{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T09:44:42Z","timestamp":1793094282047,"version":"4.5.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"21","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T00:00:00Z","timestamp":1717027200000},"content-version":"vor","delay-in-days":395,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.jacc.2023.03.419","type":"journal-article","created":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T14:27:29Z","timestamp":1684765649000},"page":"2059-2071","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Screening for Dilated Cardiomyopathy in\u00a0At-Risk First-Degree Relatives"],"prefix":"10.1016","volume":"81","author":[{"given":"Hanyu","family":"Ni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2073-3258","authenticated-orcid":false,"given":"Elizabeth","family":"Jordan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0867-5227","authenticated-orcid":false,"given":"Daniel D.","family":"Kinnamon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinwen","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garrie J.","family":"Haas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Hofmeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Kransdorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A.","family":"Ewald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alanna A.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Owens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Lowes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Stoller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8335-735X","authenticated-orcid":false,"given":"W.H. Wilson","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry H.","family":"Trachtenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8175-168X","authenticated-orcid":false,"given":"Palak","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salpy V.","family":"Pamboukian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy K.","family":"Sweitzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew T.","family":"Wheeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane E.","family":"Wilcox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Katz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Jimenez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel P.","family":"Fishbein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Smart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7348-0509","authenticated-orcid":false,"given":"Jessica","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen S.","family":"Gottlieb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel P.","family":"Judge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles K.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon S.","family":"Huggins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ray E.","family":"Hershberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"23","key":"10.1016\/j.jacc.2023.03.419_bib1","doi-asserted-by":"crossref","first-page":"e579","DOI":"10.1161\/CIR.0000000000000455","article-title":"Current diagnostic and treatment strategies for specific dilated cardiomyopathies: a scientific statement from the American Heart Association","volume":"134","author":"Bozkurt","year":"2016","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.jacc.2023.03.419_bib2","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1001\/jama.2021.24674","article-title":"Prevalence and cumulative risk of familial idiopathic dilated cardiomyopathy","volume":"327","author":"Huggins","year":"2022","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.jacc.2023.03.419_bib3","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cardfail.2018.03.004","article-title":"Genetic evaluation of cardiomyopathy-a Heart\u00a0Failure Society of America practice guideline","volume":"24","author":"Hershberger","year":"2018","journal-title":"J\u00a0Card Fail"},{"issue":"4","key":"10.1016\/j.jacc.2023.03.419_bib4","doi-asserted-by":"crossref","DOI":"10.1161\/HCG.0000000000000067","article-title":"Genetic testing for inherited cardiovascular diseases: a scientific statement from the American Heart Association","volume":"13","author":"Musunuru","year":"2020","journal-title":"Circ Genom Precis Med"},{"issue":"17","key":"10.1016\/j.jacc.2023.03.419_bib5","doi-asserted-by":"crossref","first-page":"e263","DOI":"10.1016\/j.jacc.2021.12.012","article-title":"2022 AHA\/ACC\/HFSA guideline for the management of heart failure: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"79","author":"Heidenreich","year":"2022","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"2","key":"10.1016\/j.jacc.2023.03.419_bib6","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGEN.119.002480","article-title":"Variant interpretation for dilated cardiomyopathy: refinement of the American College of Medical Genetics and Genomics\/ClinGen guidelines for the DCM Precision Medicine Study","volume":"13","author":"Morales","year":"2020","journal-title":"Circ Genom Precis Med"},{"key":"10.1016\/j.jacc.2023.03.419_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejim.2017.06.014","article-title":"Alcoholic cardiomyopathy: what is known and what is not known","volume":"43","author":"Mirijello","year":"2017","journal-title":"Eur J Intern Med"},{"issue":"1","key":"10.1016\/j.jacc.2023.03.419_bib8","first-page":"49","article-title":"Heavy burden of toxic dilated cardiomyopathy among young adults: a retrospective study and review of the literature","volume":"38","author":"Cinq-Mars","year":"2022","journal-title":"Can J Cardiol"},{"issue":"6","key":"10.1016\/j.jacc.2023.03.419_bib9","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGENETICS.117.001826","article-title":"Toward genetics-driven early intervention in dilated cardiomyopathy: design and implementation of the DCM Precision Medicine Study","volume":"10","author":"Kinnamon","year":"2017","journal-title":"Circ Cardiovasc Genet"},{"issue":"6","key":"10.1016\/j.jacc.2023.03.419_bib10","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1161\/01.CIR.96.6.1863","article-title":"Distribution and categorization of echocardiographic measurements in relation to reference limits. The Framingham Heart Study: formulation of a height- and sex-specific classification and its prospective validation","volume":"96","author":"Vasan","year":"1997","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.jacc.2023.03.419_bib11","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.121.008877","article-title":"Validating an idiopathic