{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T08:00:04Z","timestamp":1793260804350,"version":"4.5.0"},"reference-count":87,"publisher":"Elsevier BV","issue":"21","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T00:00:00Z","timestamp":1632787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.jacc.2021.09.019","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T16:05:32Z","timestamp":1636992332000},"page":"2092-2105","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":111,"title":["Basic and Translational Research in Cardiac Repair and Regeneration"],"prefix":"10.1016","volume":"78","author":[{"given":"Jianyi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Bolli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Garry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Marb\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Menasch\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfram-Hubertus","family":"Zimmermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Kamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph C.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor J.","family":"Dzau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2021.09.019_bib1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0140-6736(00)03617-5","article-title":"Myoblast transplantation for heart failure","volume":"357","author":"Menasch\u00e9","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2021.09.019_bib2","article-title":"Cell therapy in patients with heart failure: a comprehensive review and emerging concepts","author":"Bolli","year":"2021","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jacc.2021.09.019_bib3","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1139\/cjpp-2020-0406","article-title":"After the storm: an objective appraisal of the efficacy of c-kit+ cardiac progenitor cells in preclinical models of heart disease","volume":"99","author":"Bolli","year":"2021","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.jacc.2021.09.019_bib4","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1161\/CIRCRESAHA.116.303614","article-title":"Use of mesenchymal stem cells for therapy of cardiac disease","volume":"116","author":"Karantalis","year":"2015","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2021.09.019_bib5","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1161\/CIRCRESAHA.118.312978","article-title":"Rationale and design of the CONCERT-HF Trial (Combination of Mesenchymal and c-kit(+) Cardiac Stem Cells As Regenerative Therapy for Heart\u00a0Failure)","volume":"122","author":"Bolli","year":"2018","journal-title":"Circ Res"},{"issue":"4","key":"10.1016\/j.jacc.2021.09.019_bib6","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/ejhf.2178","article-title":"A\u00a0phase II study of autologous mesenchymal stromal cells and c-kit positive cardiac cells, alone or in combination, in patients with ischaemic heart failure: the CCTRN CONCERT-HF trial","volume":"23","author":"Bolli","year":"2021","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jacc.2021.09.019_bib7","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/s41551-018-0216-z","article-title":"A\u00a0mechanistic roadmap for the clinical application of cardiac cell therapies","volume":"2","author":"Marb\u00e1n","year":"2018","journal-title":"Nat Biomed Eng"},{"key":"10.1016\/j.jacc.2021.09.019_bib8","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.stemcr.2018.01.023","article-title":"Exosome-mediated benefits of cell therapy in mouse and human models of duchenne muscular dystrophy","volume":"10","author":"Aminzadeh","year":"2018","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.jacc.2021.09.019_bib9","doi-asserted-by":"crossref","first-page":"e866","DOI":"10.1212\/WNL.0000000000006950","article-title":"Cardiac and skeletal muscle effects in the randomized HOPE-Duchenne trial","volume":"92","author":"Taylor","year":"2019","journal-title":"Neurology"},{"issue":"7","key":"10.1016\/j.jacc.2021.09.019_bib10","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.125754","article-title":"Disease-modifying bioactivity of intravenous cardiosphere-derived cells and exosomes in mdx mice","volume":"4","author":"Rogers","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.jacc.2021.09.019_bib11","doi-asserted-by":"crossref","first-page":"S168","DOI":"10.1016\/j.nmd.2020.09.013","article-title":"Late breaking news e-poster presentation: LBP5HOPE -2 one-year results show clinically relevant improvements in upper limb & cardiac function in patients with later stage Duchenne Muscular Dystrophy (abstr)","volume":"30","author":"Marban","year":"2020","journal-title":"Neuromuscular Disorders"},{"key":"10.1016\/j.jacc.2021.09.019_bib12","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.jacc.2021.09.019_bib13","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1126\/science.282.5391.1145","article-title":"Embryonic stem cell lines derived from human blastocysts","volume":"282","author":"Thomson","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.jacc.2021.09.019_bib14","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1172\/JCI200112131","article-title":"Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes","volume":"108","author":"Kehat","year":"2001","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jacc.2021.09.019_bib15","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.stem.2011.12.013","article-title":"Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming","volume":"10","author":"Burridge","year":"2012","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jacc.2021.09.019_bib16","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1161\/CIRCRESAHA.115.306985","article-title":"Human