{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:22:50Z","timestamp":1790734970690,"version":"4.1.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"21","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T00:00:00Z","timestamp":1635811200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005035","name":"Biotronik","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005035","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL-123483"],"award-info":[{"award-number":["HL-123483"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL-33843"],"award-info":[{"award-number":["HL-33843"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL-51618"],"award-info":[{"award-number":["HL-51618"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013410","name":"LivaNova","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.jacc.2021.09.017","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T16:05:10Z","timestamp":1636992310000},"page":"2076-2088","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Effectiveness of Implantable Cardioverter-Defibrillators to Reduce\u00a0Mortality in Patients With Long\u00a0QT Syndrome"],"prefix":"10.1016","volume":"78","author":[{"given":"Meng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derick R.","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spencer","family":"Rosero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"McNitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Q.","family":"Rich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher L.","family":"Seplaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bronislava","family":"Polonsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilan","family":"Goldenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Zareba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.jacc.2021.09.017_bib1","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.cpcardiol.2008.07.002","article-title":"Long QT syndrome","volume":"33","author":"Goldenberg","year":"2008","journal-title":"Curr Probl Cardiol"},{"issue":"21","key":"10.1016\/j.jacc.2021.09.017_bib2","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1093\/eurheartj\/ehv063","article-title":"Sudden cardiac death in the young: the molecular autopsy and a practical approach to surviving relatives","volume":"36","author":"Semsarian","year":"2015","journal-title":"Eur Heart J"},{"issue":"12","key":"10.1016\/j.jacc.2021.09.017_bib3","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1056\/NEJMoa013474","article-title":"Multicenter Automatic Defibrillator Implantation Trial II Investigators. Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction","volume":"346","author":"Moss","year":"2002","journal-title":"N\u00a0Engl J Med"},{"issue":"3","key":"10.1016\/j.jacc.2021.09.017_bib4","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1056\/NEJMoa043399","article-title":"Amiodarone or an implantable cardioverter\u2013defibrillator for congestive heart failure","volume":"352","author":"Bardy","year":"2005","journal-title":"N\u00a0Engl J Med"},{"issue":"4","key":"10.1016\/j.jacc.2021.09.017_bib5","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1046\/j.1540-8167.2003.02545.x","article-title":"Implantable cardioverter defibrillator in high-risk long QT syndrome patients","volume":"14","author":"Zareba","year":"2003","journal-title":"J\u00a0Cardiovasc Electrophysiol"},{"issue":"13","key":"10.1016\/j.jacc.2021.09.017_bib6","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1161\/CIRCULATIONAHA.110.950147","article-title":"Who are the long-QT syndrome patients who receive an implantable cardioverter-defibrillator and what happens to them? Data from the European Long-QT Syndrome Implantable Cardioverter-Defibrillator (LQTS ICD) Registry","volume":"122","author":"Schwartz","year":"2010","journal-title":"Circulation"},{"issue":"41","key":"10.1016\/j.jacc.2021.09.017_bib7","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1093\/eurheartj\/ehv316","volume":"36","author":"Priori","year":"2015","journal-title":"Eur Heart J"},{"issue":"14","key":"10.1016\/j.jacc.2021.09.017_bib8","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.1016\/j.jacc.2017.10.054","volume":"72","author":"Al-Khatib","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"9","key":"10.1016\/j.jacc.2021.09.017_bib9","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1161\/01.CIR.0000157069.91834.DA","article-title":"25th anniversary of the International Long-QT Syndrome Registry: an ongoing quest to uncover the secrets of long-QT syndrome","volume":"111","author":"Moss","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2021.09.017_bib10","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1161\/CIRCULATIONAHA.107.701243","article-title":"Risk factors for aborted cardiac arrest and sudden cardiac death in children with the congenital long-QT