{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T21:25:54Z","timestamp":1793049954637,"version":"4.5.0"},"reference-count":122,"publisher":"Elsevier BV","issue":"17","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T00:00:00Z","timestamp":1620172800000},"content-version":"vor","delay-in-days":369,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL135093"],"award-info":[{"award-number":["R01HL135093"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL130423"],"award-info":[{"award-number":["R01HL130423"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.jacc.2020.03.019","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T16:45:28Z","timestamp":1588005928000},"page":"2204-2218","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":134,"title":["Myocardial Interstitial Fibrosis in Nonischemic Heart Disease, Part 3\/4"],"prefix":"10.1016","volume":"75","author":[{"given":"Javier","family":"D\u00edez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arantxa","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason C.","family":"Kovacic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2020.03.019_bib1","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.yjmcc.2009.08.024","article-title":"The extracellular matrix: at the center of it all","volume":"48","author":"Bowers","year":"2010","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1016\/j.jacc.2020.03.019_bib2","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1161\/CIRCRESAHA.114.302533","article-title":"Myocardial extracellular matrix: an ever-changing and diverse entity","volume":"114","author":"Rienks","year":"2014","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2020.03.019_bib3","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1172\/JCI87491","article-title":"The extracellular matrix in myocardial injury, repair, and remodeling","volume":"127","author":"Frangogiannis","year":"2017","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jacc.2020.03.019_bib4","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.ejcts.2006.07.006","article-title":"The relationship between myocardial extracellular matrix remodeling and ventricular function","volume":"30","author":"Brower","year":"2006","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.jacc.2020.03.019_bib5","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.hfc.2011.08.012","article-title":"Changes in the myocardial interstitium and contribution to the progression of heart failure","volume":"8","author":"Eckhouse","year":"2012","journal-title":"Heart Fail Clin"},{"key":"10.1016\/j.jacc.2020.03.019_bib6","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1161\/CIRCRESAHA.114.302819","article-title":"Dynamic changes in myocardial matrix and relevance to disease: translational perspectives","volume":"114","author":"Li","year":"2014","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2020.03.019_bib7","first-page":"280","article-title":"Computer-assisted quantitation of myocardial fibrosis in histologic sections","volume":"108","author":"Hoyt","year":"1984","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.jacc.2020.03.019_bib8","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1161\/01.CIR.82.3.848","article-title":"A\u00a0comparison of the pathological spectrum of hypertensive, diabetic, and hypertensive-diabetic heart disease","volume":"82","author":"van Hoeven","year":"1990","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2020.03.019_bib9","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1136\/jcp.46.1.32","article-title":"Collagen remodelling in myocardia of patients with diabetes","volume":"46","author":"Shimizu","year":"1993","journal-title":"J\u00a0Clin Pathol"},{"key":"10.1016\/j.jacc.2020.03.019_bib10","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1093\/eurheartj\/ehx353","article-title":"Reappraising myocardial fibrosis in severe aortic stenosis: an invasive and non-invasive study in 133 patients","volume":"39","author":"Treibel","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2020.03.019_bib11","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0735-1097(99)00492-1","article-title":"Morphology and significance of the left ventricular collagen network in young patients with hypertrophic cardiomyopathy and sudden cardiac death","volume":"35","author":"Shirani","year":"2000","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2020.03.019_bib12","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1136\/heart.89.10.1255","article-title":"Interstitial fibrosis in the dilated non-ischaemic myocardium","volume":"89","author":"Brooks","year":"2003","journal-title":"Heart"},{"key":"10.1016\/j.jacc.2020.03.019_bib13","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1161\/CIRCULATIONAHA.111.025270","article-title":"Diabetes mellitus worsens diastolic left ventricular dysfunction in aortic stenosis through altered myocardial structure and cardiomyocyte stiffness","volume":"124","author":"Falcao-Pires","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2020.03.019_bib14","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/path.1711280205","article-title":"Histopathological