{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:32:11Z","timestamp":1791232331644,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.jacc.2021.11.059","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T15:06:57Z","timestamp":1645456017000},"page":"789-801","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"title":["Impact of Autophagy on Prognosis of Patients With Dilated Cardiomyopathy"],"prefix":"10.1016","volume":"79","author":[{"given":"Hiromitsu","family":"Kanamori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genki","family":"Naruse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Endo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Minatoguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takatomo","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomonori","family":"Kawaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiki","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihisa","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Takasugi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuma","family":"Ishihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Mikami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagisa","family":"Miyazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Nishigaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Minatoguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuhiko","family":"Miyazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Okura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2021.11.059_bib1","doi-asserted-by":"crossref","first-page":"e579","DOI":"10.1161\/CIR.0000000000000455","article-title":"Current diagnostic and treatment strategies for specific dilated cardiomyopathies: a scientific statement from the American Heart Association","volume":"134","author":"Bozkurt","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2021.11.059_bib2","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/S0140-6736(09)62023-7","article-title":"Dilated cardiomyopathy","volume":"375","author":"Jefferies","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2021.11.059_bib3","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/ejhf.1103","article-title":"Evolving concepts in dilated cardiomyopathy","volume":"20","author":"Merlo","year":"2018","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jacc.2021.11.059_bib4","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/ejhf.16","article-title":"Long-term prognostic impact of therapeutic strategies in patients with idiopathic dilated cardiomyopathy: changing mortality over the last 30 years","volume":"16","author":"Merlo","year":"2014","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jacc.2021.11.059_bib5","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1016\/j.jacc.2010.11.030","article-title":"Prevalence and prognostic significance of left ventricular reverse remodeling in dilated cardiomyopathy receiving tailored medical treatment","volume":"57","author":"Merlo","year":"2011","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.11.059_bib6","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.amjcard.2011.10.033","article-title":"How can optimization of medical treatment avoid unnecessary implantable cardioverter-defibrillator implantations in patients with idiopathic dilated cardiomyopathy presenting with \u201cSCD-HeFT criteria\u201d?","volume":"109","author":"Zecchin","year":"2012","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2021.11.059_bib7","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.118.005220","article-title":"Clinical phenotype and genotype associations with improvement in left ventricular function in dilated cardiomyopathy","volume":"11","author":"Verdonschot","year":"2018","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jacc.2021.11.059_bib8","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0002-9149(99)00414-2","article-title":"Prevalence, predictors, and prognosis of reversal of maladaptive remodeling with intensive medical therapy in idiopathic dilated cardiomyopathy","volume":"84","author":"Kawai","year":"1999","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2021.11.059_bib9","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jacc.2012.07.072","article-title":"Novel predictors of left ventricular reverse remodeling in individuals with recent-onset dilated cardiomyopathy","volume":"61","author":"Kubanek","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.11.059_bib10","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S0002-8703(03)00148-0","article-title":"Prognostic significance of morphometric endomyocardial biopsy analysis in patients with idiopathic dilated cardiomyopathy","volume":"146","author":"Grimm","year":"2003","journal-title":"Am Heart J"},{"key":"10.1016\/j.jacc.2021.11.059_bib11","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.amjcard.2015.06.022","article-title":"Contemporary outcome in patients with idiopathic dilated cardiomyopathy","volume":"116","author":"Broch","year":"2015","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2021.11.059_bib12","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1007\/s00380-016-0815-0","article-title":"Clinical significance of endomyocardial biopsy in conjunction with cardiac magnetic resonance imaging to predict left ventricular reverse remodeling in idiopathic dilated cardiomyopathy","volume":"31","author":"Ishii","year":"2016","journal-title":"Heart Vessels"},{"key":"10.1016\/j.jacc.2021.11.059_bib13","first-page":"670","article-title":"Quantification of DNA damage in heart tissue as a novel prediction tool for therapeutic prognosis of patients with dilated cardiomyopathy","volume":"4","author":"Ko","year":"2019","journal-title":"J\u00a0Am Coll Cardiol Basic Trans Science"},{"key":"10.1016\/j.jacc.2021.11.059_bib14","doi-asserted-by":"crossref","first-page":"e147","DOI":"10.1016\/j.jacc.2013.05.019","article-title":"2013 ACCF\/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines","volume":"62","author":"Yancy","year":"2013","journal-title":"J Am Coll Cardiol."