{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:12:17Z","timestamp":1777709537645,"version":"3.51.4"},"reference-count":31,"publisher":"Elsevier BV","issue":"19","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.jacc.2025.07.060","type":"journal-article","created":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T06:39:11Z","timestamp":1756622351000},"page":"1724-1734","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Computed Tomography Angiography or Standard Care After Left Main PCI?"],"prefix":"10.1016","volume":"86","author":[{"given":"Fabrizio","family":"D\u2019Ascenzo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1260-7534","authenticated-orcid":false,"given":"Enrico","family":"Cerrato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ovidio","family":"De Filippo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Gaido","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Franz\u00e8","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Iannaccone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1220-9496","authenticated-orcid":false,"given":"Wojciech","family":"Wa\u0144ha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Santarelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Guiducci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umberto","family":"Barbero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Fernandez Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8168-5280","authenticated-orcid":false,"given":"Marco","family":"Gatti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2805-8090","authenticated-orcid":false,"given":"Matteo","family":"Tebaldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Giammaria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomo","family":"Boccuzzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"Wojakowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"di Pietro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Placido","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastiano","family":"Gili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Depaoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6103-8510","authenticated-orcid":false,"given":"Giuseppe","family":"Biondi Zoccai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Tomassini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0019-0273","authenticated-orcid":false,"given":"Francesco","family":"Bruno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Zugna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Faletti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6074-2370","authenticated-orcid":false,"given":"Simone","family":"Biscaglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"Caglioni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferdinando","family":"Varbella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4940-0876","authenticated-orcid":false,"given":"Gaetano Maria","family":"de Ferrari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Campo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"36","key":"10.1016\/j.jacc.2025.07.060_bib1","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1093\/eurheartj\/ehae177","article-title":"2024 ESC guidelines for the management of chronic coronary syndromes","volume":"45","author":"Vrints","year":"2024","journal-title":"Eur Heart J"},{"issue":"2","key":"10.1016\/j.jacc.2025.07.060_bib2","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jacasi.2021.12.011","article-title":"Percutaneous coronary intervention for left main coronary artery disease: present status and future perspectives","volume":"2","author":"Park","year":"2022","journal-title":"JACC Asia"},{"issue":"11","key":"10.1016\/j.jacc.2025.07.060_bib3","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/j.jacc.2016.05.089","article-title":"Left main coronary artery disease: secular trends in patient characteristics, treatments, and outcomes","volume":"68","author":"Lee","year":"2016","journal-title":"J Am Coll Cardiol"},{"issue":"7","key":"10.1016\/j.jacc.2025.07.060_bib4","doi-asserted-by":"crossref","first-page":"809","DOI":"10.4244\/EIJV9I7A134","article-title":"Two-year outcomes following unprotected left main stenting with first vs new-generation drug-eluting stents: the FINE registry","volume":"9","author":"Buchanan","year":"2013","journal-title":"EuroIntervention"},{"issue":"5","key":"10.1016\/j.jacc.2025.07.060_bib5","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1093\/ehjqcco\/qcaa041","article-title":"Percutaneous vs surgical revascularization for patients with unprotected left main stenosis: a meta-analysis of 5-year follow-up randomized controlled trials","volume":"7","author":"d\u2019Ascenzo","year":"2021","journal-title":"Eur Heart J Qual Care Clin