types of cardiac fibrosis in myocardial disease","volume":"128","author":"Anderson","year":"1979","journal-title":"J\u00a0Pathol"},{"issue":"9","key":"10.1016\/j.jacc.2020.03.019_bib15","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.116.003090","article-title":"Histological and histometric characterization of myocardial fibrosis in end-stage hypertrophic cardiomyopathy: a clinical-pathological study of 30 explanted hearts","volume":"9","author":"Galati","year":"2016","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jacc.2020.03.019_bib16","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1136\/hrt.55.6.575","article-title":"Quantitative analysis of myocardial fibrosis in normals, hypertensive hearts, and hypertrophic cardiomyopathy","volume":"55","author":"Tanaka","year":"1986","journal-title":"Br Heart J"},{"key":"10.1016\/j.jacc.2020.03.019_bib17","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1161\/HYPERTENSIONAHA.113.02654","article-title":"Association of cardiotrophin-1 with myocardial fibrosis in hypertensive patients with heart failure","volume":"63","author":"L\u00f3pez","year":"2014","journal-title":"Hypertension"},{"key":"10.1016\/j.jacc.2020.03.019_bib18","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.recesp.2016.12.018","article-title":"Role of myocardial collagen in severe aortic stenosis with preserved ejection fraction and symptoms of heart failure","volume":"70","author":"Echegaray","year":"2017","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"key":"10.1016\/j.jacc.2020.03.019_bib19","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1023\/A:1003492407387","article-title":"Immunohistochemical video-microdensitometry of myocardial collagen type I and type III","volume":"30","author":"Boerrigter","year":"1998","journal-title":"Histochem J"},{"key":"10.1016\/j.jacc.2020.03.019_bib20","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1146\/annurev.biochem.77.032207.120833","article-title":"Collagen structure and stability","volume":"78","author":"Shoulders","year":"2009","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.jacc.2020.03.019_bib21","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1096\/fasebj.6.7.1348714","article-title":"Enzymatic and nonenzymatic cross-linking of collagen and elastin","volume":"6","author":"Reiser","year":"1992","journal-title":"FASEB J"},{"key":"10.1016\/j.jacc.2020.03.019_bib22","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.jacc.2010.10.024","article-title":"Diastolic tissue Doppler indexes correlate with the degree of collagen expression and cross-linking in heart failure and normal ejection fraction","volume":"57","author":"Kasner","year":"2011","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2020.03.019_bib23","doi-asserted-by":"crossref","first-page":"40696","DOI":"10.1038\/srep40696","article-title":"MicroRNA-19b is a potential biomarker of increased myocardial collagen cross-linking in patients with aortic stenosis and heart failure","volume":"7","author":"Beaumont","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jacc.2020.03.019_bib24","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1161\/CIRCULATIONAHA.107.728550","article-title":"Diastolic stiffness of the failing diabetic heart: importance of fibrosis, advanced glycation end products, and myocyte resting tension","volume":"117","author":"van Heerebeek","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2020.03.019_bib25","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1161\/HYPERTENSIONAHA.112.196113","article-title":"Collagen cross-linking but not collagen amount associates with elevated filling pressures in hypertensive patients with stage C heart failure: potential role of lysyl oxidase","volume":"60","author":"L\u00f3pez","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.jacc.2020.03.019_bib26","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1161\/CIRCULATIONAHA.114.013215","article-title":"Myocardial stiffness in patients with heart failure and a preserved ejection fraction: contributions of collagen and titin","volume":"131","author":"Zile","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2020.03.019_bib27","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1097\/HJH.0000000000001258","article-title":"Phenotyping of myocardial fibrosis in hypertensive patients with heart failure. Influence on clinical outcome","volume":"35","author":"Ravassa","year":"2017","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.jacc.2020.03.019_bib28","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mam.2018.06.003","article-title":"Organ and tissue fibrosis: molecular signals, cellular mechanisms and translational implications","volume":"65","author":"Weiskirchen","year":"2019","journal-title":"Mol Aspects Med"},{"key":"10.1016\/j.jacc.2020.03.019_bib29","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.trsl.2019.03.004","article-title":"Mechanisms of cardiac collagen deposition in experimental