{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T08:12:22Z","timestamp":1791447142274,"version":"4.3.3"},"reference-count":14,"publisher":"Elsevier BV","issue":"22","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"vor","delay-in-days":372,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100005039","name":"Leids Universitair Medisch Centrum","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005039","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015264","name":"Claret Medical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015264","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006520","name":"Edwards Lifesciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006520","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005035","name":"Biotronik","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005035","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.jacc.2021.04.014","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T14:00:03Z","timestamp":1622469603000},"page":"2796-2803","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":121,"title":["Moderate Aortic Stenosis in Patients With\u00a0Heart\u00a0Failure and Reduced\u00a0Ejection\u00a0Fraction"],"prefix":"10.1016","volume":"77","author":[{"given":"Guillaume","family":"Jean","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas M.","family":"Van Mieghem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tea","family":"Gegenava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennart","family":"van Gils","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Bernard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel L.","family":"Geleijnse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Mara","family":"Vollema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikram","family":"El Azzouzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernest","family":"Spitzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Delgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen J.","family":"Bax","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Pibarot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Annick","family":"Clavel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2021.04.014_bib1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jcmg.2017.01.002","article-title":"Cardiac imaging for assessing low-gradient severe aortic\u00a0stenosis","volume":"10","author":"Clavel","year":"2017","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jacc.2021.04.014_bib2","doi-asserted-by":"crossref","first-page":"e57","DOI":"10.1016\/j.jacc.2014.02.536","article-title":"2014 AHA\/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines","volume":"63","author":"Nishimura","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.04.014_bib3","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1016\/j.jacc.2019.08.004","article-title":"Poor long-term survival in patients with moderate aortic stenosis","volume":"74","author":"Strange","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.04.014_bib4","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1016\/j.jacc.2017.03.023","article-title":"Prognostic implications of moderate aortic stenosis in patients with left ventricular systolic\u00a0dysfunction","volume":"69","author":"van Gils","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.04.014_bib5","doi-asserted-by":"crossref","first-page":"S234","DOI":"10.1161\/CIRCULATIONAHA.107.757427","article-title":"Predictors of outcomes in low-flow, low-gradient aortic stenosis: results of the multicenter TOPAS Study","volume":"118","author":"Clavel","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2021.04.014_bib6","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.echo.2010.02.002","article-title":"Validation of conventional and simplified methods to calculate projected valve area at normal flow rate in patients with low flow, low gradient aortic stenosis: the multicenter TOPAS (True or Pseudo Severe Aortic Stenosis) study","volume":"23","author":"Clavel","year":"2010","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.jacc.2021.04.014_bib7","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1093\/eurheartj\/ehs176","article-title":"Outcomes of pseudo-severe aortic stenosis under conservative treatment","volume":"33","author":"Foug\u00e8res","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2021.04.014_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2008.11.029","article-title":"Echocardiographic assessment of valve stenosis: EAE\/ASE recommendations for clinical practice","volume":"22","author":"Baumgartner","year":"2009","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.jacc.2021.04.014_bib9","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0894-7317(03)00335-3","article-title":"Recommendations for evaluation of the severity of native valvular regurgitation with two-dimensional and Doppler echocardiography","volume":"16","author":"Zoghbi","year":"2003","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.jacc.2021.04.014_bib10","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ahj.2016.08.009","article-title":"Rationale and design of the Transcatheter Aortic Valve Replacement to UNload the Left ventricle in patients with ADvanced heart failure (TAVR UNLOAD) trial","volume":"182","author":"Spitzer","year":"2016","journal-title":"Am Heart J"},{"key":"10.1016\/j.jacc.2021.04.014_bib11","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.jacc.2014.06.1195","article-title":"Incidence and sequelae of prosthesis-patient mismatch in transcatheter versus surgical valve replacement in high-risk patients with severe aortic stenosis--a PARTNER trial cohort A analysis","volume":"64","author":"Pibarot","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.04.014_bib12","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1016\/j.jacc.2009.01.060","article-title":"Comparison of the hemodynamic performance of percutaneous and surgical bioprostheses for the treatment of severe aortic stenosis","volume":"53","author":"Clavel","year":"2009","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.04.014_bib13","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1161\/01.CIR.0000085167.67105.32","article-title":"Impact of valve prosthesis-patient mismatch on short-term mortality after aortic valve replacement","volume":"108","author":"Blais","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2021.04.014_bib14","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.jtcvs.2005.10.028","article-title":"Prosthesis-patient mismatch after aortic valve replacement predominantly affects patients with pre-existing left ventricular dysfunction: effect on survival, freedom from heart failure, and left ventricular mass regression","volume":"131","author":"Ruel","year":"2006","journal-title":"J\u00a0Thorac Cardiovasc Surg"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109721012365?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109721012365?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:43:14Z","timestamp":1760017394000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109721012365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":14,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["S0735109721012365"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2021.04.014","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.740204605.793587065","asserted-by":"object"}]},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Moderate Aortic Stenosis in Patients With\u00a0Heart\u00a0Failure and Reduced\u00a0Ejection\u00a0Fraction","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2021.04.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}