Outcomes"},{"issue":"2","key":"10.1016\/j.jacc.2025.07.060_bib6","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1093\/eurheartj\/ehu383","article-title":"Prognostic role of restenosis in 10 004 patients undergoing routine control angiography after coronary stenting","volume":"36","author":"Cassese","year":"2015","journal-title":"Eur Heart J"},{"issue":"2","key":"10.1016\/j.jacc.2025.07.060_bib7","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jcin.2016.10.018","article-title":"The ReACT trial: randomized evaluation of Routine Follow-up Coronary Angiography After Percutaneous Coronary Intervention Trial","volume":"10","author":"Shiomi","year":"2017","journal-title":"JACC Cardiovasc Interv"},{"issue":"10","key":"10.1016\/j.jacc.2025.07.060_bib8","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1056\/NEJMoa2208335","article-title":"routine functional testing or standard care in high-risk patients after PCI","volume":"387","author":"Park","year":"2022","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2025.07.060_bib9","doi-asserted-by":"crossref","DOI":"10.1007\/s00330-025-11459-7","article-title":"Coronary CT angiography alone versus with CT perfusion: a systematic review and meta-analysis assessing approaches for chest pain","author":"d\u2019Ascenzo","year":"2025","journal-title":"Eur Radiol"},{"key":"10.1016\/j.jacc.2025.07.060_bib10","doi-asserted-by":"crossref","DOI":"10.5402\/2012\/139823","article-title":"CT imaging of coronary stents: past, present, and future","volume":"2012","author":"Mahnken","year":"2012","journal-title":"ISRN Cardiol"},{"issue":"2","key":"10.1016\/j.jacc.2025.07.060_bib11","doi-asserted-by":"crossref","DOI":"10.1136\/openhrt-2020-001253","article-title":"Angiographic control versus ischaemia-driven management of patients undergoing percutaneous revascularisation of the unprotected left main coronary artery with second-generation drug-eluting stents: rationale and design of the PULSE trial","volume":"7","author":"de Filippo","year":"2020","journal-title":"Open Heart"},{"issue":"6","key":"10.1016\/j.jacc.2025.07.060_bib12","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jcct.2016.10.002","article-title":"Society of Cardiovascular Computed Tomography guidelines for the performance and acquisition of coronary computed tomography angiography","volume":"10","author":"Abbara","year":"2016","journal-title":"J Cardiovasc Comput Tomogr"},{"issue":"5","key":"10.1016\/j.jacc.2025.07.060_bib13","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.jcct.2014.07.003","article-title":"SCCT guidelines for the interpretation and reporting of coronary CT angiography: a report of the Society of Cardiovascular Computed Tomography Guidelines Committee","volume":"8","author":"Leipsic","year":"2014","journal-title":"J Cardiovasc Comput Tomogr"},{"issue":"2","key":"10.1016\/j.jacc.2025.07.060_bib14","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/eurheartj\/ehy394","article-title":"2018 ESC\/EACTS guidelines on myocardial revascularization","volume":"40","author":"Neumann","year":"2019","journal-title":"Eur Heart J"},{"issue":"18","key":"10.1016\/j.jacc.2025.07.060_bib15","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/j.jacc.2018.08.1038","volume":"72","author":"Thygesen","year":"2018","journal-title":"J Am Coll Cardiol"},{"issue":"9","key":"10.1016\/j.jacc.2025.07.060_bib16","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1161\/CIRCULATIONAHA.117.033502","article-title":"Standardized Data Collection for Cardiovascular Trials Initiative (SCTI). 2017 cardiovascular and stroke endpoint definitions for clinical trials","volume":"137","author":"Hicks","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2025.07.060_bib17","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/j.jacc.2010.10.041","article-title":"Incidence, predictors, treatment, and long-term prognosis of patients with restenosis after drug- eluting stent implantation for unprotected left main coronary artery disease","volume":"57","author":"Lee","year":"2011","journal-title":"J Am Coll Card"},{"issue":"5","key":"10.1016\/j.jacc.2025.07.060_bib18","doi-asserted-by":"crossref","first-page":"582","DOI":"10.5603\/CJ.a2018.0092","article-title":"Clinical impact of routine angiographic follow-up after percutaneous coronary interventions on unprotected left main","volume":"25","author":"Aurigemma","year":"2018","journal-title":"Cardiol J"},{"issue":"7","key":"10.1016\/j.jacc.2025.07.060_bib19","first-page":"1616","article-title":"Twenty years of experience in one thousand de-novo left main coronary angioplasty with angiographic control in a high-volume centre without on-site cardiac surgery","volume":"105","author":"Franz\u00e9","year":"2025","journal-title":"Catheter Cardiovasc Interv"},{"issue":"10","key":"10.1016\/j.jacc.2025.07.060_bib20","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1056\/NEJMoa1805971","article-title":"Coronary