models and human disease","volume":"209","author":"Cowling","year":"2019","journal-title":"Transl Res"},{"key":"10.1016\/j.jacc.2020.03.019_bib30","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.mam.2018.07.001","article-title":"Cardiac fibrosis: cell biological mechanisms, molecular pathways and therapeutic opportunities","volume":"65","author":"Frangogiannis","year":"2019","journal-title":"Mol Aspects Med"},{"key":"10.1016\/j.jacc.2020.03.019_bib31","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s10741-016-9536-9","article-title":"The fibrosis-cell death axis in heart failure","volume":"21","author":"Piek","year":"2016","journal-title":"Heart Fail Rev"},{"key":"10.1016\/j.jacc.2020.03.019_bib32","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1161\/HYPERTENSIONAHA.118.11125","article-title":"Myocardial remodeling in hypertension","volume":"72","author":"Gonz\u00e1lez","year":"2018","journal-title":"Hypertension"},{"key":"10.1016\/j.jacc.2020.03.019_bib33","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.jtcvs.2011.04.044","article-title":"Myocardial remodeling with aortic stenosis and after aortic valve replacement: mechanisms and future prognostic implications","volume":"143","author":"Yarbrough","year":"2012","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jacc.2020.03.019_bib34","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1161\/CIRCRESAHA.117.311059","article-title":"Hypertrophic cardiomyopathy: genetics, pathogenesis, clinical manifestations, diagnosis, and therapy","volume":"121","author":"Marian","year":"2017","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2020.03.019_bib35","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.yjmcc.2015.12.011","article-title":"Diabetes-associated cardiac fibrosis: cellular effectors, molecular mechanisms and therapeutic opportunities","volume":"90","author":"Russo","year":"2016","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1016\/j.jacc.2020.03.019_bib36","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jacc.2013.02.092","article-title":"A\u00a0novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation","volume":"62","author":"Paulus","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2020.03.019_bib37","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.yjmcc.2015.11.002","article-title":"Inflammatory and fibrotic responses of cardiac fibroblasts to myocardial damage associated molecular patterns (DAMPs)","volume":"94","author":"Turner","year":"2016","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.jacc.2020.03.019_bib38","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.diff.2016.06.004","article-title":"The cardiac fibroblast: origin, identity and role in homeostasis and disease","volume":"92","author":"Furtado","year":"2016","journal-title":"Differentiation"},{"key":"10.1016\/j.jacc.2020.03.019_bib39","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1161\/HYPERTENSIONAHA.107.098459","article-title":"Angiotensin II-induced extracellular signal-regulated kinase 1\/2 activation is mediated by protein kinase Cdelta and intracellular calcium in adult rat cardiac fibroblasts","volume":"51","author":"Olson","year":"2008","journal-title":"Hypertension"},{"key":"10.1016\/j.jacc.2020.03.019_bib40","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.yjmcc.2014.01.008","article-title":"Myocardial fibroblast-matrix interactions and potential therapeutic targets","volume":"70","author":"Goldsmith","year":"2014","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1016\/j.jacc.2020.03.019_bib41","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/nrcardio.2012.158","article-title":"Myofibroblast-mediated mechanisms of pathological remodelling of the heart","volume":"10","author":"Weber","year":"2013","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jacc.2020.03.019_bib42","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1586\/14779072.2016.1147348","article-title":"Myofibroblast secretome and its auto-\/paracrine signaling","volume":"14","author":"Bomb","year":"2016","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"10.1016\/j.jacc.2020.03.019_bib43","doi-asserted-by":"crossref","first-page":"a004978","DOI":"10.1101\/cshperspect.a004978","article-title":"The collagen family","volume":"3","author":"Ricard-Blum","year":"2011","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.jacc.2020.03.019_bib44","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1152\/physrev.00008.2011","article-title":"Matricellular proteins in cardiac adaptation and disease","volume":"92","author":"Frangogiannis","year":"2012","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jacc.2020.03.019_bib45","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/cvr\/cvt100","article-title":"Osteopontin-mediated myocardial fibrosis in heart failure: a role for lysyl oxidase?","volume":"99","author":"L\u00f3pez","year":"2013","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jacc.2020.03.019_bib46","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s00395-013-0375-8","article-title":"Fibronectin