{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T11:13:03Z","timestamp":1787829183774,"version":"build-2784847793"},"reference-count":53,"publisher":"Elsevier BV","issue":"18","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T00:00:00Z","timestamp":1652227200000},"content-version":"vor","delay-in-days":375,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016534","name":"Luitpold Pharmaceuticals","doi-asserted-by":"publisher","award":["5K23HL146887-02"],"award-info":[{"award-number":["5K23HL146887-02"]}],"id":[{"id":"10.13039\/100016534","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016619","name":"MyoKardia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5K23HL146887-02"],"award-info":[{"award-number":["5K23HL146887-02"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR001417"],"award-info":[{"award-number":["UL1TR001417"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.jacc.2021.03.291","type":"journal-article","created":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T16:03:32Z","timestamp":1620057812000},"page":"2291-2303","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Chronobiology of Natriuretic Peptides\u00a0and Blood Pressure in Lean\u00a0and\u00a0Obese Individuals"],"prefix":"10.1016","volume":"77","author":[{"given":"Vibhu","family":"Parcha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirav","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orlando M.","family":"Gutierrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L.","family":"Gamble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran","family":"Musunuru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth B.","family":"Margulies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas P.","family":"Cappola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garima","family":"Arora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Arora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2021.03.291_bib1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1152\/physiolgenomics.2000.3.1.45","article-title":"ANP in regulation of arterial pressure and fluid-electrolyte balance: lessons from genetic mouse models","volume":"3","author":"Melo","year":"2000","journal-title":"Physiol Genomics"},{"key":"10.1016\/j.jacc.2021.03.291_bib2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0024-3205(81)90370-2","article-title":"A\u00a0rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats","volume":"28","author":"de Bold","year":"1981","journal-title":"Life Sciences"},{"key":"10.1016\/j.jacc.2021.03.291_bib3","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/332078a0","article-title":"A\u00a0new natriuretic peptide in porcine brain","volume":"332","author":"Sudoh","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.jacc.2021.03.291_bib4","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1056\/NEJM199807303390507","article-title":"Natriuretic peptides","volume":"339","author":"Levin","year":"1998","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2021.03.291_bib5","first-page":"428","article-title":"Circadian rhythms of atrial natriuretic peptide, blood pressure and heart rate in normal subjects","volume":"76","author":"Portaluppi","year":"1989","journal-title":"Cardiology"},{"key":"10.1016\/j.jacc.2021.03.291_bib6","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/00004872-199001000-00013","article-title":"Circadian rhythms of atrial natriuretic peptide, renin, aldosterone, cortisol, blood pressure and heart rate in normal and hypertensive subjects","volume":"8","author":"Portaluppi","year":"1990","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.jacc.2021.03.291_bib7","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1373\/clinchem.2011.178921","article-title":"Diurnal plasma concentrations of natriuretic propeptides in healthy young males","volume":"58","author":"Goetze","year":"2012","journal-title":"Clin Chem"},{"key":"10.1016\/j.jacc.2021.03.291_bib8","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1002\/ehf2.12673","article-title":"Prognostic biomarker soluble ST2 exhibits diurnal variation in chronic heart failure patients","volume":"7","author":"Crnko","year":"2020","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.jacc.2021.03.291_bib9","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.regpep.2009.12.010","article-title":"Chamber-dependent circadian expression of cardiac natriuretic peptides","volume":"160","author":"Goetze","year":"2010","journal-title":"Regul Pept"},{"key":"10.1016\/j.jacc.2021.03.291_bib10","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1161\/01.CIR.0000112582.16683.EA","article-title":"Impact of obesity on plasma natriuretic peptide levels","volume":"109","author":"Wang","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2021.03.291_bib11","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1161\/CIRCULATIONAHA.105.555573","article-title":"Impact of body mass and body composition on circulating levels of natriuretic peptides: results from the Dallas Heart Study","volume":"112","author":"Das","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2021.03.291_bib12","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.ahj.2004.07.010","article-title":"Effect of body mass index on natriuretic peptide levels in patients with acute congestive heart failure: a ProBNP Investigation of Dyspnea in the Emergency Department (PRIDE) substudy","volume":"149","author":"Krauser","year":"2005","journal-title":"Am Heart J"},{"key":"10.1016\/j.jacc.2021.03.291_bib13","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.1172\/JCI67383","article-title":"Atrial natriuretic peptide is negatively regulated by microRNA-425","volume":"123","author":"Arora","year":"2013","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jacc.2021.03.291_bib14","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1161\/CIRCRESAHA.119.315026","article-title":"Race, natriuretic peptides, and high-carbohydrate challenge: a clinical trial","volume":"125","author":"Patel","year":"2019","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2021.03.291_bib15","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/ng.328","article-title":"Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure","volume":"41","author":"Newton-Cheh","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.jacc.2021.03.291_bib16","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/ng.361","article-title":"Genome-wide