{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:43:16Z","timestamp":1760056996597,"version":"build-2065373602"},"reference-count":24,"publisher":"Elsevier BV","issue":"23","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T00:00:00Z","timestamp":1718236800000},"content-version":"vor","delay-in-days":378,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.jacc.2023.04.024","type":"journal-article","created":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T14:03:06Z","timestamp":1685973786000},"page":"2269-2271","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Changing Complexities of Opioid-Related Sudden Death"],"prefix":"10.1016","volume":"81","author":[{"given":"Lee L.","family":"Eckhardt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew C.","family":"Nickel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"year":"2023","series-title":"Provisional drug overdose death counts","author":"Ahmad","key":"10.1016\/j.jacc.2023.04.024_bib1"},{"issue":"6","key":"10.1016\/j.jacc.2023.04.024_bib2","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1592\/phco.23.6.802.32186","article-title":"Dose-related effects of methadone on QT prolongation in a series of patients with torsade de pointes","volume":"23","author":"Krantz","year":"2003","journal-title":"Pharmacotherapy"},{"issue":"6","key":"10.1016\/j.jacc.2023.04.024_bib3","doi-asserted-by":"crossref","first-page":"501","DOI":"10.7326\/0003-4819-137-6-200209170-00010","article-title":"Torsade de pointes associated with very-high-dose methadone","volume":"137","author":"Krantz","year":"2002","journal-title":"Ann Intern Med"},{"issue":"22","key":"10.1016\/j.jacc.2023.04.024_bib4","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1001\/archinte.167.22.2469","article-title":"QT-interval effects of methadone, levomethadyl, and buprenorphine in a randomized trial","volume":"167","author":"Wedam","year":"2007","journal-title":"Arch Intern Med"},{"issue":"2","key":"10.1016\/j.jacc.2023.04.024_bib5","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1124\/jpet.102.038240","article-title":"Influence of opioid agonists on cardiac human ether-a-go-go-related gene K(+) currents","volume":"303","author":"Katchman","year":"2002","journal-title":"J\u00a0Pharmacol Exp Ther"},{"issue":"11","key":"10.1016\/j.jacc.2023.04.024_bib6","article-title":"Methadone blockade of cardiac inward rectifier K(+) current augments membrane instability and amplifies U waves on surface ECGs: a translational study","volume":"11","author":"Klein","year":"2022","journal-title":"J\u00a0Am Heart Assoc"},{"issue":"8","key":"10.1016\/j.jacc.2023.04.024_bib7","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/j.hrthm.2021.04.008","article-title":"Cardiac potassium inward rectifier Kir2: Review of structure, regulation, pharmacology, and arrhythmogenesis","volume":"18","author":"Reilly","year":"2021","journal-title":"Heart Rhythm"},{"issue":"11","key":"10.1016\/j.jacc.2023.04.024_bib8","article-title":"Arrhythmogenesis and prolonged repolarization from synthetic opioids: finally sorted?","volume":"11","author":"Eckhardt","year":"2022","journal-title":"J\u00a0Am Heart Assoc"},{"issue":"7","key":"10.1016\/j.jacc.2023.04.024_bib9","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.amjcard.2013.05.037","article-title":"QTc interval screening in an opioid treatment program","volume":"112","author":"Katz","year":"2013","journal-title":"Am J Cardiol"},{"issue":"11","key":"10.1016\/j.jacc.2023.04.024_bib10","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1111\/jce.14129","article-title":"Electrocardiographic changes in loperamide toxicity: case report and review of literature","volume":"30","author":"Teigeler","year":"2019","journal-title":"J\u00a0Cardiovasc Electrophysiol"},{"issue":"2S","key":"10.1016\/j.jacc.2023.04.024_bib11","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.1016\/j.japh.2016.11.011","article-title":"Adverse event detection using the FDA post-marketing drug safety surveillance system: cardiotoxicity associated with loperamide abuse and misuse","volume":"57","author":"Swank","year":"2017","journal-title":"J\u00a0Am Pharm Assoc (2003)"},{"issue":"6","key":"10.1016\/j.jacc.2023.04.024_bib12","doi-asserted-by":"crossref","first-page":"e792","DOI":"10.1097\/MJT.0000000000001134","article-title":"Kratom-associated ventricular fibrillation","volume":"28","author":"ELJack","year":"2020","journal-title":"Am J Ther"},{"key":"10.1016\/j.jacc.2023.04.024_bib13","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1016\/j.jacc.2023.04.009","article-title":"Ventricular arrhythmias associated with over-the-counter and recreational