contributes to pathological cardiac hypertrophy but not physiological growth","volume":"108","author":"Konstandin","year":"2013","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.jacc.2020.03.019_bib47","doi-asserted-by":"crossref","first-page":"3770","DOI":"10.1172\/JCI94753","article-title":"Fibroblast-specific TGF-beta-Smad2\/3 signaling underlies cardiac fibrosis","volume":"127","author":"Khalil","year":"2017","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jacc.2020.03.019_bib48","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1161\/CIRCRESAHA.118.314438","article-title":"Protective effects of activated myofibroblasts in the pressure-overloaded myocardium are mediated through Smad-dependent activation of a matrix-preserving program","volume":"124","author":"Russo","year":"2019","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2020.03.019_bib49","first-page":"230","article-title":"CCR2(+) monocyte-derived infiltrating macrophages are required for adverse cardiac remodeling during pressure overload","volume":"3","author":"Patel","year":"2018","journal-title":"J\u00a0Am Coll Cardiol Basic Transl Science"},{"key":"10.1016\/j.jacc.2020.03.019_bib50","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.yjmcc.2015.11.005","article-title":"Aging and the cardiac collagen matrix: novel mediators of fibrotic remodelling","volume":"93","author":"Horn","year":"2016","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1016\/j.jacc.2020.03.019_bib51","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s10741-010-9161-y","article-title":"The role of inflammatory and fibrogenic pathways in heart failure associated with aging","volume":"15","author":"Chen","year":"2010","journal-title":"Heart Fail Rev"},{"key":"10.1016\/j.jacc.2020.03.019_bib52","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1089\/ars.2011.4179","article-title":"Cardiac aging: from molecular mechanisms to significance in human health and disease","volume":"16","author":"Dai","year":"2012","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.jacc.2020.03.019_bib53","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1093\/oxfordjournals.eurheartj.a060749","article-title":"Sex-dependent differences in left ventricular function and structure in chronic pressure overload","volume":"16","author":"Villari","year":"1995","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2020.03.019_bib54","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1002\/ejhf.171","article-title":"Sex-dependent regulation of fibrosis and inflammation in human left ventricular remodelling under pressure overload","volume":"16","author":"Kararigas","year":"2014","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jacc.2020.03.019_bib55","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1093\/cvr\/cvy185","article-title":"Sex-specific regulation of collagen I and III expression by 17beta-estradiol in cardiac fibroblasts: role of estrogen receptors","volume":"115","author":"Dworatzek","year":"2019","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jacc.2020.03.019_bib56","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3109\/13685538.2012.754008","article-title":"Androgen modulates cardiac fibrosis contributing to gender differences on heart failure","volume":"16","author":"Chung","year":"2013","journal-title":"Aging Male"},{"key":"10.1016\/j.jacc.2020.03.019_bib57","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1016\/j.jacc.2018.02.021","article-title":"Myocardial interstitial fibrosis in heart failure: biological and translational perspectives","volume":"71","author":"Gonz\u00e1lez","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2020.03.019_bib58","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1161\/01.CIR.0000017264.66561.3D","article-title":"Losartan-dependent regression of myocardial fibrosis is associated with reduction of left ventricular chamber stiffness in hypertensive patients","volume":"105","author":"D\u00edez","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2020.03.019_bib59","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s10554-017-1214-z","article-title":"Left ventricular function in patients with hypertrophic cardiomyopathy and its relation to myocardial fibrosis and exercise tolerance","volume":"34","author":"Maragiannis","year":"2018","journal-title":"Int J Cardiovasc Imaging"},{"key":"10.1016\/j.jacc.2020.03.019_bib60","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1016\/j.jacc.2016.02.018","article-title":"Extracellular volume fraction for characterization of patients with heart failure and preserved ejection fraction","volume":"67","author":"Rommel","year":"2016","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2020.03.019_bib61","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.bbadis.2005.02.007","article-title":"The type of collagen cross-link determines the reversibility of experimental skin fibrosis","volume":"1740","author":"van der