{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:00:26Z","timestamp":1791828026405,"version":"4.3.4"},"reference-count":38,"publisher":"Elsevier BV","issue":"21","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.jacc.2021.03.320","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T13:59:20Z","timestamp":1621864760000},"page":"2625-2634","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":75,"title":["Effects of Diet and Sodium Reduction on Cardiac Injury, Strain, and Inflammation"],"prefix":"10.1016","volume":"77","author":[{"given":"Stephen P.","family":"Juraschek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara C.","family":"Kovell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence J.","family":"Appel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Edgar R.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank M.","family":"Sacks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex R.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Christenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Rebuck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth J.","family":"Mukamal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2021.03.320_bib1","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1161\/CIR.0000000000000558","article-title":"Heart disease and stroke statistics\u20142018 update: a report from the American Heart Association","volume":"137","author":"Benjamin","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2021.03.320_bib2","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1001\/jama.2020.14545","article-title":"Trends in blood pressure control among US adults with hypertension, 1999-2000 to 2017-2018","volume":"324","author":"Muntner","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.jacc.2021.03.320_bib3","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1001\/jama.2016.7491","article-title":"Dietary intake among US adults, 1999-2012","volume":"315","author":"Rehm","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.jacc.2021.03.320_bib4","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1093\/ajh\/hpaa104","article-title":"Dietary sodium intake and sodium density in the United States: estimates from NHANES 2005-2006 and 2015-2016","volume":"33","author":"Hu","year":"2020","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.jacc.2021.03.320_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002661","article-title":"Cost-effectiveness of financial incentives and disincentives for improving food purchases and health through the US Supplemental Nutrition Assistance Program (SNAP): a microsimulation study","volume":"15","author":"Mozaffarian","year":"2018","journal-title":"PLOS Medicine"},{"key":"10.1016\/j.jacc.2021.03.320_bib6","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1503\/cmaj.141011","article-title":"Controversial sodium guidelines: scientific solution or perpetual debate?","volume":"187","author":"MacLeod","year":"2015","journal-title":"CMAJ"},{"key":"10.1016\/j.jacc.2021.03.320_bib7","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/ajh.2012.52","article-title":"Dietary sodium intake and cardiovascular mortality: controversy resolved?","volume":"25","author":"Alderman","year":"2012","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.jacc.2021.03.320_bib8","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1056\/NEJMc1612304","article-title":"Dietary sodium and cardiovascular disease risk","volume":"375","author":"O\u2019Donnell","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2021.03.320_bib9","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.1056\/NEJMoa1800389","article-title":"Primary prevention of cardiovascular disease with a mediterranean diet supplemented with extra-virgin olive oil or nuts","volume":"378","author":"Estruch","year":"2018","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2021.03.320_bib10","doi-asserted-by":"crossref","first-page":"786","DOI":"10.7326\/M20-0336","article-title":"Associations between dietary patterns and subclinical cardiac injury: an observational analysis from the DASH trial","volume":"172","author":"Juraschek","year":"2020","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jacc.2021.03.320_bib11","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.ijcard.2019.07.102","article-title":"Healthy diet reduces markers of cardiac injury and inflammation regardless of macronutrients: results from the OmniHeart trial","volume":"299","author":"Kovell","year":"2020","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacc.2021.03.320_bib12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1056\/NEJM200101043440101","article-title":"Effects on Blood Pressure of Reduced Dietary Sodium and the Dietary Approaches to Stop Hypertension (DASH) Diet","volume":"344","author":"Sacks","year":"2001","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2021.03.320_bib13","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1056\/NEJM199704173361601","article-title":"A\u00a0clinical trial of the effects of dietary patterns on blood pressure","volume":"336","author":"Appel","year":"1997","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2021.03.320_bib14","doi-asserted-by":"crossref","first-page":"S96","DOI":"10.1016\/S0002-8223(99)00423-X","article-title":"The DASH Diet, Sodium Intake and Blood Pressure Trial (DASH-sodium): rationale and design","volume":"99","author":"Svetkey","year":"1999","journal-title":"J\u00a0Am Diet Assoc"},{"key":"10.1016\/j.jacc.2021.03.320_bib15","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1161\/CIRCULATIONAHA.118.038772","article-title":"High-sensitivity troponin I and incident coronary events, stroke, heart failure hospitalization, and mortality in the ARIC Study","volume":"139","author":"Jia","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2021.03.320_bib16","article-title":"High-sensitivity troponin I levels and coronary artery disease severity, progression, and long-term outcomes","volume":"7","author":"Samman Tahhan","year":"2018","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jacc.2021.03.320_bib17","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/j.jacc.2014.04.089","article-title":"B-type natriuretic peptides improve cardiovascular disease risk prediction in a cohort of women","volume":"64","author":"Everett","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.03.320_bib18","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1016\/j.jacc.2016.09.931","article-title":"Prognostic implications of changes in N-terminal pro-B-type natriuretic peptide in patients with heart failure","volume":"68","author":"Zile","year":"2016","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.03.320_bib19","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.ahj.2015.04.017","article-title":"Six-year change in high-sensitivity C-reactive protein and risk of diabetes, cardiovascular disease, and mortality","volume":"170","author":"Parrinello","year":"2015","journal-title":"Am