engineered heart muscles engraft and survive long term in a rodent myocardial infarction model","volume":"117","author":"Riegler","year":"2015","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2021.09.019_bib17","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.scr.2015.08.002","article-title":"Development of a scalable suspension culture for cardiac differentiation from human pluripotent stem cells","volume":"15","author":"Chen","year":"2015","journal-title":"Stem Cell Res"},{"key":"10.1016\/j.jacc.2021.09.019_bib18","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1038\/nprot.2015.089","article-title":"Cardiac differentiation of human pluripotent stem cells in scalable suspension culture","volume":"10","author":"Kempf","year":"2015","journal-title":"Nat Protoc"},{"key":"10.1016\/j.jacc.2021.09.019_bib19","doi-asserted-by":"crossref","first-page":"363ra148","DOI":"10.1126\/scitranslmed.aaf8781","article-title":"Cardiac repair in guinea pigs with human engineered heart tissue from induced pluripotent stem cells","volume":"8","author":"Weinberger","year":"2016","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jacc.2021.09.019_bib20","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.stemcr.2019.04.005","article-title":"Human embryonic stem cell-derived cardiomyocytes regenerate the infarcted pig heart but induce ventricular tachyarrhythmias","volume":"12","author":"Romagnuolo","year":"2019","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.jacc.2021.09.019_bib21","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nbt.4162","article-title":"Human embryonic stem cell-derived cardiomyocytes restore function in infarcted hearts of non-human primates","volume":"36","author":"Liu","year":"2018","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jacc.2021.09.019_bib22","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.jacc.2017.11.047","article-title":"Transplantation of human embryonic stem cell-derived cardiovascular progenitors for severe ischemic left ventricular dysfunction","volume":"71","author":"Menasch\u00e9","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.09.019_bib23","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/d41586-018-05278-8","article-title":"Reprogrammed' stem cells approved to mend human hearts for the first time","volume":"557","author":"Cyranoski","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.jacc.2021.09.019_bib24","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1161\/CIRCULATIONAHA.116.024145","article-title":"Defined engineered human myocardium with advanced maturation for applications in heart failure modeling and repair","volume":"135","author":"Tiburcy","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2021.09.019_bib25","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/nm1394","article-title":"Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts","volume":"12","author":"Zimmermann","year":"2006","journal-title":"Nat Med"},{"key":"10.1016\/j.jacc.2021.09.019_bib26","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1172\/JCI66854","article-title":"Parthenogenetic stem cells for tissue-engineered heart repair","volume":"123","author":"Didi\u00e9","year":"2013","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jacc.2021.09.019_bib27","first-page":"E6072","article-title":"Functional characterization of human pluripotent stem cell-derived arterial endothelial cells","volume":"114","author":"Zhang","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jacc.2021.09.019_bib28","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1038\/s41467-019-09831-5","article-title":"Functional cardiac fibroblasts derived from human pluripotent stem cells via second heart field progenitors","volume":"10","author":"Zhang","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jacc.2021.09.019_bib29","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1161\/CIRCRESAHA.119.315491","article-title":"Generation of quiescent cardiac fibroblasts from human induced pluripotent stem cells for in\u00a0vitro modeling of cardiac fibrosis","volume":"125","author":"Zhang","year":"2019","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2021.09.019_bib30","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.stem.2019.07.010","article-title":"Human pluripotent stem cell-derived cardiovascular cells: from developmental biology to therapeutic applications","volume":"25","author":"Protze","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jacc.2021.09.019_bib31","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/s42003-021-02237-4","article-title":"Immunological considerations and challenges for regenerative cellular therapies","volume":"4","author":"Petrus-Reurer","year":"2021","journal-title":"Commun Biol"},{"key":"10.1016\/j.jacc.2021.09.019_bib32","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1161\/CIRCRESAHA.117.310712","volume":"121","author":"Bartolucci","year":"2017","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2021.09.019_bib33","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1161\/CIRCRESAHA.117.310599","article-title":"Intravenously delivered mesenchymal stem cells: systemic anti-inflammatory effects improve left ventricular dysfunction in acute myocardial infarction and ischemic cardiomyopathy","volume":"120","author":"Luger","year":"2017","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2021.09.019_bib34","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1161\/CIRCRESAHA.116.308030","article-title":"Chronic heart failure and inflammation: what do we really