Slot-Verhoeven","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jacc.2020.03.019_bib62","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.yjmcc.2011.10.002","article-title":"Getting to the heart of cardiac remodeling; how collagen subtypes may contribute to phenotype","volume":"52","author":"Collier","year":"2012","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1016\/j.jacc.2020.03.019_bib63","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/0735-1097(94)00557-7","article-title":"Dilated cardiomyopathy is associated with an increase in the type I\/type III collagen ratio: a quantitative assessment","volume":"25","author":"Marijianowski","year":"1995","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2020.03.019_bib64","first-page":"1639","article-title":"Remodeling of human myocardial collagen in idiopathic dilated cardiomyopathy. Role of metalloproteinases and pyridinoline cross-links","volume":"148","author":"Gunja-Smith","year":"1996","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jacc.2020.03.019_bib65","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/0735-1097(93)90560-N","article-title":"Influence of collagen network on left ventricular systolic and diastolic function in aortic valve disease","volume":"22","author":"Villari","year":"1993","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2020.03.019_bib66","doi-asserted-by":"crossref","first-page":"H122","DOI":"10.1152\/ajpheart.00233.2002","article-title":"Changes in extracellular collagen matrix alter myocardial systolic performance","volume":"284","author":"Baicu","year":"2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jacc.2020.03.019_bib67","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jacc.2006.01.077","article-title":"Alterations in the pattern of collagen deposition may contribute to the deterioration of systolic function in hypertensive patients with heart failure","volume":"48","author":"L\u00f3pez","year":"2006","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2020.03.019_bib68","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1161\/01.CIR.0000051865.66123.B7","article-title":"Progression from compensated hypertrophy to failure in the pressure-overloaded human heart: structural deterioration and compensatory mechanisms","volume":"107","author":"Hein","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2020.03.019_bib69","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1093\/eurheartj\/ehq136","article-title":"Clinicopathological profiles of progressive heart failure in hypertrophic cardiomyopathy","volume":"31","author":"Melacini","year":"2010","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2020.03.019_bib70","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1002\/j.2040-4603.2017.tb00771.x","article-title":"Cardiac fibrosis and arrhythmogenesis","volume":"7","author":"Nguyen","year":"2017","journal-title":"Compr Physiol"},{"key":"10.1016\/j.jacc.2020.03.019_bib71","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1161\/hc5001.100833","article-title":"Activation delay after premature stimulation in chronically diseased human myocardium relates to the architecture of interstitial fibrosis","volume":"104","author":"Kawara","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2020.03.019_bib72","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1093\/ajh\/3.10.735","article-title":"Ventricular arrhythmias in hypertensive left ventricular hypertrophy. Relationship to coronary artery disease, left ventricular dysfunction, and myocardial fibrosis","volume":"3","author":"McLenachan","year":"1990","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.jacc.2020.03.019_bib73","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1007\/s11886-012-0297-3","article-title":"A\u00a0primer on arrhythmias in patients with hypertrophic cardiomyopathy","volume":"14","author":"Bockstall","year":"2012","journal-title":"Curr Cardiol Rep"},{"key":"10.1016\/j.jacc.2020.03.019_bib74","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ijcard.2017.03.002","article-title":"Hypertension, left ventricular hypertrophy, and sudden cardiac death","volume":"237","author":"Shenasa","year":"2017","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacc.2020.03.019_bib75","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1001\/jama.2013.1363","article-title":"Association of fibrosis with mortality and sudden cardiac death in patients with nonischemic dilated cardiomyopathy","volume":"309","author":"Gulati","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.jacc.2020.03.019_bib76","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.jacc.2015.06.1313","article-title":"Cardiac fibrosis in patients with atrial fibrillation: mechanisms and clinical implications","volume":"66","author":"Dzeshka","year":"2015","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2020.03.019_bib77","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1093\/europace\/euw161","article-title":"EHRA\/HRS\/APHRS\/SOLAECE expert consensus on atrial cardiomyopathies: definition, characterization, and clinical