Heart J"},{"key":"10.1016\/j.jacc.2021.03.320_bib20","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1093\/ajh\/hpv026","article-title":"N-terminal pro-brain natriuretic peptide (NT-proBNP) and risk of hypertension in the Atherosclerosis Risk in Communities (ARIC) Study","volume":"28","author":"Bower","year":"2015","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.jacc.2021.03.320_bib21","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.jacc.2011.10.875","article-title":"Chronic hyperglycemia and subclinical myocardial injury","volume":"59","author":"Rubin","year":"2012","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.03.320_bib22","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.cca.2018.10.012","article-title":"Evaluation of the Siemens ADVIA Centaur high-sensitivity cardiac troponin I assay in serum","volume":"487","author":"Kavsak","year":"2018","journal-title":"Clinica Chimica Acta"},{"key":"10.1016\/j.jacc.2021.03.320_bib23","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1093\/ajcn\/74.1.80","article-title":"Effects on blood lipids of a blood pressure\u2013lowering diet: the Dietary Approaches to Stop Hypertension (DASH) Trial","volume":"74","author":"Obarzanek","year":"2001","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jacc.2021.03.320_bib24","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1002\/sim.4344","article-title":"Analysis of non-ignorable missing and left-censored longitudinal data using a weighted random effects tobit model","volume":"30","author":"Sattar","year":"2011","journal-title":"Stat Med"},{"key":"10.1016\/j.jacc.2021.03.320_bib25","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1001\/archinte.168.7.713","article-title":"Adherence to a DASH-style diet and risk of coronary heart disease and stroke in women","volume":"168","author":"Fung","year":"2008","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jacc.2021.03.320_bib26","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1056\/NEJMoa1613502","article-title":"Association of changes in diet quality with total and cause-specific mortality","volume":"377","author":"Sotos-Prieto","year":"2017","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2021.03.320_bib27","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.amjhyper.2006.09.003","article-title":"Degree of concordance with DASH diet guidelines and incidence of hypertension and fatal cardiovascular disease","volume":"20","author":"Folsom","year":"2007","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.jacc.2021.03.320_bib28","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/j.2042-3306.2010.00244.x","article-title":"Plasma aldosterone concentration and cardiovascular response to low sodium intake in horses in training","author":"Jansson","year":"2010","journal-title":"Equine Vet J Suppl"},{"key":"10.1016\/j.jacc.2021.03.320_bib29","first-page":"1413","article-title":"Associations of 24-hour urinary sodium and potassium excretion with cardiac biomarkers: the Maastricht Study","volume":"150","author":"Martens","year":"2020","journal-title":"J\u00a0Nutr"},{"key":"10.1016\/j.jacc.2021.03.320_bib30","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.ahj.2014.11.013","article-title":"The long-term effects of dietary sodium restriction on clinical outcomes in patients with heart failure. The SODIUM-HF (Study of Dietary Intervention Under 100\u00a0mmol in Heart\u00a0Failure): a pilot study","volume":"169","author":"Colin-Ramirez","year":"2015","journal-title":"Am Heart J"},{"key":"10.1016\/j.jacc.2021.03.320_bib31","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1093\/eurheartj\/ehm396","article-title":"Altered sodium intake affects plasma concentrations of BNP but not proBNP in healthy individuals and patients with compensated heart failure","volume":"28","author":"Damgaard","year":"2007","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2021.03.320_bib32","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1079\/BJN20051400","article-title":"Total antioxidant capacity of the diet is inversely and independently related to plasma concentration of high-sensitivity C-reactive protein in adult Italian subjects","volume":"93","author":"Brighenti","year":"2005","journal-title":"Br J Nutr"},{"key":"10.1016\/j.jacc.2021.03.320_bib33","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.atherosclerosis.2018.06.877","article-title":"Adherence to Mediterranean diet, high-sensitive C-reactive protein, and severity of coronary artery disease: contemporary data from the INTERCATH cohort","volume":"275","author":"Waldeyer","year":"2018","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jacc.2021.03.320_bib34","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3390\/nu10030379","article-title":"Relationship of the adherence to a Mediterranean diet and its main components with CRP levels in the Spanish population","volume":"10","author":"Lahoz","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.jacc.2021.03.320_bib35","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1161\/01.CIR.0000080288.30567.86","article-title":"Inflammation modifies the effects of a reduced-fat low-cholesterol diet on lipids: results from the DASH-sodium trial","volume":"108","author":"Erlinger","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2021.03.320_bib36","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.atherosclerosis.2007.12.034","article-title":"Dietary salt restriction increases plasma lipoprotein and inflammatory marker concentrations in hypertensive patients","volume":"200","author":"Nakandakare","year":"2008","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jacc.2021.03.320_bib37","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1097\/HJH.0b013e328360ddd5","article-title":"Procalcitonin and the inflammatory response to salt in essential hypertension: a randomized cross-over clinical trial","volume":"31","author":"Mallamaci","year":"2013","journal-title":"Journal of Hypertension"},{"key":"10.1016\/j.jacc.2021.03.320_bib38","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1161\/HYPERTENSIONAHA.118.11128","article-title":"Salt intake and immunity","volume":"72","author":"Baris","year":"2018","journal-title":"Hypertension"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109721011104?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109721011104?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:42:34Z","timestamp":1760017354000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109721011104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":38,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["S0735109721011104"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2021.03.320","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of Diet and Sodium Reduction on Cardiac Injury, Strain, and Inflammation","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2021.03.320","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}