{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T15:42:38Z","timestamp":1793806958273,"version":"4.6.1"},"reference-count":78,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T00:00:00Z","timestamp":1639958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007723","name":"Takeda Pharmaceuticals U.S.A.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007723","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.jacc.2021.12.002","type":"journal-article","created":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T15:25:05Z","timestamp":1643037905000},"page":"372-389","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":637,"title":["Diagnosis and Evaluation of Hypertrophic\u00a0Cardiomyopathy"],"prefix":"10.1016","volume":"79","author":[{"given":"Barry J.","family":"Maron","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milind Y.","family":"Desai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick A.","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Spirito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Rakowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Towbin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan J.","family":"Rowin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin S.","family":"Maron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark V.","family":"Sherrid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2021.12.002_bib1","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1056\/NEJMra1710575","article-title":"Clinical course and management of hypertrophic cardiomyopathy","volume":"379","author":"Maron","year":"2018","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2021.12.002_bib2","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1001\/jamacardio.2015.0354","article-title":"How hypertrophic cardiomyopathy became a contemporary treatable genetic disease with low mortality: shaped by 50 years of clinical research and practice","volume":"1","author":"Maron","year":"2016","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jacc.2021.12.002_bib3","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.jcmg.2016.05.003","article-title":"The remarkable 50 years of imaging in HCM and how it has changed diagnosis and management: from M-mode echocardiography to CMR","volume":"9","author":"Maron","year":"2016","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jacc.2021.12.002_bib4","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1016\/j.jcmg.2019.09.020","article-title":"The hypertrophic cardiomyopathy phenotype viewed through the prism of multimodality imaging: clinical and etiologic implications","volume":"13","author":"Rowin","year":"2020","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jacc.2021.12.002_bib5","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jacc.2009.05.006","article-title":"Hypertrophic cardiomyopathy phenotype revisited after 50 years with cardiovascular magnetic resonance","volume":"54","author":"Maron","year":"2009","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.12.002_bib6","doi-asserted-by":"crossref","first-page":"e159","DOI":"10.1016\/j.jacc.2020.08.045","article-title":"2020 AHA\/ACC Guideline for the diagnosis and treatment of patients with hypertrophic cardiomyopathy","volume":"76","author":"Ommen","year":"2020","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"25","key":"10.1016\/j.jacc.2021.12.002_bib7","doi-asserted-by":"crossref","first-page":"e212","DOI":"10.1016\/j.jacc.2011.06.011","volume":"58","author":"Gersh","year":"2011","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.12.002_bib8","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1093\/eurheartj\/ehu284","article-title":"2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy: the Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC)","volume":"35","author":"Elliott","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2021.12.002_bib9","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1016\/j.amjcard.2017.08.048","article-title":"Interaction of adverse disease-related pathways in hypertrophic cardiomyopathy","volume":"120","author":"Rowin","year":"2017","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2021.12.002_bib10","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1001\/jama.281.7.650","article-title":"Clinical course of hypertrophic cardiomyopathy in a regional United States cohort","volume":"281","author":"Maron","year":"1999","journal-title":"JAMA"},{"key":"10.1016\/j.jacc.2021.12.002_bib11","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1161\/CIRCULATIONAHA.112.123174","article-title":"Evolution of hypertrophic cardiomyopathy to a contemporary treatable disease","volume":"126","author":"Maron","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2021.12.002_bib12","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1016\/j.amjcard.2020.01.040","article-title":"Hypertrophic cardiomyopathy in \u201cReal World\u201d community cardiology practice","volume":"125","author":"Rowin","year":"2020","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2021.12.002_bib13","doi-asserted-by":"crossref","first-page":"329","DOI":"10.21037\/acs.2017.07.03","article-title":"Hypertrophic obstructive cardiomyopathy: the Mayo Clinic experience","volume":"6","author":"Kotkar","year":"2017","journal-title":"Ann