syndrome","volume":"117","author":"Goldenberg","year":"2008","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.jacc.2021.09.017_bib11","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1093\/aje\/kwm324","article-title":"Immortal time bias in pharmacoepidemiology","volume":"167","author":"Suissa","year":"2007","journal-title":"Am J Epidemiol"},{"issue":"8","key":"10.1016\/j.jacc.2021.09.017_bib12","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.jacc.2009.11.042","article-title":"Risk of fatal arrhythmic events in long QT syndrome patients after syncope","volume":"55","author":"Jons","year":"2010","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"3","key":"10.1016\/j.jacc.2021.09.017_bib13","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.jacc.2006.08.057","article-title":"Long QT syndrome in adults","volume":"49","author":"Sauer","year":"2007","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"19","key":"10.1016\/j.jacc.2021.09.017_bib14","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1056\/NEJMoa022147","article-title":"Risk stratification in the long-QT syndrome","volume":"348","author":"Priori","year":"2003","journal-title":"N\u00a0Engl J Med"},{"issue":"6","key":"10.1016\/j.jacc.2021.09.017_bib15","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1161\/01.CIR.101.6.616","article-title":"Effectiveness and limitations of beta-blocker therapy in congenital long-QT syndrome","volume":"101","author":"Moss","year":"2000","journal-title":"Circulation"},{"issue":"9","key":"10.1016\/j.jacc.2021.09.017_bib16","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.jacc.2009.05.029","article-title":"Clinical implications for patients with long QT syndrome who experience a cardiac event during infancy","volume":"54","author":"Spazzolini","year":"2009","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"11","key":"10.1016\/j.jacc.2021.09.017_bib17","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1016\/j.hrthm.2010.08.023","article-title":"Implantable cardioverter defibrillator therapy for congenital long QT syndrome: a single-center experience","volume":"7","author":"Horner","year":"2010","journal-title":"Heart Rhythm"},{"issue":"2","key":"10.1016\/j.jacc.2021.09.017_bib18","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1093\/europace\/euy149","article-title":"Primary prevention with the implantable cardioverter-defibrillator in high-risk long-QT syndrome patients","volume":"21","author":"Biton","year":"2019","journal-title":"Europace"},{"issue":"10","key":"10.1016\/j.jacc.2021.09.017_bib19","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1001\/jamainternmed.2013.428","article-title":"Implantable cardioverter-defibrillator shocks: epidemiology, outcomes, and therapeutic approaches","volume":"173","author":"Borne","year":"2013","journal-title":"JAMA Intern Med"},{"issue":"14","key":"10.1016\/j.jacc.2021.09.017_bib20","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1016\/j.jacc.2007.09.073","article-title":"Inappropriate implantable cardioverter-defibrillator shocks in MADIT II: frequency, mechanisms, predictors, and survival impact","volume":"51","author":"Daubert","year":"2008","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"24","key":"10.1016\/j.jacc.2021.09.017_bib21","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1056\/NEJMoa1211107","article-title":"Reduction in inappropriate therapy and mortality through ICD programming","volume":"367","author":"Moss","year":"2012","journal-title":"N\u00a0Engl J Med"},{"issue":"5","key":"10.1016\/j.jacc.2021.09.017_bib22","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.hrthm.2005.02.008","article-title":"Implantable cardioverter-defibrillator therapy in patients with congenital long-QT syndrome: a long-term follow-up","volume":"2","author":"M\u00f6nnig","year":"2005","journal-title":"Heart Rhythm"},{"issue":"1","key":"10.1016\/j.jacc.2021.09.017_bib23","first-page":"1","article-title":"2015 HRS\/EHRA\/APHRS\/SOLAECE expert consensus statement on optimal implantable cardioverter-defibrillator programming and testing","volume":"32","author":"Wilkoff","year":"2016","journal-title":"J\u00a0Arrhythm"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109721063178?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109721063178?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:46:52Z","timestamp":1760017612000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109721063178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":23,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["S0735109721063178"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2021.09.017","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effectiveness of Implantable Cardioverter-Defibrillators to Reduce\u00a0Mortality in Patients With Long\u00a0QT Syndrome","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2021.09.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}]}}