{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T12:58:53Z","timestamp":1794315533290,"version":"4.9.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.jacc.2024.10.103","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T15:02:32Z","timestamp":1736348552000},"page":"578-591","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":67,"title":["Myocardial Fibroblast Activation After Acute Myocardial Infarction"],"prefix":"10.1016","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7953-3015","authenticated-orcid":false,"given":"Anna K.","family":"Barton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2882-578X","authenticated-orcid":false,"given":"Neil J.","family":"Craig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1378-306X","authenticated-orcid":false,"given":"Krithika","family":"Loganath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shruti","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasiliki","family":"Tsampasian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menaka","family":"Mahendran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Lenell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0038-043X","authenticated-orcid":false,"given":"Evangelos","family":"Tzolos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trisha","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Whittington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Nash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle C.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin J.R.","family":"van Beek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5355-3109","authenticated-orcid":false,"given":"Mark G.","family":"MacAskill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bronwyn","family":"Berkeley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Vezaides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mairi","family":"Brittan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew H.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Sellers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Fletcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clint","family":"Waight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riemer H.J.A.","family":"Slart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Berman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damini","family":"Dey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6110-938X","authenticated-orcid":false,"given":"Piotr","family":"Slomka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Newby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc R.","family":"Dweck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2024.10.103_bib1","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1161\/01.CIR.0000087480.94275.97","article-title":"From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: part I","volume":"108","author":"Naghavi","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2024.10.103_bib2","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1161\/CIRCRESAHA.115.306565","article-title":"Cardiac fibrosis: the fibroblast awakens","volume":"118","author":"Travers","year":"2016","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2024.10.103_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vph.2013.06.002","article-title":"Effects of interleukin-1 on cardiac fibroblast function: relevance to post-myocardial infarction remodelling","volume":"60","author":"Turner","year":"2014","journal-title":"Vascul Pharmacol"},{"key":"10.1016\/j.jacc.2024.10.103_bib4","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.pharmthera.2009.05.002","article-title":"Cardiac fibroblasts: at the heart of myocardial remodeling","volume":"123","author":"Porter","year":"2009","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jacc.2024.10.103_bib5","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jacc.2010.02.047","article-title":"Assessment of nonischemic myocardial fibrosis","volume":"56","author":"Jellis","year":"2010","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2024.10.103_bib6","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.2967\/jnumed.119.226993","article-title":"Molecular imaging of fibroblast activity after myocardial infarction using a (68)Ga-labeled fibroblast activation protein inhibitor, FAPI-04","volume":"60","author":"Varasteh","year":"2019","journal-title":"J\u00a0Nucl Med"},{"key":"10.1016\/j.jacc.2024.10.103_bib7","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1136\/heartjnl-2019-315560","article-title":"Myocardial fibrosis: why image, how to image and clinical implications","volume":"105","author":"Bing","year":"2019","journal-title":"Heart"},{"key":"10.1016\/j.jacc.2024.10.103_bib8","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.crad.2016.02.013","article-title":"Assessment of myocardial fibrosis with T1 mapping MRI","volume":"71","author":"Everett","year":"2016","journal-title":"Clin Radiol"},{"key":"10.1016\/j.jacc.2024.10.103_bib9","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-09790-1","article-title":"Global fibroblast activation throughout the left ventricle but localized fibrosis after myocardial infarction","volume":"7","author":"Nagaraju","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jacc.2024.10.103_bib10","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1016\/j.jacc.2019.02.049","article-title":"Myofibroblast phenotype and reversibility of fibrosis in patients with end-stage heart failure","volume":"73","author":"Nagaraju","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2024.10.103_bib11","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.yjmcc.2015.08.016","article-title":"Fibroblast activation protein alpha expression identifies activated fibroblasts after myocardial infarction","volume":"87","author":"Tillmanns","year":"2015","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1016\/j.jacc.2024.10.103_bib12","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41586-019-1546-z","article-title":"Targeting cardiac fibrosis with engineered T cells","volume":"573","author":"Aghajanian","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.jacc.2024.10.103_bib13","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/ehjci\/jeac242","article-title":"Emerging