{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T21:54:00Z","timestamp":1793483640079,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"17","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T00:00:00Z","timestamp":1724112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","award":["NCT04788511"],"award-info":[{"award-number":["NCT04788511"]}],"id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","award":["NCT04916470"],"award-info":[{"award-number":["NCT04916470"]}],"id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.jacc.2024.08.028","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T03:34:13Z","timestamp":1724988853000},"page":"1646-1662","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":107,"title":["Inflammation in Obesity-Related HFpEF"],"prefix":"10.1016","volume":"84","author":[{"given":"Subodh","family":"Verma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark C.","family":"Petrie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry A.","family":"Borlaug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javed","family":"Butler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie J.","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalane W.","family":"Kitzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjiv J.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"R\u00f6nnb\u00e4ck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steen Z.","family":"Abildstr\u00f8m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karoline","family":"Liisberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"von Lewinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Lelonek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vojtech","family":"Melenovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5502-7882","authenticated-orcid":false,"given":"Michele","family":"Senni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail N.","family":"Kosiborod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2024.08.028_bib1","doi-asserted-by":"crossref","first-page":"3434","DOI":"10.1093\/cvr\/cvac120","article-title":"Obesity and heart failure with preserved ejection fraction: new insights and pathophysiological targets","volume":"118","author":"Borlaug","year":"2023","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jacc.2024.08.028_bib2","first-page":"0","article-title":"Inflammatory mechanisms in heart failure with preserved ejection fraction","volume":"38","author":"Daou","year":"2023","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.jacc.2024.08.028_bib3","doi-asserted-by":"crossref","first-page":"3536","DOI":"10.1093\/cvr\/cvac133","article-title":"Inflammatory pathways in heart failure with preserved left ventricular ejection fraction: implications for future interventions","volume":"118","author":"Pugliese","year":"2023","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jacc.2024.08.028_bib4","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1097\/HCO.0000000000001113","article-title":"Obesity\/cardiometabolic phenotype of heart failure with preserved ejection fraction: mechanisms to recent trials","volume":"39","author":"Verma","year":"2024","journal-title":"Curr Opin Cardiol"},{"key":"10.1016\/j.jacc.2024.08.028_bib5","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s11897-022-00546-1","article-title":"Targeting the metabolic-inflammatory circuit in heart failure with preserved ejection fraction","volume":"19","author":"Yap","year":"2022","journal-title":"Curr Heart Fail Rep"},{"key":"10.1016\/j.jacc.2024.08.028_bib6","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1002\/ejhf.2741","article-title":"Connecting epicardial adipose tissue and heart failure with preserved ejection fraction: mechanisms, management and modern perspectives","volume":"24","author":"van Woerden","year":"2022","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jacc.2024.08.028_bib7","article-title":"Inflamed adipose tissue: a culprit underlying obesity and heart failure with preserved ejection fraction","volume":"13","author":"Li","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.jacc.2024.08.028_bib8","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13453","article-title":"Chronic low-grade inflammation in heart failure with preserved ejection fraction","volume":"20","author":"Mesquita","year":"2021","journal-title":"Aging Cell"},{"key":"10.1016\/j.jacc.2024.08.028_bib9","doi-asserted-by":"crossref","first-page":"H2031","DOI":"10.1152\/ajpheart.01058.2004","article-title":"Adipokines: molecular links between obesity and atheroslcerosis","volume":"288","author":"Lau","year":"2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jacc.2024.08.028_bib10","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1007\/s10741-017-9644-1","article-title":"Epicardial adipose tissue as a metabolic transducer: role in heart failure and coronary artery disease","volume":"22","author":"Patel","year":"2017","journal-title":"Heart Fail Rev"},{"key":"10.1016\/j.jacc.2024.08.028_bib11","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.jchf.2018.08.007","article-title":"Pivotal role of excess intra-abdominal adipose in the pathogenesis of metabolic\/obese HFpEF","volume":"6","author":"Kitzman","year":"2018","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.jacc.2024.08.028_bib12","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jcmg.2023.07.014","article-title":"Body composition, coronary microvascular dysfunction, and future risk of cardiovascular events including heart