implication","volume":"18","author":"Goette","year":"2016","journal-title":"Europace"},{"key":"10.1016\/j.jacc.2020.03.019_bib78","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.117.007131","article-title":"Myocardial fibrosis predicts 10-year survival in patients undergoing aortic valve replacement","volume":"11","author":"Herrmann","year":"2018","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.jacc.2020.03.019_bib79","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1161\/CIRCULATIONAHA.108.847772","article-title":"Impact of myocardial fibrosis in patients with symptomatic severe aortic stenosis","volume":"120","author":"Weidemann","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2020.03.019_bib80","first-page":"416","article-title":"Coronary perivascular fibrosis is associated with impairment of coronary blood flow in patients with non-ischemic heart failure","volume":"60","author":"Dai","year":"2012","journal-title":"J\u00a0Cardiol"},{"key":"10.1016\/j.jacc.2020.03.019_bib81","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/BF00944780","article-title":"Progression of heart failure: a role for interstitial fibrosis","volume":"147","author":"Sabbah","year":"1995","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.jacc.2020.03.019_bib82","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1161\/CIRCULATIONAHA.114.009625","article-title":"Coronary microvascular rarefaction and myocardial fibrosis in heart failure with preserved ejection fraction","volume":"131","author":"Mohammed","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2020.03.019_bib83","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1253\/circj.CJ-11-0568","article-title":"Prognostic impact of myocardial interstitial fibrosis in non-ischemic heart failure. Comparison between preserved and reduced ejection fraction heart failure","volume":"75","author":"Aoki","year":"2011","journal-title":"Circ J"},{"key":"10.1016\/j.jacc.2020.03.019_bib84","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1093\/eurheartj\/eht193","article-title":"Myocardial extracellular volume fraction quantified by cardiovascular magnetic resonance is increased in diabetes and associated with mortality and incident heart failure admission","volume":"35","author":"Wong","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2020.03.019_bib85","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1136\/heartjnl-2015-307682","article-title":"Myocardial fibrosis on cardiac magnetic resonance and cardiac outcomes in hypertrophic cardiomyopathy: a meta-analysis","volume":"101","author":"Briasoulis","year":"2015","journal-title":"Heart"},{"issue":"12","key":"10.1016\/j.jacc.2020.03.019_bib86","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.116.005277","article-title":"Interstitial fibrosis, functional status, and outcomes in heart failure with preserved ejection fraction: insights from a prospective cardiac magnetic resonance imaging study","volume":"9","author":"Duca","year":"2016","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.jacc.2020.03.019_bib87","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1001\/jamacardio.2017.2511","article-title":"Temporal relation between myocardial fibrosis and heart failure with preserved ejection fraction: association with baseline disease severity and subsequent outcome","volume":"2","author":"Schelbert","year":"2017","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jacc.2020.03.019_bib88","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jacc.2015.10.063","article-title":"Myocardial collagen cross-linking is associated with heart failure hospitalization in patients with hypertensive heart failure","volume":"67","author":"L\u00f3pez","year":"2016","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2020.03.019_bib89","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jacc.2009.12.074","article-title":"Prognostic significance of myocardial fibrosis quantification by histopathology and magnetic resonance imaging in patients with severe aortic valve disease","volume":"56","author":"Azevedo","year":"2010","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2020.03.019_bib90","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/ejhf.1406","article-title":"Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart\u00a0Failure Association (HFA) of the European Society of Cardiology","volume":"21","author":"de Boer","year":"2019","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jacc.2020.03.019_bib91","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1161\/CIRCULATIONAHA.13.001414","article-title":"Contribution and risks of left ventricular endomyocardial biopsy in patients with cardiomyopathies: a retrospective study over a 28-year period","volume":"128","author":"Chimenti","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2020.03.019_bib92","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1253\/circj.CJ-16-0927","article-title":"Significance and value of endomyocardial biopsy based on our own experience","volume":"81","author":"Ishibashi-Ueda","year":"2017","journal-title":"Circ J"},{"key":"10.1016\/j.jacc.2020.03.019_bib93","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.crad.2016.02.013","article-title":"Assessment of myocardial fibrosis with T1 mapping MRI","volume":"71","author":"Everett","year":"2016","journal-title":"Clin Radiol"},{"key":"10.1016\/j.jacc.2020.03.019_bib94","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s12968-016-0313-7","article-title":"Histologic validation of myocardial fibrosis measured by T1 mapping: a systematic review and meta-analysis","volume":"18","author":"Diao","year":"2016","journal-title":"J\u00a0Cardiovasc Magn Reson"},{"key":"10.1016\/j.jacc.2020.03.019_bib95","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s12968-017-0389-8","volume":"19","author":"Messroghli","year":"2017","journal-title":"J\u00a0Cardiovasc Magn Reson"},{"key":"10.1016\/j.jacc.2020.03.019_bib96","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1016\/j.jacc.2015.04.026","article-title":"Circulating biomarkers of myocardial fibrosis: the need for a reappraisal","volume":"65","author":"L\u00f3pez","year":"2015","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2020.03.019_bib97","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1097\/FJC.0b013e31821823d9","article-title":"Biomarkers of myocardial fibrosis","volume":"57","author":"de Jong","year":"2011","journal-title":"J\u00a0Cardiovasc Pharmacol"},{"key":"10.1016\/j.jacc.2020.03.019_bib98","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.cca.2014.09.006","article-title":"Markers of fibrosis, inflammation, and remodeling pathways in heart failure","volume":"443","author":"Passino","year":"2015","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.jacc.2020.03.019_bib99","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0002-9149(99)80686-9","article-title":"Measuring extracellular matrix turnover in the serum of patients with idiopathic or ischemic dilated cardiomyopathy and impact on diagnosis and prognosis","volume":"75","author":"Klappacher","year":"1995","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2020.03.019_bib100","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1016\/j.jacc.2018.12.074","article-title":"Combination of circulating type I collagen-related biomarkers is associated with atrial fibrillation","volume":"73","author":"Ravassa","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2020.03.019_bib101","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1172\/JCI93563","article-title":"Resolution of organ fibrosis","volume":"128","author":"Jun","year":"2018","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jacc.2020.03.019_bib102","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.jhep.2015.03.039","article-title":"Mechanisms of liver fibrosis resolution","volume":"63","author":"Tacke","year":"2015","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jacc.2020.03.019_bib103","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1016\/j.jacc.2018.08.2147","article-title":"Macrophage trafficking, inflammatory resolution, and genomics in atherosclerosis: JACC macrophage in CVD series (part 2)","volume":"72","author":"Moore","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2020.03.019_bib104","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1161\/01.CIR.91.9.2353","article-title":"Normalization of diastolic dysfunction in aortic stenosis late after valve replacement","volume":"91","author":"Villari","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2020.03.019_bib105","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1161\/01.CIR.104.3.286","article-title":"Usefulness of serum carboxy-terminal propeptide of procollagen type I in assessment of the cardioreparative ability of antihypertensive treatment in hypertensive patients","volume":"104","author":"L\u00f3pez","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2020.03.019_bib106","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1161\/01.CIR.102.12.1388","article-title":"Lisinopril-mediated regression of myocardial fibrosis in patients with hypertensive heart disease","volume":"102","author":"Brilla","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2020.03.019_bib107","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1161\/CIRCULATIONAHA.105.571653","article-title":"Mineralocorticoid receptor antagonism ameliorates left ventricular diastolic dysfunction and myocardial fibrosis in mildly symptomatic patients with idiopathic dilated cardiomyopathy: a pilot study","volume":"112","author":"Izawa","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2020.03.019_bib108","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1016\/j.jacc.2003.12.052","article-title":"Effects of loop diuretics on myocardial fibrosis and collagen type I turnover in chronic heart failure","volume":"43","author":"L\u00f3pez","year":"2004","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2020.03.019_bib109","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.jacc.2007.04.080","article-title":"Identification of a potential cardiac antifibrotic mechanism of torasemide in patients with chronic heart