{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:57:19Z","timestamp":1792637839257,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"24","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T00:00:00Z","timestamp":1687305600000},"content-version":"vor","delay-in-days":385,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.jacc.2022.03.385","type":"journal-article","created":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T14:05:43Z","timestamp":1655129143000},"page":"2367-2378","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":100,"title":["Safety of Provocative Testing With Intracoronary Acetylcholine and Implications for Standard Protocols"],"prefix":"10.1016","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0423-4715","authenticated-orcid":false,"given":"Tatsunori","family":"Takahashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce A.","family":"Samuels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7787-4353","authenticated-orcid":false,"given":"Weijia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish A.","family":"Parikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery W.","family":"Moses","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William F.","family":"Fearon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy D.","family":"Henry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Tremmel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhei","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2022.03.385_bib1","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1161\/CIRCULATIONAHA.116.024534","article-title":"Ischemia and no obstructive coronary artery disease (INOCA): developing evidence-based therapies and research agenda for the next decade","volume":"135","author":"Bairey Merz","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2022.03.385_bib2","first-page":"143","article-title":"ESC working group position paper on myocardial infarction with non-obstructive coronary arteries","volume":"38","author":"Agewall","year":"2017","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2022.03.385_bib3","doi-asserted-by":"crossref","first-page":"3504","DOI":"10.1093\/eurheartj\/ehaa503","volume":"41","author":"Kunadian","year":"2020","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2022.03.385_bib4","first-page":"2565","article-title":"International standardization of diagnostic criteria for vasospastic angina","volume":"38","author":"Beltrame","year":"2017","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2022.03.385_bib5","doi-asserted-by":"crossref","first-page":"e187","DOI":"10.1016\/j.jacc.2021.07.053","article-title":"2021 AHA\/ACC\/ASE\/CHEST\/SAEM\/SCCT\/SCMR guideline for the evaluation and diagnosis of chest pain: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"78","author":"Gulati","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2022.03.385_bib6","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1016\/j.jacc.2018.09.006","article-title":"Stratified medical therapy using invasive coronary function testing in angina: the CorMicA Trial","volume":"72","author":"Ford","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2022.03.385_bib7","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1016\/j.jcin.2020.05.009","article-title":"Long-term follow-up in patients with stable angina and unobstructed coronary arteries undergoing intracoronary acetylcholine testing","volume":"13","author":"Seitz","year":"2020","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jacc.2022.03.385_bib8","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ijcard.2017.05.109","article-title":"Safety of intracoronary provocative testing for the diagnosis of coronary artery spasm","volume":"244","author":"Ciliberti","year":"2017","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacc.2022.03.385_bib9","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/S0735-1097(99)00073-X","article-title":"Racial heterogeneity in coronary artery vasomotor reactivity: differences between Japanese and Caucasian patients","volume":"33","author":"Beltrame","year":"1999","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2022.03.385_bib10","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1161\/01.CIR.101.10.1102","article-title":"Major racial differences in coronary constrictor response between Japanese and Caucasians with recent myocardial infarction","volume":"101","author":"Pristipino","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2022.03.385_bib11","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.jacc.2022.03.385_bib12","author":"National Heart"},{"key":"10.1016\/j.jacc.2022.03.385_bib13","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/2049-3258-72-39","article-title":"Metaprop: a Stata command to perform meta-analysis of binomial data","volume":"72","author":"Nyaga","year":"2014","journal-title":"Arch Public Health"},{"key":"10.1016\/j.jacc.2022.03.385_bib14","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1136\/jech-2013-203104","article-title":"Meta-analysis of prevalence","volume":"67","author":"Barendregt","year":"2013","journal-title":"J\u00a0Epidemiol Community Health"},{"key":"10.1016\/j.jacc.2022.03.385_bib15","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1016\/j.jacc.2022.03.385_bib16","doi-asserted-by":"crossref","first-page":"d4002","DOI":"10.1136\/bmj.d4002","article-title":"Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials","volume":"343","author":"Sterne","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.jacc.2022.03.385_bib17","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.jclinepi.2014.03.003","article-title":"In meta-analyses of proportion studies, funnel plots were found to be an inaccurate method of assessing publication bias","volume":"67","author":"Hunter","year":"2014","journal-title":"J\u00a0Clin Epidemiol"},{"key":"10.1016\/j.jacc.2022.03.385_bib18","article-title":"Closing the gap between methodologists and end-users: R as a computational back-end","volume":"49","author":"Wallace","year":"2011","journal-title":"J\u00a0Stat Softw"},{"key":"10.1016\/j.jacc.2022.03.385_bib19","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.trsl.2020.11.009","article-title":"Revisiting the use of the provocative acetylcholine test in patients with chest pain and nonobstructive coronary arteries: a five-year follow-up of the AChPOL registry, with special focus on patients with MINOCA","volume":"231","author":"Bil","year":"2021","journal-title":"Transl Res"},{"key":"10.1016\/j.jacc.2022.03.385_bib20","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ijcard.2017.08.002","article-title":"Effect of coronary artery spasm on long-term outcomes in survivors of acute myocardial infarction","volume":"257","author":"Deyama","year":"2018","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacc.2022.03.385_bib21","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.119.008126","article-title":"Ischemia and no obstructive coronary artery disease: prevalence and correlates of coronary vasomotion disorders","volume":"12","author":"Ford","year":"2019","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.jacc.2022.03.385_bib22","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.jacc.2020.12.019","article-title":"Absolute coronary blood flow measured by continuous thermodilution in patients with ischemia and nonobstructive