association study identifies eight loci associated with blood pressure","volume":"41","author":"Newton-Cheh","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.jacc.2021.03.291_bib17","article-title":"Increased awareness, inadequate treatment, and poor control of cardiovascular risk factors in American young adults: 2005\u20132016","author":"Kalra","year":"2020","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.jacc.2021.03.291_bib18","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/j.amjmed.2019.06.004","article-title":"Ideal cardiovascular health among American adults after the economic recession of 2008\u20132009: insights from NHANES","volume":"132","author":"Patel","year":"2019","journal-title":"Am J Med"},{"key":"10.1016\/j.jacc.2021.03.291_bib19","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1001\/jama.2018.3060","article-title":"Trends in obesity and severe obesity prevalence in us youth and adults by sex and age, 2007\u20132008 to 2015\u20132016","volume":"319","author":"Hales","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.jacc.2021.03.291_bib20","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/j.mayocp.2020.01.041","article-title":"Prevalence, awareness, treatment, and poor control of hypertension among young American adults: race-stratified analysis of the National Health and Nutrition Examination Survey","volume":"95","author":"Parcha","year":"2020","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.jacc.2021.03.291_bib21","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1161\/01.HYP.0000158261.86674.8e","article-title":"Impact of obesity on 24-hour ambulatory blood pressure and hypertension","volume":"45","author":"Kotsis","year":"2005","journal-title":"Hypertension"},{"key":"10.1016\/j.jacc.2021.03.291_bib22","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1161\/HYPERTENSIONAHA.107.100727","article-title":"Daytime and nighttime blood pressure as predictors of death and cause-specific cardiovascular events in hypertension","volume":"51","author":"Fagard","year":"2008","journal-title":"Hypertension"},{"key":"10.1016\/j.jacc.2021.03.291_bib23","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/S0140-6736(07)61538-4","article-title":"Prognostic accuracy of day versus night ambulatory blood pressure: a cohort study","volume":"370","author":"Boggia","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2021.03.291_bib24","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1161\/HYPERTENSIONAHA.115.06981","article-title":"Prognostic effect of the nocturnal blood pressure fall in hypertensive patients: the Ambulatory Blood Pressure Collaboration in Patients With Hypertension (ABC-H) meta-analysis","volume":"67","author":"Salles","year":"2016","journal-title":"Hypertension"},{"key":"10.1016\/j.jacc.2021.03.291_bib25","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.3109\/07420528.2010.510230","article-title":"Influence of circadian time of hypertension treatment on cardiovascular risk: results of the MAPEC study","volume":"27","author":"Hermida","year":"2010","journal-title":"Chronobiol Int"},{"key":"10.1016\/j.jacc.2021.03.291_bib26","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1161\/HYPERTENSIONAHA.118.10971","article-title":"Nocturnal hypertension: new technology and evidence","volume":"71","author":"Kario","year":"2018","journal-title":"Hypertension"},{"key":"10.1016\/j.jacc.2021.03.291_bib27","article-title":"Nocturnal blood pressure dipping in treated hypertensives: insights from the SPRINT trial","author":"Parcha","year":"2020","journal-title":"Eur Jor Prev Cardiol"},{"key":"10.1016\/j.jacc.2021.03.291_bib28","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1378\/chest.15-0903","article-title":"STOP-Bang questionnaire: a practical approach to screen for obstructive sleep apnea","volume":"149","author":"Chung","year":"2016","journal-title":"Chest"},{"key":"10.1016\/j.jacc.2021.03.291_bib29","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/MBP.0000000000000424","article-title":"Validation of the Spacelabs 90227 OnTrak device according to the European and British Hypertension Societies as well as the American protocols","volume":"25","author":"de Greeff","year":"2020","journal-title":"Blood Press Monit"},{"key":"10.1016\/j.jacc.2021.03.291_bib30","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1161\/01.HYP.0000150859.47929.8e","volume":"45","author":"Pickering","year":"2005","journal-title":"Hypertension"},{"key":"10.1016\/j.jacc.2021.03.291_bib31","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1136\/bmj.320.7242.1128","article-title":"Use and interpretation of ambulatory blood pressure monitoring: recommendations of the British hypertension society","volume":"320","author":"O'Brien","year":"2000","journal-title":"BMJ"},{"key":"10.1016\/j.jacc.2021.03.291_bib32","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1097\/00004872-200305000-00001","article-title":"European Society of Hypertension recommendations for conventional, ambulatory and home blood pressure measurement","volume":"21","author":"O'Brien","year":"2003","journal-title":"J\u00a0Hyperten"},{"key":"10.1016\/j.jacc.2021.03.291_bib33","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1056\/NEJMra060433","article-title":"Ambulatory blood-pressure monitoring","volume":"354","author":"Pickering","year":"2006","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2021.03.291_bib34","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1001\/jama.2009.943","article-title":"Novel and conventional biomarkers for prediction of incident cardiovascular events in the community","volume":"302","author":"Melander","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.jacc.2021.03.291_bib35","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.jacc.2015.11.049","article-title":"Acute metabolic influences on the natriuretic peptide system in