{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T00:14:04Z","timestamp":1794269644212,"version":"4.9.0"},"reference-count":74,"publisher":"Elsevier BV","issue":"24","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T00:00:00Z","timestamp":1655856000000},"content-version":"vor","delay-in-days":386,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.jacc.2021.04.051","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T13:58:04Z","timestamp":1623679084000},"page":"3058-3078","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":107,"title":["Current Status and Future Prospects of Transcatheter Mitral Valve Replacement"],"prefix":"10.1016","volume":"77","author":[{"given":"Alberto","family":"Alperi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan F.","family":"Granada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Bernier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Dagenais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Rod\u00e9s-Cabau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2021.04.051_bib1","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0140-6736(06)69208-8","article-title":"Burden of valvular heart diseases: a population-based study","volume":"368","author":"Nkomo","year":"2006","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.jacc.2021.04.051_bib2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1136\/heartjnl-2014-307020","article-title":"The modern epidemiology of heart valve disease","volume":"102","author":"Coffey","year":"2016","journal-title":"Heart"},{"key":"10.1016\/j.jacc.2021.04.051_bib3","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1093\/eurheartj\/ehm001","article-title":"What are the characteristics of patients with severe, symptomatic, mitral regurgitation who are denied surgery?","volume":"28","author":"Mirabel","year":"2007","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2021.04.051_bib4","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1056\/NEJMoa1806640","article-title":"Transcatheter mitral-valve repair in patients with heart failure","volume":"379","author":"Stone","year":"2018","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2021.04.051_bib5","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.jacc.2017.03.011","article-title":"2017 AHA\/ACC focused update of the 2014 AHA\/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"70","author":"Nishimura","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.04.051_bib6","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1056\/NEJMoa1009355","article-title":"Percutaneous repair or surgery for mitral regurgitation","volume":"364","author":"Feldman","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2021.04.051_bib7","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/S0140-6736(16)00558-4","article-title":"Mitral valve disease - Current management and future challenges","volume":"387","author":"Nishimura","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2021.04.051_bib8","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1136\/heartjnl-2017-311412","article-title":"Outcome after percutaneous edge-to-edge mitral repair for functional and degenerative mitral regurgitation: a systematic review and meta-analysis","volume":"104","author":"Chiarito","year":"2018","journal-title":"Heart"},{"key":"10.1016\/j.jacc.2021.04.051_bib9","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1161\/CIRCULATIONAHA.112.118083","article-title":"Quantitative analysis of mitral valve morphology in mitral valve prolapse with real-time 3-dimensional echocardiography: Importance of annular saddle shape in the pathogenesis of mitral regurgitation","volume":"127","author":"Lee","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2021.04.051_bib10","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.116.005971","article-title":"Pathophysiology of degenerative mitral regurgitation: new 3-dimensional imaging insights","volume":"11","author":"Antoine","year":"2018","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.jacc.2021.04.051_bib11","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.echo.2013.06.014","article-title":"Calcification of the mitral valve and annulus: systematic evaluation of effects on valve anatomy and function","volume":"26","author":"Movva","year":"2013","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.jacc.2021.04.051_bib12","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/s41569-020-0395-7","article-title":"Mitral valve regurgitation: a disease with a wide spectrum of therapeutic options","volume":"17","author":"Del Forno","year":"2020","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jacc.2021.04.051_bib13","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1161\/ATVBAHA.107.156752","article-title":"Calcific aortic stenosis. Lessons learned from experimental and clinical studies","volume":"29","author":"Rajamannan","year":"2009","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jacc.2021.04.051_bib14","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.echo.2018.01.011","article-title":"Role of echocardiography