{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T01:30:48Z","timestamp":1793064648950,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"18","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,4]],"date-time":"2021-09-04T00:00:00Z","timestamp":1630713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004362","name":"Schweizerische Herzstiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004362","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["32003B_169309"],"award-info":[{"award-number":["32003B_169309"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.jacc.2021.08.048","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T17:34:10Z","timestamp":1635183250000},"page":"1753-1764","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":136,"title":["Targeting Higher Intraoperative Blood Pressures Does Not Reduce Adverse Cardiovascular Events Following Noncardiac Surgery"],"prefix":"10.1016","volume":"78","author":[{"given":"Patrick M.","family":"Wanner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk U.","family":"Wulff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjana","family":"Djurdjevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Korte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W.","family":"Schnider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miodrag","family":"Filipovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2021.08.048_bib1","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1056\/NEJMoa1401105","article-title":"Aspirin in patients undergoing noncardiac surgery","volume":"370","author":"Devereaux","year":"2014","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2021.08.048_bib2","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1097\/ALN.0000000000000113","article-title":"Myocardial injury after noncardiac surgery","volume":"120","author":"Botto","year":"2014","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jacc.2021.08.048_bib3","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.bja.2018.04.036","article-title":"Intraoperative hypotension and the risk of postoperative adverse outcomes: a systematic review","volume":"121","author":"Wesselink","year":"2018","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.jacc.2021.08.048_bib4","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ijcard.2018.01.137","article-title":"Association between intraoperative hypotension and 30-day mortality, major adverse cardiac events, and acute kidney injury after non-cardiac surgery: A meta-analysis of cohort studies","volume":"258","author":"Gu","year":"2018","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacc.2021.08.048_bib5","doi-asserted-by":"crossref","first-page":"zraa018","DOI":"10.1093\/bjsopen\/zraa018","article-title":"Association of intraoperative hypotension with postoperative morbidity and mortality: systematic review and meta-analysis","volume":"5","author":"Wijnberge","year":"2021","journal-title":"BJS Open"},{"key":"10.1016\/j.jacc.2021.08.048_bib6","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1001\/jama.2017.14172","article-title":"Effect of individualized vs standard blood pressure management strategies on postoperative organ dysfunction 6among high-risk patients undergoing major surgery: a randomized clinical trial","volume":"318","author":"Futier","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.jacc.2021.08.048_bib7","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.bja.2019.01.013","article-title":"Perioperative Quality Initiative consensus statement on intraoperative blood pressure, risk and outcomes for elective surgery","volume":"122","author":"Sessler","year":"2019","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.jacc.2021.08.048_bib8","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/j.jacc.2007.09.001","article-title":"ACC\/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery: executive summary","volume":"50","author":"Fleisher","year":"2007","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.08.048_bib9","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.recesp.2014.11.001","volume":"67","author":"Kristensen","year":"2014","journal-title":"Rev Esp Cardiol"},{"key":"10.1016\/j.jacc.2021.08.048_bib10","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1097\/00000542-199805000-00006","article-title":"The\u00a0influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers","volume":"88","author":"Schnider","year":"1998","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jacc.2021.08.048_bib11","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1097\/00000542-199906000-00003","article-title":"The Influence of age on propofol pharmacodynamics","volume":"90","author":"Schnider","year":"1999","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jacc.2021.08.048_bib12","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/00000542-199701000-00004","article-title":"Influence of age and gender on the pharmacokinetics and pharmacodynamics of remifentanil: I. model development","volume":"86","author":"Minto","year":"1997","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jacc.2021.08.048_bib13","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1097\/00000542-199701000-00005","article-title":"Pharmacokinetics and pharmacodynamics of remifentanil: ii. model application","volume":"86","author":"Minto","year":"1997","journal-title":"Anesthesiology"},{"issue":"5","key":"10.1016\/j.jacc.2021.08.048_bib14","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.bja.2019.01.019","article-title":"Perioperative Quality Initiative consensus statement on postoperative blood pressure, risk and outcomes for elective surgery","volume":"122","author":"McEvoy","year":"2019","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.jacc.2021.08.048_bib15","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1097\/CCM.0000000000000249","article-title":"Perioperative levels and changes of high-sensitivity troponin T are associated with cardiovascular events in vascular surgery patients","volume":"42","author":"Gillmann","year":"2014","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jacc.2021.08.048_bib16","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1001\/jama.2012.5502","article-title":"Association between postoperative troponin levels and 30-day mortality among patients undergoing noncardiac surgery","volume":"307","author":"Devereaux","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.jacc.2021.08.048_bib17","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1001\/jama.2017.4360","article-title":"Association of postoperative high-sensitivity troponin levels with myocardial injury and 30-day mortality among patients undergoing noncardiac