},{"key":"10.1016\/j.jacc.2021.11.059_bib15","doi-asserted-by":"crossref","first-page":"445","DOI":"10.4161\/auto.19496","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy","volume":"8","author":"Klionsky","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.jacc.2021.11.059_bib16","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1056\/NEJMra1205406","article-title":"Autophagy in human health and disease","volume":"368","author":"Choi","year":"2013","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2021.11.059_bib17","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1080\/15548627.2016.1145326","article-title":"Autophagic vacuoles in cardiomyocytes of dilated cardiomyopathy with initially decompensated heart failure predict improved prognosis","volume":"12","author":"Saito","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.jacc.2021.11.059_bib18","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1161\/01.RES.0000067471.95890.5C","article-title":"Myocytes die by multiple mechanisms in failing human hearts","volume":"92","author":"Kostin","year":"2003","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2021.11.059_bib19","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.ajpath.2012.11.009","article-title":"Resveratrol reverses remodeling in hearts with large, old myocardial infarctions through enhanced autophagy-activating AMP kinase pathway","volume":"182","author":"Kanamori","year":"2013","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jacc.2021.11.059_bib20","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1093\/cvr\/cvs282","article-title":"Prior starvation mitigates acute doxorubicin cardiotoxicity through restoration of autophagy in affected cardiomyocytes","volume":"96","author":"Kawaguchi","year":"2012","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jacc.2021.11.059_bib21","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.ajpath.2014.01.011","article-title":"Restriction of food intake prevents postinfarction heart failure by enhancing autophagy in the surviving cardiomyocytes","volume":"184","author":"Watanabe","year":"2014","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jacc.2021.11.059_bib22","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1080\/15548627.2015.1051295","article-title":"Autophagic adaptations in diabetic cardiomyopathy differ between type 1 and type 2 diabetes","volume":"11","author":"Kanamori","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.jacc.2021.11.059_bib23","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.118.005418","article-title":"Metformin enhances autophagy and provides cardioprotection in \u03b4-sarcoglycan deficiency\u2013induced dilated cardiomyopathy","volume":"12","author":"Kanamori","year":"2019","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jacc.2021.11.059_bib24","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1136\/hrt.44.6.672","article-title":"Report of the WHO\/ISFC Task Force on the Definition and Classification of Cardiomyopathies","volume":"44","year":"1980","journal-title":"Br Heart J"},{"key":"10.1016\/j.jacc.2021.11.059_bib25","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1161\/01.CIR.93.5.841","article-title":"Report of the 1995 World Health Organization\/International Society and Federation of Cardiology Task Force on the Definition and Classification of cardiomyopathies","volume":"93","author":"Richardson","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2021.11.059_bib26","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1002\/ehf2.13216","article-title":"A\u00a0clinical score for predicting left ventricular reverse remodelling in patients with dilated cardiomyopathy","volume":"8","author":"Kimura","year":"2021","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.jacc.2021.11.059_bib27","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S0894-7317(89)80014-8","article-title":"Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms","volume":"2","author":"Schiller","year":"1989","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.jacc.2021.11.059_bib28","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.ejheart.2004.09.016","article-title":"Semiquantitative histomorphometric analysis of myocardium following partial left ventriculectomy: 1-year follow-up","volume":"7","author":"Vasiljevi\u0107","year":"2005","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jacc.2021.11.059_bib29","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.amjcard.2014.06.021","article-title":"Frequency of recovery and relapse in patients with nonischemic dilated cardiomyopathy on guideline-directed medical therapy","volume":"114","author":"Gupta","year":"2014","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2021.11.059_bib30","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/BF00174615","article-title":"Developmental cell death: morphological diversity and multiple mechanisms","volume":"181","author":"Clarke","year":"1990","journal-title":"Anat Embryol (Berl)"},{"key":"10.1016\/j.jacc.2021.11.059_bib31","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1056\/NEJMra063052","article-title":"The failing heart\u2014an engine out of fuel","volume":"356","author":"Stefan","year":"2007","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2021.11.059_bib32","doi-asserted-by":"crossref","first-page":"S191","DOI":"10.1161\/CIRCULATIONAHA.108.842252","article-title":"Markers of autophagy are downregulated in failing human heart after mechanical unloading","volume":"120","author":"Kassiotis","year":"2009","journal-title":"Circulation"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109721084527?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109721084527?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:47:59Z","timestamp":1760017679000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109721084527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["S0735109721084527"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2021.11.059","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of Autophagy on Prognosis of Patients With Dilated Cardiomyopathy","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2021.11.059","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}