humans","volume":"67","author":"Arora","year":"2016","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.03.291_bib36","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1742-4682-11-16","article-title":"Cosinor-based rhythmometry","volume":"11","author":"Cornelissen","year":"2014","journal-title":"Theor Biol Med Model"},{"key":"10.1016\/j.jacc.2021.03.291_bib37","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1080\/09291010600903692","article-title":"Procedures for numerical analysis of circadian rhythms","volume":"38","author":"Refinetti","year":"2007","journal-title":"Biol Rhythm Res"},{"key":"10.1016\/j.jacc.2021.03.291_bib38","first-page":"397","article-title":"Inferential statistical methods for estimating and comparing cosinor parameters","volume":"9","author":"Bingham","year":"1982","journal-title":"Chronobiologia"},{"key":"10.1016\/j.jacc.2021.03.291_bib39","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/S0002-9149(03)00741-0","article-title":"Biological variation for N-terminal pro- and B-type natriuretic peptides and implications for therapeutic monitoring of patients with congestive heart failure","volume":"92","author":"Wu","year":"2003","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2021.03.291_bib40","doi-asserted-by":"crossref","first-page":"e1054","DOI":"10.1161\/CIR.0000000000000490","article-title":"Role of biomarkers for the prevention, assessment, and management of heart failure: a scientific statement from the American Heart Association","volume":"135","author":"Chow","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2021.03.291_bib41","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1161\/CIRCULATIONAHA.120.046374","article-title":"Racial differences in serial NT-proBNP levels in heart failure management: insights from the GUIDE-IT trial","volume":"142","author":"Parcha","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2021.03.291_bib42","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.jacc.2019.06.055","article-title":"Natriuretic peptide response and outcomes in chronic heart failure with reduced ejection fraction","volume":"74","author":"Januzzi","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.03.291_bib43","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ijcard.2019.02.034","article-title":"Race-based demographic, anthropometric and clinical correlates of N-terminal-pro B-type natriuretic peptide","volume":"286","author":"Patel","year":"2019","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacc.2021.03.291_bib44","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1002\/oby.21418","article-title":"Adipose tissue natriuretic peptide receptor expression is related to insulin sensitivity in obesity and diabetes","volume":"24","author":"Kovacova","year":"2016","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.jacc.2021.03.291_bib45","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aam6870","article-title":"Enhancing natriuretic peptide signaling in adipose tissue, but not in muscle, protects against diet-induced obesity and insulin resistance","volume":"10","author":"Wu","year":"2017","journal-title":"Sci Signal"},{"key":"10.1016\/j.jacc.2021.03.291_bib46","doi-asserted-by":"crossref","first-page":"611","DOI":"10.21037\/atm.2019.10.59","article-title":"Glycosylation of natriuretic peptides in obese heart failure: mechanistic insights","volume":"7","author":"Parcha","year":"2019","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.jacc.2021.03.291_bib47","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1056\/NEJMoa1409077","article-title":"Angiotensin\u2013neprilysin inhibition versus enalapril in heart failure","volume":"371","author":"McMurray","year":"2014","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2021.03.291_bib48","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/S0140-6736(09)61966-8","article-title":"Blood-pressure reduction with LCZ696, a novel dual-acting inhibitor of the angiotensin II receptor and neprilysin: a randomised, double-blind, placebo-controlled, active comparator study","volume":"375","author":"Ruilope","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2021.03.291_bib49","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1001\/jamacardio.2016.5804","article-title":"Association of body mass index with cardiometabolic disease in the UK Biobank: a Mendelian randomization study","volume":"2","author":"Lyall","year":"2017","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jacc.2021.03.291_bib50","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/S0140-6736(09)60318-4","article-title":"Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies","volume":"373","author":"Whitlock","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2021.03.291_bib51","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/ijo.2008.11","article-title":"Accuracy of body mass index in diagnosing obesity in the adult general population","volume":"32","author":"Romero-Corral","year":"2008","journal-title":"Int J Obesity"},{"key":"10.1016\/j.jacc.2021.03.291_bib52","first-page":"189","article-title":"Analytical issues with natriuretic peptides - has this been overly simplified?","volume":"27","author":"Semenov","year":"2016","journal-title":"EJIFCC"},{"key":"10.1016\/j.jacc.2021.03.291_bib53","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1373\/clinchem.2003.021204","article-title":"Immunoluminometric assay for the midregion of pro-atrial natriuretic peptide in human plasma","volume":"50","author":"Morgenthaler","year":"2004","journal-title":"Clin Chem"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109721010032?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109721010032?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T18:15:12Z","timestamp":1777572912000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109721010032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":53,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["S0735109721010032"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2021.03.291","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronobiology of Natriuretic Peptides\u00a0and Blood Pressure in Lean\u00a0and\u00a0Obese Individuals","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2021.03.291","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}