{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T08:07:21Z","timestamp":1791446841034,"version":"4.3.3"},"reference-count":28,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.jacc.2022.06.040","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T19:41:03Z","timestamp":1663011663000},"page":"1115-1126","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":64,"title":["Clinical Risk Score to Predict Pathogenic\u00a0Genotypes in Patients With\u00a0Dilated Cardiomyopathy"],"prefix":"10.1016","volume":"80","author":[{"given":"Luis","family":"Escobar-Lopez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Pablo","family":"Ochoa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Royuela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Job A.J.","family":"Verdonschot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Dal Ferro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Angeles","family":"Espinosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Sabater-Molina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Gallego-Delgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose M.","family":"Larra\u00f1aga-Moreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose M.","family":"Garcia-Pinilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Basurte-Elorz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 F.","family":"Rodr\u00edguez-Palomares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Climent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"Bermudez-Jimenez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Victoria","family":"Mogoll\u00f3n-Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luisa","family":"Pe\u00f1a-Pe\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Garcia-Alvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardo","family":"L\u00f3pez-Abel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Ripoll-Vera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Palomino-Doza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni","family":"Bayes-Genis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon","family":"Brugada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uxua","family":"Idiazabal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus G.","family":"Mirelis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8408-363X","authenticated-orcid":false,"given":"Fernando","family":"Dominguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiel T.H.M.","family":"Henkens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid P.C.","family":"Krapels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han G.","family":"Brunner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Paldino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5938-4000","authenticated-orcid":false,"given":"Denise","family":"Zaffalon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Mestroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Sinagra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane R.B.","family":"Heymans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Merlo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5470-2257","authenticated-orcid":false,"given":"Pablo","family":"Garcia-Pavia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2022.06.040_bib1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41569-020-0428-2","article-title":"Epidemiology of the inherited cardiomyopathies","volume":"18","author":"McKenna","year":"2021","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jacc.2022.06.040_bib2","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1093\/eurheartj\/ehv727","article-title":"Proposal for a revised definition of dilated cardiomyopathy, hypokinetic non-dilated cardiomyopathy, and its implications for clinical practice: a position statement of the ESC Working Group on Myocardial and Pericardial Diseases","volume":"37","author":"Pinto","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2022.06.040_bib3","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1016\/j.jacc.2019.10.011","article-title":"Precision medicine in the management of dilated cardiomyopathy: JACC state-of-the-art review","volume":"74","author":"Fatkin","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2022.06.040_bib4","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/s41436-018-0039-z","article-title":"Genetic evaluation of cardiomyopathy: a clinical practice resource of the American College of Medical Genetics and Genomics (ACMG)","volume":"20","author":"Hershberger","year":"2018","journal-title":"Genet Med"},{"key":"10.1016\/j.jacc.2022.06.040_bib5","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1161\/CIRCGEN.120.003031","article-title":"Implications of genetic testing in dilated cardiomyopathy","volume":"13","author":"Verdonschot","year":"2020","journal-title":"Circ Genomic Precis Med"},{"issue":"3","key":"10.1016\/j.jacc.2022.06.040_bib6","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.117.004682","article-title":"Prevalence of pathogenic gene mutations and prognosis do not differ in isolated left ventricular dysfunction compared with dilated cardiomyopathy","volume":"11","author":"Hazebroek","year":"2018","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jacc.2022.06.040_bib7","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1136\/heartjnl-2016-311017","article-title":"Association between mutation status and left ventricular reverse remodelling in dilated cardiomyopathy","volume":"103","author":"Dal Ferro","year":"2017","journal-title":"Heart"},{"key":"10.1016\/j.jacc.2022.06.040_bib8","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1016\/j.jacc.2016.08.058","article-title":"Long-term arrhythmic and nonarrhythmic outcomes of lamin A\/C mutation carriers","volume":"68","author":"Kumar","year":"2016","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2022.06.040_bib9","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1016\/j.jacc.2018.08.2181","article-title":"Dilated cardiomyopathy due to BLC2-associated athanogene 3 (BAG3) mutations","volume":"72","author":"Dom\u00ednguez","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2022.06.040_bib10","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1161\/CIRCHEARTFAILURE.119.006832","article-title":"Clinical