{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T08:14:57Z","timestamp":1792052097159,"version":"4.4.0"},"reference-count":62,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T00:00:00Z","timestamp":1658275200000},"content-version":"vor","delay-in-days":384,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.jacc.2021.05.021","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T13:59:02Z","timestamp":1626098342000},"page":"278-290","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":102,"title":["Pathophysiology of the Lymphatic System in Patients With Heart\u00a0Failure"],"prefix":"10.1016","volume":"78","author":[{"given":"Maxim","family":"Itkin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley G.","family":"Rockson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Burkhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"16","key":"10.1016\/j.jacc.2021.05.021_bib1","doi-asserted-by":"crossref","first-page":"e840","DOI":"10.1161\/CIR.0000000000000664","article-title":"Cardiorenal syndrome: classification, pathophysiology, diagnosis, and treatment strategies: a scientific statement from the American Heart Association","volume":"139","author":"Rangaswami","year":"2019","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.jacc.2021.05.021_bib2","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/s41569-020-0379-7","article-title":"Congestion in heart failure: a contemporary look at physiology, diagnosis and treatment","volume":"17","author":"Boorsma","year":"2020","journal-title":"Nat Rev Cardiol"},{"issue":"5 Pt 2","key":"10.1016\/j.jacc.2021.05.021_bib3","first-page":"H706","article-title":"Some consequences of capillary permeability to macromolecules: Starling's hypothesis reconsidered","volume":"250","author":"Renkin","year":"1986","journal-title":"Am J Physiol"},{"issue":"1","key":"10.1016\/j.jacc.2021.05.021_bib4","article-title":"Gross and microscopic anatomy of the lymphatic vessels and lymphaticovenous communications","volume":"5","author":"Threefoot","year":"1968","journal-title":"Cancer Chemother Rep"},{"issue":"3","key":"10.1016\/j.jacc.2021.05.021_bib5","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1152\/physrev.1971.51.3.527","article-title":"Interstitial fluid pressure","volume":"51","author":"Guyton","year":"1971","journal-title":"Physiol Rev"},{"issue":"1","key":"10.1016\/j.jacc.2021.05.021_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.1993.73.1.1","article-title":"Interstitial-lymphatic mechanisms in the control of extracellular fluid volume","volume":"73","author":"Aukland","year":"1993","journal-title":"Physiol Rev"},{"issue":"20","key":"10.1016\/j.jacc.2021.05.021_bib7","doi-asserted-by":"crossref","first-page":"5749","DOI":"10.1113\/JP272088","article-title":"Lymphatic pumping: mechanics, mechanisms and malfunction","volume":"594","author":"Scallan","year":"2016","journal-title":"J\u00a0Physiol"},{"issue":"7","key":"10.1016\/j.jacc.2021.05.021_bib8","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.biocel.2003.12.008","article-title":"Lymphatic smooth muscle: the motor unit of lymph drainage","volume":"36","author":"von der Weid","year":"2004","journal-title":"Int J Biochem Cell Biol"},{"issue":"6","key":"10.1016\/j.jacc.2021.05.021_bib9","first-page":"H775","article-title":"Intrinsic contractility of prenodal lymph vessels and lymph flow in human leg","volume":"239","author":"Olszewski","year":"1980","journal-title":"Am J Physiol"},{"issue":"Pt 2","key":"10.1016\/j.jacc.2021.05.021_bib10","first-page":"H2059","article-title":"Characterization of intact mesenteric lymphatic pump and its responsiveness to acute edemagenic stress","volume":"2576","author":"Benoit","year":"1989","journal-title":"Am J Physiol"},{"issue":"1","key":"10.1016\/j.jacc.2021.05.021_bib11","doi-asserted-by":"crossref","first-page":"H48","DOI":"10.1152\/ajpheart.00133.2011","article-title":"Determinants of valve gating in collecting lymphatic vessels from rat mesentery","volume":"301","author":"Davis","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"3","key":"10.1016\/j.jacc.2021.05.021_bib12","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1148\/radiol.2531082036","article-title":"Terminal part of thoracic duct: high-resolution US imaging","volume":"252","author":"Seeger","year":"2009","journal-title":"Radiology"},{"issue":"3","key":"10.1016\/j.jacc.2021.05.021_bib13","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/BF00580768","article-title":"Thoracic duct lymph flow and composition in conscious dogs and the influence of anaesthesia and passive limb movement","volume":"371","author":"Schad","year":"1977","journal-title":"Pflugers Arch"},{"issue":"2","key":"10.1016\/j.jacc.2021.05.021_bib14","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1748-1716.1977.tb10364.x","article-title":"Twenty-four hour variation in flow and composition of leg lymph in normal men","volume":"99","author":"Engeset","year":"1977","journal-title":"Acta Physiol