in transcatheter mitral valve replacement in native mitral valves and mitral rings","volume":"31","author":"Mackensen","year":"2018","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.jacc.2021.04.051_bib15","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1148\/radiol.2018172758","article-title":"Mitral valve imaging with CT: Relationship with transcatheter mitral valve interventions","volume":"288","author":"Weir-McCall","year":"2018","journal-title":"Radiology"},{"key":"10.1016\/j.jacc.2021.04.051_bib16","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.4244\/EIJY15M11_10","article-title":"Quantitative multi-slice computed tomography assessment of the mitral valvular complex for transcatheter mitral valve interventions part 2: geometrical measurements in patients with functional mitral regurgitation","volume":"12","author":"Th\u00e9riault-lauzier","year":"2016","journal-title":"EuroIntervention"},{"key":"10.1016\/j.jacc.2021.04.051_bib17","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.jcmg.2014.07.028","article-title":"Mitral annular evaluation with CT in the context of transcatheter mitral valve replacement","volume":"8","author":"Blanke","year":"2015","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jacc.2021.04.051_bib18","doi-asserted-by":"crossref","first-page":"144","DOI":"10.21037\/cdt.2016.02.04","article-title":"Peri-procedural imaging for transcatheter mitral valve replacement","volume":"6","author":"Natarajan","year":"2016","journal-title":"Cardiovasc Diagn Ther"},{"key":"10.1016\/j.jacc.2021.04.051_bib19","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1016\/j.jcmg.2020.03.013","article-title":"A\u00a0cardiac computed tomography\u2013based score to categorize mitral annular calcification severity and predict valve embolization","volume":"13","author":"Guerrero","year":"2020","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jacc.2021.04.051_bib20","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.117.007508","article-title":"Mitral annulus calcium score","volume":"12","author":"Brodov","year":"2019","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.jacc.2021.04.051_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jcmg.2018.12.003","article-title":"Computed tomography imaging in the context of Transcatheter Aortic Valve Implantation (TAVI)\/Transcatheter Aortic Valve Replacement (TAVR): an expert consensus document of the Society of Cardiovascular Computed Tomography","volume":"12","author":"Blanke","year":"2019","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jacc.2021.04.051_bib22","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jcin.2018.12.001","article-title":"Predictors of left ventricular outflow tract obstruction after transcatheter mitral valve replacement","volume":"12","author":"Yoon","year":"2019","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jacc.2021.04.051_bib23","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.jcmg.2016.01.005","article-title":"Predicting LVOT obstruction in transcatheter mitral valve implantation: concept of the neo-LVOT","volume":"10","author":"Blanke","year":"2017","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jacc.2021.04.051_bib24","first-page":"379","article-title":"Validating a prediction modeling tool for left ventricular outflow tract (LVOT) obstruction after transcatheter mitral valve replacement (TMVR)","volume":"92","author":"Wang","year":"2018","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.jacc.2021.04.051_bib25","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s11936-018-0694-z","article-title":"Transcatheter mitral valve planning and the neo-LVOT: utilization of virtual simulation models and 3D Printing","volume":"20","author":"Kohli","year":"2018","journal-title":"Curr Treat Options Cardiovasc Med"},{"key":"10.1016\/j.jacc.2021.04.051_bib26","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1111\/echo.14370","article-title":"Mechanisms, pathophysiology, and diagnostic imaging of left ventricular outflow tract obstruction following mitral valve surgery and transcatheter mitral valve replacement","volume":"36","author":"Silbiger","year":"2019","journal-title":"Echocardiography"},{"key":"10.1016\/j.jacc.2021.04.051_bib27","first-page":"1","article-title":"Use of cardiac computerized tomography to predict neo-left ventricular outflow tract obstruction before transcatheter mitral valve replacement","volume":"6","author":"Murphy","year":"2017","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jacc.2021.04.051_bib28","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.jcmg.2020.09.027","article-title":"Neo-LVOT and transcatheter mitral valve replacement: expert recommendations","volume":"14","author":"Reid","year":"2021","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jacc.2021.04.051_bib29","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1016\/j.jcin.2019.06.015","article-title":"Novel multiphase assessment for predicting left ventricular outflow tract obstruction before transcatheter mitral valve