{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:44:40Z","timestamp":1793317480855,"version":"4.5.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T00:00:00Z","timestamp":1758326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011635","name":"Chinese Academy of Medical Sciences and Peking Union Medical College Fuwai Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011635","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.jacc.2025.08.092","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T15:23:38Z","timestamp":1760541818000},"page":"4-16","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of Intensive Blood Pressure Control in Patients With Frailty"],"prefix":"10.1016","volume":"87","author":[{"given":"Shitian","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofang","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingshan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieyun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiqing","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaojuan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2025.08.092_bib1","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/S0140-6736(19)31786-6","article-title":"Frailty: implications for clinical practice and public health","volume":"394","author":"Hoogendijk","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2025.08.092_bib2","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1093\/gerona\/62.7.731","article-title":"Frailty: an emerging research and clinical paradigm--issues and controversies","volume":"62","author":"Bergman","year":"2007","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.jacc.2025.08.092_bib3","doi-asserted-by":"crossref","DOI":"10.1093\/ageing\/afac054","article-title":"A multi-centre cohort study on healthcare use due to medication-related harm: the role of frailty and polypharmacy","volume":"51","author":"Stevenson","year":"2022","journal-title":"Age Ageing"},{"key":"10.1016\/j.jacc.2025.08.092_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1004223","article-title":"The association between antihypertensive treatment and serious adverse events by age and frailty: A cohort study","volume":"20","author":"Sheppard","year":"2023","journal-title":"PLoS Med"},{"key":"10.1016\/j.jacc.2025.08.092_bib5","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1161\/CIRCULATIONAHA.123.064003","article-title":"The effect of frailty on the efficacy and safety of intensive blood pressure control: a post hoc analysis of the SPRINT trial","volume":"148","author":"Wang","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2025.08.092_bib6","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1136\/heartjnl-2024-324360","article-title":"The impact of frailty on the effectiveness of intensive blood pressure control for patients with type 2 diabetes: a secondary analysis of a randomised controlled trial","volume":"111","author":"Wenjie","year":"2025","journal-title":"Heart"},{"key":"10.1016\/j.jacc.2025.08.092_bib7","doi-asserted-by":"crossref","first-page":"3912","DOI":"10.1093\/eurheartj\/ehae178","article-title":"2024 ESC Guidelines for the management of elevated blood pressure and hypertension","volume":"45","author":"McEvoy","year":"2024","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2025.08.092_bib8","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1038\/s41440-023-01310-1","article-title":"Current issues in frailty and hypertension management","volume":"46","author":"Yamamoto","year":"2023","journal-title":"Hypertens Res"},{"key":"10.1016\/j.jacc.2025.08.092_bib9","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0140-6736(24)01261-3","article-title":"Mounting evidence in favour of the lower, the better blood pressure paradigm","volume":"404","author":"Rahimi","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2025.08.092_bib10","doi-asserted-by":"crossref","DOI":"10.1093\/ageing\/afab192","article-title":"Do we AGREE on the targets of antihypertensive drug treatment in older adults: a systematic review of guidelines on primary prevention of cardiovascular diseases","volume":"51","author":"Bogaerts","year":"2022","journal-title":"Age Ageing"},{"key":"10.1016\/j.jacc.2025.08.092_bib11","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ahj.2022.12.003","article-title":"Rationale and design of the Effects of intensive Systolic blood Pressure lowering treatment in reducing RIsk of vascular evenTs (ESPRIT): a multicenter open-label randomized controlled trial","volume":"257","author":"Liu","year":"2023","journal-title":"Am Heart J"},{"key":"10.1016\/j.jacc.2025.08.092_bib12","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0140-6736(24)01028-6","article-title":"Lowering systolic blood pressure to less than 120 mm Hg versus less than 140 mm Hg in patients with high cardiovascular risk with and without diabetes or previous stroke: an open-label, blinded-outcome, randomised trial","volume":"404","author":"Liu","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2025.08.092_bib13","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.jacc.2022.06.037","article-title":"Sacubitril\/valsartan and frailty in patients with heart failure and preserved ejection fraction","volume":"80","author":"Butt","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2025.08.092_bib14","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1161\/CIRCULATIONAHA.122.061754","article-title":"Efficacy