Scand"},{"issue":"3-4","key":"10.1016\/j.jacc.2021.05.021_bib15","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1113\/jphysiol.1894.sp000500","article-title":"The Influence of mechanical factors on lymph production","volume":"16","author":"Starling","year":"1894","journal-title":"J\u00a0Physiol"},{"issue":"4","key":"10.1016\/j.jacc.2021.05.021_bib16","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1113\/jphysiol.1896.sp000596","article-title":"On the absorption of fluids from the connective tissue spaces","volume":"19","author":"Starling","year":"1896","journal-title":"J\u00a0Physiol"},{"issue":"2","key":"10.1016\/j.jacc.2021.05.021_bib17","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1093\/cvr\/cvq062","article-title":"Microvascular fluid exchange and the revised Starling principle","volume":"87","author":"Levick","year":"2010","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jacc.2021.05.021_bib18","series-title":"Lymphedema: A Concise Compendium of Theory and Practice","article-title":"Differential diagnosis of edema","author":"Rockson","year":"2018"},{"issue":"3","key":"10.1016\/j.jacc.2021.05.021_bib19","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1172\/JCI71608","article-title":"New developments in clinical aspects of lymphatic disease","volume":"124","author":"Mortimer","year":"2014","journal-title":"J\u00a0Clin Invest"},{"issue":"24","key":"10.1016\/j.jacc.2021.05.021_bib20","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1016\/j.jacc.2020.10.022","article-title":"Reduced lymphatic reserve in heart failure with preserved ejection fraction","volume":"76","author":"Rossitto","year":"2020","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"6","key":"10.1016\/j.jacc.2021.05.021_bib21","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/ar.20681","article-title":"Lymph Circulation in the liver","volume":"291","author":"Ohtani","year":"2008","journal-title":"Anat Rec (Hoboken)"},{"key":"10.1016\/j.jacc.2021.05.021_bib22","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/2040-2384-2-14","article-title":"Physiologic upper limits of pore size of different blood capillary types and another perspective on the dual pore theory of microvascular permeability","volume":"2","author":"Sarin","year":"2010","journal-title":"J\u00a0Angiogenes Res"},{"key":"10.1016\/j.jacc.2021.05.021_bib23","series-title":"Lymphatics, Lymph and the Lymphomyeloid Complex","author":"Yoffey","year":"1970"},{"issue":"5","key":"10.1016\/j.jacc.2021.05.021_bib24","first-page":"604","article-title":"Effect of hepatic venous outflow obstruction on pores and fenestration in sinusoidal endothelium","volume":"57","author":"Nopanitaya","year":"1976","journal-title":"Br J Exp Pathol"},{"issue":"5","key":"10.1016\/j.jacc.2021.05.021_bib25","first-page":"551","article-title":"Hepatic lymph drainage in cirrhosis and congestive heart failure. A postmortem lymphangiographic study","volume":"86","author":"Ludwig","year":"1968","journal-title":"Arch Pathol"},{"issue":"2","key":"10.1016\/j.jacc.2021.05.021_bib26","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3350\/cmh.2013.19.2.99","article-title":"The lymphatic vascular system in liver diseases: its role in ascites formation","volume":"19","author":"Chung","year":"2013","journal-title":"Clin Mol Hepatol"},{"issue":"7","key":"10.1016\/j.jacc.2021.05.021_bib27","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1369\/jhc.2009.953067","article-title":"Intralobular pulmonary lymphatic distribution in normal human lung using D2-40 antipodoplanin immunostaining","volume":"57","author":"Kambouchner","year":"2009","journal-title":"J\u00a0Histochem Cytochem"},{"issue":"7","key":"10.1016\/j.jacc.2021.05.021_bib28","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1097\/00003246-199207000-00024","article-title":"Pulmonary capillary pressure: a review","volume":"20","author":"Cope","year":"1992","journal-title":"Crit Care Med"},{"issue":"3","key":"10.1016\/j.jacc.2021.05.021_bib29","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1161\/01.RES.37.3.271","article-title":"Effect of increased vascular pressure on lung fluid balance in unanesthetized sheep","volume":"37","author":"Erdmann","year":"1975","journal-title":"Circ Res"},{"issue":"2","key":"10.1016\/j.jacc.2021.05.021_bib30","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/0002-9610(67)90380-7","article-title":"Significance of changes in the pulmonary lymph flow in acute and chronic experimental pulmonary edema","volume":"114","author":"Leeds","year":"1967","journal-title":"Am J Surg"},{"issue":"4","key":"10.1016\/j.jacc.2021.05.021_bib31","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1152\/jappl.1986.60.4.1293","article-title":"Effects of hypoproteinemia on lung microvascular protein sieving and lung lymph flow","volume":"60","author":"Parker","year":"1986","journal-title":"J\u00a0Appl Physiol"},{"key":"10.1016\/j.jacc.2021.05.021_bib32","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1749-6632.1982.tb21369.x","article-title":"The