{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:22:32Z","timestamp":1790796152476,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"24","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T00:00:00Z","timestamp":1624406400000},"content-version":"vor","delay-in-days":387,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.jacc.2020.04.045","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T15:54:52Z","timestamp":1592236492000},"page":"3033-3043","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":170,"title":["Outcomes in Patients With Hypertrophic Cardiomyopathy and Left Ventricular Systolic Dysfunction"],"prefix":"10.1016","volume":"75","author":[{"given":"Ethan J.","family":"Rowin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry J.","family":"Maron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard T.","family":"Carrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parth P.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Koethe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Wells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin S.","family":"Maron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2020.04.045_bib1","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1016\/j.jacc.2015.02.061","article-title":"Hypertrophic cardiomyopathy in adulthood associated with low cardiovascular mortality with contemporary management strategies","volume":"65","author":"Maron","year":"2015","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2020.04.045_bib2","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1001\/jamacardio.2015.0354","article-title":"How hypertrophic cardiomyopathy became a contemporary treatable genetic disease with low mortality","volume":"1","author":"Maron","year":"2016","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jacc.2020.04.045_bib3","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.jacc.2005.02.090","article-title":"Long-term effects of surgical septal myectomy on survival in patients with obstructive hypertrophic cardiomyopathy","volume":"46","author":"Ommen","year":"2005","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2020.04.045_bib4","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1161\/01.CIR.0000162460.36735.71","article-title":"Clinical and echocardiographic determinants of long-term survival after surgical myectomy in obstructive hypertrophic cardiomyopathy","volume":"111","author":"Woo","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2020.04.045_bib5","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.athoracsur.2019.03.026","article-title":"Survival after myectomy for obstructive hypertrophic cardiomyopathy: what causes late mortality?","volume":"108","author":"Nguyen","year":"2019","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jacc.2020.04.045_bib6","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1161\/CIRCHEARTFAILURE.112.969626","article-title":"Outcome and complications after implantable cardioverter defibrillator therapy in hypertrophic cardiomyopathy: systematic review and meta-analysis","volume":"5","author":"Schinkel","year":"2012","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jacc.2020.04.045_bib7","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1001\/jamacardio.2019.1391","article-title":"Enhanced American College of Cardiology\/American Heart Association strategy for prevention of sudden cardiac death in high-risk patients with hypertrophic cardiomyopathy","volume":"4","author":"Maron","year":"2019","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jacc.2020.04.045_bib8","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1161\/CIRCULATIONAHA.105.583500","article-title":"Prevalence, clinical profile, and significance of left ventricular remodeling in the end-stage phase of hypertrophic cardiomyopathy","volume":"114","author":"Harris","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2020.04.045_bib9","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1136\/hrt.2003.031161","article-title":"Prevalence and clinical significance of systolic impairment in hypertrophic cardiomyopathy","volume":"91","author":"Thaman","year":"2005","journal-title":"Heart"},{"key":"10.1016\/j.jacc.2020.04.045_bib10","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.amjcard.2006.05.063","article-title":"Prevalence of systolic impairment in an unselected regional population with hypertrophic cardiomyopathy","volume":"98","author":"Efthimiadis","year":"2006","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2020.04.045_bib11","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1161\/CIRCHEARTFAILURE.114.001843","article-title":"Clinical spectrum, therapeutic options, and outcome of advanced heart failure in hypertrophic cardiomyopathy","volume":"8","author":"Pasqualucci","year":"2015","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jacc.2020.04.045_bib12","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.cardfail.2011.01.015","article-title":"Risk of sudden death in end-stage hypertrophic cardiomyopathy","volume":"17","author":"Kawarai","year":"2011","journal-title":"J\u00a0Cardiac Fail"},{"key":"10.1016\/j.jacc.2020.04.045_bib13","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/j.jacc.2005.04.062","article-title":"Dilated-hypokinetic evolution of hypertrophic cardiomyopathy: prevalence, incidence, risk factors, and prognostic implications in pediatric and adult patients","volume":"46","author":"Biagini","year":"2005","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2020.04.045_bib14","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1136\/heartjnl-2016-310138","article-title":"Relationship