replacement","volume":"12","author":"Meduri","year":"2019","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jacc.2021.04.051_bib30","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jcct.2017.04.002","article-title":"Left ventricular access point determination for a coaxial approach to the mitral annular landing zone in transcatheter mitral valve replacement","volume":"11","author":"Blanke","year":"2017","journal-title":"J\u00a0Cardiovasc Comput Tomogr"},{"key":"10.1016\/j.jacc.2021.04.051_bib31","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.jacc.2016.10.068","article-title":"Transcatheter mitral valve replacement for patients with symptomatic mitral regurgitation: a global feasibility trial","volume":"69","author":"Muller","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.04.051_bib32","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/j.jacc.2019.07.069","article-title":"Novel transcatheter mitral valve prosthesis for patients with severe mitral annular calcification","volume":"74","author":"Sorajja","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.04.051_bib33","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.jacc.2018.12.066","article-title":"Initial feasibility study of a new transcatheter mitral prosthesis: the first 100 patients","volume":"73","author":"Sorajja","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.04.051_bib34","unstructured":"Muller D. Two-year outcomes of Tendyne Transcatheter Mitral Valve Implantation (TMVI) to treat symptomatic severe mitral regurgitation. Presented at: PCR e-course 2020. June 25\u201327, 2020. Online. Available at: https:\/\/www.tctmd.com\/slide\/transapical-ii-tendyne-device-description-results-and-ongoing-studies. Accessed October 20, 2020."},{"key":"10.1016\/j.jacc.2021.04.051_bib35","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1016\/j.jcin.2020.06.009","article-title":"Left ventricular remodeling after transcatheter mitral valve replacement with tendyne: new insights from computed tomography","volume":"13","author":"Fukui","year":"2020","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jacc.2021.04.051_bib36","unstructured":"Sorajja P. Transcatheter mitral valve implantation (TMVI) in patients with severe mitral annular calcification: early results from the Tendyne MAC Study. Presented at: PCR e-course 2020. 25th-27th June 2020. Online. Available at: https:\/\/www.pcronline.com\/Cases-resources-images\/Resources\/Educational-interviews\/2020\/PCR-e-Course\/TMVI-in-patients-with-severe-mitra. Accessed October 20, 2020."},{"key":"10.1016\/j.jacc.2021.04.051_bib37","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1016\/j.jacc.2014.06.1208","article-title":"Short-term results of transapical transcatheter mitral valve implantation for mitral regurgitation","volume":"64","author":"Cheung","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.04.051_bib38","unstructured":"Conradi L. Transcatheter mitral valve implantation with tiara: transapical results and transseptal design. Presented at: PCR e-course 2020. June 25\u201327, 2020. Online. Available at: https:\/\/www.pcronline.com\/Cases-resources-images\/Resources\/Course-videos-slides\/2020\/Abstracts-on-Mitral-interventions-PCR-e-Course-2020. Accessed October 20, 2020."},{"key":"10.1016\/j.jacc.2021.04.051_bib39","unstructured":"Cheung A. Tiara: device description, results, and ongoing studies. Presented at: Transcatheter Cardiovascular Therapeutics 2019; September 25\u201329, 2019; San Francisco, CA. Available at: https:\/\/www.tctmd.com\/slide\/transapical-iii-tiara-device-description-results-and-ongoing-studies. Accessed October 20, 2020."},{"key":"10.1016\/j.jacc.2021.04.051_bib40","doi-asserted-by":"crossref","first-page":"Y78","DOI":"10.4244\/EIJV12SYA21","article-title":"Intrepid transcatheter mitral valve replacement system: technical and product description","volume":"12","author":"Meredith","year":"2016","journal-title":"EuroIntervention"},{"key":"10.1016\/j.jacc.2021.04.051_bib41","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jacc.2017.10.061","article-title":"Early experience with new transcatheter mitral valve replacement","volume":"71","author":"Bapat","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.04.051_bib42","article-title":"Early experience with transcatheter mitral valve replacement: a systematic review","volume":"8","author":"Del Val","year":"2019","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jacc.2021.04.051_bib43","unstructured":"Leon MB. The Intrepid TMVR program. Apollo trial expansion, device updates and transfemoral EFS. Presented at; Transcatheter Cardiovascular Therapeutics 2019, September 25\u201329, 2019; San Francisco, CA."},{"key":"10.1016\/j.jacc.2021.04.051_bib44","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1016\/j.jcin.2017.06.046","article-title":"Transcatheter mitral valve implantation using the HighLife System","volume":"10","author":"Barbanti","year":"2017","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jacc.2021.04.051_bib45","unstructured":"Piazza N. The HIGHLIFE program: attributes, challenges, and clinical data. Presented at: The Structural Heart Disease Summit 2018; June 19\u201323, 2018; Chicago, IL."