{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:38:05Z","timestamp":1788781085878,"version":"build-2803163510"},"reference-count":32,"publisher":"Elsevier BV","issue":"15","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":372,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100015223","name":"Danish Diabetes and Endocrine Academy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015223","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.jacc.2024.07.015","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T10:06:00Z","timestamp":1727690760000},"page":"1424-1433","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Risk of Ischemic Stroke After Patent\u00a0Foramen Ovale Closure"],"prefix":"10.1016","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8626-2372","authenticated-orcid":false,"given":"Kasper","family":"Bonnesen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasper","family":"Korsholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9102-3130","authenticated-orcid":false,"given":"Asger","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus Ziegler","family":"Simonsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Erik","family":"Nielsen-Kudsk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2024.07.015_bib1","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2015.86","article-title":"Patent foramen ovale","volume":"2","author":"Homma","year":"2016","journal-title":"Nat Rev Dis Primers"},{"issue":"12","key":"10.1016\/j.jacc.2024.07.015_bib2","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s11910-018-0910-y","article-title":"Closure of patent foramen ovale and cryptogenic stroke: unresolved issues","volume":"18","author":"Diener","year":"2018","journal-title":"Curr Neurol Neurosci Rep"},{"issue":"4","key":"10.1016\/j.jacc.2024.07.015_bib3","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S1474-4422(13)70310-7","article-title":"Embolic strokes of undetermined source: the case for a new clinical construct","volume":"13","author":"Hart","year":"2014","journal-title":"Lancet Neurol"},{"issue":"4","key":"10.1016\/j.jacc.2024.07.015_bib4","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1161\/STROKEAHA.108.529883","article-title":"Analysis of 1008 consecutive patients aged 15 to 49 with first-ever ischemic stroke: the Helsinki young stroke registry","volume":"40","author":"Putaala","year":"2009","journal-title":"Stroke"},{"issue":"7","key":"10.1016\/j.jacc.2024.07.015_bib5","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2018-023761","article-title":"Patent foramen ovale closure, antiplatelet therapy or anticoagulation in patients with patent foramen ovale and cryptogenic stroke: a systematic review and network meta-analysis incorporating complementary external evidence","volume":"8","author":"Mir","year":"2018","journal-title":"BMJ Open"},{"issue":"22","key":"10.1016\/j.jacc.2024.07.015_bib6","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1001\/jama.2021.20956","article-title":"Heterogeneity of treatment effects in an analysis of pooled individual patient data from randomized trials of device closure of patent foramen ovale after stroke","volume":"326","author":"Kent","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.jacc.2024.07.015_bib7","doi-asserted-by":"crossref","first-page":"563","DOI":"10.2147\/CLEP.S179083","article-title":"The Danish health care system and epidemiological research: from health care contacts to database records","volume":"11","author":"Schmidt","year":"2019","journal-title":"Clin Epidemiol"},{"issue":"8","key":"10.1016\/j.jacc.2024.07.015_bib8","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s10654-014-9930-3","article-title":"The Danish Civil Registration System as a tool in epidemiology","volume":"29","author":"Schmidt","year":"2014","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.jacc.2024.07.015_bib10","doi-asserted-by":"crossref","first-page":"449","DOI":"10.2147\/CLEP.S91125","article-title":"The Danish National Patient Registry: a review of content, data quality, and research potential","volume":"7","author":"Schmidt","year":"2015","journal-title":"Clin Epidemiol"},{"issue":"1","key":"10.1016\/j.jacc.2024.07.015_bib11","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/sim.4780050106","article-title":"Choosing the number of controls in a matched case-control study, some sample size, power and efficiency considerations","volume":"5","author":"Taylor","year":"1986","journal-title":"Stat Med"},{"key":"10.1016\/j.jacc.2024.07.015_bib12","doi-asserted-by":"crossref","first-page":"697","DOI":"10.2147\/CLEP.S103662","article-title":"The Danish Stroke Registry","volume":"8","author":"Johnsen","year":"2016","journal-title":"Clin Epidemiol"},{"key":"10.1016\/j.jacc.2024.07.015_bib13","first-page":"27","article-title":"Registration of acute stroke: validity in the Danish Stroke Registry and the Danish National Registry of Patients","volume":"6","author":"Wildenschild","year":"2014","journal-title":"Clin Epidemiol"},{"issue":"3","key":"10.1016\/j.jacc.2024.07.015_bib14","article-title":"Data resource profile: the Danish National Prescription Registry","volume":"46","author":"Potteg\u00e5rd","year":"2017","journal-title":"Int J Epidemiol"},{"issue":"3","key":"10.1016\/j.jacc.2024.07.015_bib15","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1214\/aos\/1176344198","article-title":"Nonparametric estimation of partial transition probabilities in multiple decrement models","volume":"6","author":"Aalen","year":"1978","journal-title":"Ann Stat"},{"issue":"2","key":"10.1016\/j.jacc.2024.07.015_bib16","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life-tables","volume":"34","author":"Cox","year":"1972","journal-title":"J\u00a0R Stat Soc Series B Stat Methodol"},{"issue":"7","key":"10.1016\/j.jacc.2024.07.015_bib17","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1002\/sim.5984","article-title":"The use of propensity score methods with survival or time-to-event outcomes: reporting measures of effect similar to those used in randomized