{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:20:00Z","timestamp":1790770800253,"version":"4.1.0"},"reference-count":16,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T00:00:00Z","timestamp":1614729600000},"content-version":"vor","delay-in-days":367,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.jacc.2019.12.042","type":"journal-article","created":{"date-parts":[[2020,2,24]],"date-time":"2020-02-24T16:42:50Z","timestamp":1582562570000},"page":"854-856","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Aortic Dissection Risk in Marfan\u00a0Syndrome"],"prefix":"10.1016","volume":"75","author":[{"given":"Mary J.","family":"Roman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B.","family":"Devereux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2019.12.042_bib1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1161\/01.CIR.11.3.321","article-title":"The cardiovascular aspects of Marfan\u2019s syndrome: a heritable disorder of connective tissue","volume":"11","author":"McKusick","year":"1955","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2019.12.042_bib2","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1056\/NEJM197204132861502","article-title":"Life expectancy and causes of death in Marfan syndrome","volume":"286","author":"Murdoch","year":"1972","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2019.12.042_bib3","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1083\/jcb.103.6.2499","article-title":"Fibrillin, a new 35kd glycoprotein, is a component of extracellular microfibrils","volume":"103","author":"Sakai","year":"1986","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.jacc.2019.12.042_bib4","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/352330a0","article-title":"Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes","volume":"352","author":"Lee","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.jacc.2019.12.042_bib5","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1136\/jmg.2009.072785","article-title":"The revised Ghent nosology for the Marfan syndrome","volume":"47","author":"Loeys","year":"2010","journal-title":"J\u00a0Med Genet"},{"key":"10.1016\/j.jacc.2019.12.042_bib6","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0002-9149(00)80066-1","article-title":"Life expectancy in the Marfan syndrome","volume":"75","author":"Silverman","year":"1995","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2019.12.042_bib7","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1056\/NEJMoa1404731","article-title":"Randomized trial of atenolol versus losartan in children and young adults with Marfan syndrome","volume":"371","author":"Lacro","year":"2014","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2019.12.042_bib8","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.jtcvs.2009.06.014","article-title":"Long-term results of aortic valve-sparing operations in patients with Marfan syndrome","volume":"138","author":"David","year":"2009","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jacc.2019.12.042_bib9","first-page":"2915","article-title":"ESC guidelines for the management of grown-up congenital heart disease","volume":"31","author":"Baumgartner","year":"2010","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2019.12.042_bib10","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.1016\/j.jacc.2010.02.015","volume":"55","author":"Hiratzka","year":"2010","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2019.12.042_bib11","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1161\/CIRCULATIONAHA.111.054676","article-title":"Aortic event rate in the Marfan population: a cohort study","volume":"125","author":"Jondeau","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2019.12.042_bib12","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.jacc.2019.12.043","article-title":"Pathogenic FBN1 genetic variation and aortic dissection in patients with marfan syndrome","volume":"75","author":"Milleron","year":"2020","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2019.12.042_bib13","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1002\/humu.22802","article-title":"Performant mutation identification using targeted next-generation sequencing of 14 thoracic aortic aneurysm genes","volume":"36","author":"Proost","year":"2015","journal-title":"Hum Mutat"},{"key":"10.1016\/j.jacc.2019.12.042_bib14","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.jacc.2014.10.050","article-title":"The risk for type B aortic dissection in Marfan syndrome","volume":"65","author":"Den Hartog","year":"2015","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2019.12.042_bib15","article-title":"Associations of age and sex with Marfan phenotype: the NHLBI GenTAC Registry","volume":"10","author":"Roman","year":"2017","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1016\/j.jacc.2019.12.042_bib16","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1093\/eurheartj\/ehr218","article-title":"ESC guidelines on the management of cardiovascular disease during pregnancy","volume":"32","author":"Regitz-Zagrosek","year":"2011","journal-title":"Eur Heart J"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109720300929?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109720300929?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:30:30Z","timestamp":1760016630000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109720300929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":16,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S0735109720300929"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2019.12.042","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aortic Dissection Risk in Marfan\u00a0Syndrome","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2019.12.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2019.12.043","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}