{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T22:19:58Z","timestamp":1793398798831,"version":"4.5.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":393,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100008497","name":"Boston Scientific Corp","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.jacc.2025.05.011","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T05:05:41Z","timestamp":1747803941000},"page":"225-238","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Valve Underexpansion and Clinical Outcomes With ACURATE neo2"],"prefix":"10.1016","volume":"86","author":[{"given":"Raj R.","family":"Makkar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarun","family":"Chakravarty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9103-9872","authenticated-orcid":false,"given":"Aakriti","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0758-3539","authenticated-orcid":false,"given":"Osama","family":"Soliman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Gnall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi K.","family":"Ramana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basel","family":"Ramlawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pantelis","family":"Diamantouros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivasa","family":"Potluri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4334-8133","authenticated-orcid":false,"given":"Neal S.","family":"Kleiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Samy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Rassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Thourani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Yakubov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Frawley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhairya","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Kapadia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Chalekian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Modolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janarthanan","family":"Sathananthan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won-Keun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Reardon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2025.05.011_bib1","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1056\/NEJMoa1910555","article-title":"Five-year outcomes of transcatheter or surgical aortic-valve replacement","volume":"382","author":"Makkar","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2025.05.011_bib2","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1056\/NEJMoa2307447","article-title":"Transcatheter aortic-valve replacement in low-risk patients at five years","volume":"389","author":"Mack","year":"2023","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2025.05.011_bib3","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1001\/jamacardio.2022.2695","article-title":"Self-expanding transcatheter vs surgical aortic valve replacement in intermediate-risk patients: 5-year outcomes of the SURTAVI randomized clinical trial","volume":"7","author":"Van Mieghem","year":"2022","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jacc.2025.05.011_bib4","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1056\/NEJMoa1816885","article-title":"Transcatheter aortic-valve replacement with a self-expanding valve in low-risk patients","volume":"380","author":"Popma","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2025.05.011_bib5","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1016\/j.jacc.2023.09.813","article-title":"4-Year outcomes of patients with aortic stenosis in the Evolut low risk trial","volume":"82","author":"Forrest","year":"2023","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2025.05.011_bib6","doi-asserted-by":"crossref","first-page":"83","DOI":"10.4244\/EIJ-D-22-00914","article-title":"Clinical outcomes of the ACURATE neo2 transcatheter heart valve: a prospective, multicenter, observational, post-market surveillance study","volume":"19","author":"Kim","year":"2022","journal-title":"EuroIntervention"},{"key":"10.1016\/j.jacc.2025.05.011_bib7","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1007\/s00392-021-01882-3","article-title":"The ACURATE neo2 valve system for transcatheter aortic valve implantation: 30-day and 1-year outcomes","volume":"110","author":"M\u00f6llmann","year":"2021","journal-title":"Clin Res Cardiol"},{"key":"10.1016\/j.jacc.2025.05.011_bib8","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1016\/S0140-6736(25)00319-8","article-title":"ACURATE neo2 valve versus commercially available transcatheter heart valves in patients with severe aortic stenosis (ACURATE IDE): a multicentre, randomised, controlled, non-inferiority trial","volume":"405(10494)","author":"Makkar","year":"2025","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2025.05.011_bib9","doi-asserted-by":"crossref","first-page":"85","DOI":"10.4244\/EIJ-D-23-00823","article-title":"Outcomes and performance of the ACURATE neo2 transcatheter heart valve in clinical practice: oneyear results of the ACURATE neo2 PMCF Study","volume":"20","author":"Kim","year":"2024","journal-title":"EuroIntervention"},{"key":"10.1016\/j.jacc.2025.05.011_bib10","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.jcin.2022.02.027","article-title":"Transcatheter aortic valve replacement with self-expanding ACURATE neo2. Postprocedural hemodynamic and short-term clinical outcomes","volume":"15","author":"Buono","year":"2022","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.jacc.2025.05.011_bib11","doi-asserted-by":"crossref","first-page":"804","DOI":"10.4244\/EIJ-D-22-00289","article-title":"Haemodynamic performance and clinical outcomes of transcatheter aortic valve replacement with the self-expanding ACURATE neo2","volume":"18","author":"Scotti","year":"2022","journal-title":"EuroIntervention"},{"key":"10.1016\/j.jacc.2025.05.011_bib12","doi-asserted-by":"crossref","first-page":"e951","DOI":"10.4244\/EIJ-D-23-00852","article-title":"Five-year