between aetiology and left ventricular systolic dysfunction in hypertrophic cardiomyopathy","volume":"103","author":"Rosmini","year":"2017","journal-title":"Heart"},{"key":"10.1016\/j.jacc.2020.04.045_bib15","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S1053-2498(03)00225-0","article-title":"Cardiac transplantation for hypertrophic cardiomyopathy: a valid therapeutic option","volume":"23","author":"Coutu","year":"2004","journal-title":"J\u00a0Heart Lung Transplant"},{"key":"10.1016\/j.jacc.2020.04.045_bib16","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.amjcard.2007.09.085","article-title":"Heart transplantation in hypertrophic cardiomyopathy","volume":"101","author":"Biagini","year":"2008","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2020.04.045_bib17","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1093\/eurheartj\/ehq136","article-title":"Clinicopathological profiles of progressive heart failure in hypertrophic cardiomyopathy","volume":"31","author":"Melacini","year":"2010","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2020.04.045_bib18","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.amjcard.2010.03.020","article-title":"Spectrum and clinical significance of systolic function and myocardial fibrosis assessed by cardiovascular magnetic resonance in hypertrophic cardiomyopathy","volume":"106","author":"Olivotto","year":"2010","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2020.04.045_bib19","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.amjcard.2017.12.044","article-title":"Impact of advanced therapies for improving survival to heart transplant in patients with hypertrophic cardiomyopathy","volume":"121","author":"Rowin","year":"2018","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2020.04.045_bib20","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1161\/CIRCHEARTFAILURE.109.922872","article-title":"Survival after cardiac transplantation in patients with hypertrophic cardiomyopathy","volume":"3","author":"Maron","year":"2010","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jacc.2020.04.045_bib21","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1161\/CIRCHEARTFAILURE.110.959288","article-title":"Left ventricular assist device therapy in patients with restrictive and hypertrophic cardiomyopathy","volume":"4","author":"Topilsky","year":"2011","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jacc.2020.04.045_bib22","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.117.004665","article-title":"Mechanical circulatory support device utilization and heart transplant waitlist outcomes in patients with restrictive and hypertrophic cardiomyopathy","volume":"11","author":"Sridharan","year":"2018","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jacc.2020.04.045_bib23","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.jacc.2017.11.040","article-title":"Cardiac resynchronization therapy for end-stage hypertrophic cardiomyopathy: the need for disease-specific criteria","volume":"71","author":"Cappelli","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2020.04.045_bib24","first-page":"131","article-title":"Benefit of cardiac resynchronization therapy in end-stage nonobstructive hypertrophic cardiomyopathy","volume":"5","author":"Rowin","year":"2019","journal-title":"J\u00a0Am Coll Cardiol EP"},{"key":"10.1016\/j.jacc.2020.04.045_bib25","first-page":"353","article-title":"Clinical spectrum and management of heart failure in hypertrophic cardiomyopathy","volume":"6","author":"Maron","year":"2018","journal-title":"J\u00a0Am Coll Cardiol HF"},{"key":"10.1016\/j.jacc.2020.04.045_bib26","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1093\/eurheartj\/ehu284","article-title":"2014 ESC guidelines on diagnosis and management of hypertrophic cardiomyopathy","volume":"35","author":"Elliott","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2020.04.045_bib27","doi-asserted-by":"crossref","first-page":"e212","DOI":"10.1016\/j.jacc.2011.06.011","article-title":"2011 ACCF\/AHA guideline for the diagnosis and treatment of hypertrophic cardiomyopathy","volume":"58","author":"Gersh","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2020.04.045_bib28","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1161\/CIRCHEARTFAILURE.114.001435","article-title":"Advanced heart failure with preserved systolic function in nonobstructive hypertrophic cardiomyopathy: under-recognized subset of candidates for heart transplant","volume":"7","author":"Rowin","year":"2014","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jacc.2020.04.045_bib29","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1161\/CIRCULATIONAHA.113.007094","article-title":"Prognostic value of quantitative contrast-enhanced cardiovascular magnetic resonance for the evaluation of sudden death risk in patients with hypertrophic cardiomyopathy","volume":"130","author":"Chan","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2020.04.045_bib30","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.amjcard.2011.03.083","article-title":"Comparison of prevalence, clinical course, and pathological findings of left ventricular systolic impairment versus normal systolic function in patients with hypertrophic cardiomyopathy","volume":"108","author":"Fernandez","year":"2011","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2020.04.045_bib31","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.116.003090","article-title":"Histological and histometric characterization of myocardial fibrosis in end-stage hypertrophic cardiomyopathy: a clinical-pathological study of 30 explanted