pulmonary interstitium in capillary exchange","volume":"384","author":"Taylor","year":"1982","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jacc.2021.05.021_bib33","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1161\/01.RES.11.6.966","article-title":"Role of pulmonary lymphatics in chronic pulmonary edema","volume":"11","author":"Uhley","year":"1962","journal-title":"Circ Res"},{"issue":"3 Pt 1","key":"10.1016\/j.jacc.2021.05.021_bib34","first-page":"G389","article-title":"Lymphatic pathways and role of valves in lymph propulsion from small intestine","volume":"254","author":"Unthank","year":"1988","journal-title":"Am J Physiol"},{"issue":"2","key":"10.1016\/j.jacc.2021.05.021_bib35","doi-asserted-by":"crossref","first-page":"H203","DOI":"10.1152\/ajpheart.00677.2012","article-title":"Adaptation of mesenteric lymphatic vessels to prolonged changes in transmural pressure","volume":"305","author":"Dongaonkar","year":"2013","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"4","key":"10.1016\/j.jacc.2021.05.021_bib36","first-page":"228","article-title":"Canine renal lymph formation during acute ECF expansion","volume":"16","author":"Bell","year":"1983","journal-title":"Lymphology"},{"key":"10.1016\/j.jacc.2021.05.021_bib37","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1152\/ajplegacy.1960.198.5.1037","article-title":"Influence of elevated venous pressure on flow and composition of renal lymph","volume":"198","author":"Lebrie","year":"1960","journal-title":"Am J Physiol"},{"issue":"2","key":"10.1016\/j.jacc.2021.05.021_bib38","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0090-4295(77)90180-7","article-title":"Lymphatic network of kidney. I. Anatomic and physiologic considerations","volume":"9","author":"Cockett","year":"1977","journal-title":"Urology"},{"issue":"2","key":"10.1016\/j.jacc.2021.05.021_bib39","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/BF02926482","article-title":"Microradiographic demonstration of human intrarenal microlymphatic pathways","volume":"11","author":"Cuttino","year":"1989","journal-title":"Urol Radiol"},{"issue":"6","key":"10.1016\/j.jacc.2021.05.021_bib40","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1161\/01.CIR.39.6.723","article-title":"Lymph circulation in congestive heart failure: effect of external thoracic duct drainage","volume":"39","author":"Witte","year":"1969","journal-title":"Circulation"},{"issue":"6 Pt 2","key":"10.1016\/j.jacc.2021.05.021_bib41","first-page":"R1465","article-title":"Regulation of microvascular filtration in the myocardium by interstitial fluid pressure","volume":"271","author":"Stewart","year":"1996","journal-title":"Am J Physiol"},{"issue":"6","key":"10.1016\/j.jacc.2021.05.021_bib42","doi-asserted-by":"crossref","first-page":"H2428","DOI":"10.1152\/ajpheart.00860.2007","article-title":"Mechanics of the left ventricular myocardial interstitium: effects of acute and chronic myocardial edema","volume":"294","author":"Desai","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"5","key":"10.1016\/j.jacc.2021.05.021_bib43","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.jvir.2012.01.078","article-title":"Feasibility of ultrasound-guided intranodal lymphangiogram for thoracic duct embolization","volume":"23","author":"Nadolski","year":"2012","journal-title":"J\u00a0Vasc Interv Radiol"},{"issue":"2","key":"10.1016\/j.jacc.2021.05.021_bib44","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1148\/radiol.14132616","article-title":"Dynamic contrast-enhanced MR lymphangiography: feasibility study in swine","volume":"273","author":"Dori","year":"2014","journal-title":"Radiology"},{"issue":"1","key":"10.1016\/j.jacc.2021.05.021_bib45","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jvir.2013.09.002","article-title":"Transhepatic lymphatic embolization of intractable hepatic lymphorrhea","volume":"25","author":"Guez","year":"2014","journal-title":"J\u00a0Vasc Interv Radiol"},{"issue":"24","key":"10.1016\/j.jacc.2021.05.021_bib46","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1016\/j.jacc.2017.04.023","article-title":"Protein-losing enteropathy in patients with congenital heart disease","volume":"69","author":"Itkin","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"12","key":"10.1016\/j.jacc.2021.05.021_bib47","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1161\/CIRCULATIONAHA.115.019710","article-title":"Percutaneous lymphatic embolization of abnormal pulmonary lymphatic flow as treatment of plastic bronchitis in patients with congenital heart disease","volume":"133","author":"Dori","year":"2016","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.jacc.2021.05.021_bib48","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1177\/2150135112438107","article-title":"Plastic bronchitis in patients with Fontan physiology: review of the literature and preliminary experience with Fontan conversion and cardiac