dilated cardiomyopathy diagnosis using cardiovascular magnetic resonance: the Dilated Cardiomyopathy Precision Medicine Study","volume":"15","author":"Haas","year":"2022","journal-title":"Circ Heart Fail"},{"issue":"5","key":"10.1016\/j.jacc.2023.03.419_bib12","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"},{"issue":"4","key":"10.1016\/j.jacc.2023.03.419_bib13","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/bimj.200390021","article-title":"Small sample correction for the variance of GEE estimators","volume":"45","author":"Morel","year":"2003","journal-title":"Biometrical J"},{"issue":"3","key":"10.1016\/j.jacc.2023.03.419_bib14","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1093\/ije\/dyu029","article-title":"Estimating predicted probabilities from logistic regression: different methods correspond to different target populations","volume":"43","author":"Muller","year":"2014","journal-title":"Int J Epidemiol"},{"issue":"1","key":"10.1016\/j.jacc.2023.03.419_bib15","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0735-1097(97)00433-6","article-title":"Familial dilated cardiomyopathy: cardiac abnormalities are common in asymptomatic relatives and may represent early disease","volume":"31","author":"Baig","year":"1998","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"2","key":"10.1016\/j.jacc.2023.03.419_bib16","doi-asserted-by":"crossref","first-page":"108","DOI":"10.7326\/0003-4819-143-2-200507190-00009","article-title":"Echocardiographic evaluation in asymptomatic relatives of patients with dilated cardiomyopathy reveals preclinical disease","volume":"143","author":"Mahon","year":"2005","journal-title":"Ann Intern Med"},{"issue":"4","key":"10.1016\/j.jacc.2023.03.419_bib17","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1161\/CIRCGENETICS.110.958918","article-title":"Evaluation of left ventricular enlargement as a marker of early disease in familial dilated cardiomyopathy","volume":"4","author":"Fatkin","year":"2011","journal-title":"Circ Cardiovasc Genet"},{"issue":"8","key":"10.1016\/j.jacc.2023.03.419_bib18","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1161\/01.CIR.0000085166.44904.79","article-title":"Natural history of asymptomatic left ventricular systolic dysfunction in the community","volume":"108","author":"Wang","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2023.03.419_bib19","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1056\/NEJM199705083361903","article-title":"Left ventricular dilatation and the risk of congestive heart failure in people without myocardial infarction","volume":"336","author":"Vasan","year":"1997","journal-title":"N\u00a0Eng J Med"},{"issue":"11","key":"10.1016\/j.jacc.2023.03.419_bib20","first-page":"792","article-title":"Family screening in dilated cardiomyopathy: prevalence, incidence, and potential for limiting follow-up","volume":"10","author":"Vissing","year":"2022","journal-title":"J\u00a0Am Coll Cardiol HF"},{"issue":"10","key":"10.1016\/j.jacc.2023.03.419_bib21","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.119.006701","article-title":"Clinical and genetic investigations of 109 index patients with dilated cardiomyopathy and 445 of their relatives","volume":"13","author":"Hey","year":"2020","journal-title":"Circ Heart Fail"},{"issue":"4","key":"10.1016\/j.jacc.2023.03.419_bib22","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1097\/00001648-199407000-00012","article-title":"The epidemiology of idiopathic dilated cardiomyopathy in women: the Washington DC Dilated Cardiomyopathy Study","volume":"5","author":"Coughlin","year":"1994","journal-title":"Epidemiology"},{"issue":"12","key":"10.1016\/j.jacc.2023.03.419_bib23","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1016\/j.jacc.2003.11.064","article-title":"Increased left ventricular mass is a risk factor for the development of a depressed left ventricular ejection fraction within five years: the Cardiovascular Health Study","volume":"43","author":"Drazner","year":"2004","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"1","key":"10.1016\/j.jacc.2023.03.419_bib24","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.pcad.2019.11.009","article-title":"Left ventricular hypertrophy and hypertension","volume":"63","author":"Yildiz","year":"2020","journal-title":"Prog Cardiovasc Dis"},{"issue":"4","key":"10.1016\/j.jacc.2023.03.419_bib25","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1152\/physrev.00030.2020","article-title":"Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications","volume":"101","author":"Ren","year":"2021","journal-title":"Physiol Rev"},{"issue":"6","key":"10.1016\/j.jacc.2023.03.419_bib26","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1097\/00001648-199611000-00011","article-title":"Obesity and idiopathic dilated cardiomyopathy","volume":"7","author":"Coughlin","year":"1996","journal-title":"Epidemiology"},{"issue":"12","key":"10.1016\/j.jacc.2023.03.419_bib27","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1055\/s-0040-1712451","article-title":"Pre-pregnancy obesity and the risk of peripartum cardiomyopathy","volume":"38","author":"Cho","year":"2021","journal-title":"Am J Perinatol"},{"issue":"1","key":"10.1016\/j.jacc.2023.03.419_bib28","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1161\/CIRCULATIONAHA.120.053033","article-title":"Evidence-based assessment of genes in dilated cardiomyopathy","volume":"144","author":"Jordan","year":"2021","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.jacc.2023.03.419_bib29","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGEN.117.002038","article-title":"Multigenic disease and bilineal inheritance in dilated cardiomyopathy is illustrated in nonsegregating LMNA pedigrees","volume":"11","author":"Cowan","year":"2018","journal-title":"Circ Genom Precis Med"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109723052336?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109723052336?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:56:31Z","timestamp":1760018191000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109723052336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":29,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["S0735109723052336"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2023.03.419","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Screening for Dilated Cardiomyopathy in\u00a0At-Risk First-Degree Relatives","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2023.03.419","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}