experiments","volume":"33","author":"Austin","year":"2014","journal-title":"Stat Med"},{"issue":"11","key":"10.1016\/j.jacc.2024.07.015_bib18","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1056\/NEJMoa1610057","article-title":"Long-term outcomes of patent foramen ovale closure or medical therapy after stroke","volume":"377","author":"Saver","year":"2017","journal-title":"N\u00a0Engl J Med"},{"issue":"11","key":"10.1016\/j.jacc.2024.07.015_bib19","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1056\/NEJMoa1707404","article-title":"Patent foramen ovale closure or antiplatelet therapy for cryptogenic stroke","volume":"377","author":"S\u00f8ndergaard","year":"2017","journal-title":"N\u00a0Engl J Med"},{"issue":"12","key":"10.1016\/j.jacc.2024.07.015_bib20","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1056\/NEJMoa1211716","article-title":"Percutaneous closure of patent foramen ovale in cryptogenic embolism","volume":"368","author":"Meier","year":"2013","journal-title":"N\u00a0Engl J Med"},{"issue":"11","key":"10.1016\/j.jacc.2024.07.015_bib21","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1056\/NEJMoa1705915","article-title":"Patent foramen ovale closure or anticoagulation vs antiplatelets after stroke","volume":"377","author":"Mas","year":"2017","journal-title":"N\u00a0Engl J Med"},{"issue":"3","key":"10.1016\/j.jacc.2024.07.015_bib22","first-page":"578","article-title":"Patent foramen ovale closure versus medical therapy in cases with cryptogenic stroke, meta-analysis of randomized controlled trials","volume":"265","author":"Abo-Salem","year":"2018","journal-title":"J\u00a0Neurol"},{"issue":"7","key":"10.1016\/j.jacc.2024.07.015_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0271117","article-title":"Patent foramen ovale closure: a prospective UK registry linked to hospital episode statistics","volume":"17","author":"Willits","year":"2022","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.jacc.2024.07.015_bib24","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1093\/ije\/dyr213","article-title":"Competing risks in epidemiology: possibilities and pitfalls","volume":"41","author":"Andersen","year":"2012","journal-title":"Int J Epidemiol"},{"issue":"7","key":"10.1016\/j.jacc.2024.07.015_bib25","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1212\/WNL.0b013e3182a08d59","article-title":"An index to identify stroke-related vs incidental patent foramen ovale in cryptogenic stroke","volume":"81","author":"Kent","year":"2013","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.jacc.2024.07.015_bib26","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1046\/j.1468-1331.2003.00561.x","article-title":"Transcranial Doppler and risk of recurrence in patients with stroke and patent foramen ovale","volume":"10","author":"Anzola","year":"2003","journal-title":"Eur J Neurol"},{"issue":"24","key":"10.1016\/j.jacc.2024.07.015_bib27","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1056\/NEJMoa011503","article-title":"Recurrent cerebrovascular events associated with patent foramen ovale, atrial septal aneurysm, or both","volume":"345","author":"Mas","year":"2001","journal-title":"N\u00a0Engl J Med"},{"issue":"5","key":"10.1016\/j.jacc.2024.07.015_bib28","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1161\/STROKEAHA.109.577742","article-title":"Hyperthyroidism and risk of ischemic stroke in young adults: a 5-year follow-up study","volume":"41","author":"Sheu","year":"2010","journal-title":"Stroke"},{"issue":"4","key":"10.1016\/j.jacc.2024.07.015_bib29","doi-asserted-by":"crossref","first-page":"e329","DOI":"10.1212\/WNL.0000000000013118","article-title":"Risks of stroke recurrence and mortality after first and recurrent strokes in Denmark: a nationwide registry study","volume":"98","author":"Skajaa","year":"2022","journal-title":"Neurology"},{"issue":"12","key":"10.1016\/j.jacc.2024.07.015_bib30","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2016-012817","article-title":"Positive predictive value of cardiac examination, procedure and surgery codes in the Danish National Patient Registry: a population-based validation study","volume":"6","author":"Adelborg","year":"2016","journal-title":"BMJ Open"},{"issue":"11","key":"10.1016\/j.jacc.2024.07.015_bib31","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2016-012832","article-title":"Positive predictive value of cardiovascular diagnoses in the Danish National Patient Registry: a validation study","volume":"6","author":"Sundb\u00f8ll","year":"2016","journal-title":"BMJ Open"},{"issue":"36","key":"10.1016\/j.jacc.2024.07.015_bib32","doi-asserted-by":"crossref","first-page":"3469","DOI":"10.1093\/eurheartj\/ehad305","article-title":"Long-term risk of atrial fibrillation or flutter after transcatheter patent foramen ovale closure: a nationwide Danish study","volume":"44","author":"Skibsted","year":"2023","journal-title":"Eur Heart J"},{"issue":"13","key":"10.1016\/j.jacc.2024.07.015_bib33","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.4244\/EIJ-D-18-00622","article-title":"European position paper on the management of patients with patent foramen ovale. General approach and left circulation thromboembolism","volume":"14","author":"Pristipino","year":"2019","journal-title":"EuroIntervention"}],"container-title":["JACC"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073510972407904X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073510972407904X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:23:02Z","timestamp":1785428582000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S073510972407904X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":32,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["S073510972407904X"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2024.07.015","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risk of Ischemic Stroke After Patent\u00a0Foramen Ovale Closure","name":"articletitle","label":"Article Title"},{"value":"JACC","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2024.07.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}