{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:54:45Z","timestamp":1790841285562,"version":"4.1.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T00:00:00Z","timestamp":1626825600000},"content-version":"vor","delay-in-days":385,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.jacc.2020.05.051","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T16:25:27Z","timestamp":1594657527000},"page":"233-246","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["Concomitant Mitral Regurgitation in Patients With Chronic Aortic\u00a0Regurgitation"],"prefix":"10.1016","volume":"76","author":[{"given":"Li-Tan","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice","family":"Enriquez-Sarano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratnasari","family":"Padang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph F.","family":"Maalouf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia A.","family":"Pellikka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector I.","family":"Michelena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2020.05.051_bib1","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0140-6736(06)69208-8","article-title":"Burden of valvular heart diseases: a population-based study","volume":"368","author":"Nkomo","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2020.05.051_bib2","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.jacc.2019.04.065","article-title":"Staging cardiac damage in patients with asymptomatic aortic valve stenosis","volume":"74","author":"Tastet","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2020.05.051_bib3","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.jacc.2019.05.048","article-title":"Staging cardiac damage in patients with symptomatic aortic valve stenosis","volume":"74","author":"Vollema","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2020.05.051_bib4","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/j.jacc.2019.01.024","article-title":"Outcomes in chronic hemodynamically significant aortic regurgitation and limitations of current guidelines","volume":"73","author":"Yang","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2020.05.051_bib5","series-title":"Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine","author":"Lindman","year":"2019"},{"key":"10.1016\/j.jacc.2020.05.051_bib6","series-title":"ESC Textbook of Cardiovascular Medicine","author":"Tornos","year":"2019"},{"key":"10.1016\/j.jacc.2020.05.051_bib7","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1016\/j.jacc.2016.08.045","article-title":"Long-term outcomes in patients with aortic regurgitation and preserved left ventricular ejection fraction","volume":"68","author":"Mentias","year":"2016","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2020.05.051_bib8","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1161\/CIRCULATIONAHA.109.927921","article-title":"Prognostic implications of mitral regurgitation in patients with severe aortic regurgitation","volume":"122","author":"Pai","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2020.05.051_bib9","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1136\/heartjnl-2017-311552","article-title":"Mitral regurgitation in patients with severe aortic stenosis: diagnosis and management","volume":"104","author":"Sannino","year":"2018","journal-title":"Heart"},{"key":"10.1016\/j.jacc.2020.05.051_bib10","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jacc.2019.10.047","article-title":"Diastolic blood pressure and heart rate are independently associated with mortality in chronic aortic regurgitation","volume":"75","author":"Yang","year":"2020","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2020.05.051_bib11","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.echo.2005.10.005","volume":"18","author":"Lang","year":"2005","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.jacc.2020.05.051_bib12","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.echo.2017.01.007","article-title":"Recommendations for noninvasive evaluation of native valvular regurgitation: a report from the American Society of Echocardiography Developed in Collaboration with the Society for Cardiovascular Magnetic Resonance","volume":"30","author":"Zoghbi","year":"2017","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.jacc.2020.05.051_bib13","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0022-5223(19)39144-5","article-title":"Cardiac valve surgery\u2014the \u201cFrench correction\u201d","volume":"86","author":"Carpentier","year":"1983","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jacc.2020.05.051_bib14","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1093\/eurheartj\/ehz314","article-title":"Causes and mechanisms of isolated mitral regurgitation in the community: clinical context and outcome","volume":"40","author":"Dziadzko","year":"2019","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2020.05.051_bib15","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/j.mayocp.2018.11.034","article-title":"Contemporary etiologies, mechanisms, and surgical approaches in pure native aortic regurgitation","volume":"94","author":"Yang","year":"2019","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.jacc.2020.05.051_bib16","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1016\/j.jacc.2014.02.573","article-title":"Significant mitral regurgitation left untreated at the time of aortic valve replacement: a comprehensive review of a frequent entity in the transcatheter aortic valve replacement era","volume":"63","author":"Nombela-Franco","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2020.05.051_bib17","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1016\/j.jacc.2013.01.064","article-title":"Mitral valve enlargement in chronic aortic regurgitation as a compensatory mechanism to prevent functional mitral regurgitation in the dilated left ventricle","volume":"61","author":"Beaudoin","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2020.05.051_bib18","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1001\/jama.2013.8643","article-title":"Association between early surgical intervention vs watchful waiting and outcomes for mitral regurgitation due to flail mitral valve leaflets","volume":"310","author":"Suri","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.jacc.2020.05.051_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM199907013410101","article-title":"Prevalence and clinical outcome of mitral-valve prolapse","volume":"341","author":"Freed","year":"1999","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2020.05.051_bib20","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.jacc.2019.11.039","article-title":"Attenuated mitral leaflet enlargement contributes to functional mitral regurgitation after myocardial infarction","volume":"75","author":"Marsit","year":"2020","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2020.05.051_bib21","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1056\/NEJMoa1806640","article-title":"Transcatheter mitral-valve repair in patients with heart failure","volume":"379","author":"Stone","year":"2018","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2020.05.051_bib22","doi-asserted-by":"crossref","first-page":"e57","DOI":"10.1016\/j.jacc.2014.02.536","article-title":"2014 AHA\/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines","volume":"63","author":"Nishimura","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2020.05.051_bib23","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/S0735-1097(99)00250-8","article-title":"Cause of death in clinical research: time for a reassessment?","volume":"34","author":"Lauer","year":"1999","journal-title":"J\u00a0Am Coll Cardiol"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109720354255?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109720354255?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:34:16Z","timestamp":1760016856000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109720354255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["S0735109720354255"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2020.05.051","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.738319930.793577182","asserted-by":"object"}]},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Concomitant Mitral Regurgitation in Patients With Chronic Aortic\u00a0Regurgitation","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2020.05.051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}