and safety of dapagliflozin according to frailty in patients with heart failure: a prespecified analysis of the DELIVER Trial","volume":"146","author":"Butt","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2025.08.092_bib15","doi-asserted-by":"crossref","DOI":"10.1093\/ageing\/afad221","article-title":"How to construct a frailty index from an existing dataset in 10 steps","volume":"52","author":"Theou","year":"2023","journal-title":"Age Ageing"},{"key":"10.1016\/j.jacc.2025.08.092_bib16","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12916-015-0328-1","volume":"13","author":"Warwick","year":"2015","journal-title":"BMC Med"},{"key":"10.1016\/j.jacc.2025.08.092_bib17","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1093\/gerona\/glv228","article-title":"Characterizing frailty status in the systolic blood pressure intervention trial","volume":"71","author":"Pajewski","year":"2016","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.jacc.2025.08.092_bib18","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.2337\/dc20-2664","article-title":"The impact of frailty on the effectiveness and safety of intensive glucose control and blood pressure-lowering therapy for people with type 2 diabetes: results from the ADVANCE trial","volume":"44","author":"Nguyen","year":"2021","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jacc.2025.08.092_bib19","article-title":"Prevalence, awareness, treatment, and control of hypertension in China,. 2004-18: findings from six rounds of a national survey","volume":"380","author":"Zhang","year":"2023","journal-title":"BMJ"},{"key":"10.1016\/j.jacc.2025.08.092_bib20","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14029","article-title":"Effect of canakinumab on frailty: a post hoc analysis of the CANTOS trial","volume":"23","author":"Orkaby","year":"2024","journal-title":"Aging Cell"},{"key":"10.1016\/j.jacc.2025.08.092_bib21","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/s12916-018-1174-8","article-title":"Effect of 24-month physical activity on cognitive frailty and the role of inflammation: the LIFE randomized clinical trial","volume":"16","author":"Liu","year":"2018","journal-title":"BMC Med"},{"key":"10.1016\/j.jacc.2025.08.092_bib22","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1186\/s12916-020-01870-w","article-title":"Clinical outcomes in patients with atrial fibrillation and frailty: insights from the ENGAGE AF-TIMI 48 trial","volume":"18","author":"Wilkinson","year":"2020","journal-title":"BMC Med"},{"key":"10.1016\/j.jacc.2025.08.092_bib23","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/jcsm.13393","article-title":"Efficacy of empagliflozin in heart failure with preserved ejection fraction according to frailty status in EMPEROR-Preserved","volume":"15","author":"Coats","year":"2024","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.jacc.2025.08.092_bib24","doi-asserted-by":"crossref","first-page":"e96","DOI":"10.1016\/S2666-7568(20)30059-3","article-title":"Changes in the severity and lethality of age-related health deficit accumulation in the USA between 1999 and. 2018: a population-based cohort study","volume":"2","author":"Blodgett","year":"2021","journal-title":"Lancet Healthy Longev"},{"key":"10.1016\/j.jacc.2025.08.092_bib25","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1002\/alz.12708","article-title":"Cardiometabolic multimorbidity accelerates cognitive decline and dementia progression","volume":"19","author":"Dove","year":"2023","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.jacc.2025.08.092_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2023.102265","article-title":"Chronic diseases and multimorbidity patterns, their recent onset, and risk of new-onset Parkinson's disease and related functional degeneration in older adults: a prospective cohort study","volume":"65","author":"Ren","year":"2023","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.jacc.2025.08.092_bib27","doi-asserted-by":"crossref","DOI":"10.1093\/ageing\/afac185","article-title":"Frailty: understanding the difference between age and ageing","volume":"51","author":"Gordon","year":"2022","journal-title":"Age Ageing"},{"key":"10.1016\/j.jacc.2025.08.092_bib28","doi-asserted-by":"crossref","first-page":"M146","DOI":"10.1093\/gerona\/56.3.M146","article-title":"Frailty in older adults: evidence for a phenotype","volume":"56","author":"Fried","year":"2001","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.jacc.2025.08.092_bib29","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1056\/NEJMra2301292","article-title":"Frailty in older adults","volume":"391","author":"Kim","year":"2024","journal-title":"N Engl J Med"}],"container-title":["JACC"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109725077836?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109725077836?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:59:52Z","timestamp":1788307192000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109725077836"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S0735109725077836"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2025.08.092","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of Intensive Blood Pressure Control in Patients With Frailty","name":"articletitle","label":"Article Title"},{"value":"JACC","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2025.08.092","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}]}}