opioids","volume":"81","author":"Krantz","year":"2023","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"10","key":"10.1016\/j.jacc.2023.04.024_bib14","doi-asserted-by":"crossref","first-page":"735","DOI":"10.7326\/0003-4819-158-10-201305210-00008","article-title":"Trends in reporting methadone-associated cardiac arrhythmia, 1997-2011: an analysis of registry data","volume":"158","author":"Kao","year":"2013","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jacc.2023.04.024_bib15","doi-asserted-by":"crossref","first-page":"726003","DOI":"10.3389\/fphar.2021.726003","article-title":"The adverse\u00a0cardiovascular effects and cardiotoxicity of Kratom (Mitragyna speciosa Korth.): A comprehensive review","volume":"12","author":"Leong Bin Abdullah","year":"2021","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jacc.2023.04.024_bib16","doi-asserted-by":"crossref","first-page":"e115648","DOI":"10.1371\/journal.pone.0115648","article-title":"Evaluation of the cardiotoxicity of mitragynine and its analogues using human induced pluripotent stem cell-derived cardiomyocytes","volume":"9(12)","author":"Lu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jacc.2023.04.024_bib17","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.pharmthera.2017.10.001","article-title":"The immature electrophysiological phenotype of iPSC-CMs still hampers in\u00a0vitro drug screening: special focus on IK1","volume":"183","author":"Goversen","year":"2018","journal-title":"Pharmacol Ther"},{"issue":"1","key":"10.1016\/j.jacc.2023.04.024_bib18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/sj.bjp.0706140","article-title":"Pentamidine reduces hERG expression to prolong the QT interval","volume":"145","author":"Cordes","year":"2005","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jacc.2023.04.024_bib19","doi-asserted-by":"crossref","first-page":"19757","DOI":"10.1038\/s41598-019-56106-6","article-title":"Mitragynine, an euphoric compound inhibits hERG1a\/1b channel current and upregulates the complexation of hERG1a-Hsp90 in HEK293-hERG1a\/1b cells","volume":"9","author":"Tay","year":"2019","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.jacc.2023.04.024_bib20","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2020-237837","article-title":"Report of ventricular fibrillation in a 44-year-old man using kratom","volume":"14","author":"Sheikh","year":"2021","journal-title":"BMJ Case Rep"},{"issue":"5","key":"10.1016\/j.jacc.2023.04.024_bib21","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1080\/15563650.2020.1812627","article-title":"Is kratom (Mitragyna speciosa Korth.) use associated with ECG abnormalities? Electrocardiogram comparisons between regular kratom users and controls","volume":"59","author":"Leong Abdullah","year":"2021","journal-title":"Clin Toxicol (Phila)"},{"issue":"1","key":"10.1016\/j.jacc.2023.04.024_bib22","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/s12024-018-0049-9","article-title":"Fatal combination of mitragynine and quetiapine - a case report with discussion of a potential herb-drug interaction","volume":"15","author":"Hughes","year":"2019","journal-title":"Forensic Sci Med Pathol"},{"issue":"3","key":"10.1016\/j.jacc.2023.04.024_bib23","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.wem.2018.05.001","article-title":"Recurrent ventricular arrhythmia caused by ingestion of aconitum (monkshood) flowers","volume":"29","author":"Adami","year":"2018","journal-title":"Wilderness Environ Med"},{"issue":"5","key":"10.1016\/j.jacc.2023.04.024_bib24","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1080\/15563650.2017.1291944","article-title":"The management of ventricular dysrhythmia in aconite poisoning","volume":"55","author":"Coulson","year":"2017","journal-title":"Clin Toxicol (Phila)"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109723054645?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109723054645?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:56:37Z","timestamp":1760018197000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109723054645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":24,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["S0735109723054645"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2023.04.024","relation":{},"ISSN":["0735-1097"],"issn-type":[{"type":"print","value":"0735-1097"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Changing Complexities of Opioid-Related Sudden Death","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2023.04.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2023.04.009","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}