hearts","volume":"9","author":"Galati","year":"2016","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jacc.2020.04.045_bib32","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1016\/j.amjcard.2018.08.041","article-title":"Long-term left ventricular remodeling of patients with hypertrophic cardiomyopathy","volume":"122","author":"Musumeci","year":"2018","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2020.04.045_bib33","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.amjcard.2015.11.013","article-title":"What do patients with hypertrophic cardiomyopathy die from?","volume":"117","author":"Maron","year":"2016","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2020.04.045_bib34","article-title":"Determining hypertrophic cardiomyopathy mortality: gaining wisdom from knowledge","author":"Rakowski","year":"2019","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jacc.2020.04.045_bib35","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1016\/j.jacc.2017.08.074","article-title":"Heart failure with preserved, borderline, and reduced ejection fraction: 5-year outcomes","volume":"70","author":"Shah","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2020.04.045_bib36","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1093\/eurheartj\/ehw128","article-title":"2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"37","author":"Ponikowski","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2020.04.045_bib37","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.jacc.2017.04.025","article-title":"2017 ACC\/AHA\/HFSA focused update of the 2013 ACCF\/AHA guideline for the management of heart failure","volume":"70","author":"Yancy","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2020.04.045_bib38","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s10554-017-1263-3","article-title":"CMR assessment and clinical outcomes of hypertrophic cardiomyopathy with or without ventricular remodeling in the end-stage phase","volume":"34","author":"Cheng","year":"2018","journal-title":"Int J Cardiovasc Imaging"},{"key":"10.1016\/j.jacc.2020.04.045_bib39","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1161\/hc4601.097997","article-title":"Impact of atrial fibrillation on the clinical course of hypertrophic cardiomyopathy","volume":"104","author":"Olivotto","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2020.04.045_bib40","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1161\/CIRCULATIONAHA.117.029267","article-title":"Clinical profile and consequences of atrial fibrillation in hypertrophic cardiomyopathy","volume":"136","author":"Rowin","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2020.04.045_bib41","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.cardfail.2019.05.012","article-title":"Chronic heart failure is infrequently associated with renal dysfunction in hypertrophic cardiomyopathy","volume":"25","author":"Rowin","year":"2019","journal-title":"J\u00a0Cardiac Fail"},{"key":"10.1016\/j.jacc.2020.04.045_bib42","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1093\/europace\/euw327","article-title":"Cardiac resynchronization therapy in patients with end-stage hypertrophic cardiomyopathy","volume":"20","author":"Killu","year":"2018","journal-title":"Europace"},{"key":"10.1016\/j.jacc.2020.04.045_bib43","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1093\/eurjhf\/hfr110","article-title":"Genetic basis of end-stage hypertrophic cardiomyopathy","volume":"13","author":"Garcia-Pavia","year":"2011","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jacc.2020.04.045_bib44","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.amjcard.2014.05.065","article-title":"Significance of sarcomere gene mutations analysis in the end-stage phase of hypertrophic cardiomyopathy","volume":"114","author":"Biagini","year":"2014","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2020.04.045_bib45","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1161\/CIRCULATIONAHA.117.033200","article-title":"Genotype and lifetime burden of disease in hypertrophic cardiomyopathy: insights from the sarcomeric human cardiomyopathy registry (SHaRe)","volume":"138","author":"Ho","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2020.04.045_bib46","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ijcard.2018.12.012","article-title":"Genetic characterization and genotype-phenotype associations in a large cohort of patients with hypertrophic cardiomyopathy\u2014an ancillary study of the Portuguese registry of hypertrophic cardiomyopathy","volume":"278","author":"Lopes","year":"2019","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacc.2020.04.045_bib47","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/clc.22082","article-title":"Impact of systolic dysfunction in genotyped hypertrophic cardiomyopathy","volume":"36","author":"Fujino","year":"2013","journal-title":"Clin Cardiol"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109720350920?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109720350920?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:33:38Z","timestamp":1760016818000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109720350920"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":47,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["S0735109720350920"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2020.04.045","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Outcomes in Patients With Hypertrophic Cardiomyopathy and Left Ventricular Systolic Dysfunction","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2020.04.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}