitral regurgitation","volume":"150","author":"Enriquez-Sarano","year":"2015","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jacc.2019.06.033_bib4","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1093\/eurheartj\/ehm199","article-title":"Left atrial remodelling in mitral regurgitation--methodologic approach, physiological determinants, and outcome implications: a prospective quantitative Doppler-echocardiographic and electron beam-computed tomographic study","volume":"28","author":"Messika-Zeitoun","year":"2007","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2019.06.033_bib5","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1161\/01.RES.62.3.543","article-title":"Role of the left atrium in adaptation of the heart to chronic mitral regurgitation in conscious dogs","volume":"62","author":"Kihara","year":"1988","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2019.06.033_bib6","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.jacc.2010.02.059","article-title":"Impact of left atrial volume on clinical outcome in organic mitral regurgitation","volume":"56","author":"Le Tourneau","year":"2010","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2019.06.033_bib7","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1161\/CIRCIMAGING.110.961011","article-title":"Left atrial size is a potent predictor of mortality in mitral regurgitation due to flail leaflets: results from a large international multicenter study","volume":"4","author":"Rusinaru","year":"2011","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.jacc.2019.06.033_bib8","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.jacc.2019.06.032","article-title":"Prognostic implications of left atrial enlargement in degenerative mitral regurgitation","volume":"74","author":"Essayagh","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2019.06.033_bib9","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1161\/CIRCULATIONAHA.117.033173","article-title":"Clinical outcome of degenerative mitral regurgitation","volume":"138","author":"Antoine","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2019.06.033_bib10","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1016\/j.jacc.2019.01.059","article-title":"Left atrial structure and function, and\u00a0left ventricular diastolic dysfunction: JACC state-of-the-art review","volume":"73","author":"Thomas","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2019.06.033_bib11","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.echo.2016.01.011","article-title":"Recommendations for the evaluation of left ventricular diastolic function by echocardiography: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"29","author":"Nagueh","year":"2016","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.jacc.2019.06.033_bib12","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jacc.2018.10.067","article-title":"Long-term implications of atrial fibrillation in patients with degenerative mitral regurgitation","volume":"73","author":"Grigioni","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2019.06.033_bib13","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.echo.2017.01.007","article-title":"Recommendations for noninvasive evaluation of native valvular regurgitation: a report from the American Society of Echocardiography developed in collaboration with the Society for Cardiovascular Magnetic Resonance","volume":"30","author":"Zoghbi","year":"2017","journal-title":"J\u00a0Am Soc Echocardiogr"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073510971935689X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073510971935689X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:24:28Z","timestamp":1760016268000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S073510971935689X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":13,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["S073510971935689X"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2019.06.033","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Should Left Atrial Size Influence the Decision to Intervene in Degenerative\u00a0Mitral Regurgitation?","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2019.06.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2019.06.032","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}