Cardiothorac Surg"},{"key":"10.1016\/j.jacc.2021.12.002_bib14","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.jacc.2005.02.090","article-title":"Long-term effects of surgical septal myectomy on survival in patients with obstructive hypertrophic cardiomyopathy","volume":"46","author":"Ommen","year":"2005","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.12.002_bib15","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1161\/CIRCULATIONAHA.112.000849","article-title":"Predictors of long-term outcomes in symptomatic hypertrophic obstructive cardiomyopathy patients undergoing surgical relief of left ventricular outflow tract obstruction","volume":"128","author":"Desai","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2021.12.002_bib16","first-page":"2289","article-title":"Surgical management of left ventricular outflow tract obstruction in a specialized hypertrophic obstructive cardiomyopathy center","volume":"157","author":"Hodges","year":"2019","journal-title":"J\u00a0Cardiovasc Surg"},{"key":"10.1016\/j.jacc.2021.12.002_bib17","first-page":"353","article-title":"Clinical spectrum and management of heart failure in hypertrophic cardiomyopathy","volume":"6","author":"Maron","year":"2018","journal-title":"J\u00a0Am Coll Cardiol HF"},{"key":"10.1016\/j.jacc.2021.12.002_bib18","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1001\/jamacardio.2019.1391","article-title":"Enhanced American College Cardiology\/American Heart Association strategy for prevention of sudden cardiac death in high risk patients with hypertrophic cardiomyopathy","volume":"4","author":"Maron","year":"2019","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jacc.2021.12.002_bib19","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.hrthm.2021.01.019","article-title":"Evolution of risk stratification and sudden death prevention in hypertrophic cardiomyopathy: twenty years with the implantable cardioverter-defibrillator","volume":"18","author":"Maron","year":"2021","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacc.2021.12.002_bib20","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1161\/CIRCULATIONAHA.117.029267","article-title":"Clinical profile and consequences of atrial fibrillation in hypertrophic cardiomyopathy","volume":"136","author":"Rowin","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2021.12.002_bib21","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.jacc.2016.01.023","article-title":"Contemporary natural history and management of nonobstructive hypertrophic cardiomyopathy","volume":"67","author":"Maron","year":"2016","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.12.002_bib22","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1016\/j.jacc.2020.04.045","article-title":"Outcomes in patients with hypertrophic cardiomyopathy and left ventricular systolic dysfunction","volume":"75","author":"Rowin","year":"2020","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.12.002_bib23","series-title":"A\u00a0Guide to Hypertrophic Cardiomyopathy for Patients, Their Families, and Interested Physicians","author":"Maron","year":"2014"},{"key":"10.1016\/j.jacc.2021.12.002_bib24","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1016\/S0735-1097(03)00941-0","article-title":"American College of Cardiology\/European Society of Cardiology clinical expert consensus document of hypertrophic cardiomyopathy","volume":"42","author":"Maron","year":"2003","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.12.002_bib25","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/j.amjcard.2018.06.055","article-title":"Clinical spectrum and management implications of left ventricular outflow obstruction with mild ventricular septal thickness in hypertrophic cardiomyopathy","volume":"122","author":"Rowin","year":"2018","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2021.12.002_bib26","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1161\/CIRCULATIONAHA.118.037264","article-title":"Clinical course and significance of hypertrophic cardiomyoapthy without left ventricular hypertrophy","volume":"139","author":"Maurizi","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2021.12.002_bib27","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1001\/jamacardio.2019.2861","article-title":"Development of a novel risk prediction model for sudden cardiac death in childhood hypertrophic cardiomyopathy (HCM Risk-Kids)","volume":"4","author":"Norrish","year":"2019","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jacc.2021.12.002_bib28","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jcmg.2008.09.008","article-title":"Hypertrophic cardiomyopathy without hypertrophy: an emerging preclinical subgroup composed of genetically affected family members","volume":"2","author":"Maron","year":"2009","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jacc.2021.12.002_bib29","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.jcmg.2017.07.016","article-title":"Role of exercise testing in hypertrophic cardiomyopathy","volume":"10","author":"Rowin","year":"2017","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jacc.2021.12.002_bib30","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1016\/j.jcmg.2018.07.016","article-title":"Prognostic value of global longitudinal strain in hypertrophic cardiomyopathy: a systematic review of existing literature","volume":"12","author":"Tower-Radar","year":"2019","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jacc.2021.12.002_bib31","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.amjcard.2021.04.021","article-title":"Usefulness of global longitudinal strain to predict heart failure progression in patients with nonobstructive hypertrophic cardiomyopathy","volume":"151","author":"Rowin","year":"2021","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2021.12.002_bib32","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1161\/CIRCULATIONAHA.110.985812","article-title":"Mitral valve abnormalities identified by cardiovascular magnetic resonance represent a primary phenotypic expression of hypertrophic cardiomyopathy","volume":"124","author":"Maron","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2021.12.002_bib33","first-page":"1394","article-title":"Spectrum and clinical significance of systolic function and myocardial fibrosis assessed by cardiovascular magnetic resonance in hypertrophic cardiomyopathy","volume":"113","author":"Olivotto","year":"2014","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2021.12.002_bib34","article-title":"Prevalence of unxplained left ventricular hypertrophy by cardiac magnetic resonance imaging in MESA","volume":"8","author":"Massera","year":"2019","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jacc.2021.12.002_bib35","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1161\/CIRCULATIONAHA.113.007094","article-title":"Prognostic value of quantitative contrast-enhanced cardiovascular magnetic resonance for the evaluation of sudden death risk in patients with hypertrophic cardiomyopathy","volume":"130","author":"Chan","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2021.12.002_bib36","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.jcmg.2016.02.031","article-title":"Prognostic value of LGE-CMR in HCM: a meta-analysis","volume":"9","author":"Weng","year":"2016","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jacc.2021.12.002_bib37","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.jcmg.2020.09.037","article-title":"Progression of myocardial fibrosis in hypertrophic cardiomyopathy: A cardiac magnetic resonance study","volume":"14","author":"Habib","year":"2021","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jacc.2021.12.002_bib38","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1161\/CIRCULATIONAHA.117.032966","article-title":"Prevance and progression of late gadolinium enhancement in children and adolscents with hypertrophic cardiomyopathy","volume":"138","author":"Raja","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2021.12.002_bib39","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1161\/01.CIR.91.5.1596","article-title":"Cardiac disease in young trained athletes. Insights into methods for distinguishing athlete\u2019s heart from structural heart disease with particular emphasis on hypertrophic cardiomyopathy","volume":"91","author":"Maron","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2021.12.002_bib40","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1001\/jamacardio.2017.2352","article-title":"Role of genetic testing in inherited cardiovascular disease: a review","volume":"2","author":"Cirino","year":"2017","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jacc.2021.12.002_bib41","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1016\/j.jacc.2016.08.079","article-title":"Clinical and mechanistic insights into the genetics of cardiomyopathy","volume":"68","author":"Burke","year":"2016","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.12.002_bib42","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.jacc.2012.02.068","article-title":"Genetics of hypertrophic cardiomyopathy after 20 years: clinical perspectives","volume":"60","author":"Maron","year":"2012","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.12.002_bib43","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1161\/CIRCULATIONAHA.111.090514","article-title":"Penetrance of hypertrophic cardiomyopathy in children and adolscents: a 12-year follow-up study of clinical screening and predictive genetic testing","volume":"127","author":"Jensen","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2021.12.002_bib44","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.jacc.2020.06.011","article-title":"Penetrance of hypertrophic cardiomyopathy in sarcomere protein mutation carriers","volume":"76","author":"Lorenzi","year":"2020","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.12.002_bib45","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1038\/s41431-019-0377-6","article-title":"Perceptions of genetic variant reclassification in patients with inherited cardiac disease","volume":"27","author":"Wong","year":"2019","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.jacc.2021.12.002_bib46","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGEN.119.002460","article-title":"Evaluating the clinical validity of hypertrophic cardiomyopathy genes","volume":"12","author":"Ingles","year":"2019","journal-title":"Circ Genom Precis Med"},{"key":"10.1016\/j.jacc.2021.12.002_bib47","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1016\/j.jacc.2019.01.061","article-title":"Moving beyond the