failure","volume":"50","author":"L\u00f3pez","year":"2007","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2020.03.019_bib110","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1161\/HYPERTENSIONAHA.108.125278","article-title":"Impact of treatment on myocardial lysyl oxidase expression and collagen cross-linking in patients with heart failure","volume":"53","author":"L\u00f3pez","year":"2009","journal-title":"Hypertension"},{"key":"10.1016\/j.jacc.2020.03.019_bib111","first-page":"311","article-title":"Enabling precision cardiology through multiscale biology and systems medicine","volume":"2","author":"Johnson","year":"2017","journal-title":"J\u00a0Am Coll Cardiol Basic Transl Science"},{"key":"10.1016\/j.jacc.2020.03.019_bib112","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1002\/ejhf.1194","volume":"20","author":"Ravassa","year":"2018","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jacc.2020.03.019_bib113","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/ejhf.474","article-title":"LCZ696, an angiotensin receptor-neprilysin inhibitor, improves cardiac function with the attenuation of fibrosis in heart failure with reduced ejection fraction in streptozotocin-induced diabetic mice","volume":"18","author":"Suematsu","year":"2016","journal-title":"Eur J Heart Fail"},{"issue":"4","key":"10.1016\/j.jacc.2020.03.019_bib114","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.118.005565","article-title":"Sacubitril\/valsartan decreases cardiac fibrosis in left ventricle pressure overload by restoring PKG signaling in cardiac fibroblasts","volume":"12","author":"Burke","year":"2019","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jacc.2020.03.019_bib115","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1056\/NEJMoa1908655","article-title":"Angiotensin-neprilysin inhibition in heart failure with preserved ejection fraction","volume":"381","author":"Solomon","year":"2019","journal-title":"N\u00a0Engl J Med"},{"issue":"1","key":"10.1016\/j.jacc.2020.03.019_bib116","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12933-016-0489-z","article-title":"Sodium glucose transporter 2 (SGLT2) inhibition with empagliflozin improves cardiac diastolic function in a female rodent model of diabetes","volume":"16","author":"Habibi","year":"2017","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.jacc.2020.03.019_bib117","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1001\/jamacardio.2017.2275","article-title":"Effects of sodium-glucose cotransporter 2 inhibitors for the treatment of patients with heart failure: proposal of a novel mechanism of action","volume":"2","author":"Packer","year":"2017","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jacc.2020.03.019_bib118","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1056\/NEJMoa1911303","article-title":"Dapagliflozin in patients with heart failure and reduced ejection fraction","volume":"381","author":"McMurray","year":"2019","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2020.03.019_bib119","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.1111\/j.1755-5922.2010.00228.x","article-title":"Targeting fibrosis for the treatment of heart failure: a role for transforming growth factor-beta","volume":"30","author":"Edgley","year":"2012","journal-title":"Cardiovasc Ther"},{"key":"10.1016\/j.jacc.2020.03.019_bib120","doi-asserted-by":"crossref","first-page":"186","DOI":"10.3389\/fphar.2017.00186","article-title":"A\u00a0clinical perspective of anti-fibrotic therapies for cardiovascular disease","volume":"8","author":"Fang","year":"2017","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jacc.2020.03.019_bib121","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.trsl.2019.03.001","article-title":"Cardiac fibrosis: potential therapeutic targets","volume":"209","author":"Park","year":"2019","journal-title":"Transl Res"},{"key":"10.1016\/j.jacc.2020.03.019_bib122","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/ejhf.696","article-title":"Myocardial fibrosis: biomedical research from bench to bedside","volume":"19","author":"Gyongyosi","year":"2017","journal-title":"Eur J Heart Fail"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109720345599?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109720345599?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T18:15:15Z","timestamp":1777572915000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109720345599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":122,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["S0735109720345599"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2020.03.019","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Myocardial Interstitial Fibrosis in Nonischemic Heart Disease, Part 3\/4","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2020.03.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2020.03.018","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2020.03.020","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2020.03.024","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}