outcomes of transcatheter aortic valve implantation with the ACURATE neo2 valve system","volume":"20","author":"Mollmann","year":"2024","journal-title":"EuroIntervention"},{"key":"10.1016\/j.jacc.2025.05.011_bib13","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/S0140-6736(19)32220-2","article-title":"Safety and efficacy of a self-expanding versus a balloon-expandable bioprosthesis for transcatheter aortic valve replacement in patients with symptomatic severe aortic stenosis: a randomised non-inferiority trial","volume":"394","author":"Lanz","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2025.05.011_bib14","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1161\/CIRCULATIONAHA.120.051547","article-title":"Comparison of self-expanding bioprostheses for transcatheter aortic valve replacement in patients with symptomatic severe aortic stenosis: SCOPE 2 randomized clinical trial","volume":"142","author":"Tamburino","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2025.05.011_bib15","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1007\/s10439-014-1008-6","article-title":"An in vitro evaluation of the impact of eccentric deployment on transcatheter aortic valve hemodynamics","volume":"42","author":"Gunning","year":"2014","journal-title":"Ann Biomed Eng"},{"key":"10.1016\/j.jacc.2025.05.011_bib16","doi-asserted-by":"crossref","first-page":"e105","DOI":"10.1016\/j.jtcvs.2020.10.139","article-title":"The role of flow stasis in transcatheter aortic valve leaflet thrombosis","volume":"164","author":"Trusty","year":"2022","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jacc.2025.05.011_bib17","first-page":"927","article-title":"Valve thrombosis following transcatheter aortic valve replacement: significance of blood stasis on the leaflets","volume":"51","author":"Vahidkhah","year":"2017","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.jacc.2025.05.011_bib18","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/j.jcin.2024.07.018","article-title":"Impact of balloon-expandable TAVR valve deformation and calcium distribution on outcomes in bicuspid aortic valve","volume":"17","author":"Nagasaka","year":"2024","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.jacc.2025.05.011_bib19","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1161\/CIRCULATIONAHA.121.058339","article-title":"Deformation of transcatheter aortic valve prostheses: implications for hypoattenuating leaflet thickening and clinical outcomes","volume":"146","author":"Fukui","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2025.05.011_bib20","doi-asserted-by":"crossref","first-page":"e1067","DOI":"10.4244\/EIJ-D-17-00373","article-title":"Subclinical leaflet thickening and stent frame geometry in self-expanding transcatheter heart valves","volume":"13","author":"Fuchs","year":"2017","journal-title":"EuroIntervention"},{"key":"10.1016\/j.jacc.2025.05.011_bib21","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.124.014617","article-title":"Novel real-time fluoroscopic assessment method of THV expansion following balloon-expandable TAVR","volume":"18","author":"Husain","year":"2025","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.jacc.2025.05.011_bib22","doi-asserted-by":"crossref","first-page":"e28","DOI":"10.15420\/icr.2020.35","article-title":"Pre-dilation and post-dilation in transcatheter aortic valve replacement: indications, benefits and risks","volume":"16","author":"McInerney","year":"2021","journal-title":"Interv Cardiol"},{"key":"10.1016\/j.jacc.2025.05.011_bib23","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1016\/j.jacc.2012.09.001","article-title":"Updated standardized endpoint definitions for transcatheter aortic valve implantation: the Valve Academic Research Consortium-2 consensus document","volume":"60","author":"Kappetein","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2025.05.011_bib24","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1161\/CIRCULATIONAHA.117.029479","article-title":"The fluid mechanics of transcatheter heart valve leaflet thrombosis in the neosinus","volume":"136","author":"Midha","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2025.05.011_bib25","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1016\/j.jcin.2021.09.019","article-title":"Subclinical leaflet thrombosis after transcatheter aortic valve replacement: a meta-analysis","volume":"14","author":"Bogyi","year":"2021","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.jacc.2025.05.011_bib26","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1056\/NEJMoa1509233","article-title":"Possible subclinical leaflet thrombosis in bioprosthetic aortic valves","volume":"373","author":"Makkar","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2025.05.011_bib27","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1016\/S0140-6736(17)30757-2","article-title":"Subclinical leaflet thrombosis in surgical and transcatheter bioprosthetic aortic valves: an observational study","volume":"389","author":"Chakravarty","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2025.05.011_bib28","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.jcin.2025.02.013","article-title":"Clinical impact of midframe underexpansion following TAVR using a self-expanding transcatheter heart valve","volume":"18","author":"Kim","year":"2025","journal-title":"JACC Cardiovasc Interv"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109725064848?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109725064848?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:45:46Z","timestamp":1785307546000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109725064848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S0735109725064848"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2025.05.011","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Valve Underexpansion and Clinical Outcomes With ACURATE neo2","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2025.05.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}