phenotypes and prognosis of dilated cardiomyopathy caused by truncating variants in the TTN Gene","volume":"13","author":"Akhtar","year":"2020","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jacc.2022.06.040_bib11","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1016\/j.jacc.2021.08.039","article-title":"Association of genetic variants with outcomes in non-ischemic dilated cardiomyopathy","volume":"17","author":"Escobar-Lopez","year":"2021","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2022.06.040_bib12","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1038\/s41436-019-0582-2","article-title":"A\u00a0cost-effectiveness model of genetic testing and periodical clinical screening for the evaluation of families with dilated cardiomyopathy","volume":"21","author":"Catchpool","year":"2019","journal-title":"Genet Med"},{"key":"10.1016\/j.jacc.2022.06.040_bib13","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1161\/CIRCULATIONAHA.120.053033","article-title":"Evidence-based assessment of genes in dilated cardiomyopathy","volume":"144","author":"Jordan","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2022.06.040_bib14","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"},{"key":"10.1016\/j.jacc.2022.06.040_bib15","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/s41586-020-2308-7","article-title":"The mutational constraint spectrum quantified from variation in 141,456 humans","volume":"581","author":"Karczewski","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jacc.2022.06.040_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s41512-019-0060-y","article-title":"Methodological standards for the development and evaluation of clinical prediction rules: a review of the literature","volume":"3","author":"Cowley","year":"2019","journal-title":"Diagnostic Progn Res"},{"key":"10.1016\/j.jacc.2022.06.040_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12916-014-0241-z","article-title":"Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): The TRIPOD Statement","volume":"13","author":"Collins","year":"2015","journal-title":"BMC Med"},{"key":"10.1016\/j.jacc.2022.06.040_bib18","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1136\/bmj.b605","article-title":"Prognosis and prognostic research: validating a prognostic model","volume":"338","author":"Altman","year":"2009","journal-title":"BMJ"},{"key":"10.1016\/j.jacc.2022.06.040_bib19","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jclinepi.2016.03.031","article-title":"Regression coefficient-based scoring system should be used to assign weights to the risk index","volume":"79","author":"Mehta","year":"2016","journal-title":"J\u00a0Clin Epidemiol"},{"key":"10.1016\/j.jacc.2022.06.040_bib20","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1093\/eurheartj\/ehu301","article-title":"Atlas of the clinical genetics of human dilated cardiomyopathy","volume":"36","author":"Haas","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2022.06.040_bib21","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.healun.2015.12.014","article-title":"Genetic basis of familial dilated cardiomyopathy patients undergoing heart transplantation","volume":"35","author":"Cuenca","year":"2016","journal-title":"J\u00a0Hear Lung Transplant"},{"key":"10.1016\/j.jacc.2022.06.040_bib22","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1002\/ejhf.255","article-title":"A\u00a0systematic analysis of genetic dilated cardiomyopathy reveals numerous ubiquitously expressed and muscle-specific genes","volume":"17","author":"Harakalova","year":"2015","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jacc.2022.06.040_bib23","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1002\/ejhf.1815","article-title":"The electrocardiogram in the diagnosis and management of patients with dilated cardiomyopathy","volume":"22","author":"Finocchiaro","year":"2020","journal-title":"Eur J Heart Fail"},{"issue":"22","key":"10.1016\/j.jacc.2022.06.040_bib24","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1016\/j.jacc.2016.09.927","article-title":"Truncating FLNC mutations are associated with high-risk dilated and arrhythmogenic cardiomyopathies","volume":"68","author":"Ortiz-Genga","year":"2016","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2022.06.040_bib25","article-title":"Clinical phenotypes and prognosis of dilated cardiomyopathy caused by truncating variants in the TTN gene","volume":"13","author":"Akhtar","year":"2020","journal-title":"Circ Hear Fail"},{"key":"10.1016\/j.jacc.2022.06.040_bib26","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1161\/CIRCULATIONAHA.119.044934","article-title":"Desmoplakin cardiomyopathy, a fibrotic and inflammatory form of cardiomyopathy distinct from typical dilated or arrhythmogenic right ventricular cardiomyopathy","volume":"141","author":"Smith","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2022.06.040_bib27","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ijcard.2019.06.008","article-title":"Left\u00a0bundle branch block-induced cardiomyopathy: a diagnostic proposal for a poorly explored pathological entity","volume":"15","author":"Sanna","year":"2020","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacc.2022.06.040_bib28","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1161\/HYPERTENSIONAHA.118.11125","article-title":"Myocardial remodeling in hypertension toward a new view of hypertensive heart disease","volume":"72","author":"Gonz\u00e1lez","year":"2018","journal-title":"Hypertension"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109722056042?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109722056042?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:50:42Z","timestamp":1760017842000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109722056042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":28,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["S0735109722056042"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2022.06.040","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical Risk Score to Predict Pathogenic\u00a0Genotypes in Patients With\u00a0Dilated Cardiomyopathy","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2022.06.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}]}}