{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:31:58Z","timestamp":1790631118434,"version":"4.1.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T00:00:00Z","timestamp":1614729600000},"content-version":"vor","delay-in-days":367,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.jacc.2019.12.056","type":"journal-article","created":{"date-parts":[[2020,2,24]],"date-time":"2020-02-24T16:43:03Z","timestamp":1582562583000},"page":"901-915","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Diminished Reactive Hematopoiesis and Cardiac Inflammation in a Mouse Model of Recurrent Myocardial Infarction"],"prefix":"10.1016","volume":"75","author":[{"given":"Sebastian","family":"Cremer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian J.","family":"Schloss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Vinegoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brody H.","family":"Foy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Rohde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"Hulsmans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Fumene Feruglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Wojtkiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Higgins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Weissleder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip K.","family":"Swirski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Nahrendorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2019.12.056_bib1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1093\/eurjhf\/hfq194","article-title":"Predictors and prognostic impact of recurrent myocardial infarction in patients with left ventricular dysfunction, heart failure, or both following a first myocardial infarction","volume":"13","author":"Thune","year":"2011","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jacc.2019.12.056_bib2","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1161\/CIRCINTERVENTIONS.114.001360","article-title":"Incidence, predictors, and implications of reinfarction after primary percutaneous coronary intervention in ST-segment-elevation myocardial infarction: the Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction Trial","volume":"7","author":"Stone","year":"2014","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.jacc.2019.12.056_bib3","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/s41591-018-0064-0","article-title":"Myeloid cell contributions to cardiovascular health and disease","volume":"24","author":"Nahrendorf","year":"2018","journal-title":"Nat Med"},{"key":"10.1016\/j.jacc.2019.12.056_bib4","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1084\/jem.20070885","article-title":"The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions","volume":"204","author":"Nahrendorf","year":"2007","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jacc.2019.12.056_bib5","doi-asserted-by":"crossref","first-page":"1251086","DOI":"10.1126\/science.1251086","article-title":"Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity","volume":"345","author":"Saeed","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.jacc.2019.12.056_bib6","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.cell.2017.11.034","article-title":"Modulation of myelopoiesis progenitors is an integral component of trained immunity","volume":"172","author":"Mitroulis","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.jacc.2019.12.056_bib7","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.cell.2017.12.013","article-title":"Western diet triggers NLRP3-dependent innate immune reprogramming","volume":"172","author":"Christ","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.jacc.2019.12.056_bib8","first-page":"12","article-title":"The coronary arteries of the C57BL\/6 mouse strains: implications for comparison with mutant models","volume":"212","author":"Fern\u00e1ndez","year":"2008","journal-title":"J\u00a0Anat"},{"key":"10.1016\/j.jacc.2019.12.056_bib9","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1006\/jmcc.1998.0702","article-title":"Left-ventricular structural and functional remodeling in the mouse after myocardial infarction: assessment with the isovolumetrically-contracting Langendorff heart","volume":"30","author":"Eberli","year":"1998","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1016\/j.jacc.2019.12.056_bib10","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.cell.2015.06.067","article-title":"Clarifying tissue clearing","volume":"162","author":"Richardson","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.jacc.2019.12.056_bib11","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.cell.2014.03.042","article-title":"Whole-brain imaging with single-cell resolution using chemical cocktails and computational analysis","volume":"157","author":"Susaki","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.jacc.2019.12.056_bib12","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.stem.2015.04.008","article-title":"Myocardial infarction activates CCR2(+) hematopoietic stem and progenitor cells","volume":"16","author":"Dutta","year":"2015","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jacc.2019.12.056_bib13","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1126\/science.1175202","article-title":"Identification of splenic reservoir monocytes and their deployment to inflammatory sites","volume":"325","author":"Swirski","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.jacc.2019.12.056_bib14","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nature12984","article-title":"The bone marrow niche for haematopoietic stem cells","volume":"505","author":"Morrison","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jacc.2019.12.056_bib15","doi-asserted-by":"crossref","first-page":"H812","DOI":"10.1152\/ajpheart.00335.2017","article-title":"Guidelines for experimental models of myocardial ischemia and infarction","volume":"314","author":"Lindsey","year":"2018","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jacc.2019.12.056_bib16","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1084\/jem.20101688","article-title":"Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche","volume":"208","author":"Chow","year":"2011","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jacc.2019.12.056_bib17","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.05521","article-title":"Hematopoietic stem and progenitor cells regulate the regeneration of their niche by secreting angiopoietin-1","volume":"4","author":"Zhou","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.jacc.2019.12.056_bib18","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.immuni.2012.12.001","article-title":"Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis","volume":"38","author":"Yona","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.jacc.2019.12.056_bib19","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nature11260","article-title":"Myocardial infarction accelerates atherosclerosis","volume":"487","author":"Dutta","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.jacc.2019.12.056_bib20","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1161\/CIRCULATIONAHA.115.016160","article-title":"Targeting interleukin-1\u03b2 reduces leukocyte production after acute myocardial infarction","volume":"132","author":"Sager","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2019.12.056_bib21","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1084\/jem.20170689","article-title":"The infarcted myocardium solicits GM-CSF for the detrimental oversupply of inflammatory leukocytes","volume":"214","author":"Anzai","year":"2017","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jacc.2019.12.056_bib22","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1161\/CIRCHEARTFAILURE.108.827071","article-title":"Leukocyte count and incidence of hospitalizations due to\u00a0heart failure","volume":"2","author":"Engstrom","year":"2009","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jacc.2019.12.056_bib23","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory therapy with canakinumab for atherosclerotic disease","volume":"377","author":"Ridker","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2019.12.056_bib24","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1161\/01.CIR.0000124490.27666.B2","article-title":"Targeted anticytokine therapy in patients with chronic heart failure: results of the Randomized Etanercept Worldwide Evaluation (RENEWAL)","volume":"109","author":"Mann","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2019.12.056_bib25","first-page":"131","article-title":"Anti-inflammatory treatment with colchicine in stable chronic heart failure: a prospective, randomized study","volume":"2","author":"Deftereos","year":"2014","journal-title":"J\u00a0Am Coll Cardiol HF"},{"key":"10.1016\/j.jacc.2019.12.056_bib26","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1161\/01.ATV.0000156877.94472.a5","article-title":"Leukocytosis and ischemic vascular disease morbidity and mortality: is it time to intervene","volume":"25","author":"Coller","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jacc.2019.12.056_bib27","doi-asserted-by":"crossref","first-page":"1250684","DOI":"10.1126\/science.1250684","article-title":"mTOR- and HIF-1\u03b1-mediated aerobic glycolysis as metabolic basis for trained immunity","volume":"345","author":"Cheng","year":"2014","journal-title":"Science"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109720301650?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109720301650?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:29:39Z","timestamp":1760016579000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109720301650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S0735109720301650"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2019.12.056","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/659359","asserted-by":"object"}],"has-review":[{"id-type":"doi","id":"10.3410\/f.737446128.793575342","asserted-by":"object"}]},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diminished Reactive Hematopoiesis and Cardiac Inflammation in a Mouse Model of Recurrent Myocardial Infarction","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2019.12.056","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}