},{"key":"10.1016\/j.jacc.2021.04.051_bib46","unstructured":"Maisano F. Cardiovalve: device attributes, implant, procedure and early results. Presented at: Transcatheter Cardiovascular Therapeutics 2019; September 21\u201325, 2018; San Diego, CA."},{"key":"10.1016\/j.jacc.2021.04.051_bib47","doi-asserted-by":"crossref","first-page":"e163","DOI":"10.1016\/j.jcin.2020.05.032","article-title":"2-year follow-up after transseptal transcatheter mitral valve replacement with the Cardiovalve","volume":"13","author":"Maisano","year":"2020","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jacc.2021.04.051_bib48","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1080\/17434440.2020.1781616","article-title":"Device profile of the AltaValve system for transcatheter mitral valve replacement: overview of its safety and efficacy","volume":"17","author":"Alperi","year":"2020","journal-title":"Expert Rev Med Devices"},{"key":"10.1016\/j.jacc.2021.04.051_bib49","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jcin.2018.10.056","article-title":"Transcatheter mitral valve replacement with a new supra-annular valve: first-in-human experience with the AltaValve System","volume":"12","author":"Nunes Ferreira-Neto","year":"2019","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jacc.2021.04.051_bib50","first-page":"761","article-title":"Transcatheter mitral valve therapy with novel supra-annular AltaValve","volume":"1","author":"Goel","year":"2019","journal-title":"J\u00a0Am Coll Cardiol Case Rep"},{"key":"10.1016\/j.jacc.2021.04.051_bib51","unstructured":"G\u00e9n\u00e9reux P. AltaValve 4C medical first-in-human transseptal experience. Presented at: Transcatheter Cardiovascular Therapeutics 2019; September 25\u201329, 2019; San Francisco, CA."},{"key":"10.1016\/j.jacc.2021.04.051_bib52","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1016\/j.jacc.2014.09.026","article-title":"Multicenter evaluation of a next-generation balloon-expandable transcatheter aortic valve","volume":"64","author":"Webb","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.04.051_bib53","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.jacc.2018.12.065","article-title":"Percutaneous transcatheter mitral valve replacement: first-in-human experience with a new transseptal system","volume":"73","author":"Webb","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.04.051_bib54","unstructured":"Webb J. Transseptal SAPIEN M3: device, results, and ongoing studies. Presented at: TVT 2019: Structural Heart Summit; June 12\u201315, 2019; Chicago, Il."},{"key":"10.1016\/j.jacc.2021.04.051_bib55","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1016\/j.jcin.2020.06.040","article-title":"Transcatheter mitral valve replacement with the transseptal EVOQUE System","volume":"13","author":"Webb","year":"2020","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jacc.2021.04.051_bib56","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1016\/j.jcin.2020.08.006","article-title":"Early experience with a novel transfemoral mitral valve implantation system in complex degenerative mitral regurgitation","volume":"13","author":"Alperi","year":"2020","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jacc.2021.04.051_bib57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/CIRCINTERVENTIONS.119.008003","article-title":"First-in-human implant of the Cephea transseptal mitral valve replacement system","volume":"12","author":"Modine","year":"2019","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.jacc.2021.04.051_bib58","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jcin.2018.10.042","article-title":"Causes and clinical outcomes of patients who are ineligible for transcatheter mitral valve replacement","volume":"12","author":"Niikura","year":"2019","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jacc.2021.04.051_bib59","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1016\/j.jacc.2015.08.881","article-title":"Predictors and impact of myocardial injury after transcatheter aortic valve replacement: a multicenter registry","volume":"66","author":"Ribeiro","year":"2015","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.04.051_bib60","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.jacc.2014.11.027","article-title":"Late cardiac death in patients undergoing transcatheter aortic valve replacement: incidence and predictors of advanced heart failure and sudden cardiac death","volume":"65","author":"Urena","year":"2015","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.04.051_bib61","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1161\/CIRCULATIONAHA.120.051989","article-title":"Closure of iatrogenic atrial septal defect after transcatheter mitral valve repair: the randomized MITHRAS trial","volume":"143","author":"Lurz","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2021.04.051_bib62","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1001\/jama.2019.7525","article-title":"Association between transcatheter aortic valve replacement and early