sarcomere to explain heterogeneity in hypertrophic cardiomyopathy: JACC Review Topic of the Week","volume":"73","author":"Maron","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.12.002_bib48","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s12265-014-9542-z","article-title":"Distinguishing hypertrophic cardiomyopathy from background genetic noise","volume":"7","author":"Kapplinger","year":"2014","journal-title":"J\u00a0Cardiovasc Transl Res"},{"key":"10.1016\/j.jacc.2021.12.002_bib49","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1161\/CIRCULATIONAHA.117.033200","article-title":"Genotype and lifetime burden of disease in hypertrophic cardiomyopathy: insights from the Sarcomeric Human Cardiomyopathy Registry (SHaRE)","volume":"138","author":"Ho","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2021.12.002_bib50","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1056\/NEJMsa1507092","article-title":"Genetic misdiagnoses and the potential for health disparities","volume":"375","author":"Manari","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2021.12.002_bib51","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.jacc.2021.07.017","article-title":"Phenotypic expression and outcomes in individuals with rare genetic variants of hypertrophic cardiomyopathy","volume":"78","author":"deMarvao","year":"2021","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.12.002_bib52","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.mayocp.2014.01.025","article-title":"Characterization of a phenotype-based genetic test prediction score for unrelated patients with hypertrophic cardiomyopathy","volume":"89","author":"Bos","year":"2014","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.jacc.2021.12.002_bib53","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1161\/CIRCGENETICS.112.963363","article-title":"Toronto hypertrophic cardiomyopathy genotype score for prediction of a positive genotype in hypertrophic cardiomyopathy","volume":"6","author":"Gruner","year":"2013","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1016\/j.jacc.2021.12.002_bib54","doi-asserted-by":"crossref","first-page":"641","DOI":"10.5114\/aoms.2018.78767","article-title":"The utility of the Mayo Score for predicting the yield of genetic testing in patients with hypertrophic cardiomyopathy","volume":"15","author":"Bonaventura","year":"2019","journal-title":"Arch Med Sci"},{"key":"10.1016\/j.jacc.2021.12.002_bib55","first-page":"121","article-title":"Diagnostic yield of genetic testing in a heterogeneous cohort of 1376 HCM patients","author":"Hathaway","year":"2021","journal-title":"BMC Cardiovasc Discord"},{"key":"10.1016\/j.jacc.2021.12.002_bib56","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/s41467-021-21146-y","article-title":"Individualized interactomes for network-based precision medicine in hypertrophic cardiomyopathy with implications for other clinical pathophenotypes","volume":"12","author":"Maron","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.jacc.2021.12.002_bib57","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1161\/CIRCULATIONAHA.119.042339","article-title":"Myosin sequestration regulates sarcomere function, cardiomyocyte energetics and metabolism, informing the pathogenesis of hypertrophic cardiomyopathy","volume":"141","author":"Toepfer","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2021.12.002_bib58","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1001\/jama.2009.371","article-title":"Clinical outcome and phenotypic expression in LAMP2 cardiomyopathy","volume":"301","author":"Maron","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.jacc.2021.12.002_bib59","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1016\/j.jacc.2004.08.052","article-title":"Proposal for contemporary screening strategies in families with hypertrophic cardiomyopathy","volume":"44","author":"Maron","year":"2004","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.12.002_bib60","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/0002-9149(89)90187-2","article-title":"Relation of electrocardiographic abnormalities to evolving left ventricular hypertrophy abnormalities to evolving left ventricular hypertrophy in hypertrophic cardiomyopathy during childhood","volume":"63","author":"Panza","year":"1989","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2021.12.002_bib61","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1161\/CIRCULATIONAHA.118.038846","article-title":"Yield of clinical screening for hypertrophic cardiomyopathy in child first-degree relatives","volume":"140","author":"Norrish","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2021.12.002_bib62","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1016\/j.amjcard.2011.07.048","article-title":"Onset of apical hypertrophic cardiomyopathy in adulthood","volume":"108","author":"Maron","year":"2011","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2021.12.002_bib63","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGENETICS.116.001620","article-title":"Nonfamilial hypertrophic cardiomyopathy: prevalence, natural history, and clinical implications","volume":"10","author":"Ingles","year":"2017","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1016\/j.jacc.2021.12.002_bib64","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.amjmed.2016.02.031","article-title":"Demographics