disease","volume":"77","author":"Konst","year":"2021","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2022.03.385_bib23","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.atherosclerosis.2016.09.015","article-title":"Impact of vasomotion type on prognosis of coronary artery spasm induced by acetylcholine provocation test of left coronary artery","volume":"257","author":"Lee","year":"2017","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jacc.2022.03.385_bib24","article-title":"Interplay between myocardial bridging and coronary spasm in patients with myocardial ischemia and non-obstructive coronary arteries: pathogenic and prognostic implications","volume":"10","author":"Montone","year":"2021","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jacc.2022.03.385_bib25","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1161\/CIRCULATIONAHA.113.004096","article-title":"Clinical usefulness, angiographic characteristics, and safety evaluation of intracoronary acetylcholine provocation testing among 921 consecutive white patients with unobstructed coronary arteries","volume":"129","author":"Ong","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2022.03.385_bib26","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.119.008587","article-title":"Dose-response relationship between intracoronary acetylcholine and minimal lumen diameter in coronary endothelial function testing of women and men with angina and no obstructive coronary artery disease","volume":"13","author":"Pargaonkar","year":"2020","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.jacc.2022.03.385_bib27","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1177\/2048872620932422","article-title":"Safety assessment and results of coronary spasm provocation testing in patients with myocardial infarction with unobstructed coronary arteries compared to patients with stable angina and unobstructed coronary arteries","volume":"10","author":"Probst","year":"2021","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"key":"10.1016\/j.jacc.2022.03.385_bib28","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.4244\/EIJ-D-18-00920","article-title":"Prevalence of myocardial bridging associated with coronary endothelial dysfunction in patients with chest pain and nonobstructive coronary artery disease","volume":"15","author":"Sara","year":"2020","journal-title":"EuroIntervention"},{"issue":"4","key":"10.1016\/j.jacc.2022.03.385_bib29","article-title":"Coronary vasomotor response to intracoronary acetylcholine injection, clinical features, and long-term prognosis in 873 consecutive patients with coronary spasm: analysis of a single-center study over 20 years","volume":"2","author":"Sato","year":"2013","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jacc.2022.03.385_bib30","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1007\/s00380-020-01616-x","article-title":"Pharmacological spasm provocation testing in 2500 patients: provoked spasm incidence, complications and cardiac events","volume":"35","author":"Sueda","year":"2020","journal-title":"Heart Vessels"},{"key":"10.1016\/j.jacc.2022.03.385_bib31","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1093\/eurheartj\/ehs199","article-title":"Clinical implications of provocation tests for coronary artery spasm: safety, arrhythmic complications, and prognostic impact: multicentre registry study of the Japanese Coronary Spasm Association","volume":"34","author":"Takagi","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2022.03.385_bib32","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ijcard.2018.06.108","article-title":"Safety and usefulness of acetylcholine provocation test in patients with no culprit lesions on emergency coronary angiography","volume":"269","author":"Tateishi","year":"2018","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacc.2022.03.385_bib33","doi-asserted-by":"crossref","first-page":"133","DOI":"10.2310\/6650.2002.31305","article-title":"Safety evaluation of routine intracoronary acetylcholine infusion in patients undergoing a first diagnostic coronary angiogram","volume":"50","author":"Tio","year":"2002","journal-title":"J\u00a0Investig Med"},{"key":"10.1016\/j.jacc.2022.03.385_bib34","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.jcin.2012.01.023","article-title":"Safety of coronary reactivity testing in women with no obstructive coronary artery disease: results from the NHLBI-sponsored WISE (Women\u2019s Ischemia Syndrome Evaluation) study","volume":"5","author":"Wei","year":"2012","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jacc.2022.03.385_bib35","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0002-9149(80)90080-6","article-title":"Refractory ergonovine-induced coronary vasospasm: importance of intracoronary nitroglycerin","volume":"46","author":"Buxton","year":"1980","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2022.03.385_bib36","first-page":"1","article-title":"Overview of complications during pharmacological spasm provocation tests","volume":"68","author":"Sueda","year":"2016","journal-title":"J\u00a0Cardiol"},{"key":"10.1016\/j.jacc.2022.03.385_bib37","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1253\/circj.CJ-66-0098","article-title":"Guidelines for diagnosis and treatment of patients with vasospastic angina (Coronary Spastic Angina) (JCS 2013)","volume":"78","year":"2014","journal-title":"Circ J"},{"key":"10.1016\/j.jacc.2022.03.385_bib38","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1016\/j.jacc.2017.09.016","article-title":"Sex-related differences in vasomotor function in patients with angina and unobstructed coronary arteries","volume":"70","author":"Aziz","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2022.03.385_bib39","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/S0895-4356(00)00313-9","article-title":"Sources of heterogeneity in the meta-analysis of observational studies: the example of SIDS and sleeping position","volume":"54","author":"Dwyer","year":"2001","journal-title":"J\u00a0Clin Epidemiol"},{"key":"10.1016\/j.jacc.2022.03.385_bib40","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s12874-018-0495-9","article-title":"Methods to systematically review and meta-analyse observational studies: a systematic scoping review of recommendations","volume":"18","author":"Mueller","year":"2018","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.jacc.2022.03.385_bib41","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/jrsm.1348","article-title":"Seriously misleading results using inverse of Freeman-Tukey double arcsine transformation in meta-analysis of single proportions","volume":"10","author":"Schwarzer","year":"2019","journal-title":"Res Synth Methods"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109722048227?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109722048227?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T01:34:02Z","timestamp":1718415242000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109722048227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":41,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["S0735109722048227"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2022.03.385","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety of Provocative Testing With Intracoronary Acetylcholine and Implications for Standard Protocols","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2022.03.385","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}