molecular imaging targets and tools for myocardial fibrosis detection","volume":"24","author":"Barton","year":"2023","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.jacc.2024.10.103_bib14","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1007\/s12350-021-02603-z","article-title":"Imaging of cardiac fibroblast activation in a patient after acute myocardial infarction using (68)Ga-FAPI-04","volume":"29","author":"Notohamiprodjo","year":"2022","journal-title":"J\u00a0Nucl Cardiol"},{"key":"10.1016\/j.jacc.2024.10.103_bib15","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.2967\/jnumed.121.263555","article-title":"Cardiac fibroblast activation in patients early after acute myocardial infarction: integration with magnetic resonance tissue characterization and subsequent functional outcome","volume":"63","author":"Diekmann","year":"2022","journal-title":"J\u00a0Nucl Med"},{"key":"10.1016\/j.jacc.2024.10.103_bib16","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1097\/RLU.0000000000003745","article-title":"Visualization of fibroblast activation after myocardial infarction using 68Ga-FAPI PET","volume":"46","author":"Kessler","year":"2021","journal-title":"Clin Nucl Med"},{"key":"10.1016\/j.jacc.2024.10.103_bib17","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1016\/j.jacc.2021.02.019","article-title":"Molecular imaging identifies fibroblast activation beyond the infarct region after acute myocardial infarction","volume":"77","author":"Diekmann","year":"2021","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2024.10.103_bib18","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s00259-022-06015-0","article-title":"[(68)Ga]Ga-DOTA-FAPI-04 PET\/MR in patients with acute myocardial infarction: potential role of predicting left ventricular remodeling","volume":"50","author":"Zhang","year":"2023","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.jacc.2024.10.103_bib19","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1007\/s12350-020-02307-w","article-title":"Cardiac fibroblast activation detected by Ga-68 FAPI PET imaging as a potential novel biomarker of cardiac injury\/remodeling","volume":"28","author":"Siebermair","year":"2021","journal-title":"J\u00a0Nucl Cardiol"},{"key":"10.1016\/j.jacc.2024.10.103_bib20","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.jcmg.2017.07.008","article-title":"MR\/PET imaging of the cardiovascular system","volume":"10","author":"Robson","year":"2017","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jacc.2024.10.103_bib21","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s12350-011-9496-3","article-title":"Automated quantitative Rb-82 3D PET\/CT myocardial perfusion imaging: normal limits and correlation with invasive coronary angiography","volume":"19","author":"Nakazato","year":"2012","journal-title":"J\u00a0Nucl Cardiol"},{"key":"10.1016\/j.jacc.2024.10.103_bib22","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/s12350-020-02201-5","article-title":"Quantitative assessment of cardiac hypermetabolism and perfusion for diagnosis of cardiac sarcoidosis","volume":"29","author":"Miller","year":"2022","journal-title":"J\u00a0Nucl Cardiol"},{"key":"10.1016\/j.jacc.2024.10.103_bib23","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1161\/hc0402.102975","article-title":"Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association","volume":"105","author":"Cerqueira","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2024.10.103_bib24","doi-asserted-by":"crossref","first-page":"160","DOI":"10.2967\/jnumed.120.244806","article-title":"The latest developments in imaging of fibroblast activation protein","volume":"62","author":"Altmann","year":"2021","journal-title":"J\u00a0Nucl Med"},{"key":"10.1016\/j.jacc.2024.10.103_bib25","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1038\/s41591-021-01452-0","article-title":"Pirfenidone in heart failure with preserved ejection fraction: a randomized phase 2 trial","volume":"27","author":"Lewis","year":"2021","journal-title":"Nat Med"},{"key":"10.1016\/j.jacc.2024.10.103_bib26","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0140-6736(12)61855-8","article-title":"Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial","volume":"381","author":"Teerlink","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2024.10.103_bib27","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/eurheartj\/ehaa898","article-title":"Novel antisense therapy targeting microRNA-132 in patients with heart failure: results of a first-in-human phase 1b randomized, double-blind, placebo-controlled study","volume":"42","author":"T\u00e4ubel","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2024.10.103_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejcb.2023.151288","article-title":"Mechanical stress regulates the mechanotransduction and metabolism of cardiac fibroblasts in fibrotic cardiac diseases","volume":"102","author":"Tian","year":"2023","journal-title":"Eur J Cell Biol"},{"key":"10.1016\/j.jacc.2024.10.103_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115663","article-title":"Promising small molecule anti-fibrotic agents: Newly developed or repositioned drugs targeting myofibroblast transdifferentiation","volume":"214","author":"Ishikane","year":"2023","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jacc.2024.10.103_bib30","first-page":"555","article-title":"Treatment of cardiac fibrosis: from neuro-hormonal inhibitors to CAR-T cell therapy","volume":"28","author":"Morfino","year":"2023","journal-title":"Heart Fail Rev"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109724103154?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109724103154?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T12:48:45Z","timestamp":1740487725000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109724103154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S0735109724103154"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2024.10.103","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Myocardial Fibroblast Activation After Acute Myocardial Infarction","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2024.10.103","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}]}}