know?","volume":"119","author":"Dick","year":"2016","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2021.09.019_bib35","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1093\/eurheartj\/ehy012","article-title":"Acellular therapeutic approach for heart failure: in\u00a0vitro production of extracellular vesicles from human cardiovascular progenitors","volume":"39","author":"El Harane","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2021.09.019_bib36","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.healun.2016.01.013","article-title":"Cardiovascular progenitor-derived extracellular vesicles recapitulate the beneficial effects of their parent cells in the treatment of chronic heart failure","volume":"35","author":"Kervadec","year":"2016","journal-title":"J\u00a0Heart Lung Transplant"},{"key":"10.1016\/j.jacc.2021.09.019_bib37","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1093\/cvr\/cvaa028","article-title":"Extracellular vesicles from human cardiovascular progenitors trigger a reparative immune response in infarcted hearts","volume":"117","author":"Lima Correa","year":"2021","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jacc.2021.09.019_bib38","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1161\/CIRCRESAHA.108.176826","article-title":"Paracrine mechanisms in adult stem cell signaling and therapy","volume":"103","author":"Gnecchi","year":"2008","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2021.09.019_bib39","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1161\/CIRCRESAHA.115.305373","article-title":"Emerging concepts in paracrine mechanisms in regenerative cardiovascular medicine and biology","volume":"118","author":"Hodgkinson","year":"2016","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2021.09.019_bib40","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1172\/JCI200522326","article-title":"Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction","volume":"115","author":"Yoon","year":"2005","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jacc.2021.09.019_bib41","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1161\/CIRCULATIONAHA.104.500447","article-title":"Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy","volume":"112","author":"Nagaya","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2021.09.019_bib42","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1073\/pnas.0610024104","article-title":"Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair","volume":"104","author":"Mirotsou","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jacc.2021.09.019_bib43","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1634\/stemcells.2007-0475","article-title":"SFRP2 regulates cardiomyogenic differentiation by inhibiting a positive transcriptional autofeedback loop of Wnt3a","volume":"26","author":"Deb","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.jacc.2021.09.019_bib44","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/nm1619","article-title":"Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair","volume":"13","author":"Kuhn","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.jacc.2021.09.019_bib45","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1161\/CIRCRESAHA.113.301075","article-title":"C3orf58, a novel paracrine protein, stimulates cardiomyocyte cell-cycle progression through the PI3K-AKT-CDK7 pathway","volume":"113","author":"Beigi","year":"2013","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2021.09.019_bib46","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.yjmcc.2013.11.010","article-title":"HASF is a stem cell paracrine factor that activates PKC epsilon mediated cytoprotection","volume":"66","author":"Huang","year":"2014","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1016\/j.jacc.2021.09.019_bib47","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1042\/BCJ20160976","article-title":"HASF (C3orf58) is a novel ligand of the insulin-like growth factor 1 receptor","volume":"474","author":"Bareja","year":"2017","journal-title":"Biochem J"},{"key":"10.1016\/j.jacc.2021.09.019_bib48","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.cellsig.2018.02.013","article-title":"Understanding the mechanism of bias signaling of the insulin-like growth factor 1 receptor: Effects of LL37 and HASF","volume":"46","author":"Bareja","year":"2018","journal-title":"Cell Signal"},{"key":"10.1016\/j.jacc.2021.09.019_bib49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0060161","article-title":"Bone marrow progenitor cell therapy-mediated paracrine regulation of cardiac miRNA-155 modulates fibrotic response in diabetic hearts","volume":"8","author":"Kishore","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jacc.2021.09.019_bib50","doi-asserted-by":"crossref","first-page":"H1675","DOI":"10.1152\/ajpheart.00665.2008","article-title":"Release of proinflammatory mediators and expression of proinflammatory adhesion molecules by endothelial progenitor cells","volume":"296","author":"Zhang","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jacc.2021.09.019_bib51","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1161\/CIRCRESAHA.108.178475","article-title":"Interleukin-10 from transplanted bone marrow mononuclear cells contributes to cardiac protection after myocardial infarction","volume":"103","author":"Burchfield","year":"2008","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2021.09.019_bib52","doi-asserted-by":"crossref","first-page":"H2670","DOI":"10.1152\/ajpheart.01071.2003","article-title":"Intravenous administration of mesenchymal stem cells improves cardiac function in rats with acute myocardial infarction through angiogenesis and