surgery","volume":"317","author":"Devereaux","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.jacc.2021.08.048_bib18","doi-asserted-by":"crossref","first-page":"R31","DOI":"10.1186\/cc5713","article-title":"Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury","volume":"11","author":"Mehta","year":"2007","journal-title":"Crit Care"},{"key":"10.1016\/j.jacc.2021.08.048_bib19","doi-asserted-by":"crossref","first-page":"638","DOI":"10.3758\/s13428-016-0739-8","article-title":"Default \u201cGunel and Dickey\u201d Bayes factors for contingency tables","volume":"49","author":"Jamil","year":"2017","journal-title":"Behav Res Methods"},{"key":"10.1016\/j.jacc.2021.08.048_bib20","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1097\/ALN.0b013e31825683dc","article-title":"Hospital stay and mortality are increased in patients having a triple low of low blood pressure, low bispectral index, and low minimum alveolar concentration of volatile anesthesia","volume":"116","author":"Sessler","year":"2012","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jacc.2021.08.048_bib21","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1080\/01621459.1995.10476572","article-title":"Bayes Factors","volume":"90","author":"Kass","year":"1995","journal-title":"J\u00a0Am Stat Assoc"},{"key":"10.1016\/j.jacc.2021.08.048_bib22","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1016\/S0140-6736(08)60601-7","article-title":"Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial","volume":"371","author":"Group","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2021.08.048_bib23","first-page":"17","article-title":"Canadian Cardiovascular Society guidelines on perioperative cardiac risk assessment and management for patients who undergo noncardiac surgery","volume":"33","author":"Duceppe","year":"2017","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.jacc.2021.08.048_bib24","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/ALN.0000000000001432","article-title":"Relationship between intraoperative hypotension, defined by either reduction from baseline or absolute thresholds, and acute kidney and myocardial injury after noncardiac surgery","volume":"126","author":"Salmasi","year":"2017","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jacc.2021.08.048_bib25","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/ALN.0000000000000686","article-title":"Intraoperative mean arterial pressure variability and 30-day mortality in patients having noncardiac surgery","volume":"123","author":"Mascha","year":"2015","journal-title":"Anesthesiology"},{"issue":"2","key":"10.1016\/j.jacc.2021.08.048_bib26","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1213\/ANE.0000000000005287","article-title":"Development and evaluation of a risk-adjusted measure of intraoperative hypotension in patients having nonemergent, noncardiac surgery","volume":"133","author":"Christensen","year":"2021","journal-title":"Anesth Analg"},{"key":"10.1016\/j.jacc.2021.08.048_bib27","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1053\/j.ajkd.2015.07.022","article-title":"Acute kidney injury after major surgery: a retrospective analysis of veterans health administration data","volume":"67","author":"Grams","year":"2016","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.jacc.2021.08.048_bib28","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1093\/ckj\/sfv144","article-title":"Acute kidney injury, long-term renal function and mortality in patients undergoing major abdominal surgery: a cohort analysis","volume":"9","author":"Gameiro","year":"2016","journal-title":"Clin Kidney J"},{"key":"10.1016\/j.jacc.2021.08.048_bib29","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s00134-015-4157-7","article-title":"Incidence and associations of acute kidney injury after major abdominal surgery","volume":"42","author":"O\u2019Connor","year":"2016","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jacc.2021.08.048_bib30","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1161\/CIRCULATIONAHA.117.030114","article-title":"Perioperative myocardial injury after noncardiac surgery","volume":"137","author":"Puelacher","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2021.08.048_bib31","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1097\/SLA.0000000000000732","article-title":"Cost and mortality associated with postoperative acute kidney injury","volume":"261","author":"Hobson","year":"2015","journal-title":"Ann Surg"},{"key":"10.1016\/j.jacc.2021.08.048_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/ALN.0000000000000282","article-title":"Untangling the triple low","volume":"121","author":"Myles","year":"2014","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jacc.2021.08.048_bib33","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1213\/ANE.0000000000005281","article-title":"Is a mean arterial pressure less than 65\u00a0mm hg an appropriate indicator of the quality of anesthesia care?","volume":"132","author":"Kamenetsky","year":"2021","journal-title":"Anesth Analg"},{"key":"10.1016\/j.jacc.2021.08.048_bib34","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1001\/jamasurg.2019.1163","article-title":"Effect of targeting mean arterial pressure during cardiopulmonary bypass by monitoring cerebral autoregulation on postsurgical delirium among older patients","volume":"154","author":"Brown","year":"2019","journal-title":"JAMA Surg"},{"key":"10.1016\/j.jacc.2021.08.048_bib35","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1097\/ALN.0b013e3182a10e26","article-title":"Relationship between intraoperative mean arterial pressure and clinical outcomes after noncardiac surgery","volume":"119","author":"Walsh","year":"2013","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jacc.2021.08.048_bib36","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.jvs.2018.05.017","article-title":"Epidemiology, outcomes, and management of acute kidney injury in the vascular surgery patient","volume":"68","author":"Hobson","year":"2018","journal-title":"J\u00a0Vasc Surg"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109721061118?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109721061118?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T18:14:21Z","timestamp":1777572861000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109721061118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":36,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["S0735109721061118"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2021.08.048","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting Higher Intraoperative Blood Pressures Does Not Reduce Adverse Cardiovascular Events Following Noncardiac Surgery","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2021.08.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}]}}