failure","volume":"17","author":"Souza","year":"2024","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jacc.2024.08.028_bib13","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.jchf.2018.01.009","article-title":"Obesity-related heart failure with a preserved ejection fraction: the mechanistic rationale for combining inhibitors of aldosterone, neprilysin, and sodium-glucose cotransporter-2","volume":"6","author":"Packer","year":"2018","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.jacc.2024.08.028_bib14","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.jchf.2018.07.009","article-title":"Adiposity and incident heart failure and its subtypes: MESA (Multi-Ethnic Study of Atherosclerosis)","volume":"6","author":"Rao","year":"2018","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.jacc.2024.08.028_bib15","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.123.010618","article-title":"Obesity-related biomarkers are associated with exercise intolerance and HFpEF","volume":"16","author":"Ramirez","year":"2023","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jacc.2024.08.028_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijcard.2024.131818","article-title":"High-sensitivity C-reactive protein in heart failure with preserved ejection fraction: Findings from TOPCAT","volume":"402","author":"Ferreira","year":"2024","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacc.2024.08.028_bib17","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.2147\/JIR.S459989","article-title":"Prognostic value of inflammatory cytokines in predicting hospital readmissions in heart failure with preserved ejection fraction","volume":"17","author":"Zhao","year":"2024","journal-title":"J\u00a0Inflamm Res"},{"key":"10.1016\/j.jacc.2024.08.028_bib18","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41569-019-0315-x","article-title":"Reappraising the role of inflammation in heart failure","volume":"17","author":"Adamo","year":"2020","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jacc.2024.08.028_bib19","doi-asserted-by":"crossref","first-page":"34","DOI":"10.18087\/cardio.2024.3.n2534","article-title":"Interleukin 6 signalling in heart failure with preserved and reduced ejection fraction","volume":"64","author":"Samoilova","year":"2024","journal-title":"Kardiologiia"},{"key":"10.1016\/j.jacc.2024.08.028_bib20","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/j.jchf.2023.06.031","article-title":"Interleukin-6 in patients with heart failure and preserved ejection fraction","volume":"11","author":"Alogna","year":"2023","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.jacc.2024.08.028_bib21","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.2527\/jas1988.66102626x","article-title":"A\u00a0review of early mouse embryogenesis and its applications to domestic species","volume":"66","author":"Prather","year":"1988","journal-title":"J\u00a0Anim Sci"},{"key":"10.1016\/j.jacc.2024.08.028_bib22","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1161\/CIRCULATIONAHA.118.038010","article-title":"Anti-inflammatory therapy with canakinumab for the prevention of hospitalization for heart failure","volume":"139","author":"Everett","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2024.08.028_bib23","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1056\/NEJMoa2306963","article-title":"Semaglutide in patients with heart failure with preserved ejection fraction and obesity","volume":"389","author":"Kosiborod","year":"2023","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2024.08.028_bib24","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1056\/NEJMoa2313917","article-title":"Semaglutide in patients with obesity-related heart failure and type 2 diabetes","volume":"390","author":"Kosiborod","year":"2024","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2024.08.028_bib25","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1016\/S0140-6736(24)00469-0","article-title":"Semaglutide versus placebo in people with obesity-related heart failure with preserved ejection fraction: a pooled analysis of the STEP-HFpEF and STEP-HFpEF DM randomised trials","volume":"403","author":"Butler","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2024.08.028_bib26","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1056\/NEJMoa2107038","article-title":"Empagliflozin in heart failure with a preserved ejection fraction","volume":"385","author":"Anker","year":"2021","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2024.08.028_bib27","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1056\/NEJMoa2206286","article-title":"DapagliFLOZIN IN Heart\u00a0Failure with Mildly Reduced or Preserved Ejection Fraction","volume":"387","author":"Solomon","year":"2022","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2024.08.028_bib28","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1002\/ejhf.3253","article-title":"Finerenone in patients with heart failure with mildly reduced or preserved ejection fraction: rationale and design of the FINEARTS-HF trial","volume":"26","author":"Vaduganathan","year":"2024","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jacc.2024.08.028_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2022.101737","article-title":"Effects of once-weekly semaglutide 2.4\u00a0mg on C-reactive protein in adults with overweight or obesity (STEP 1, 2, and 3): exploratory analyses of three randomised, double-blind, placebo-controlled, phase 3 trials","volume":"55","author":"Verma","year":"2023","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.jacc.2024.08.028_bib30","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1038\/s41591-023-02526-x","article-title":"Semaglutide