myogenesis","volume":"287","author":"Nagaya","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jacc.2021.09.019_bib53","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1161\/01.CIR.0000124062.31102.57","article-title":"Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms","volume":"109","author":"Kinnaird","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2021.09.019_bib54","doi-asserted-by":"crossref","first-page":"H1772","DOI":"10.1152\/ajpheart.00242.2007","article-title":"Functional and bioenergetic modulations in the infarct border zone following autologous mesenchymal stem cell transplantation","volume":"293","author":"Feygin","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jacc.2021.09.019_bib55","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1002\/stem.12","article-title":"Early beneficial effects of bone marrow-derived mesenchymal stem cells overexpressing Akt on cardiac metabolism after myocardial infarction","volume":"27","author":"Gnecchi","year":"2009","journal-title":"Stem Cells"},{"key":"10.1016\/j.jacc.2021.09.019_bib56","doi-asserted-by":"crossref","first-page":"C1141","DOI":"10.1152\/ajpcell.00516.2019","article-title":"Sequential paracrine mechanisms are necessary for the therapeutic benefits of stem cell therapy","volume":"319","author":"Sun","year":"2020","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.jacc.2021.09.019_bib57","doi-asserted-by":"crossref","first-page":"11002","DOI":"10.1073\/pnas.0704421104","article-title":"Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury","volume":"104","author":"Ortiz","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jacc.2021.09.019_bib58","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1182\/blood-2004-09-3696","article-title":"Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells","volume":"105","author":"Glennie","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.jacc.2021.09.019_bib59","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1182\/blood-2007-02-074997","article-title":"Mesenchymal stem cells inhibit natural killer-cell proliferation, cytotoxicity, and cytokine production: role of indoleamine 2,3-dioxygenase and prostaglandin E2","volume":"111","author":"Spaggiari","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.jacc.2021.09.019_bib60","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/j.1365-3083.2007.01905.x","article-title":"Mesenchymal stem cells stimulate antibody secretion in human B cells","volume":"65","author":"Rasmusson","year":"2007","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.jacc.2021.09.019_bib61","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1093\/cvr\/cvy055","article-title":"Cardioprotection by cardiac progenitor cell-secreted exosomes: role of pregnancy-associated plasma protein-A","volume":"114","author":"Barile","year":"2018","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jacc.2021.09.019_bib62","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1161\/CIRCRESAHA.116.309935","article-title":"Experimental, systems, and computational approaches to understanding the microRNA-mediated reparative potential of cardiac progenitor cell-derived exosomes from pediatric patients","volume":"120","author":"Agarwal","year":"2017","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2021.09.019_bib63","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.molmed.2020.10.006","article-title":"Extracellular vesicles and biomaterial design: new therapies for cardiac repair","volume":"27","author":"Pezzana","year":"2021","journal-title":"Trends Mol Med"},{"issue":"9","key":"10.1016\/j.jacc.2021.09.019_bib64","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/s41569-021-00594-5","article-title":"Nanotherapeutics for cardiovascular disease","volume":"18","author":"Smith","year":"2021","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jacc.2021.09.019_bib65","doi-asserted-by":"crossref","first-page":"5634","DOI":"10.7150\/thno.57243","article-title":"An exosomal-carried short periostin isoform induces cardiomyocyte proliferation","volume":"11","author":"Balbi","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.jacc.2021.09.019_bib66","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1126\/science.1200708","article-title":"Transient regenerative potential of the neonatal mouse heart","volume":"331","author":"Porrello","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.jacc.2021.09.019_bib67","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1161\/CIRCULATIONAHA.118.034886","article-title":"Regenerative potential of neonatal porcine hearts","volume":"138","author":"Zhu","year":"2018","journal-title":"Circulation"},{"issue":"24","key":"10.1016\/j.jacc.2021.09.019_bib68","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1161\/CIRCULATIONAHA.117.031542","article-title":"Early regenerative capacity in the porcine heart","volume":"138","author":"Ye","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2021.09.019_bib69","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1161\/CIRCULATIONAHA.119.044619","article-title":"Apical resection prolongs the cell cycle activity and promotes myocardial regeneration after left ventricular injury in neonatal pig","volume":"142","author":"Zhao","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2021.09.019_bib70","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature20173","article-title":"Hypoxia induces heart regeneration in adult mice","volume":"541","author":"Nakada","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.jacc.2021.09.019_bib71","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1161\/CIRCRESAHA.118.312792","article-title":"Midbody positioning and distance between daughter nuclei enable unequivocal identification of cardiomyocyte cell