transplantation","volume":"3","author":"Larue","year":"2012","journal-title":"World J Pediatr Congenit Heart Surg"},{"issue":"19","key":"10.1016\/j.jacc.2021.05.021_bib49","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1016\/j.jacc.2017.03.021","article-title":"Post-operative chylothorax in patients with congenital heart disease","volume":"69","author":"Savla","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"10","key":"10.1016\/j.jacc.2021.05.021_bib50","first-page":"1689","article-title":"Diagnosis and treatment of lymphatic plastic bronchitis in adults using advanced lymphatic imaging and percutaneous embolization","volume":"13","author":"Itkin","year":"2016","journal-title":"Ann Am Thorac Soc"},{"issue":"5","key":"10.1016\/j.jacc.2021.05.021_bib51","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.ahj.2007.11.043","article-title":"Albumin levels predict survival in patients with systolic heart failure","volume":"155","author":"Horwich","year":"2008","journal-title":"Am Heart J"},{"key":"10.1016\/j.jacc.2021.05.021_bib52","series-title":"Sleisenger and Fordtran\u2019s Gastrointestinal and Liver Disease","article-title":"Protein-losing gastroenteropathy","author":"Greenwald","year":"2016"},{"issue":"6","key":"10.1016\/j.jacc.2021.05.021_bib53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ehjcr\/ytaa415","article-title":"Case report: hepatobronchial lymphatic communications in single ventricle patients as a pathophysiological mechanism of plastic bronchitis: diagnosis and treatment","volume":"4","author":"Rabinowitz","year":"2020","journal-title":"Eur Heart J Case Rep"},{"key":"10.1016\/j.jacc.2021.05.021_bib54","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1097\/00000658-196912000-00021","article-title":"Observations on the origin of ascites from experimental extrahepatic portal congestion","volume":"170","author":"Witte","year":"1969","journal-title":"Ann Surg"},{"issue":"2","key":"10.1016\/j.jacc.2021.05.021_bib55","doi-asserted-by":"crossref","first-page":"426","DOI":"10.2214\/AJR.13.11797","article-title":"MRI of lymphatic abnormalities after functional single-ventricle palliation surgery","volume":"203","author":"Dori","year":"2014","journal-title":"AJR Am J Roentgenol"},{"issue":"1","key":"10.1016\/j.jacc.2021.05.021_bib56","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1148\/radiol.2020192337","article-title":"Quantification of thoracic lymphatic flow patterns using dynamic contrast-enhanced MR lymphangiography","volume":"296","author":"Zheng","year":"2020","journal-title":"Radiology"},{"issue":"1","key":"10.1016\/j.jacc.2021.05.021_bib57","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1152\/jappl.1991.71.1.314","article-title":"Effect of thoracic duct drainage on hydrostatic pulmonary edema and pleural effusion in sheep","volume":"71","author":"Allen","year":"1991","journal-title":"J\u00a0Appl Physiol (1985)"},{"issue":"4","key":"10.1016\/j.jacc.2021.05.021_bib58","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1161\/01.CIR.36.4.539","article-title":"Thoracic duct-to-pulmonary vein shunt in the treatment of experimental right heart failure","volume":"36","author":"Cole","year":"1967","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2021.05.021_bib59","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1056\/NEJM196310312691804","article-title":"Lymph drainage in patients with congestive heart failure. Comparison with findings in hepatic cirrhosis","volume":"269","author":"Dumont","year":"1963","journal-title":"N\u00a0Engl J Med"},{"issue":"5","key":"10.1016\/j.jacc.2021.05.021_bib60","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/0002-9610(70)90186-8","article-title":"Controlled rate of drainage of thoracic duct lymph","volume":"119","author":"Clauss","year":"1970","journal-title":"Am J Surg"},{"issue":"2","key":"10.1016\/j.jacc.2021.05.021_bib61","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.athoracsur.2013.02.046","article-title":"Decompression of thoracic duct: new approach for the treatment of failing Fontan","volume":"96","author":"Hraska","year":"2013","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jacc.2021.05.021_bib62","series-title":"Levick's Introduction to Cardiovascular Physiology","author":"Herring","year":"2018"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073510972105138X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073510972105138X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:43:45Z","timestamp":1760017425000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S073510972105138X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":62,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S073510972105138X"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2021.05.021","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pathophysiology of the Lymphatic System in Patients With Heart\u00a0Failure","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2021.05.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}