CT angiography and 5-year risk of myocardial infarction","volume":"379","author":"Newby","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2025.07.060_bib21","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.ijcard.2017.10.084","article-title":"Diagnostic performance of coronary CT angiography carried out with a novel whole-heart coverage high-definition CT scanner in patients with high heart rate","volume":"257","author":"Andreini","year":"2018","journal-title":"Int. J. Cardiol"},{"key":"10.1016\/j.jacc.2025.07.060_bib22","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.jcmg.2018.09.018","article-title":"Selective referral using CCTA versus direct referral for individuals referred to invasive coronary angiography for suspected CAD","volume":"12","author":"Chang","year":"2019","journal-title":"JACC Cardiovasc Imaging"},{"issue":"7","key":"10.1016\/j.jacc.2025.07.060_bib23","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1161\/CIRCULATIONAHA.105.608950","article-title":"Multislice spiral computed tomography for the evaluation of stent patency after left main coronary artery stenting: a comparison with conventional coronary angiography and intravascular ultrasound","volume":"114","author":"van Mieghem","year":"2006","journal-title":"Circulation"},{"issue":"9","key":"10.1016\/j.jacc.2025.07.060_bib24","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.jacc.2023.12.027","article-title":"Surveillance stress testing after percutaneous intervention for patients with multivessel or left main coronary disease","volume":"83","author":"Lee","year":"2024","journal-title":"J Am Coll Cardiol"},{"issue":"13","key":"10.1016\/j.jacc.2025.07.060_bib25","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1161\/CIRCULATIONAHA.120.049755","article-title":"Outcomes in the ISCHEMIA trial based on coronary artery disease and ischemia severity","volume":"144","author":"Reynolds","year":"2021","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.jacc.2025.07.060_bib26","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1056\/NEJMoa1803538","article-title":"Five-year outcomes with PCI guided by fractional flow reserve","volume":"379","author":"Xaplanteris","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2025.07.060_bib27","article-title":"Impact of intravascular ultrasound for coronary bifurcations treated with last generations stents: insights from the BIFURCAT-ULTRA registry","author":"Bruno","year":"2024","journal-title":"Eur Heart J Qual Care Clin Outcomes"},{"issue":"6","key":"10.1016\/j.jacc.2025.07.060_bib28","doi-asserted-by":"crossref","first-page":"e318","DOI":"10.4244\/EIJ-D-24-00471","article-title":"Final kissing balloon dilatation in patients with coronary bifurcation lesions treated with an upfront provisional stenting strategy","volume":"21","author":"de Filippo","year":"2025","journal-title":"EuroIntervention"},{"issue":"5","key":"10.1016\/j.jacc.2025.07.060_bib29","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.jacc.2009.03.063","volume":"54","author":"Prasad","year":"2009","journal-title":"J Am Coll Cardiol"},{"issue":"7","key":"10.1016\/j.jacc.2025.07.060_bib30","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.amjcard.2016.12.005","article-title":"Incidence and management of restenosis after treatment of unprotected left main disease with second-generation drug-eluting stents (from Failure in Left Main Study With Second Generation Stents\u2014Cardiogroup III Study)","volume":"119","author":"d\u2019Ascenzo","year":"2017","journal-title":"Am J Cardiol"},{"issue":"9","key":"10.1016\/j.jacc.2025.07.060_bib31","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.121.011693","article-title":"Prevalence and impact of neoatherosclerosis on clinical outcomes after percutaneous treatment of second-generation drug-eluting stent restenosis","volume":"15","author":"Chen","year":"2022","journal-title":"Circ Cardiovasc Interv"}],"container-title":["JACC"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109725074017?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109725074017?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T01:35:55Z","timestamp":1772847355000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109725074017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":31,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S0735109725074017"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2025.07.060","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Computed Tomography Angiography or Standard Care After Left Main PCI?","name":"articletitle","label":"Article Title"},{"value":"JACC","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2025.07.060","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}