and epidemiology of sudden deaths in young competitive athletes: From the United States National Registry","volume":"129","author":"Maron","year":"2016","journal-title":"Am J Med"},{"key":"10.1016\/j.jacc.2021.12.002_bib65","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/j.amjcard.2015.07.072","article-title":"Historical perspectives on sudden deaths in young athletes with evolution over 35 years","volume":"116","author":"Maron","year":"2015","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2021.12.002_bib66","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1016\/j.jacc.2015.09.035","article-title":"Eligibility and disqualification recommendations for competitive athletes with cardiovascular abnormalities: Task Force 3: hypertrophic cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy and other cardiomyopathies, and myocarditis","volume":"66","author":"Maron","year":"2015","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.12.002_bib67","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1016\/j.jacc.2019.03.497","article-title":"Structurally normal hearts are uncommonly associated with sudden deaths in athletes and young people","volume":"73","author":"Thiene","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.12.002_bib68","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1056\/NEJMoa1510687","article-title":"A\u00a0prospective study of sudden cardiac death among children and young adults","volume":"374","author":"Bagnall","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2021.12.002_bib69","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1161\/CIRCULATIONAHA.119.040271","article-title":"Hypertrophic cardiomyopathy-related sudden cardiac death in young people in Ontario","volume":"140","author":"Weissler-Snir","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2021.12.002_bib70","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.amjcard.2020.04.021","article-title":"Hypertrophic cardiomyopathy and sudden death initially identified at autopsy","volume":"127","author":"Maron","year":"2020","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2021.12.002_bib71","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/j.jacc.2005.02.006","article-title":"36th Bethesda Conference: eligibility recommendations for competitive athletes with cardiovascular abnormalities","volume":"45","author":"Maron","year":"2005","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2021.12.002_bib72","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1161\/CIRCULATIONAHA.106.644682","article-title":"Hypertrophic cardiomyopathy is predominantly a disease of left ventricular outflow tract obstruction","volume":"114","author":"Maron","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2021.12.002_bib73","first-page":"545","article-title":"2020 ESC guidelines on sports cardiology and exercise in patients with cardiovascular disease","volume":"74","author":"Pelliccia","year":"2021","journal-title":"Rev Esp Cardiol"},{"key":"10.1016\/j.jacc.2021.12.002_bib74","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/nrcardio.2017.6","article-title":"Shared decision-making in HCM","volume":"14","author":"Maron","year":"2017","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jacc.2021.12.002_bib75","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1056\/NEJM199811263392211","article-title":"Competitive athletes with cardiovascular disease-the case of Nicholas Knapp","volume":"339","author":"Maron","year":"1998","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2021.12.002_bib76","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1161\/CIRCULATIONAHA.112.000447","article-title":"Safety of sports for athletes with implantable cardioverter-defibrillators: results of a prospective, multinational registry","volume":"127","author":"Lampert","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2021.12.002_bib77","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1001\/jama.2017.2503","article-title":"Effects of moderate-intensity exercise training on peak oxygen consumption in patients with hypertrophic cardiomyopathy: A randomized clinical trial","volume":"317","author":"Saberi","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.jacc.2021.12.002_bib78","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0140-6736(18)31825-7","article-title":"Longevity in elite athletes: The first 4-minute milers","volume":"392","author":"Maron","year":"2018","journal-title":"Lancet"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109721082735?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109721082735?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:47:57Z","timestamp":1760017677000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109721082735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":78,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["S0735109721082735"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2021.12.002","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diagnosis and Evaluation of Hypertrophic\u00a0Cardiomyopathy","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2021.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2021.11.021","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}]}}