division in mice","volume":"123","author":"Hesse","year":"2018","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2021.09.019_bib72","article-title":"Identifying the key regulators that promote cell-cycle activity in the hearts of early neonatal pigs after myocardial injury","volume":"15","author":"Zhang","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.jacc.2021.09.019_bib73","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1161\/CIRCULATIONAHA.117.031542","article-title":"Early regenerative capacity in the porcine heart","volume":"138","author":"Ye","year":"2018","journal-title":"Circulation"},{"issue":"600","key":"10.1016\/j.jacc.2021.09.019_bib74","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abd6892","article-title":"Gene therapy knockdown of Hippo signaling induces cardiomyocyte renewal in pigs after myocardial infarction","volume":"13","author":"Liu","year":"2021","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jacc.2021.09.019_bib75","doi-asserted-by":"crossref","first-page":"H1237","DOI":"10.1152\/ajpheart.00559.2015","article-title":"Cardiomyocyte proliferation in cardiac development and regeneration: a guide to methodologies and interpretations","volume":"309","author":"Leone","year":"2015","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jacc.2021.09.019_bib76","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1161\/CIRCRESAHA.116.304510","article-title":"MicroRNA induced cardiac reprogramming in\u00a0vivo: evidence for mature cardiac myocytes and improved cardiac function","volume":"116","author":"Jayawardena","year":"2015","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2021.09.019_bib77","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1161\/CIRCRESAHA.116.308741","article-title":"Demethylation of H3K27 is essential for the induction of direct cardiac reprogramming by miR combo","volume":"120","author":"Dal-Pra","year":"2017","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2021.09.019_bib78","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0223842","article-title":"Induced cardiomyocyte maturation: Cardiac transcription factors are necessary but not sufficient","volume":"14","author":"Dal-Pra","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.jacc.2021.09.019_bib79","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1100\/tsw.2011.36","article-title":"Toll-like receptors, their ligands, and atherosclerosis","volume":"11","author":"Hodgkinson","year":"2011","journal-title":"ScientificWorldJournal"},{"key":"10.1016\/j.jacc.2021.09.019_bib80","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1002\/stem.2833","article-title":"Cardiomyocyte maturation requires TLR3 activated nuclear factor kappa B","volume":"36","author":"Hodgkinson","year":"2018","journal-title":"Stem Cells"},{"key":"10.1016\/j.jacc.2021.09.019_bib81","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.omtn.2020.10.034","article-title":"Enhancing cardiac reprogramming via synthetic RNA oligonucleotides","volume":"23","author":"Hu","year":"2021","journal-title":"Mol Ther Nucleic Acids"},{"key":"10.1016\/j.jacc.2021.09.019_bib82","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.stem.2019.05.020","article-title":"Single-cell transcriptomic analyses of cell fate transitions during human cardiac reprogramming","volume":"25","author":"Zhou","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jacc.2021.09.019_bib83","first-page":"212","article-title":"Etv2 is a master regulator of hematoendothelial lineages","volume":"127","author":"Garry","year":"2016","journal-title":"Trans Am Clin Climatol Assoc"},{"key":"10.1016\/j.jacc.2021.09.019_bib84","doi-asserted-by":"crossref","first-page":"9736","DOI":"10.1038\/s41598-019-45841-5","article-title":"Etv2 transcriptionally regulates Yes1 and promotes cell proliferation during embryogenesis","volume":"9","author":"Singh","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.jacc.2021.09.019_bib85","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1161\/ATVBAHA.120.314488","article-title":"ETV2 (Ets Variant Transcription Factor 2)-Rhoj cascade regulates endothelial progenitor cell migration during embryogenesis","volume":"40","author":"Singh","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jacc.2021.09.019_bib86","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1161\/CIRCRESAHA.118.311217","article-title":"Clinical studies of cell therapy in cardiovascular medicine: recent developments and future directions","volume":"123","author":"Banerjee","year":"2018","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2021.09.019_bib87","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1161\/CIRCRESAHA.118.312823","article-title":"Safety and efficacy of intracoronary infusion of allogeneic human cardiac stem cells in patients with ST-segment elevation myocardial infarction and left ventricular dysfunction","volume":"123","author":"Fern\u00e1ndez-Avil\u00e9s","year":"2018","journal-title":"Circ Res"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109721063208?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109721063208?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:46:40Z","timestamp":1760017600000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109721063208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":87,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["S0735109721063208"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2021.09.019","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Basic and Translational Research in Cardiac Repair and Regeneration","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2021.09.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}]}}