in HFpEF across obesity class and by body weight reduction: a prespecified analysis of the STEP-HFpEF trial","volume":"29","author":"Borlaug","year":"2023","journal-title":"Nat Med"},{"key":"10.1016\/j.jacc.2024.08.028_bib31","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory therapy with canakinumab for atherosclerotic disease","volume":"377","author":"Ridker","year":"2017","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacc.2024.08.028_bib32","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s44161-022-00032-w","article-title":"Immunometabolic mechanisms of heart failure with preserved ejection fraction","volume":"1","author":"Schiattarella","year":"2022","journal-title":"Nat Cardiovasc Res"},{"key":"10.1016\/j.jacc.2024.08.028_bib33","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1001\/jamacardio.2023.0957","article-title":"Skeletal muscle mitochondrial respiration and exercise intolerance in patients with heart failure with preserved ejection fraction","volume":"8","author":"Scandalis","year":"2023","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jacc.2024.08.028_bib34","article-title":"Metabolism and chronic inflammation: the links between chronic heart failure and comorbidities","volume":"8","author":"Li","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.jacc.2024.08.028_bib35","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jacc.2013.02.092","article-title":"A\u00a0novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation","volume":"62","author":"Paulus","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2024.08.028_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.695952","article-title":"Heart failure syndrome with preserved ejection fraction is a metabolic cluster of nonresolving inflammation in obesity","volume":"8","author":"Tourki","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.jacc.2024.08.028_bib37","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1161\/CIRCRESAHA.121.319077","article-title":"Interleukin-6 signaling and anti-interleukin-6 therapeutics in cardiovascular disease","volume":"128","author":"Ridker","year":"2021","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2024.08.028_bib38","doi-asserted-by":"crossref","first-page":"4832","DOI":"10.1093\/eurheartj\/ehac444","article-title":"Inflammation drives residual risk in chronic kidney disease: a CANTOS substudy","volume":"43","author":"Ridker","year":"2022","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2024.08.028_bib39","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.122.010051","article-title":"Adverse outcomes associated with interleukin-6 in patients recently hospitalized for heart failure with preserved ejection fraction","volume":"16","author":"Mooney","year":"2023","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jacc.2024.08.028_bib40","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.jchf.2019.01.006","article-title":"Central and peripheral determinants of exercise capacity in heart failure patients with preserved ejection fraction","volume":"7","author":"Wolsk","year":"2019","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.jacc.2024.08.028_bib41","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1152\/japplphysiol.00833.2021","article-title":"The impact of obesity on the regulation of muscle blood flow during exercise in patients with heart failure with a preserved ejection fraction","volume":"132","author":"Ratchford","year":"2022","journal-title":"J\u00a0Appl Physiol (1985)"},{"key":"10.1016\/j.jacc.2024.08.028_bib42","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1161\/CIRCHEARTFAILURE.114.001825","article-title":"Mechanisms of exercise intolerance in heart failure with preserved ejection fraction: the role of abnormal peripheral oxygen extraction","volume":"8","author":"Dhakal","year":"2015","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jacc.2024.08.028_bib43","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.jchf.2024.04.016","article-title":"Autoimmune disorders in heart failure with preserved ejection fraction","volume":"16","author":"Tada","year":"2024","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.jacc.2024.08.028_bib44","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1001\/jama.2015.17346","article-title":"Effect of caloric restriction or aerobic exercise training on peak oxygen consumption and quality of life in obese older patients with heart failure with preserved ejection fraction: a randomized clinical trial","volume":"315","author":"Kitzman","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.jacc.2024.08.028_bib45","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jacc.2024.04.022","article-title":"Semaglutide and NT-proBNP in obesity-related HFpEF: insights from the STEP-HFpEF Program","volume":"84","author":"Petrie","year":"2024","journal-title":"J\u00a0Am Coll Cardiol"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109724082342?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109724082342?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T12:16:06Z","timestamp":1738412166000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109724082342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":45,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["S0735109724082342"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2024.08.028","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inflammation in Obesity-Related HFpEF","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2024.08.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}]}}