postprocedural stroke","volume":"321","author":"Huded","year":"2019","journal-title":"JAMA"},{"key":"10.1016\/j.jacc.2021.04.051_bib63","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.4244\/EIJ-D-18-00961","article-title":"Incidence and in-hospital safety outcomes of patients undergoing percutaneous mitral valve edge-to-edge repair using MitraClip: five-year German national patient sample including 13,575 implants","volume":"14","author":"von Bardeleben","year":"2019","journal-title":"EuroIntervention"},{"key":"10.1016\/j.jacc.2021.04.051_bib64","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1093\/eurheartj\/ehv627","article-title":"One-year outcomes and predictors of mortality after MitraClip therapy in contemporary clinical practice: results from the German transcatheter mitral valve interventions registry","volume":"37","author":"Puls","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2021.04.051_bib65","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1136\/heartjnl-2019-316331","article-title":"Cerebrovascular events after transcatheter mitral valve interventions: a systematic review and meta-analysis","volume":"106","author":"Ch\u00e2teauneuf","year":"2020","journal-title":"Heart"},{"key":"10.1016\/j.jacc.2021.04.051_bib66","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.jacc.2016.05.065","article-title":"Predictors of early cerebrovascular events in patients with aortic stenosis undergoing transcatheter aortic valve replacement","volume":"68","author":"Auffret","year":"2016","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.04.051_bib67","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jcin.2015.09.039","article-title":"Cerebral protection during MitraClip implantation initial experience at 2 centers","volume":"9","author":"Frerker","year":"2016","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jacc.2021.04.051_bib68","first-page":"279","article-title":"Prevention and treatment of left ventricular outflow tract obstruction after transcatheter mitral valve replacement","volume":"8","author":"Lisko","year":"2019","journal-title":"Interv Cardiol Clin"},{"key":"10.1016\/j.jacc.2021.04.051_bib69","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.case.2019.02.005","article-title":"Transcatheter aortic valve replacement to treat left ventricular outflow tract obstruction and significant paravalvular leak following transcatheter mitral valve replacement","volume":"3","author":"Duncan","year":"2019","journal-title":"CASE (Phila)"},{"key":"10.1016\/j.jacc.2021.04.051_bib70","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.1016\/j.jcin.2016.01.010","article-title":"Bail-out alcohol septal ablation for left ventricular outflow tract obstruction after transcatheter mitral valve replacement","volume":"9","author":"Deharo","year":"2016","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jacc.2021.04.051_bib71","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1016\/j.jacc.2019.02.076","article-title":"Anterior leaflet laceration to prevent ventricular outflow tract obstruction during transcatheter mitral valve replacement","volume":"73","author":"Khan","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.04.051_bib72","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.jcin.2017.01.035","article-title":"Intentional percutaneous laceration of the anterior mitral leaflet to prevent outflow obstruction during transcatheter mitral valve replacement: first-in-human experience","volume":"10","author":"Babaliaros","year":"2017","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jacc.2021.04.051_bib73","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.jacc.2014.06.1166","article-title":"Percutaneous mitral valve edge-to-edge repair: in-hospital results and 1-year follow-up of 628 patients of the 2011\u20132012 pilot European Sentinel Registry","volume":"64","author":"Nickenig","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.04.051_bib74","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1016\/j.jcin.2020.06.047","article-title":"Electrosurgical detachment of MitraClips from the anterior mitral leaflet prior to transcatheter mitral valve implantation","volume":"13","author":"Lisko","year":"2020","journal-title":"J\u00a0Am Coll Cardiol Intv"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109721048221?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109721048221?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:43:15Z","timestamp":1760017395000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109721048221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":74,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["S0735109721048221"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2021.04.051","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.740291768.793586763","asserted-by":"object"}]},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Current Status and Future Prospects of Transcatheter Mitral Valve Replacement","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2021.04.051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}